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Gene: PDE4A (phosphodiesterase 4A) Homo sapiens
Symbol: PDE4A
Name: phosphodiesterase 4A
Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase; DPDE2; PDE4; PDE46; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog; phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4
Mus musculus (house mouse) : Pde4a (phosphodiesterase 4A, cAMP specific)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde4a (phosphodiesterase 4A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4a (phosphodiesterase 4A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4A (phosphodiesterase 4A)
Canis lupus familiaris (dog) : PDE4A (phosphodiesterase 4A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4a (phosphodiesterase 4A)
Sus scrofa (pig) : PDE4A (phosphodiesterase 4A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,416,773 - 10,469,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,527,449 - 10,580,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,424,637 - 10,441,306 (+)NCBINCBI36hg18NCBI36
Build 341910,424,636 - 10,441,306NCBI
Celera1910,426,030 - 10,475,005 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,107,514 - 10,160,337 (+)NCBIHuRef
CHM1_11910,528,205 - 10,581,112 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDE4A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737080
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.