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Gene: SMC1A (structural maintenance of chromosomes 1A) Homo sapiens
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Symbol: SMC1A
Name: structural maintenance of chromosomes 1A
Description: Exhibits chromatin binding activity and protein heterodimerization activity. Involved in several processes, including regulation of mitotic spindle assembly; response to DNA damage checkpoint signaling; and sister chromatid cohesion. Localizes to several cellular components, including the chromosome; mitotic spindle pole; and nuclear lumen. Implicated in Cornelia de Lange syndrome 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDLS2; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; smc-like 1 (yeast); SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1alpha; SMC1L1; SMCB; structural maintenance of chromosomes protein 1A
Orthologs:
Mus musculus (house mouse) : Smc1a (structural maintenance of chromosomes 1A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smc1a (structural maintenance of chromosomes 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smc1a (structural maintenance of chromosomes 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : SMC1A (structural maintenance of chromosomes 1A)
Canis lupus familiaris (dog) : SMC1A (structural maintenance of chromosomes 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smc1a (structural maintenance of chromosomes 1A)
Sus scrofa (pig) : SMC1A (structural maintenance of chromosomes 1A)
Chlorocebus sabaeus (African green monkey) : SMC1A (structural maintenance of chromosomes 1A)
Heterocephalus glaber (naked mole-rat) : Smc1a (structural maintenance of chromosomes 1A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX53,374,149 - 53,422,728 (-)Ensembl
GRCh38X53,374,149 - 53,422,728 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,401,070 - 53,449,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,417,795 - 53,466,343 (-)NCBINCBI36hg18NCBI36
Build 34X53,284,090 - 53,332,639NCBI
CeleraX57,232,626 - 57,281,175 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,459,360 - 50,507,305 (-)NCBIHuRef
CHM1_1X53,391,525 - 53,440,144 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
Position Markers
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
 
More on SMC1A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737070
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.