KAT7 (lysine acetyltransferase 7) - Rat Genome Database

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Gene: KAT7 (lysine acetyltransferase 7) Homo sapiens
Analyze
Symbol: KAT7
Name: lysine acetyltransferase 7
RGD ID: 737003
HGNC Page HGNC:17016
Description: Enables DNA replication origin binding activity and histone acetyltransferase activity. Involved in several processes, including histone acetylation; positive regulation of hematopoietic stem cell proliferation; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; histone acetyltransferase complex; and site of DNA damage. Part of histone H3-K14 acetyltransferase complex. Biomarker of androgen insensitivity syndrome and breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HBO1; HBOA; histone acetyltransferase binding to ORC1; histone acetyltransferase KAT7; histone acetyltransferase MYST2; K(lysine) acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; MYST-2; MYST2; ZC2HC7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: KAT7P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,788,681 - 49,835,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1749,788,648 - 49,835,026 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,866,043 - 47,912,388 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,221,070 - 45,261,457 (+)NCBINCBI36hg18NCBI36
Build 341745,221,069 - 45,261,455NCBI
Celera1744,321,054 - 44,361,451 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1743,230,982 - 43,271,467 (+)NCBIHuRef
CHM1_11747,929,929 - 47,970,416 (+)NCBICHM1_1
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to DNA damage stimulus  (IEA)
chromatin organization  (IEA)
DNA repair  (IEA)
DNA replication  (IDA,IEA)
DNA-templated transcription  (IEA)
histone acetylation  (IEA)
histone H3 acetylation  (IDA)
histone H3-K14 acetylation  (IDA,IEA)
histone H3-K4 acetylation  (IEA)
histone H4 acetylation  (IDA)
histone H4-K12 acetylation  (IDA)
histone H4-K16 acetylation  (IDA)
histone H4-K5 acetylation  (IDA)
histone H4-K8 acetylation  (IDA)
histone modification  (IDA)
internal peptidyl-lysine acetylation  (IDA)
natural killer cell differentiation  (IEA,ISS)
negative regulation of DNA-templated transcription  (IBA)
positive regulation of DNA replication  (IDA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of DNA-templated transcription, elongation  (IEA,ISS)
positive regulation of erythrocyte differentiation  (IEA)
positive regulation of hematopoietic stem cell proliferation  (IDA,IEA)
positive regulation of histone H4 acetylation  (IMP)
positive regulation of protein localization to nucleus  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP)
regulation of cell cycle  (IDA)
regulation of cell growth  (IDA)
regulation of DNA biosynthetic process  (IDA)
regulation of DNA replication  (IDA)
regulation of DNA-templated DNA replication initiation  (IDA)
regulation of DNA-templated transcription  (IDA,IEA,TAS)
regulation of nucleotide-excision repair  (IDA)
response to actinomycin D  (IMP)
response to anisomycin  (IMP)
response to dithiothreitol  (IMP)
response to hydroxyurea  (IMP)
response to sorbitol  (IMP)
stress-activated protein kinase signaling cascade  (IDA)
transcription initiation-coupled chromatin remodeling  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Expression and characterization of androgen receptor coregulators, SRC-2 and HBO1, during human testis ontogenesis and in androgen signaling deficient patients. Vija L, etal., Mol Cell Endocrinol. 2013 Aug 15;375(1-2):140-8. doi: 10.1016/j.mce.2013.05.004. Epub 2013 May 24.
6. Estrogen receptor alpha (ERalpha) mediates 17beta-estradiol (E2)-activated expression of HBO1. Wang WZ, etal., J Exp Clin Cancer Res. 2010 Nov 1;29:140. doi: 10.1186/1756-9966-29-140.
Additional References at PubMed
PMID:10438470   PMID:10737800   PMID:10930412   PMID:11278932   PMID:11978794   PMID:12034878   PMID:12477932   PMID:14702039   PMID:15383276   PMID:15489334   PMID:15963510   PMID:16096645  
PMID:16169070   PMID:16189514   PMID:16387653   PMID:16428461   PMID:16645042   PMID:16880509   PMID:16964243   PMID:17081983   PMID:17182677   PMID:17954561   PMID:18250300   PMID:18684714  
PMID:18832067   PMID:19187766   PMID:19372580   PMID:19393168   PMID:19454010   PMID:19913121   PMID:20053357   PMID:20129055   PMID:20628086   PMID:20980834   PMID:21753189   PMID:21832049  
PMID:21856198   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22144582   PMID:22334692   PMID:22898364   PMID:23188630   PMID:23319590   PMID:23508102   PMID:23955388   PMID:24065767  
PMID:24125069   PMID:24457600   PMID:24739512   PMID:24981860   PMID:25281560   PMID:25693804   PMID:25743411   PMID:26072331   PMID:26186194   PMID:26221039   PMID:26496610   PMID:26572825  
PMID:26620551   PMID:26625199   PMID:26673895   PMID:26687479   PMID:27142060   PMID:27247147   PMID:27248496   PMID:27270040   PMID:27634302   PMID:27926873   PMID:28334966   PMID:28514442  
PMID:28552525   PMID:28719581   PMID:28769019   PMID:28796367   PMID:28977666   PMID:28986522   PMID:29382722   PMID:29467282   PMID:29507755   PMID:30415952   PMID:30554943   PMID:30745998  
PMID:30759370   PMID:30804502   PMID:30833792   PMID:30940648   PMID:31091453   PMID:31504794   PMID:31535175   PMID:31582837   PMID:31586073   PMID:31678930   PMID:31753913   PMID:31754246  
PMID:31767635   PMID:31827282   PMID:32021140   PMID:32164722   PMID:32296183   PMID:32416067   PMID:32423237   PMID:32694731   PMID:32764680   PMID:32780723   PMID:32897418   PMID:33301849  
PMID:33318144   PMID:33543443   PMID:33658012   PMID:33754016   PMID:33961781   PMID:34079125   PMID:34259319   PMID:34373451   PMID:34431785   PMID:35271311   PMID:35637972  


Genomics

Comparative Map Data
KAT7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381749,788,681 - 49,835,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1749,788,648 - 49,835,026 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,866,043 - 47,912,388 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,221,070 - 45,261,457 (+)NCBINCBI36hg18NCBI36
Build 341745,221,069 - 45,261,455NCBI
Celera1744,321,054 - 44,361,451 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1743,230,982 - 43,271,467 (+)NCBIHuRef
CHM1_11747,929,929 - 47,970,416 (+)NCBICHM1_1
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Kat7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,162,679 - 95,201,085 (-)NCBIGRCm39mm39
GRCm39 Ensembl1195,165,085 - 95,201,072 (-)Ensembl
GRCm381195,271,853 - 95,310,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,274,259 - 95,310,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,135,573 - 95,171,515 (-)NCBIGRCm37mm9NCBIm37
MGSCv361195,090,349 - 95,126,291 (-)NCBImm8
Celera11104,888,945 - 104,929,711 (-)NCBICelera
Cytogenetic Map11DNCBI
Kat7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21080,221,519 - 80,255,590 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1080,221,524 - 80,255,567 (-)Ensembl
Rnor_6.01083,095,067 - 83,128,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,095,068 - 83,128,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,905,360 - 82,938,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,960,245 - 83,995,124 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11083,974,615 - 84,009,494 (-)NCBI
Celera1078,993,963 - 79,027,148 (-)NCBICelera
Cytogenetic Map10q26NCBI
Kat7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,770,201 - 11,802,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,770,201 - 11,802,992 (-)NCBIChiLan1.0ChiLan1.0
KAT7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11748,605,488 - 48,645,784 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,605,488 - 48,645,784 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01743,875,921 - 43,916,352 (+)NCBIMhudiblu_PPA_v0panPan3
KAT7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,841,916 - 25,875,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,842,054 - 25,873,674 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,299,759 - 25,333,077 (+)NCBI
ROS_Cfam_1.0926,636,607 - 26,669,932 (+)NCBI
ROS_Cfam_1.0 Ensembl926,636,747 - 26,669,932 (+)Ensembl
UMICH_Zoey_3.1925,404,467 - 25,437,791 (+)NCBI
UNSW_CanFamBas_1.0925,663,435 - 25,696,975 (+)NCBI
UU_Cfam_GSD_1.0925,792,761 - 25,826,342 (+)NCBI
Kat7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,269,839 - 25,299,915 (+)NCBI
SpeTri2.0NW_00493649011,775,224 - 11,805,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,970,962 - 26,008,302 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,970,966 - 26,005,006 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,975,192 - 26,009,289 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,508,888 - 43,548,411 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,510,483 - 43,548,517 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607714,224,947 - 14,264,537 (-)NCBIVero_WHO_p1.0
Kat7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,859,443 - 5,892,527 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247955,859,974 - 5,892,519 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
GDB:451733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,906,276 - 47,906,398UniSTSGRCh37
GRCh37X95,226,797 - 95,226,919UniSTSGRCh37
Build 36X95,113,453 - 95,113,575RGDNCBI36
Celera1744,361,269 - 44,361,391UniSTS
CeleraX95,750,788 - 95,750,910RGD
Cytogenetic Map17q21.32UniSTS
Cytogenetic MapXq21.33UniSTS
HuRef1743,271,285 - 43,271,407UniSTS
HuRefX85,036,753 - 85,036,875UniSTS
WI-14886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,899,121 - 47,899,270UniSTSGRCh37
Build 361745,254,120 - 45,254,269RGDNCBI36
Celera1744,354,114 - 44,354,263RGD
Cytogenetic Map17q21.32UniSTS
HuRef1743,264,130 - 43,264,279UniSTS
GeneMap99-GB4 RH Map17344.85UniSTS
Whitehead-RH Map17390.0UniSTS
NCBI RH Map17638.1UniSTS
MYST2_7995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,905,737 - 47,906,658UniSTSGRCh37
Build 361745,260,736 - 45,261,657RGDNCBI36
Celera1744,360,730 - 44,361,651RGD
HuRef1743,270,746 - 43,271,667UniSTS
DXS7479  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,906,255 - 47,906,454UniSTSGRCh37
GRCh37X95,226,741 - 95,226,940UniSTSGRCh37
Build 36X95,113,397 - 95,113,596RGDNCBI36
CeleraX95,750,732 - 95,750,931RGD
Celera1744,361,248 - 44,361,447UniSTS
Cytogenetic MapXq21.33UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1743,271,264 - 43,271,463UniSTS
HuRefX85,036,697 - 85,036,896UniSTS
Whitehead-YAC Contig MapX UniSTS
RH11199  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371747,906,276 - 47,906,400UniSTSGRCh37
GRCh37X95,226,795 - 95,226,919UniSTSGRCh37
Build 36X95,113,451 - 95,113,575RGDNCBI36
CeleraX95,750,786 - 95,750,910RGD
Celera1744,361,269 - 44,361,393UniSTS
Cytogenetic MapXq21.33UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1743,271,285 - 43,271,409UniSTS
HuRefX85,036,751 - 85,036,875UniSTS
GeneMap99-GB4 RH Map17340.46UniSTS
NCBI RH Map17604.8UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5704
Count of miRNA genes:1050
Interacting mature miRNAs:1301
Transcripts:ENST00000259021, ENST00000424009, ENST00000435742, ENST00000454930, ENST00000503101, ENST00000503635, ENST00000503935, ENST00000506533, ENST00000508594, ENST00000509124, ENST00000509773, ENST00000509794, ENST00000510426, ENST00000510819, ENST00000512616, ENST00000513075, ENST00000513171, ENST00000513980, ENST00000514540
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1640 1510 1060 203 1104 108 3742 1157 1906 284 1395 1458 110 1 741 2305 5 2
Low 799 1477 666 421 846 357 615 1037 1828 135 65 155 65 463 483 1
Below cutoff 4 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_051976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011524235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC015795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC027801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF140360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF217502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW889189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC306552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000259021   ⟹   ENSP00000259021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,681 - 49,835,026 (+)Ensembl
RefSeq Acc Id: ENST00000424009   ⟹   ENSP00000398961
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,706 - 49,829,096 (+)Ensembl
RefSeq Acc Id: ENST00000435742   ⟹   ENSP00000409477
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,789,653 - 49,829,096 (+)Ensembl
RefSeq Acc Id: ENST00000454930   ⟹   ENSP00000413415
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,681 - 49,827,703 (+)Ensembl
RefSeq Acc Id: ENST00000503101
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,824,482 - 49,827,762 (+)Ensembl
RefSeq Acc Id: ENST00000503635
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,826,002 - 49,827,130 (+)Ensembl
RefSeq Acc Id: ENST00000506533   ⟹   ENSP00000421368
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,789,312 - 49,798,494 (+)Ensembl
RefSeq Acc Id: ENST00000508594
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,815,398 - 49,821,748 (+)Ensembl
RefSeq Acc Id: ENST00000509124
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,714 - 49,815,896 (+)Ensembl
RefSeq Acc Id: ENST00000509773   ⟹   ENSP00000424577
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,682 - 49,827,617 (+)Ensembl
RefSeq Acc Id: ENST00000509794
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,821,493 - 49,826,706 (+)Ensembl
RefSeq Acc Id: ENST00000510426
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,821,685 - 49,823,643 (+)Ensembl
RefSeq Acc Id: ENST00000510819   ⟹   ENSP00000423385
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,693 - 49,827,800 (+)Ensembl
RefSeq Acc Id: ENST00000512616
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,815,390 - 49,827,584 (+)Ensembl
RefSeq Acc Id: ENST00000513075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,823,234 - 49,826,377 (+)Ensembl
RefSeq Acc Id: ENST00000513171
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,814,952 - 49,826,706 (+)Ensembl
RefSeq Acc Id: ENST00000513980
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,815,332 - 49,827,816 (+)Ensembl
RefSeq Acc Id: ENST00000514540
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,815,031 - 49,826,713 (+)Ensembl
RefSeq Acc Id: ENST00000675278   ⟹   ENSP00000502732
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1749,788,648 - 49,829,090 (+)Ensembl
RefSeq Acc Id: NM_001199155   ⟹   NP_001186084
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
GRCh371747,865,922 - 47,906,458 (+)NCBI
HuRef1743,230,982 - 43,271,467 (+)ENTREZGENE
CHM1_11747,929,929 - 47,970,416 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001199156   ⟹   NP_001186085
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
GRCh371747,865,922 - 47,906,458 (+)NCBI
HuRef1743,230,982 - 43,271,467 (+)ENTREZGENE
CHM1_11747,929,929 - 47,970,416 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001199157   ⟹   NP_001186086
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
GRCh371747,865,922 - 47,906,458 (+)NCBI
HuRef1743,230,982 - 43,271,467 (+)ENTREZGENE
CHM1_11747,929,929 - 47,970,416 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001199158   ⟹   NP_001186087
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
GRCh371747,865,922 - 47,906,458 (+)NCBI
HuRef1743,230,982 - 43,271,467 (+)ENTREZGENE
CHM1_11747,929,929 - 47,970,416 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001346706   ⟹   NP_001333635
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007067   ⟹   NP_008998
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,835,026 (+)NCBI
GRCh371747,865,922 - 47,906,458 (+)NCBI
Build 361745,221,070 - 45,261,457 (+)NCBI Archive
HuRef1743,230,982 - 43,271,467 (+)ENTREZGENE
CHM1_11747,929,929 - 47,970,416 (+)NCBI
T2T-CHM13v2.01750,651,771 - 50,698,127 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_008998   ⟸   NM_007067
- Peptide Label: isoform 1
- UniProtKB: O95251 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186084   ⟸   NM_001199155
- Peptide Label: isoform 2
- UniProtKB: O95251 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186086   ⟸   NM_001199157
- Peptide Label: isoform 4
- UniProtKB: O95251 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186085   ⟸   NM_001199156
- Peptide Label: isoform 3
- UniProtKB: O95251 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001186087   ⟸   NM_001199158
- Peptide Label: isoform 5
- UniProtKB: O95251 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001333635   ⟸   NM_001346706
- Peptide Label: isoform 6
- Sequence:
RefSeq Acc Id: ENSP00000398961   ⟸   ENST00000424009
RefSeq Acc Id: ENSP00000421368   ⟸   ENST00000506533
RefSeq Acc Id: ENSP00000413415   ⟸   ENST00000454930
RefSeq Acc Id: ENSP00000259021   ⟸   ENST00000259021
RefSeq Acc Id: ENSP00000424577   ⟸   ENST00000509773
RefSeq Acc Id: ENSP00000423385   ⟸   ENST00000510819
RefSeq Acc Id: ENSP00000409477   ⟸   ENST00000435742
RefSeq Acc Id: ENSP00000502732   ⟸   ENST00000675278
Protein Domains
MYST-type HAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O95251-F1-model_v2 AlphaFold O95251 1-611 view protein structure

Promoters
RGD ID:6794380
Promoter ID:HG_KWN:26540
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000259021,   UC002IPL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361745,220,451 - 45,221,262 (+)MPROMDB
RGD ID:6811268
Promoter ID:HG_ACW:35193
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:MYST2.AAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361745,221,406 - 45,221,906 (+)MPROMDB
RGD ID:7235605
Promoter ID:EPDNEW_H23548
Type:initiation region
Name:KAT7_1
Description:lysine acetyltransferase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381749,788,681 - 49,788,741EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q21.32-22(chr17:49137864-52147810)x1 copy number loss See cases [RCV000053432] Chr17:49137864..52147810 [GRCh38]
Chr17:47215226..50225170 [GRCh37]
Chr17:44570225..47580169 [NCBI36]
Chr17:17q21.32-22
pathogenic
NM_007067.5(KAT7):c.1687C>T (p.Gln563Ter) single nucleotide variant Malignant tumor of prostate [RCV000149191] Chr17:49826752 [GRCh38]
Chr17:47904114 [GRCh37]
Chr17:17q21.33
uncertain significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q21.33(chr17:49361155-50269440)x1 copy number loss See cases [RCV000139901] Chr17:49361155..50269440 [GRCh38]
Chr17:47438517..48346801 [GRCh37]
Chr17:44793516..45701800 [NCBI36]
Chr17:17q21.33
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1 copy number loss not provided [RCV000513510] Chr17:46481089..51396368 [GRCh37]
Chr17:17q21.32-22
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_007067.5(KAT7):c.1347G>A (p.Ala449=) single nucleotide variant not provided [RCV000905559] Chr17:49821751 [GRCh38]
Chr17:47899113 [GRCh37]
Chr17:17q21.33
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17016 AgrOrtholog
COSMIC KAT7 COSMIC
Ensembl Genes ENSG00000136504 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000259021 ENTREZGENE
  ENSP00000259021.4 UniProtKB/Swiss-Prot
  ENSP00000398961 ENTREZGENE
  ENSP00000398961.2 UniProtKB/Swiss-Prot
  ENSP00000409477.2 UniProtKB/TrEMBL
  ENSP00000413415 ENTREZGENE
  ENSP00000413415.2 UniProtKB/Swiss-Prot
  ENSP00000421368.1 UniProtKB/TrEMBL
  ENSP00000423385 ENTREZGENE
  ENSP00000423385.1 UniProtKB/Swiss-Prot
  ENSP00000424577 ENTREZGENE
  ENSP00000424577.1 UniProtKB/Swiss-Prot
  ENSP00000502732.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000259021 ENTREZGENE
  ENST00000259021.9 UniProtKB/Swiss-Prot
  ENST00000424009 ENTREZGENE
  ENST00000424009.6 UniProtKB/Swiss-Prot
  ENST00000435742.2 UniProtKB/TrEMBL
  ENST00000454930 ENTREZGENE
  ENST00000454930.6 UniProtKB/Swiss-Prot
  ENST00000506533.5 UniProtKB/TrEMBL
  ENST00000509773 ENTREZGENE
  ENST00000509773.5 UniProtKB/Swiss-Prot
  ENST00000510819 ENTREZGENE
  ENST00000510819.5 UniProtKB/Swiss-Prot
  ENST00000675278.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000136504 GTEx
HGNC ID HGNC:17016 ENTREZGENE
Human Proteome Map KAT7 Human Proteome Map
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAT_MYST-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zf-MYST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11143 UniProtKB/Swiss-Prot
NCBI Gene 11143 ENTREZGENE
OMIM 609880 OMIM
Pfam MOZ_SAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2HC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MYST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134886407 PharmGKB
PROSITE MYST_HAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_CCHHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55729 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q8PHH2_HUMAN UniProtKB/TrEMBL
  D6RFZ5_HUMAN UniProtKB/TrEMBL
  E7EUP3_HUMAN UniProtKB/TrEMBL
  KAT7_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B3KN74 UniProtKB/Swiss-Prot
  B4DF85 UniProtKB/Swiss-Prot
  B4DFB4 UniProtKB/Swiss-Prot
  B4DFE0 UniProtKB/Swiss-Prot
  B4DGY4 UniProtKB/Swiss-Prot
  E7ER15 UniProtKB/Swiss-Prot
  G5E9K7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-16 KAT7  lysine acetyltransferase 7    K(lysine) acetyltransferase 7  Symbol and/or name change 5135510 APPROVED
2011-07-27 KAT7  K(lysine) acetyltransferase 7  MYST2  MYST histone acetyltransferase 2  Symbol and/or name change 5135510 APPROVED