Gene: Fbxl2 (F-box and leucine-rich repeat protein 2) Mus musculus
Analyze
Symbol:
Fbxl2
Name:
F-box and leucine-rich repeat protein 2
Description:
ENCODES a protein that exhibits ubiquitin-protein transferase activity; phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN protein monoubiquitination; ubiquitin-dependent protein catabolic process; modulation by host of viral RNA genome replication (ortholog); FOUND IN membrane (ortholog); SCF ubiquitin ligase complex (ortholog); INTERACTS WITH carbon nanotube; ethanol; tetrachloromethane
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
2810423A21Rik; F-box/LRR-repeat protein 2; Fbl3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
FBXL2 (F-box and leucine rich repeat protein 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Fbxl2 (F-box and leucine-rich repeat protein 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Fbxl2 (F-box and leucine rich repeat protein 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
FBXL2 (F-box and leucine rich repeat protein 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
FBXL2 (F-box and leucine rich repeat protein 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Fbxl2 (F-box and leucine rich repeat protein 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
FBXL2 (F-box and leucine rich repeat protein 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
FBXL20 (F-box and leucine rich repeat protein 20) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
LRRC29 (leucine rich repeat containing 29) HGNC
Panther
Alliance orthologs 3
Homo sapiens (human):
FBXL2 (F-box and leucine rich repeat protein 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Fbxl2 (F-box and leucine-rich repeat protein 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
fbxl2 (F-box and leucine-rich repeat protein 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
GRR1
Alliance
DIOPT (Ensembl Compara, OrthoInspector, Roundup)
Drosophila melanogaster (fruit fly):
CG9003
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Caenorhabditis elegans (roundworm):
fbxl-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 113,958,557 - 114,026,803 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 113,886,076 - 113,935,869 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 113,825,656 - 113,875,449 (-) NCBI mm8 Celera 9 113,686,095 - 113,734,801 (-) NCBI Celera Cytogenetic Map 9 F3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736852 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FBXL2 mRNA CTD PMID:22079256 2,2',4,4',5,5'-hexachlorobiphenyl affects expression ISO RGD:736852 6480464 2 more ... CTD PMID:20638727 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:1562243 6480464 Trinitrobenzenesulfonic Acid results in increased expression of FBXL2 mRNA CTD PMID:12163651 antirheumatic drug increases expression ISO RGD:736852 6480464 Antirheumatic Agents results in increased expression of FBXL2 mRNA CTD PMID:24449571 bisphenol A decreases expression ISO RGD:1562243 6480464 bisphenol A results in decreased expression of FBXL2 mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:1562243 6480464 fullerene C60 results in decreased expression of FBXL2 mRNA CTD PMID:19167457 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of FBXL2 mRNA CTD PMID:25554681 chromium(6+) decreases expression ISO RGD:736852 6480464 chromium hexavalent ion results in decreased expression of FBXL2 mRNA CTD PMID:30690063 cisplatin increases expression ISO RGD:736852 6480464 Cisplatin results in increased expression of FBXL2 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:736852 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of FBXL2 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:736852 6480464 cobaltous chloride results in decreased expression of FBXL2 mRNA CTD PMID:17553155 , PMID:19320972 cyclosporin A decreases expression ISO RGD:736852 6480464 Cyclosporine results in decreased expression of FBXL2 mRNA CTD PMID:27989131 doxorubicin decreases expression ISO RGD:736852 6480464 Doxorubicin results in decreased expression of FBXL2 mRNA CTD PMID:29803840 ethanol affects expression EXP 6480464 Ethanol affects the expression of FBXL2 mRNA CTD PMID:30319688 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of FBXL2 mRNA CTD PMID:30319688 lead(0) affects expression ISO RGD:736852 6480464 Lead affects the expression of FBXL2 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:736852 6480464 Lead affects the expression of FBXL2 mRNA CTD PMID:28903495 manganese(II) chloride increases expression ISO RGD:1562243 6480464 manganese chloride results in increased expression of FBXL2 mRNA CTD PMID:28801915 N-methyl-4-phenylpyridinium increases expression ISO RGD:1562243 6480464 1-Methyl-4-phenylpyridinium results in increased expression of FBXL2 mRNA CTD PMID:28801915 potassium chromate multiple interactions ISO RGD:736852 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FBXL2 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:736852 6480464 potassium chromate(VI) results in decreased expression of FBXL2 mRNA CTD PMID:22079256 , PMID:22714537 quercetin increases expression ISO RGD:736852 6480464 Quercetin results in increased expression of FBXL2 mRNA CTD PMID:21632981 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of FBXL2 mRNA CTD PMID:17484886 Tributyltin oxide increases expression EXP 6480464 bis(tri-n-butyltin)oxide results in increased expression of FBXL2 mRNA CTD PMID:25270620 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of FBXL2 mRNA CTD PMID:17963808 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of FBXL2 mRNA CTD PMID:21427059 valproic acid increases expression ISO RGD:736852 6480464 Valproic Acid results in increased expression of FBXL2 mRNA CTD PMID:23179753 , PMID:29154799 valproic acid affects expression ISO RGD:736852 6480464 Valproic Acid affects the expression of FBXL2 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:736852 6480464 Valproic Acid results in decreased expression of FBXL2 mRNA CTD PMID:24935251
Gene Ontology Annotations
Biological Process modulation by host of viral RNA genome replication ISO UniProtKB:Q9UKC9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein monoubiquitination IMP 2290270 (MGI:MGI:5009099, PMID:21343341) MGI MGI:MGI:5009099 , PMID:21343341 protein monoubiquitination IGI MGI:MGI:103575 more ... 2290270 (MGI:MGI:5009099, PMID:21343341) MGI MGI:MGI:5009099 , PMID:21343341 protein ubiquitination ISO UniProtKB:Q9UKC9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of autophagy ISO UniProtKB:Q9UKC9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of phosphatidylinositol 3-kinase signaling ISO UniProtKB:Q9UKC9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO UniProtKB:Q9UKC9 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA MGI:MGI:3052506 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin-dependent protein catabolic process IMP 2290270 (MGI:MGI:5009099, PMID:21343341) MGI MGI:MGI:5009099 , PMID:21343341 ubiquitin-dependent protein catabolic process IBA FB:FBgn0030555 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 
Gene Ontology Annotations
