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Gene: FBXL2 (F-box and leucine rich repeat protein 2) Homo sapiens
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Symbol: FBXL2
Name: F-box and leucine rich repeat protein 2
Description: Exhibits phosphatidylinositol 3-kinase regulatory subunit binding activity and protein phosphatase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; modulation by host of viral RNA genome replication; and regulation of phosphatidylinositol 3-kinase signaling. Localizes to the SCF ubiquitin ligase complex and membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp564P0622; F-box and leucine-rich repeat protein 2; F-box protein containing leucine-rich repeats; F-box protein FBL2/FBL3; F-box/LRR-repeat protein 2; FBL2; FBL3
Orthologs:
Mus musculus (house mouse) : Fbxl2 (F-box and leucine-rich repeat protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fbxl2 (F-box and leucine-rich repeat protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxl2 (F-box and leucine rich repeat protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXL2 (F-box and leucine rich repeat protein 2)
Canis lupus familiaris (dog) : FBXL2 (F-box and leucine rich repeat protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxl2 (F-box and leucine rich repeat protein 2)
Sus scrofa (pig) : FBXL2 (F-box and leucine rich repeat protein 2)
Chlorocebus sabaeus (African green monkey) : FBXL2 (F-box and leucine rich repeat protein 2)
Heterocephalus glaber (naked mole-rat) : Fbxl2 (F-box and leucine rich repeat protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl333,277,025 - 33,403,662 (+)EnsemblGRCh38hg38GRCh38
GRCh38333,277,025 - 33,422,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37333,318,934 - 33,445,505 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36333,293,938 - 33,403,129 (+)NCBINCBI36hg18NCBI36
Build 34333,293,937 - 33,403,121NCBI
Celera333,262,399 - 33,372,286 (+)NCBI
Cytogenetic Map3p22.3NCBI
HuRef333,259,441 - 33,369,309 (+)NCBIHuRef
CHM1_1333,268,994 - 33,378,729 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on FBXL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736852
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.