Cnga2 (cyclic nucleotide gated channel alpha 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cnga2 (cyclic nucleotide gated channel alpha 2) Mus musculus
Analyze
Symbol: Cnga2
Name: cyclic nucleotide gated channel alpha 2
RGD ID: 736825
MGI Page MGI
Description: Enables monoatomic ion channel activity. Acts upstream of or within sensory perception of smell. Located in non-motile cilium membrane. Is expressed in heart; lung; olfactory epithelium; and urethra. Orthologous to human CNGA2 (cyclic nucleotide gated channel subunit alpha 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cn; Cnca; Cncg; Cncg4; CNG channel alpha-2; CNG-2; CNG2; cyclic nucleotide gated channel 4; cyclic nucleotide-gated cation channel 2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated olfactory channel; OCN; OCNC1; olfactory cyclic nucleotide-gated channel subunit 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,035,455 - 71,053,824 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,035,455 - 71,053,824 (+)EnsemblGRCm39 Ensembl
GRCm38X71,991,849 - 72,010,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX71,991,849 - 72,010,218 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X69,237,214 - 69,255,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X68,244,595 - 68,262,938 (+)NCBIMGSCv36mm8
CeleraX62,970,984 - 62,989,303 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calcium signalling remodelling and disease. Berridge MJ Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.
2. Cyclic nucleotide-gated ion channels. Kaupp UB and Seifert R, Physiol Rev. 2002 Jul;82(3):769-824.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8641270   PMID:8841933   PMID:8893025   PMID:9636130   PMID:10349636   PMID:10531436   PMID:10798393   PMID:10798394   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11257220  
PMID:12122071   PMID:12466851   PMID:12477932   PMID:12649326   PMID:15071119   PMID:15186781   PMID:16141072   PMID:16141073   PMID:16261133   PMID:16481428   PMID:16980309   PMID:17079653  
PMID:17129788   PMID:17310245   PMID:17350283   PMID:17702944   PMID:17916627   PMID:18292397   PMID:18367085   PMID:18621055   PMID:19279158   PMID:19729961   PMID:20080187   PMID:21059112  
PMID:21267068   PMID:21452247   PMID:21516098   PMID:21677750   PMID:21873635   PMID:22009938   PMID:22192355   PMID:22573694   PMID:23090999   PMID:23240083   PMID:23613997   PMID:23658842  
PMID:23926254   PMID:24427155   PMID:24587340   PMID:24692514   PMID:24797530   PMID:25192635   PMID:25411495   PMID:25564662   PMID:26377105   PMID:27916458   PMID:28053034   PMID:28757304  
PMID:29078327   PMID:29743476   PMID:30233329   PMID:30652126   PMID:31171707   PMID:33780330   PMID:34186026   PMID:37290446   PMID:38355793  


Genomics

Comparative Map Data
Cnga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,035,455 - 71,053,824 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,035,455 - 71,053,824 (+)EnsemblGRCm39 Ensembl
GRCm38X71,991,849 - 72,010,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX71,991,849 - 72,010,218 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X69,237,214 - 69,255,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X68,244,595 - 68,262,938 (+)NCBIMGSCv36mm8
CeleraX62,970,984 - 62,989,303 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.15NCBI
CNGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X151,734,746 - 151,745,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX151,734,746 - 151,745,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37X150,903,218 - 150,914,036 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X150,653,874 - 150,664,692 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X150,573,785 - 150,584,604NCBI
CeleraX151,151,573 - 151,162,391 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX139,760,197 - 139,771,472 (+)NCBIHuRef
CHM1_1X150,778,166 - 150,789,044 (+)NCBICHM1_1
T2T-CHM13v2.0X150,003,054 - 150,013,922 (+)NCBIT2T-CHM13v2.0
Cnga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,741,742 - 154,759,814 (+)NCBIGRCr8
mRatBN7.2X149,696,999 - 149,715,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX149,696,997 - 149,715,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX151,891,155 - 151,909,199 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,425,353 - 155,443,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X152,966,917 - 152,984,966 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01669,878,513 - 69,899,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,243,659 - 69,246,983 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01669,549,195 - 69,554,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0170,646,269 - 70,664,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X157,558,962 - 157,575,781NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X157,632,395 - 157,649,214NCBI
Cytogenetic MapXq37NCBI
Cnga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554987,250,514 - 7,257,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554987,250,514 - 7,257,701 (+)NCBIChiLan1.0ChiLan1.0
CNGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X151,806,407 - 151,813,245 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X151,810,012 - 151,816,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X141,315,052 - 141,324,754 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X151,272,051 - 151,281,909 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX151,275,800 - 151,281,909 (+)Ensemblpanpan1.1panPan2
CNGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X119,695,898 - 119,702,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX119,695,898 - 119,702,446 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX105,078,713 - 105,085,373 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X121,916,523 - 121,923,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX121,916,523 - 121,922,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X118,636,774 - 118,643,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X121,119,721 - 121,126,381 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X121,002,320 - 121,008,981 (+)NCBIUU_Cfam_GSD_1.0
Cnga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X117,230,525 - 117,245,175 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367141,011,736 - 1,017,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367141,011,736 - 1,017,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,115,975 - 123,129,840 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,115,980 - 123,130,043 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CNGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X126,277,931 - 126,302,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX126,295,236 - 126,301,141 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606564,080,980 - 64,090,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248833,043,666 - 3,049,801 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248833,043,661 - 3,051,420 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnga2
274 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:346
Interacting mature miRNAs:376
Transcripts:ENSMUST00000006020, ENSMUST00000145642
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse


Sequence


Ensembl Acc Id: ENSMUST00000006020   ⟹   ENSMUSP00000006020
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX71,035,455 - 71,053,824 (+)Ensembl
GRCm38.p6 EnsemblX71,991,849 - 72,010,218 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145642
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX71,035,461 - 71,045,089 (+)Ensembl
GRCm38.p6 EnsemblX71,991,855 - 72,001,483 (+)Ensembl
RefSeq Acc Id: NM_001410247   ⟹   NP_001397176
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X71,044,653 - 71,053,824 (+)NCBI
RefSeq Acc Id: NM_007724   ⟹   NP_031750
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X71,035,455 - 71,053,824 (+)NCBI
GRCm38X71,991,849 - 72,010,218 (+)NCBI
MGSCv37X69,237,214 - 69,255,557 (+)RGD
CeleraX62,970,984 - 62,989,303 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527761   ⟹   XP_006527824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X71,042,446 - 71,053,824 (+)NCBI
GRCm38X71,998,840 - 72,010,218 (+)NCBI
Sequence:
RefSeq Acc Id: NP_031750   ⟸   NM_007724
- Sequence:
RefSeq Acc Id: XP_006527824   ⟸   XM_006527761
- Peptide Label: isoform X1
- UniProtKB: Q80XH6 (UniProtKB/Swiss-Prot),   Q62398 (UniProtKB/Swiss-Prot),   A3KGE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000006020   ⟸   ENSMUST00000006020
RefSeq Acc Id: NP_001397176   ⟸   NM_001410247
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62398-F1-model_v2 AlphaFold Q62398 1-664 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108040 AgrOrtholog
Ensembl Genes ENSMUSG00000005864 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000006020 ENTREZGENE
  ENSMUST00000006020.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CLZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNG_Cation_Channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12789 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108040 ENTREZGENE
NCBI Gene 12789 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-GATED OLFACTORY CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnga2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A3KGE1 ENTREZGENE, UniProtKB/TrEMBL
  CNGA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q80XH6 ENTREZGENE
UniProt Secondary Q80XH6 UniProtKB/Swiss-Prot