Slit1 (slit guidance ligand 1) - Rat Genome Database

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Gene: Slit1 (slit guidance ligand 1) Mus musculus
Analyze
Symbol: Slit1
Name: slit guidance ligand 1
RGD ID: 736743
MGI Page MGI
Description: Enables Roundabout binding activity. Acts upstream of or within several processes, including axon guidance; nuclear migration; and tangential migration from the subventricular zone to the olfactory bulb. Located in extracellular space. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; olfactory system; and retina. Orthologous to human SLIT1 (slit guidance ligand 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mKIAA0813; S; Slil1; slit homolog 1 (Drosophila); slit homolog 1 protein; slit-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,586,263 - 41,735,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,588,696 - 41,732,104 (-)EnsemblGRCm39 Ensembl
GRCm381941,597,824 - 41,747,275 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,600,257 - 41,743,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,674,747 - 41,818,346 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,653,570 - 41,797,167 (-)NCBIMGSCv36mm8
Celera1942,398,288 - 42,542,154 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
arsenite(3-)  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (ISO)
Butylparaben  (ISO)
capsaicin  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
lead(0)  (ISO)
linuron  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
panobinostat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
pioglitazone  (EXP)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Bertuzzi S, etal., Genes Dev 1999 Dec 1;13(23):3092-105.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Plump AS, etal., Neuron 2002 Jan 17;33(2):219-32.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10433822   PMID:10864954   PMID:10864955   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11472852   PMID:11520671   PMID:11748150   PMID:11804571  
PMID:11830575   PMID:12023301   PMID:12051827   PMID:12097499   PMID:12141424   PMID:12477932   PMID:12515855   PMID:12591596   PMID:12609596   PMID:12642493   PMID:12954717   PMID:14610273  
PMID:14960623   PMID:15084255   PMID:15091338   PMID:15162513   PMID:15226823   PMID:15229182   PMID:15229646   PMID:15483127   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16284245  
PMID:16291793   PMID:16410488   PMID:16439476   PMID:16540508   PMID:16602821   PMID:16682216   PMID:16828733   PMID:16854408   PMID:16885222   PMID:17329426   PMID:17360927   PMID:17376983  
PMID:17392456   PMID:17507568   PMID:17581972   PMID:17715346   PMID:17721516   PMID:18054781   PMID:18287559   PMID:18345009   PMID:18417704   PMID:18455991   PMID:18547144   PMID:18554416  
PMID:18562598   PMID:18579678   PMID:18617019   PMID:18842816   PMID:19030180   PMID:19210786   PMID:19258013   PMID:19700621   PMID:19782674   PMID:19906969   PMID:20231872   PMID:20554876  
PMID:20606719   PMID:20631173   PMID:20670830   PMID:20696379   PMID:20941780   PMID:21068056   PMID:21118670   PMID:21267068   PMID:21307234   PMID:21435555   PMID:21508241   PMID:21600986  
PMID:21677750   PMID:21688288   PMID:21862448   PMID:21873635   PMID:22000108   PMID:22306607   PMID:22349628   PMID:22365545   PMID:22399681   PMID:22627288   PMID:22696295   PMID:22772332  
PMID:22806432   PMID:22912413   PMID:22981605   PMID:23083737   PMID:23161783   PMID:23217742   PMID:23255421   PMID:23292680   PMID:23307742   PMID:23320558   PMID:23328398   PMID:23396189  
PMID:23534961   PMID:23821580   PMID:23884932   PMID:24065825   PMID:24194600   PMID:24560577   PMID:24705356   PMID:24741061   PMID:24952961   PMID:25056828   PMID:25285789   PMID:25366972  
PMID:25456121   PMID:25485759   PMID:25490618   PMID:25530182   PMID:25631876   PMID:25691540   PMID:25843547   PMID:25894826   PMID:25936505   PMID:26257608   PMID:26395479   PMID:26520399  
PMID:26620267   PMID:26743624   PMID:27466379   PMID:27626380   PMID:27667971   PMID:27770832   PMID:27806288   PMID:27819291   PMID:28137836   PMID:28219675   PMID:28234971   PMID:28676569  
PMID:28970231   PMID:28986144   PMID:29031500   PMID:29343636   PMID:29961574   PMID:30470893   PMID:30504829   PMID:30504844   PMID:30547091   PMID:31040226   PMID:31070778   PMID:31356769  
PMID:31489182   PMID:31731293   PMID:32325033   PMID:32499648   PMID:32561725   PMID:32670024   PMID:32707082   PMID:33347679   PMID:33760820   PMID:33892704   PMID:34249921   PMID:34321664  
PMID:34321999   PMID:35462405   PMID:36843585   PMID:37298722   PMID:37497580   PMID:37524711   PMID:37566909   PMID:38355793   PMID:38943353   PMID:39159057   PMID:39353435  


Genomics

Comparative Map Data
Slit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391941,586,263 - 41,735,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1941,588,696 - 41,732,104 (-)EnsemblGRCm39 Ensembl
GRCm381941,597,824 - 41,747,275 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1941,600,257 - 41,743,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,674,747 - 41,818,346 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361941,653,570 - 41,797,167 (-)NCBIMGSCv36mm8
Celera1942,398,288 - 42,542,154 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.99NCBI
SLIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381096,998,038 - 97,185,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1096,998,038 - 97,185,959 (-)EnsemblGRCh38hg38GRCh38
GRCh371098,757,795 - 98,945,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361098,750,601 - 98,935,653 (-)NCBINCBI36Build 36hg18NCBI36
Build 341098,750,600 - 98,935,653NCBI
Celera1092,499,394 - 92,687,283 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1092,385,891 - 92,573,726 (-)NCBIHuRef
CHM1_11099,040,092 - 99,227,937 (-)NCBICHM1_1
T2T-CHM13v2.01097,878,923 - 98,066,822 (-)NCBIT2T-CHM13v2.0
Slit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,358,917 - 250,507,476 (-)NCBIGRCr8
mRatBN7.21240,409,559 - 240,558,127 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,409,561 - 240,558,127 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1248,552,721 - 248,697,784 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,249,868 - 255,394,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,902,887 - 248,047,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01260,843,481 - 260,992,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,843,483 - 260,992,366 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,298,678 - 268,445,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,813,909 - 246,964,408 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11246,928,385 - 247,078,883 (-)NCBI
Celera1236,249,200 - 236,395,640 (-)NCBICelera
Cytogenetic Map1q54NCBI
Slit1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555073,201,556 - 3,365,471 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555073,204,135 - 3,365,319 (-)NCBIChiLan1.0ChiLan1.0
SLIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,910,729 - 109,098,440 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,916,049 - 109,103,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01093,618,550 - 93,806,263 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11097,116,073 - 97,303,406 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1097,119,133 - 97,303,095 (-)Ensemblpanpan1.1panPan2
SLIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,351,758 - 10,519,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,351,821 - 10,519,313 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2810,535,122 - 10,702,300 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02810,673,425 - 10,840,914 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2810,673,458 - 10,840,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,335,078 - 10,502,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,395,529 - 10,563,416 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02810,536,093 - 10,703,522 (-)NCBIUU_Cfam_GSD_1.0
Slit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,388,622 - 36,543,449 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366362,427,736 - 2,582,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366362,427,738 - 2,582,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,446,004 - 108,624,302 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,446,003 - 108,624,508 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,083,559 - 118,149,597 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,166,710 - 90,357,983 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,172,578 - 90,237,256 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604851,061,333 - 51,250,208 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247378,460,508 - 8,632,302 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247378,458,444 - 8,632,316 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slit1
5483 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1435
Count of miRNA genes:597
Interacting mature miRNAs:735
Transcripts:ENSMUST00000025993, ENSMUST00000166496, ENSMUST00000169141, ENSMUST00000169416, ENSMUST00000171586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
Slit1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
cM Map19 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025993   ⟹   ENSMUSP00000025993
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,588,698 - 41,732,104 (-)Ensembl
GRCm38.p6 Ensembl1941,600,259 - 41,743,665 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166496   ⟹   ENSMUSP00000128381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,588,890 - 41,731,931 (-)Ensembl
GRCm38.p6 Ensembl1941,600,451 - 41,743,492 (-)Ensembl
Ensembl Acc Id: ENSMUST00000169141   ⟹   ENSMUSP00000129034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,588,696 - 41,731,931 (-)Ensembl
GRCm38.p6 Ensembl1941,600,257 - 41,743,492 (-)Ensembl
Ensembl Acc Id: ENSMUST00000169416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,592,808 - 41,596,969 (-)Ensembl
GRCm38.p6 Ensembl1941,604,369 - 41,608,530 (-)Ensembl
Ensembl Acc Id: ENSMUST00000171586   ⟹   ENSMUSP00000126139
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1941,634,542 - 41,731,925 (-)Ensembl
GRCm38.p6 Ensembl1941,646,103 - 41,743,486 (-)Ensembl
RefSeq Acc Id: NM_015748   ⟹   NP_056563
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,588,696 - 41,732,295 (-)NCBI
GRCm381941,600,257 - 41,743,856 (-)NCBI
MGSCv371941,674,747 - 41,818,346 (-)RGD
Celera1942,398,288 - 42,542,154 (-)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030250829   ⟹   XP_030106689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,586,263 - 41,735,714 (-)NCBI
GRCm381941,597,824 - 41,747,275 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030250830   ⟹   XP_030106690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,586,263 - 41,732,459 (-)NCBI
GRCm381941,597,824 - 41,744,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161495   ⟹   XP_036017388
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,586,263 - 41,732,343 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161496   ⟹   XP_036017389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391941,586,263 - 41,654,459 (-)NCBI
Sequence:
RefSeq Acc Id: NP_056563   ⟸   NM_015748
- Peptide Label: precursor
- UniProtKB: Q9WVB5 (UniProtKB/Swiss-Prot),   Q80TR4 (UniProtKB/Swiss-Prot),   E9Q2P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106689   ⟸   XM_030250829
- Peptide Label: isoform X1
- UniProtKB: Q80TR4 (UniProtKB/Swiss-Prot),   Q9WVB5 (UniProtKB/Swiss-Prot),   E9Q2P0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030106690   ⟸   XM_030250830
- Peptide Label: isoform X1
- UniProtKB: Q80TR4 (UniProtKB/Swiss-Prot),   Q9WVB5 (UniProtKB/Swiss-Prot),   E9Q2P0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000025993   ⟸   ENSMUST00000025993
Ensembl Acc Id: ENSMUSP00000128381   ⟸   ENSMUST00000166496
Ensembl Acc Id: ENSMUSP00000126139   ⟸   ENSMUST00000171586
Ensembl Acc Id: ENSMUSP00000129034   ⟸   ENSMUST00000169141
RefSeq Acc Id: XP_036017388   ⟸   XM_036161495
- Peptide Label: isoform X2
- UniProtKB: E9Q2P0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036017389   ⟸   XM_036161496
- Peptide Label: isoform X3
- UniProtKB: E9Q2P0 (UniProtKB/TrEMBL)
Protein Domains
CTCK   EGF-like   Laminin G   Laminin G-like   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80TR4-F1-model_v2 AlphaFold Q80TR4 1-1531 view protein structure

Promoters
RGD ID:13679480
Promoter ID:EPDNEW_M23889
Type:initiation region
Name:Slit1_1
Description:Mus musculus slit guidance ligand 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381941,743,674 - 41,743,734EPDNEW
RGD ID:6830423
Promoter ID:MM_KWN:27063
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_015748
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361941,817,721 - 41,818,221 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1315203 AgrOrtholog
Ensembl Genes ENSMUSG00000025020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025993 ENTREZGENE
  ENSMUST00000025993.10 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Cys_knot_C UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Fol_N UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  Notch/Slit_guidance UniProtKB/Swiss-Prot
KEGG Report mmu:20562 UniProtKB/Swiss-Prot
MGD MGI:1315203 ENTREZGENE
NCBI Gene 20562 ENTREZGENE
PANTHER SLIT HOMOLOG UniProtKB/Swiss-Prot
  SLIT HOMOLOG 1 PROTEIN UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Slit1 PhenoGen
PROSITE CTCK_1 UniProtKB/Swiss-Prot
  CTCK_2 UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FOLN UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  LRR_BAC UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00041 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
UniProt E9Q117_MOUSE UniProtKB/TrEMBL
  E9Q2P0 ENTREZGENE, UniProtKB/TrEMBL
  E9QAW9_MOUSE UniProtKB/TrEMBL
  Q80TR4 ENTREZGENE
  Q9WVB5 ENTREZGENE
  SLIT1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9WVB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Slit1  slit guidance ligand 1    slit homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED