MST1 (macrophage stimulating 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MST1 (macrophage stimulating 1) Homo sapiens
Analyze
Symbol: MST1
Name: macrophage stimulating 1
RGD ID: 736655
HGNC Page HGNC:7380
Description: Enables receptor tyrosine kinase binding activity. Involved in negative regulation of gluconeogenesis and regulation of cAMP-dependent protein kinase activity. Located in extracellular space. Part of collagen-containing extracellular matrix.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: D3F15S2; DNF15S2; hepatocyte growth factor-like protein; hepatocyte growth factor-like protein homolog; HGFL; macrophage stimulating 1 (hepatocyte growth factor-like); macrophage stimulatory protein; macrophage-stimulating protein; MSP; NF15S2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC102724562   MST1L   MST1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,683,947 - 49,689,474 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl349,683,947 - 49,689,501 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,721,380 - 49,726,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,696,391 - 49,701,099 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,696,391 - 49,701,099NCBI
Celera349,686,072 - 49,690,887 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,780,360 - 49,785,175 (-)NCBIHuRef
CHM1_1349,673,436 - 49,678,251 (-)NCBICHM1_1
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
Additional References at PubMed
PMID:1655021   PMID:1827141   PMID:2902784   PMID:7508914   PMID:8125298   PMID:8393443   PMID:8621550   PMID:8889548   PMID:9045873   PMID:10068459   PMID:10728827   PMID:11274154  
PMID:11856768   PMID:12177064   PMID:12477932   PMID:12919677   PMID:14597639   PMID:14729613   PMID:15764806   PMID:16170349   PMID:16335952   PMID:17347649   PMID:17456594   PMID:17554261  
PMID:17554300   PMID:18438406   PMID:18480548   PMID:18587394   PMID:18700007   PMID:18786403   PMID:18986304   PMID:19079170   PMID:19456860   PMID:19657358   PMID:19720831   PMID:19760754  
PMID:19861958   PMID:19915572   PMID:19944697   PMID:20014019   PMID:20024904   PMID:20228799   PMID:20307617   PMID:21072187   PMID:21081472   PMID:21102463   PMID:21151127   PMID:21249150  
PMID:21297633   PMID:21619683   PMID:21723047   PMID:21873635   PMID:21875933   PMID:21931648   PMID:22087277   PMID:22245154   PMID:22554193   PMID:23011677   PMID:23128233   PMID:23376485  
PMID:23422030   PMID:23928732   PMID:24141421   PMID:24409221   PMID:25037231   PMID:25082827   PMID:25193665   PMID:25315688   PMID:25551685   PMID:25704570   PMID:27609031   PMID:29063978  
PMID:29079854   PMID:29441677   PMID:29676528   PMID:30212651   PMID:30384260   PMID:30604255   PMID:30673917   PMID:30796177   PMID:30863499   PMID:30903103   PMID:30981108   PMID:31254927  
PMID:31321952   PMID:32156191   PMID:32296183   PMID:32555725   PMID:32692720   PMID:32694731   PMID:32930944   PMID:33070035   PMID:33109096   PMID:33760220   PMID:33860801   PMID:33961781  
PMID:35054822   PMID:36263059  


Genomics

Comparative Map Data
MST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,683,947 - 49,689,474 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl349,683,947 - 49,689,501 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,721,380 - 49,726,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,696,391 - 49,701,099 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,696,391 - 49,701,099NCBI
Celera349,686,072 - 49,690,887 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,780,360 - 49,785,175 (-)NCBIHuRef
CHM1_1349,673,436 - 49,678,251 (-)NCBICHM1_1
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBIT2T-CHM13v2.0
Mst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,957,607 - 107,962,226 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,957,635 - 107,962,202 (+)EnsemblGRCm39 Ensembl
GRCm389108,080,409 - 108,085,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,080,436 - 108,085,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,982,767 - 107,987,358 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,938,552 - 107,943,099 (+)NCBIMGSCv36mm8
Celera9107,690,205 - 107,694,796 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Mst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,767,886 - 108,773,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,768,839 - 108,773,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,395,059 - 114,399,629 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08112,594,383 - 112,598,953 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08110,437,023 - 110,441,594 (+)NCBIRnor_WKY
Rnor_6.08116,857,716 - 116,862,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,857,684 - 116,862,423 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,211,755 - 116,216,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,348,203 - 113,352,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,367,657 - 113,372,228 (+)NCBI
Celera8108,073,056 - 108,077,626 (+)NCBICelera
Cytogenetic Map8q32NCBI
Mst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,590,755 - 1,595,148 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,590,685 - 1,595,655 (-)NCBIChiLan1.0ChiLan1.0
MST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,855,283 - 50,856,052 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,616,339 - 49,621,749 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,582,237 - 39,586,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,582,282 - 39,586,908 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,503,160 - 39,507,883 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,939,767 - 39,944,483 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,938,823 - 39,944,461 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,306,836 - 39,311,565 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,710,205 - 39,714,921 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,990,036 - 39,994,752 (+)NCBIUU_Cfam_GSD_1.0
Mst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,538,735 - 64,545,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,299,300 - 1,303,959 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365291,298,853 - 1,306,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,214,937 - 32,219,902 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,214,934 - 32,220,045 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,394,134 - 35,399,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,078,662 - 11,083,885 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,074,114 - 11,083,368 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041155,916,564 - 155,921,896 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mst1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,610,241 - 3,617,530 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,612,467 - 3,617,257 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MST1
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6831
Count of miRNA genes:1089
Interacting mature miRNAs:1404
Transcripts:ENST00000383728, ENST00000448220, ENST00000449682, ENST00000468847, ENST00000479115, ENST00000480268, ENST00000481055, ENST00000481930, ENST00000484144, ENST00000484269, ENST00000484673, ENST00000488350, ENST00000489007, ENST00000490966, ENST00000491943, ENST00000492329, ENST00000492370, ENST00000493836, ENST00000494809, ENST00000494828, ENST00000497359, ENST00000498021, ENST00000545762
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-16108  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,720,129 - 49,720,384UniSTSGRCh37
Build 36349,695,133 - 49,695,388RGDNCBI36
Celera349,684,821 - 49,685,076RGD
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map3p21UniSTS
HuRef349,779,109 - 49,779,364UniSTS
GeneMap99-GB4 RH Map3159.01UniSTS
Whitehead-RH Map3198.3UniSTS
GDB:180399  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,725,049 - 49,725,586UniSTSGRCh37
Build 36349,700,053 - 49,700,590RGDNCBI36
Celera349,689,741 - 49,690,277RGD
Cytogenetic Map3p21UniSTS
Cytogenetic Map3p24.3UniSTS
HuRef349,784,029 - 49,784,565UniSTS
GDB:181206  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,712,678 - 49,713,841UniSTSGRCh37
Build 36349,687,682 - 49,688,845RGDNCBI36
Celera349,677,370 - 49,678,533RGD
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map3p21UniSTS
HuRef349,771,658 - 49,772,821UniSTS
GDB:512856  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,712,679 - 49,713,841UniSTSGRCh37
Build 36349,687,683 - 49,688,845RGDNCBI36
Celera349,677,371 - 49,678,533RGD
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map3p21UniSTS
HuRef349,771,659 - 49,772,821UniSTS
APEH  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,719,998 - 49,720,338UniSTSGRCh37
GRCh37349,713,510 - 49,713,922UniSTSGRCh37
Build 36349,688,514 - 49,688,926RGDNCBI36
Celera349,684,690 - 49,685,030UniSTS
Celera349,678,202 - 49,678,614RGD
HuRef349,772,490 - 49,772,902UniSTS
HuRef349,778,978 - 49,779,318UniSTS
APEH  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37349,719,998 - 49,720,338UniSTSGRCh37
GRCh37349,713,510 - 49,713,922UniSTSGRCh37
Build 36349,688,514 - 49,688,926RGDNCBI36
Celera349,684,690 - 49,685,030UniSTS
Celera349,678,202 - 49,678,614RGD
HuRef349,772,490 - 49,772,902UniSTS
HuRef349,778,978 - 49,779,318UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1
Medium 491 191 1649 519 434 436 2134 111 1419 251 1029 979 84 724 1248
Low 1944 2782 76 103 1491 27 2216 2070 2308 167 417 626 87 480 1538 4 1
Below cutoff 3 15 20 1 6 13 7 1 12 6 2 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_146060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006713166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011533738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017006468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002959536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_427273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_940427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM672747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC315638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U28054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000448220   ⟹   ENSP00000394756
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,683,947 - 49,685,090 (-)Ensembl
RefSeq Acc Id: ENST00000449682   ⟹   ENSP00000414287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,683,947 - 49,689,474 (-)Ensembl
RefSeq Acc Id: ENST00000468847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,685,683 - 49,686,187 (-)Ensembl
RefSeq Acc Id: ENST00000479115
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,683,976 - 49,686,852 (-)Ensembl
RefSeq Acc Id: ENST00000480268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,685,407 - 49,686,270 (-)Ensembl
RefSeq Acc Id: ENST00000481055
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,687,040 - 49,688,068 (-)Ensembl
RefSeq Acc Id: ENST00000481930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,738 - 49,685,785 (-)Ensembl
RefSeq Acc Id: ENST00000484144
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,325 - 49,685,298 (-)Ensembl
RefSeq Acc Id: ENST00000484269
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,738 - 49,687,462 (-)Ensembl
RefSeq Acc Id: ENST00000484673
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,685,885 - 49,688,673 (-)Ensembl
RefSeq Acc Id: ENST00000488350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,683,976 - 49,689,493 (-)Ensembl
RefSeq Acc Id: ENST00000489007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,685,745 - 49,686,803 (-)Ensembl
RefSeq Acc Id: ENST00000490966
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,686,968 - 49,688,658 (-)Ensembl
RefSeq Acc Id: ENST00000491943
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,687,813 - 49,689,501 (-)Ensembl
RefSeq Acc Id: ENST00000492329
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,683,976 - 49,686,960 (-)Ensembl
RefSeq Acc Id: ENST00000492370
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,686,168 - 49,688,673 (-)Ensembl
RefSeq Acc Id: ENST00000493836
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,049 - 49,685,399 (-)Ensembl
RefSeq Acc Id: ENST00000494809
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,685,482 - 49,686,857 (-)Ensembl
RefSeq Acc Id: ENST00000494828
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,686,742 - 49,688,671 (-)Ensembl
RefSeq Acc Id: ENST00000497359
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,861 - 49,686,866 (-)Ensembl
RefSeq Acc Id: ENST00000498021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl349,684,844 - 49,685,874 (-)Ensembl
RefSeq Acc Id: NM_001393581   ⟹   NP_001380510
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393582   ⟹   NP_001380511
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393583   ⟹   NP_001380512
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393584   ⟹   NP_001380513
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393585   ⟹   NP_001380514
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020998   ⟹   NP_066278
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
GRCh37349,721,380 - 49,726,196 (-)ENTREZGENE
Build 36349,696,391 - 49,701,099 (-)NCBI Archive
HuRef349,780,360 - 49,785,175 (-)ENTREZGENE
CHM1_1349,673,436 - 49,678,251 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: NR_146060
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
T2T-CHM13v2.0349,713,231 - 49,718,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011533738   ⟹   XP_011532040
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,685,035 - 49,689,474 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017006460   ⟹   XP_016861949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047448158   ⟹   XP_047304114
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
RefSeq Acc Id: XM_047448159   ⟹   XP_047304115
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,683,947 - 49,689,474 (-)NCBI
RefSeq Acc Id: XM_047448160   ⟹   XP_047304116
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,684,738 - 49,689,474 (-)NCBI
RefSeq Acc Id: XM_047448161   ⟹   XP_047304117
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,685,640 - 49,689,474 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380510 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380511 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380512 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380513 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380514 (Get FASTA)   NCBI Sequence Viewer  
  NP_066278 (Get FASTA)   NCBI Sequence Viewer  
  XP_011532040 (Get FASTA)   NCBI Sequence Viewer  
  XP_016861949 (Get FASTA)   NCBI Sequence Viewer  
  XP_047304114 (Get FASTA)   NCBI Sequence Viewer  
  XP_047304115 (Get FASTA)   NCBI Sequence Viewer  
  XP_047304116 (Get FASTA)   NCBI Sequence Viewer  
  XP_047304117 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA50165 (Get FASTA)   NCBI Sequence Viewer  
  AAA59872 (Get FASTA)   NCBI Sequence Viewer  
  AAC50471 (Get FASTA)   NCBI Sequence Viewer  
  AAC63092 (Get FASTA)   NCBI Sequence Viewer  
  AAH44862 (Get FASTA)   NCBI Sequence Viewer  
  AAH48330 (Get FASTA)   NCBI Sequence Viewer  
  BAD96613 (Get FASTA)   NCBI Sequence Viewer  
  BAH11736 (Get FASTA)   NCBI Sequence Viewer  
  BAH12279 (Get FASTA)   NCBI Sequence Viewer  
  BAH12774 (Get FASTA)   NCBI Sequence Viewer  
  BAH12793 (Get FASTA)   NCBI Sequence Viewer  
  EAW64999 (Get FASTA)   NCBI Sequence Viewer  
  EAW65000 (Get FASTA)   NCBI Sequence Viewer  
  EAW65001 (Get FASTA)   NCBI Sequence Viewer  
  EAW65002 (Get FASTA)   NCBI Sequence Viewer  
  EAW65003 (Get FASTA)   NCBI Sequence Viewer  
  P26927 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_066278   ⟸   NM_020998
- Peptide Label: isoform 1 precursor
- UniProtKB: P26927 (UniProtKB/Swiss-Prot),   G3XAK1 (UniProtKB/TrEMBL),   Q53GN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011532040   ⟸   XM_011533738
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016861949   ⟸   XM_017006460
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000394756   ⟸   ENST00000448220
RefSeq Acc Id: ENSP00000414287   ⟸   ENST00000449682
RefSeq Acc Id: NP_001380513   ⟸   NM_001393584
- Peptide Label: isoform 5 precursor
RefSeq Acc Id: NP_001380510   ⟸   NM_001393581
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: NP_001380512   ⟸   NM_001393583
- Peptide Label: isoform 4 precursor
RefSeq Acc Id: NP_001380514   ⟸   NM_001393585
- Peptide Label: isoform 6 precursor
RefSeq Acc Id: NP_001380511   ⟸   NM_001393582
- Peptide Label: isoform 3 precursor
RefSeq Acc Id: XP_047304115   ⟸   XM_047448159
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047304114   ⟸   XM_047448158
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047304116   ⟸   XM_047448160
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047304117   ⟸   XM_047448161
- Peptide Label: isoform X6
Protein Domains
Apple   Kringle   PAN   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26927-F1-model_v2 AlphaFold P26927 1-711 view protein structure

Promoters
RGD ID:6864434
Promoter ID:EPDNEW_H5381
Type:initiation region
Name:MST1_1
Description:macrophage stimulating 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5383  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,688,673 - 49,688,733EPDNEW
RGD ID:6864438
Promoter ID:EPDNEW_H5383
Type:initiation region
Name:MST1_2
Description:macrophage stimulating 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5381  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38349,689,116 - 49,689,176EPDNEW
RGD ID:6801336
Promoter ID:HG_KWN:45052
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000383728,   NM_020998,   OTTHUMT00000342315,   OTTHUMT00000342316,   OTTHUMT00000342317,   OTTHUMT00000342318,   OTTHUMT00000342319,   OTTHUMT00000342320,   OTTHUMT00000342321,   OTTHUMT00000342322,   OTTHUMT00000342323,   OTTHUMT00000342324,   OTTHUMT00000342325,   OTTHUMT00000342326,   OTTHUMT00000342327,   OTTHUMT00000342328,   OTTHUMT00000342329,   OTTHUMT00000342330,   OTTHUMT00000346436,   OTTHUMT00000346437,   OTTHUMT00000346438,   OTTHUMT00000346439,   OTTHUMT00000346440,   OTTHUMT00000346441,   OTTHUMT00000346442,   OTTHUMT00000346443,   OTTHUMT00000346444,   OTTHUMT00000346445,   OTTHUMT00000346446
Position:
Human AssemblyChrPosition (strand)Source
Build 36349,700,921 - 49,701,421 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_020998.4(MST1):c.55C>T (p.Pro19Ser) single nucleotide variant not provided [RCV000144227] Chr3:49688637 [GRCh38]
Chr3:49726070 [GRCh37]
Chr3:3p21.31
uncertain significance|not provided
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic
NM_020998.3(MST1):c.848-2A>C single nucleotide variant Malignant melanoma [RCV000066123] Chr3:49686483 [GRCh38]
Chr3:49723916 [GRCh37]
Chr3:49698920 [NCBI36]
Chr3:3p21.31
not provided
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31
likely pathogenic
GRCh37/hg19 3p21.31(chr3:49723098-49728537)x3 copy number gain See cases [RCV000445938] Chr3:49723098..49728537 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_020998.4(MST1):c.939T>C (p.Thr313=) single nucleotide variant not provided [RCV000948648] Chr3:49686390 [GRCh38]
Chr3:49723823 [GRCh37]
Chr3:3p21.31
likely benign
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
NM_020998.4(MST1):c.978G>T (p.Pro326=) single nucleotide variant not provided [RCV000948261] Chr3:49686351 [GRCh38]
Chr3:49723784 [GRCh37]
Chr3:3p21.31
likely benign
NM_020998.4(MST1):c.1533C>T (p.Ser511=) single nucleotide variant not provided [RCV000895095] Chr3:49685273 [GRCh38]
Chr3:49722706 [GRCh37]
Chr3:3p21.31
benign
NM_020998.4(MST1):c.643G>C (p.Gly215Arg) single nucleotide variant not provided [RCV000964919] Chr3:49687032 [GRCh38]
Chr3:49724465 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p21.31-21.2(chr3:48807193-51363558)x1 copy number loss not provided [RCV001259686] Chr3:48807193..51363558 [GRCh37]
Chr3:3p21.31-21.2
pathogenic
NC_000003.11:g.(?_48507870)_(50340407_?)del deletion Aicardi-Goutieres syndrome 1 [RCV001380369] Chr3:48507870..50340407 [GRCh37]
Chr3:3p21.31
pathogenic
NC_000003.11:g.(?_49547968)_(50685477_?)del deletion Early infantile epileptic encephalopathy with suppression bursts [RCV001970206] Chr3:49547968..50685477 [GRCh37]
Chr3:3p21.31-21.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7380 AgrOrtholog
COSMIC MST1 COSMIC
Ensembl Genes ENSG00000173531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSP00000394756.1 UniProtKB/TrEMBL
  ENSP00000414287 ENTREZGENE
  ENSP00000414287.2 UniProtKB/TrEMBL
Ensembl Transcript ENST00000448220.5 UniProtKB/TrEMBL
  ENST00000449682 ENTREZGENE
  ENST00000449682.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000173531 GTEx
HGNC ID HGNC:7380 ENTREZGENE
Human Proteome Map MST1 Human Proteome Map
InterPro HGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MSP_HGFL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pan_app UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4485 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4485 ENTREZGENE
OMIM 142408 OMIM
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31185 PharmGKB
PIRSF HGF_MST1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MSP_HGFL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3XAK1 ENTREZGENE, UniProtKB/TrEMBL
  H7C0F8_HUMAN UniProtKB/TrEMBL
  HGFL_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q49A61_HUMAN UniProtKB/TrEMBL
  Q53GN8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6NLA3 UniProtKB/Swiss-Prot
  A8MSX3 UniProtKB/Swiss-Prot
  Q13350 UniProtKB/Swiss-Prot
  Q14870 UniProtKB/Swiss-Prot
  Q6GTN4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 MST1  macrophage stimulating 1    macrophage stimulating 1 (hepatocyte growth factor-like)  Symbol and/or name change 5135510 APPROVED