Cryba1 (crystallin, beta A1) - Rat Genome Database
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Gene: Cryba1 (crystallin, beta A1) Mus musculus
Analyze
Symbol: Cryba1
Name: crystallin, beta A1
RGD ID: 736651
MGI Page MGI
Description: Is expressed in eye. Used to study age related macular degeneration 1 and cataract 10 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 10 multiple types. Orthologous to human CRYBA1 (crystallin beta A1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BA3/; BA3/A1; beta-A1-crystallin; beta-A3/A1-crystallin; beta-crystallin A1; Cry; Cryb; MGC130310
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,609,440 - 77,616,119 (-)NCBIGRCm39mm39
GRCm39 Ensembl1177,609,441 - 77,616,109 (-)Ensembl
GRCm381177,718,614 - 77,725,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,718,615 - 77,725,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,532,234 - 77,538,795 (-)NCBIGRCm37mm9NCBIm37
MGSCv361177,534,927 - 77,541,488 (-)NCBImm8
Celera1185,217,233 - 85,223,794 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:1395724   PMID:2649248   PMID:2901325   PMID:3803920   PMID:6835368   PMID:6896514   PMID:7539358   PMID:7557995   PMID:7626882   PMID:7882978   PMID:8072529   PMID:8211130  
PMID:8425893   PMID:8575764   PMID:8666393   PMID:9177778   PMID:9400939   PMID:9512512   PMID:9573353   PMID:9693140   PMID:10080188   PMID:10349636   PMID:10603348   PMID:10780854  
PMID:11042159   PMID:11076861   PMID:11146559   PMID:11217851   PMID:11714668   PMID:12446761   PMID:12477932   PMID:14610273   PMID:14648843   PMID:14717595   PMID:15593327   PMID:15741512  
PMID:15905556   PMID:16141072   PMID:16141073   PMID:16162653   PMID:17213798   PMID:19334279   PMID:20735985   PMID:21179429   PMID:21267068   PMID:21436445   PMID:21873635   PMID:21998302  
PMID:22275127   PMID:22427112   PMID:23201579   PMID:23535650   PMID:23745585   PMID:24468901   PMID:25257511   PMID:25347445   PMID:25461968   PMID:25736717   PMID:26427489   PMID:26851658  
PMID:26863613   PMID:28026019   PMID:28083894   PMID:29959226   PMID:30059908   PMID:30098172   PMID:30683901   PMID:31552301  


Genomics

Comparative Map Data
Cryba1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,609,440 - 77,616,119 (-)NCBIGRCm39mm39
GRCm39 Ensembl1177,609,441 - 77,616,109 (-)Ensembl
GRCm381177,718,614 - 77,725,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,718,615 - 77,725,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,532,234 - 77,538,795 (-)NCBIGRCm37mm9NCBIm37
MGSCv361177,534,927 - 77,541,488 (-)NCBImm8
Celera1185,217,233 - 85,223,794 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
CRYBA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1729,246,863 - 29,254,494 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1729,246,859 - 29,254,494 (+)EnsemblGRCh38hg38GRCh38
GRCh381729,246,859 - 29,254,494 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,573,877 - 27,581,512 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,598,001 - 24,605,638 (+)NCBINCBI36hg18NCBI36
Build 341724,598,000 - 24,605,626NCBI
Celera1724,433,393 - 24,441,030 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,782,531 - 23,790,168 (+)NCBIHuRef
CHM1_11727,636,586 - 27,644,223 (+)NCBICHM1_1
Cryba1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21062,608,373 - 62,614,726 (-)NCBI
Rnor_6.0 Ensembl1065,161,152 - 65,167,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01065,160,777 - 65,167,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01066,458,061 - 66,480,390 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,758,929 - 63,765,451 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11063,772,566 - 63,776,395 (-)NCBI
Celera1061,589,011 - 61,595,363 (-)NCBICelera
Cytogenetic Map10q25NCBI
Cryba1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554813,952,988 - 3,959,764 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554813,952,976 - 3,986,548 (-)NCBIChiLan1.0ChiLan1.0
CRYBA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11728,032,799 - 28,040,525 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,032,809 - 28,040,525 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01727,522,647 - 27,530,767 (-)NCBIMhudiblu_PPA_v0panPan3
CRYBA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl943,372,505 - 43,378,590 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1943,372,507 - 43,378,561 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cryba1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365385,392,159 - 5,400,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYBA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,368,561 - 45,473,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,466,051 - 45,473,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21229,178,767 - 29,181,605 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYBA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11623,005,892 - 23,011,357 (+)NCBI
ChlSab1.1 Ensembl1623,003,874 - 23,011,206 (+)Ensembl
Cryba1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247861,757,272 - 1,777,735 (+)NCBI

Position Markers
Cryba1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371177,532,342 - 77,532,985UniSTSGRCm37
Celera1185,217,341 - 85,217,984UniSTS
Cytogenetic Map11B-C1UniSTS
cM Map1144.71UniSTS
D11Bhm151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381177,726,328 - 77,726,544UniSTSGRCm38
MGSCv371177,539,830 - 77,540,046UniSTSGRCm37
Celera1185,224,829 - 85,225,045UniSTS
Cytogenetic Map11B-C1UniSTS
cM Map1144.73UniSTS
Cryba1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B-C1UniSTS
Cryba1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B-C1UniSTS
cM Map1144.71UniSTS
Cryba1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381177,718,840 - 77,719,483UniSTSGRCm38
MGSCv371177,532,342 - 77,532,985UniSTSGRCm37
Celera1185,217,341 - 85,217,984UniSTS
Cytogenetic Map11B-C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117384671582178599Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117768304780855532Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:136
Interacting mature miRNAs:143
Transcripts:ENSMUST00000078623, ENSMUST00000124178
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000078623   ⟹   ENSMUSP00000077693
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1177,718,627 - 77,725,283 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1177,718,615 - 77,721,834 (-)Ensembl
RefSeq Acc Id: NM_001313933   ⟹   NP_001300862
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391177,609,440 - 77,616,119 (-)NCBI
GRCm381177,718,614 - 77,725,293 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009965   ⟹   NP_034095
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391177,609,440 - 77,616,119 (-)NCBI
GRCm381177,718,614 - 77,725,293 (-)NCBI
MGSCv371177,532,234 - 77,538,795 (-)RGD
Celera1185,217,233 - 85,223,794 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034095   ⟸   NM_009965
- Peptide Label: isoform 1
- UniProtKB: Q9QXC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300862   ⟸   NM_001313933
- Peptide Label: isoform 2
- UniProtKB: Q9QXC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000077693   ⟸   ENSMUST00000078623
Promoters
RGD ID:6820665
Promoter ID:MM_KWN:8624
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000018595
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361177,534,396 - 77,536,332 (-)MPROMDB
RGD ID:6849528
Promoter ID:EP07069
Type:single initiation site
Name:MM_CRBA
Description:beta-crystallin, CRYBA1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:lens
Experiment Methods:Nuclease protection with homologous sequence ladder
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371177,536,294 - 77,536,354EPD
MGSCv361177,536,294 - 77,536,354EPD
RGD ID:8675648
Promoter ID:EPDNEW_M15855
Type:multiple initiation site
Name:Cryba1_1
Description:Mus musculus crystallin, beta A1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381177,725,286 - 77,725,346EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88518 AgrOrtholog
Ensembl Genes ENSMUSG00000000724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000077693 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000078623 ENTREZGENE, UniProtKB/TrEMBL
InterPro Beta/gamma_crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12957 UniProtKB/TrEMBL
MGD MGI:88518 ENTREZGENE
NCBI Gene 12957 ENTREZGENE
Pfam Crystall UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cryba1 PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART XTALbg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CRBA1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QXC6 ENTREZGENE, UniProtKB/TrEMBL