Tagln3 (transgelin 3) - Rat Genome Database

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Gene: Tagln3 (transgelin 3) Mus musculus
Analyze
Symbol: Tagln3
Name: transgelin 3
RGD ID: 736619
MGI Page MGI
Description: Predicted to enable actin filament binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system; gut; olfactory epithelium; peripheral nervous system; and retina. Orthologous to human TAGLN3 (transgelin 3).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2700038H05Rik; 2900005O10Rik; AI426007; neuronal protein Np25; Np; Np25; transgelin-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391645,531,591 - 45,545,271 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1645,531,593 - 45,544,971 (-)EnsemblGRCm39 Ensembl
GRCm381645,711,230 - 45,724,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,711,230 - 45,724,608 (-)EnsemblGRCm38mm10GRCm38
MGSCv371645,711,343 - 45,724,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,630,562 - 45,643,863 (-)NCBIMGSCv36mm8
Celera1646,088,034 - 46,101,263 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1629.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IBA)
myelin sheath  (HDA)
nucleus  (IDA)
synapse  (EXP,IDA,IMP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15998716   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16632597   PMID:17634366  
PMID:18480465   PMID:21267068   PMID:21873635   PMID:27923395   PMID:28671696   PMID:30562941   PMID:32325033   PMID:32857879   PMID:34269176   PMID:34321999  


Genomics

Comparative Map Data
Tagln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391645,531,591 - 45,545,271 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1645,531,593 - 45,544,971 (-)EnsemblGRCm39 Ensembl
GRCm381645,711,230 - 45,724,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,711,230 - 45,724,608 (-)EnsemblGRCm38mm10GRCm38
MGSCv371645,711,343 - 45,724,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,630,562 - 45,643,863 (-)NCBIMGSCv36mm8
Celera1646,088,034 - 46,101,263 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1629.99NCBI
TAGLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383111,998,922 - 112,013,885 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3111,998,739 - 112,013,887 (+)EnsemblGRCh38hg38GRCh38
GRCh373111,717,769 - 111,732,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,200,276 - 113,215,425 (+)NCBINCBI36Build 36hg18NCBI36
Build 343113,200,275 - 113,215,424NCBI
Celera3110,116,666 - 110,131,815 (+)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3109,092,929 - 109,108,077 (+)NCBIHuRef
CHM1_13111,681,627 - 111,696,769 (+)NCBICHM1_1
T2T-CHM13v2.03114,720,030 - 114,734,995 (+)NCBIT2T-CHM13v2.0
Tagln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,562,482 - 68,576,058 (+)NCBIGRCr8
mRatBN7.21155,099,887 - 55,113,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,099,743 - 55,113,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1163,874,826 - 63,888,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,536,706 - 56,550,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01155,642,796 - 55,656,336 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,072,983 - 60,086,552 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,072,727 - 60,086,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1157,505,005 - 57,518,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,668,085 - 60,681,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,587,304 - 56,600,874 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,645,293 - 56,658,463 (+)NCBI
Celera1154,624,418 - 54,637,992 (+)NCBICelera
Cytogenetic Map11q21NCBI
Tagln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542712,412,378 - 12,426,463 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542712,412,959 - 12,426,400 (+)NCBIChiLan1.0ChiLan1.0
TAGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22109,998,587 - 110,013,763 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13110,003,367 - 110,018,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03109,143,253 - 109,158,367 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13116,067,138 - 116,082,304 (+)NCBIpanpan1.1PanPan1.1panPan2
TAGLN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13316,638,371 - 16,652,418 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3316,638,362 - 16,652,423 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3316,740,287 - 16,754,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03316,876,375 - 16,890,186 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3316,876,360 - 16,890,183 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13316,686,506 - 16,700,298 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03316,732,143 - 16,745,953 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,277,135 - 17,290,982 (+)NCBIUU_Cfam_GSD_1.0
Tagln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,757,248 - 137,771,202 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936834812,676 - 826,759 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936834812,681 - 826,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAGLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,740,917 - 147,754,848 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113147,740,913 - 147,754,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213157,488,973 - 157,500,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAGLN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,783,315 - 68,797,900 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2268,783,116 - 68,797,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604197,676,051 - 97,691,436 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tagln3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473136,559,383 - 36,574,932 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473136,560,502 - 36,575,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tagln3
548 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:145
Interacting mature miRNAs:147
Transcripts:ENSMUST00000096057
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse

Markers in Region
AI426007  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381645,711,315 - 45,711,432UniSTSGRCm38
MGSCv371645,711,428 - 45,711,545UniSTSGRCm37
Celera1646,088,119 - 46,088,236UniSTS
Cytogenetic Map16B5UniSTS
Whitehead/MRC_RH16539.26UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000096057   ⟹   ENSMUSP00000093762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1645,531,593 - 45,544,971 (-)Ensembl
GRCm38.p6 Ensembl1645,711,230 - 45,724,608 (-)Ensembl
RefSeq Acc Id: NM_019754   ⟹   NP_062728
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391645,531,593 - 45,544,894 (-)NCBI
GRCm381645,711,230 - 45,724,531 (-)ENTREZGENE
MGSCv371645,711,343 - 45,724,644 (-)RGD
Celera1646,088,034 - 46,101,263 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004939202
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391645,531,591 - 45,545,271 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062728   ⟸   NM_019754
- UniProtKB: Q9R1Q8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000093762   ⟸   ENSMUST00000096057
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1Q8-F1-model_v2 AlphaFold Q9R1Q8 1-199 view protein structure

Promoters
RGD ID:8686294
Promoter ID:EPDNEW_M21178
Type:initiation region
Name:Tagln3_1
Description:Mus musculus transgelin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21179  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381645,724,397 - 45,724,457EPDNEW
RGD ID:8686296
Promoter ID:EPDNEW_M21179
Type:initiation region
Name:Tagln3_2
Description:Mus musculus transgelin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M21178  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381645,724,536 - 45,724,596EPDNEW
RGD ID:6827548
Promoter ID:MM_KWN:21116
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   MEF_B6
Transcripts:OTTMUST00000066382
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361645,724,681 - 45,725,181 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926784 AgrOrtholog
Ensembl Genes ENSMUSG00000022658 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000096057 ENTREZGENE
  ENSMUST00000096057.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calponin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM22_calponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56370 UniProtKB/Swiss-Prot
MGD MGI:1926784 ENTREZGENE
NCBI Gene 56370 ENTREZGENE
PANTHER CALPONIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSGELIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calponin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tagln3 PhenoGen
PRINTS SM22CALPONIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSGELIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALPONIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CALPONIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q9D6K2_MOUSE UniProtKB/TrEMBL
  Q9R1Q8 ENTREZGENE, UniProtKB/Swiss-Prot