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Gene: CD59 (CD59 molecule (CD59 blood group)) Homo sapiens
Symbol: CD59
Name: CD59 molecule (CD59 blood group)
Description: Predicted to have complement binding activity. Involved in regulation of complement activation and regulation of complement-dependent cytotoxicity. Localizes to anchored component of external side of plasma membrane. Implicated in colorectal carcinoma and ovarian cancer. Biomarker of breast carcinoma; endometrial cancer; and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; cd59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 blood group antigen; CD59 glycoprotein; CD59 molecule; EJ16; EJ30; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MAC-IP; MACIF; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; membrane inhibitor of reactive lysis; MGC2354; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein
Mus musculus (house mouse) : Cd59b (CD59b antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd59 (CD59 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd59 (CD59 molecule (CD59 blood group))
Pan paniscus (bonobo/pygmy chimpanzee) : CD59 (CD59 molecule (CD59 blood group))
Canis lupus familiaris (dog) : CD59 (CD59 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd59 (CD59 molecule (CD59 blood group))
Sus scrofa (pig) : CD59 (CD59 molecule)
Chlorocebus sabaeus (African green monkey) : CD59 (CD59 molecule (CD59 blood group))
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(CD59-HBA1)Bryd  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1133,703,010 - 33,736,491 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl1133,703,010 - 33,736,479 (-)EnsemblGRCh38hg38GRCh38
GRCh381133,703,010 - 33,736,479 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371133,724,556 - 33,758,025 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361133,681,132 - 33,714,600 (-)NCBINCBI36hg18NCBI36
Build 341133,681,133 - 33,714,600NCBI
Celera1133,872,059 - 33,905,528 (-)NCBI
Cytogenetic Map11p13NCBI
HuRef1133,421,201 - 33,454,193 (-)NCBIHuRef
CHM1_11133,724,069 - 33,757,538 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CD59
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736600
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.