P2RY6 (pyrimidinergic receptor P2Y6) - Rat Genome Database

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Gene: P2RY6 (pyrimidinergic receptor P2Y6) Homo sapiens
Analyze
Symbol: P2RY6
Name: pyrimidinergic receptor P2Y6
RGD ID: 736435
HGNC Page HGNC:8543
Description: Enables G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of inositol trisphosphate biosynthetic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: G-coupled nucleotide receptor; MGC15335; P2 purinoceptor; P2Y purinoceptor 6; P2Y6; P2Y6 receptor; pyrimidinergic receptor P2Y, G-protein coupled, 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,264,506 - 73,298,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,264,498 - 73,305,103 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,975,551 - 73,009,670 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,653,218 - 72,687,312 (+)NCBINCBI36hg18NCBI36
Build 341172,658,586 - 72,686,497NCBI
Celera1170,280,653 - 70,314,752 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBIHuRef
CHM1_11172,859,110 - 72,893,227 (+)NCBICHM1_1
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8670200   PMID:8700127   PMID:9268704   PMID:9286708   PMID:9412455   PMID:9542531   PMID:11114308   PMID:11690642   PMID:11788430   PMID:12464620   PMID:12477932   PMID:12623123  
PMID:12691958   PMID:12716436   PMID:15489334   PMID:15498874   PMID:15796906   PMID:16322472   PMID:16543499   PMID:16754659   PMID:17410128   PMID:17762175   PMID:17971163   PMID:18240029  
PMID:18250478   PMID:19008857   PMID:19011163   PMID:19124756   PMID:19735076   PMID:20379614   PMID:21173118   PMID:21268712   PMID:21388279   PMID:21724990   PMID:21873635   PMID:21898410  
PMID:22102722   PMID:22249129   PMID:22558990   PMID:23723068   PMID:25243587   PMID:25416956   PMID:25445541   PMID:25816245   PMID:26760575   PMID:28219441   PMID:28277742   PMID:28318884  
PMID:28319085   PMID:28494003   PMID:28539604   PMID:29454075   PMID:30833792   PMID:32037085   PMID:32049380   PMID:32296183   PMID:32420639   PMID:32814053   PMID:34426542  


Genomics

Comparative Map Data
P2RY6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,264,506 - 73,298,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1173,264,498 - 73,305,103 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,975,551 - 73,009,670 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,653,218 - 72,687,312 (+)NCBINCBI36hg18NCBI36
Build 341172,658,586 - 72,686,497NCBI
Celera1170,280,653 - 70,314,752 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBIHuRef
CHM1_11172,859,110 - 72,893,227 (+)NCBICHM1_1
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
P2ry6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,586,837 - 100,628,528 (-)NCBIGRCm39mm39
GRCm39 Ensembl7100,586,837 - 100,623,856 (-)Ensembl
GRCm387100,937,630 - 100,975,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,937,630 - 100,974,649 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,086,148 - 108,112,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv367100,811,721 - 100,838,449 (-)NCBImm8
Celera7101,288,708 - 101,316,203 (-)NCBICelera
Cytogenetic Map7E2NCBI
P2ry6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,295,110 - 155,330,610 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1155,295,111 - 155,330,808 (-)Ensembl
Rnor_6.01165,972,439 - 166,008,348 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,972,440 - 165,997,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,169,438 - 172,204,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,381,127 - 158,406,783 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,460,144 - 158,485,800 (-)NCBI
Celera1153,376,657 - 153,401,528 (-)NCBICelera
Cytogenetic Map1q32NCBI
P2ry6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,177,406 - 18,215,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,177,406 - 18,215,428 (-)NCBIChiLan1.0ChiLan1.0
P2RY6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11171,562,990 - 71,595,540 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,594,250 - 71,595,236 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,341,722 - 68,375,923 (+)NCBIMhudiblu_PPA_v0panPan3
P2RY6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,929,502 - 24,966,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,929,771 - 24,930,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,693,846 - 24,731,202 (-)NCBI
ROS_Cfam_1.02125,136,107 - 25,173,439 (-)NCBI
ROS_Cfam_1.0 Ensembl2125,136,107 - 25,173,442 (-)Ensembl
UMICH_Zoey_3.12124,929,647 - 24,967,004 (-)NCBI
UNSW_CanFamBas_1.02125,130,680 - 25,168,052 (-)NCBI
UU_Cfam_GSD_1.02125,045,964 - 25,083,341 (-)NCBI
P2ry6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,868,422 - 60,901,890 (+)NCBI
SpeTri2.0NW_0049364982,468,020 - 2,501,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,749,375 - 7,759,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,708,452 - 7,759,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,538,019 - 8,554,097 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,508,959 - 64,543,302 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl164,541,221 - 64,542,207 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604361,343,922 - 61,369,829 (-)NCBIVero_WHO_p1.0
P2ry6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,648,829 - 3,671,852 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248173,648,829 - 3,672,051 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH45448  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,008,634 - 73,008,827UniSTSGRCh37
Build 361172,686,282 - 72,686,475RGDNCBI36
Celera1170,313,722 - 70,313,915RGD
Cytogenetic Map11q13.5UniSTS
HuRef1169,303,936 - 69,304,129UniSTS
GeneMap99-GB4 RH Map11271.04UniSTS
NCBI RH Map11625.5UniSTS
SHGC-145961  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,003,544 - 73,003,814UniSTSGRCh37
Build 361172,681,192 - 72,681,462RGDNCBI36
Celera1170,308,626 - 70,308,896RGD
Cytogenetic Map11q13.5UniSTS
HuRef1169,298,845 - 69,299,115UniSTS
TNG Radiation Hybrid Map1132839.0UniSTS
SHGC-149374  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,997,581 - 72,997,877UniSTSGRCh37
Build 361172,675,229 - 72,675,525RGDNCBI36
Celera1170,302,687 - 70,302,983RGD
Cytogenetic Map11q13.5UniSTS
HuRef1169,292,901 - 69,293,199UniSTS
TNG Radiation Hybrid Map1132827.0UniSTS
PMC156657P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,008,065 - 73,008,594UniSTSGRCh37
Build 361172,685,713 - 72,686,242RGDNCBI36
Celera1170,313,153 - 70,313,682RGD
Cytogenetic Map11q13.5UniSTS
HuRef1169,303,367 - 69,303,896UniSTS
RH18466  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371173,008,687 - 73,008,831UniSTSGRCh37
Build 361172,686,335 - 72,686,479RGDNCBI36
Celera1170,313,775 - 70,313,919RGD
Cytogenetic Map11q13.5UniSTS
HuRef1169,303,989 - 69,304,133UniSTS
GeneMap99-GB4 RH Map11264.3UniSTS
D11S353  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371172,990,878 - 72,991,027UniSTSGRCh37
Build 361172,668,526 - 72,668,675RGDNCBI36
Celera1170,295,984 - 70,296,133RGD
Cytogenetic Map11q13.5UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3189
Count of miRNA genes:836
Interacting mature miRNAs:1011
Transcripts:ENST00000349767, ENST00000393590, ENST00000393591, ENST00000393592, ENST00000535931, ENST00000536225, ENST00000538328, ENST00000540124, ENST00000540342, ENST00000542092, ENST00000544437
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 29 80 80 8 258 10 19 13 15 15 99 141 2 4 16 2
Low 1919 1867 1248 296 551 185 2797 1526 1383 352 817 1341 118 1018 1974 3
Below cutoff 437 1023 385 312 818 263 1506 634 2238 47 521 97 50 181 798

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_176798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047427039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF007891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF218005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL520218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL525099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ718871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX337204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX381745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX397649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR004482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR006998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY271000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000349767   ⟹   ENSP00000309771
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,264,517 - 73,297,805 (+)Ensembl
RefSeq Acc Id: ENST00000393590   ⟹   ENSP00000377215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,272,202 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000393591   ⟹   ENSP00000377216
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,269,894 - 73,297,805 (+)Ensembl
RefSeq Acc Id: ENST00000393592   ⟹   ENSP00000377217
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,264,498 - 73,297,802 (+)Ensembl
RefSeq Acc Id: ENST00000535931   ⟹   ENSP00000440770
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,289,407 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000536225   ⟹   ENSP00000442509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,272,420 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000538328   ⟹   ENSP00000442990
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,292,765 - 73,298,870 (+)Ensembl
RefSeq Acc Id: ENST00000540124   ⟹   ENSP00000442551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,272,338 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000540342   ⟹   ENSP00000443427
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,264,501 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000542092   ⟹   ENSP00000445652
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,264,510 - 73,297,805 (+)Ensembl
RefSeq Acc Id: ENST00000544437   ⟹   ENSP00000441079
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,289,407 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000618468   ⟹   ENSP00000480966
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,265,236 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000679753   ⟹   ENSP00000504879
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,264,505 - 73,305,103 (+)Ensembl
RefSeq Acc Id: ENST00000680825   ⟹   ENSP00000506026
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,295,730 - 73,298,625 (+)Ensembl
RefSeq Acc Id: ENST00000680915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,272,348 - 73,273,221 (+)Ensembl
RefSeq Acc Id: ENST00000680955   ⟹   ENSP00000505646
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1173,292,760 - 73,299,066 (+)Ensembl
RefSeq Acc Id: NM_001277204   ⟹   NP_001264133
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,272,338 - 73,298,625 (+)NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,866,747 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,201,506 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277205   ⟹   NP_001264134
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,298,625 (+)NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,859,110 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277206   ⟹   NP_001264135
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,265,230 - 73,298,625 (+)NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,859,841 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,194,398 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277207   ⟹   NP_001264136
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,298,625 (+)NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,859,157 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001277208   ⟹   NP_001264137
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,272,142 - 73,298,625 (+)NCBI
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,866,747 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,201,310 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176796   ⟹   NP_789766
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,298,625 (+)NCBI
GRCh371172,975,550 - 73,009,670 (+)NCBI
Build 361172,653,218 - 72,686,498 (+)NCBI Archive
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,859,110 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176797   ⟹   NP_789767
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,298,625 (+)NCBI
GRCh371172,975,550 - 73,009,670 (+)NCBI
Build 361172,653,218 - 72,686,498 (+)NCBI Archive
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,859,110 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,193,675 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: NM_176798   ⟹   NP_789768
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
GRCh371172,975,550 - 73,009,670 (+)NCBI
Build 361172,658,587 - 72,686,498 (+)NCBI Archive
HuRef1169,270,867 - 69,304,972 (+)NCBI
CHM1_11172,864,499 - 72,893,227 (+)NCBI
T2T-CHM13v2.01173,199,062 - 73,227,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005274022   ⟹   XP_005274079
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,292,787 - 73,298,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006718571   ⟹   XP_006718634
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,292,787 - 73,298,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545076   ⟹   XP_011543378
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545079   ⟹   XP_011543381
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,298,625 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047427036   ⟹   XP_047282992
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
RefSeq Acc Id: XM_047427037   ⟹   XP_047282993
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
RefSeq Acc Id: XM_047427038   ⟹   XP_047282994
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
RefSeq Acc Id: XM_047427039   ⟹   XP_047282995
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,269,894 - 73,298,625 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001264133 (Get FASTA)   NCBI Sequence Viewer  
  NP_001264134 (Get FASTA)   NCBI Sequence Viewer  
  NP_001264135 (Get FASTA)   NCBI Sequence Viewer  
  NP_001264136 (Get FASTA)   NCBI Sequence Viewer  
  NP_001264137 (Get FASTA)   NCBI Sequence Viewer  
  NP_789766 (Get FASTA)   NCBI Sequence Viewer  
  NP_789767 (Get FASTA)   NCBI Sequence Viewer  
  NP_789768 (Get FASTA)   NCBI Sequence Viewer  
  XP_005274079 (Get FASTA)   NCBI Sequence Viewer  
  XP_006718634 (Get FASTA)   NCBI Sequence Viewer  
  XP_011543378 (Get FASTA)   NCBI Sequence Viewer  
  XP_011543381 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282992 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282993 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282994 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03572 (Get FASTA)   NCBI Sequence Viewer  
  AAB80712 (Get FASTA)   NCBI Sequence Viewer  
  AAB80713 (Get FASTA)   NCBI Sequence Viewer  
  AAG17247 (Get FASTA)   NCBI Sequence Viewer  
  AAH00571 (Get FASTA)   NCBI Sequence Viewer  
  AAH09391 (Get FASTA)   NCBI Sequence Viewer  
  AAM18129 (Get FASTA)   NCBI Sequence Viewer  
  AAP35417 (Get FASTA)   NCBI Sequence Viewer  
  CAA65770 (Get FASTA)   NCBI Sequence Viewer  
  CAE11651 (Get FASTA)   NCBI Sequence Viewer  
  EAW74886 (Get FASTA)   NCBI Sequence Viewer  
  EAW74887 (Get FASTA)   NCBI Sequence Viewer  
  EAW74888 (Get FASTA)   NCBI Sequence Viewer  
  EAW74889 (Get FASTA)   NCBI Sequence Viewer  
  EAW74890 (Get FASTA)   NCBI Sequence Viewer  
  Q15077 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_789766   ⟸   NM_176796
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_789767   ⟸   NM_176797
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_789768   ⟸   NM_176798
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264134   ⟸   NM_001277205
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264136   ⟸   NM_001277207
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264135   ⟸   NM_001277206
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264133   ⟸   NM_001277204
- Peptide Label: isoform 1
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264137   ⟸   NM_001277208
- Peptide Label: isoform 2
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005274079   ⟸   XM_005274022
- Peptide Label: isoform X3
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006718634   ⟸   XM_006718571
- Peptide Label: isoform X3
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011543381   ⟸   XM_011545079
- Peptide Label: isoform X3
- UniProtKB: Q15077 (UniProtKB/Swiss-Prot),   A0A024R5I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011543378   ⟸   XM_011545076
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000445652   ⟸   ENST00000542092
RefSeq Acc Id: ENSP00000441079   ⟸   ENST00000544437
RefSeq Acc Id: ENSP00000309771   ⟸   ENST00000349767
RefSeq Acc Id: ENSP00000440770   ⟸   ENST00000535931
RefSeq Acc Id: ENSP00000442509   ⟸   ENST00000536225
RefSeq Acc Id: ENSP00000442990   ⟸   ENST00000538328
RefSeq Acc Id: ENSP00000377215   ⟸   ENST00000393590
RefSeq Acc Id: ENSP00000377217   ⟸   ENST00000393592
RefSeq Acc Id: ENSP00000377216   ⟸   ENST00000393591
RefSeq Acc Id: ENSP00000480966   ⟸   ENST00000618468
RefSeq Acc Id: ENSP00000443427   ⟸   ENST00000540342
RefSeq Acc Id: ENSP00000442551   ⟸   ENST00000540124
RefSeq Acc Id: ENSP00000504879   ⟸   ENST00000679753
RefSeq Acc Id: ENSP00000506026   ⟸   ENST00000680825
RefSeq Acc Id: ENSP00000505646   ⟸   ENST00000680955
RefSeq Acc Id: XP_047282994   ⟸   XM_047427038
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047282992   ⟸   XM_047427036
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047282993   ⟸   XM_047427037
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047282995   ⟸   XM_047427039
- Peptide Label: isoform X3
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15077-F1-model_v2 AlphaFold Q15077 1-328 view protein structure

Promoters
RGD ID:6789194
Promoter ID:HG_KWN:13670
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_004154,   UC001OTS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361172,660,831 - 72,661,331 (+)MPROMDB
RGD ID:7221481
Promoter ID:EPDNEW_H16486
Type:initiation region
Name:P2RY6_1
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16488  EPDNEW_H16487  EPDNEW_H16489  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,506 - 73,264,566EPDNEW
RGD ID:7221485
Promoter ID:EPDNEW_H16487
Type:initiation region
Name:P2RY6_4
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16486  EPDNEW_H16488  EPDNEW_H16489  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,264,630 - 73,264,690EPDNEW
RGD ID:7221483
Promoter ID:EPDNEW_H16488
Type:initiation region
Name:P2RY6_2
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16486  EPDNEW_H16487  EPDNEW_H16489  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,272,244 - 73,272,304EPDNEW
RGD ID:7221487
Promoter ID:EPDNEW_H16489
Type:initiation region
Name:P2RY6_3
Description:pyrimidinergic receptor P2Y6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16486  EPDNEW_H16488  EPDNEW_H16487  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381173,272,376 - 73,272,436EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_001277208.1(P2RY6):c.117G>A (p.Ser39_Val40=) single nucleotide variant not provided [RCV000949972] Chr11:73272314 [GRCh38]
Chr11:72983359 [GRCh37]
Chr11:11q13.4
benign
NM_001277204.2(P2RY6):c.786C>T (p.Tyr262=) single nucleotide variant not provided [RCV000883339] Chr11:73297304 [GRCh38]
Chr11:73008349 [GRCh37]
Chr11:11q13.4
benign
NM_001277204.2(P2RY6):c.826T>C (p.Leu276=) single nucleotide variant not provided [RCV000962431] Chr11:73297344 [GRCh38]
Chr11:73008389 [GRCh37]
Chr11:11q13.4
benign
GRCh37/hg19 11q13.4(chr11:72998686-73156844)x3 copy number gain not provided [RCV000847025] Chr11:72998686..73156844 [GRCh37]
Chr11:11q13.4
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8543 AgrOrtholog
COSMIC P2RY6 COSMIC
Ensembl Genes ENSG00000171631 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000309771 ENTREZGENE
  ENSP00000309771.2 UniProtKB/Swiss-Prot
  ENSP00000377215.2 UniProtKB/Swiss-Prot
  ENSP00000377216 ENTREZGENE
  ENSP00000377216.1 UniProtKB/Swiss-Prot
  ENSP00000377217 ENTREZGENE
  ENSP00000377217.2 UniProtKB/Swiss-Prot
  ENSP00000440770 UniProtKB/TrEMBL
  ENSP00000440770.2 UniProtKB/Swiss-Prot
  ENSP00000441079 UniProtKB/TrEMBL
  ENSP00000441079.2 UniProtKB/Swiss-Prot
  ENSP00000442509.2 UniProtKB/TrEMBL
  ENSP00000442551 ENTREZGENE
  ENSP00000442551.1 UniProtKB/Swiss-Prot
  ENSP00000442990 ENTREZGENE
  ENSP00000442990.1 UniProtKB/Swiss-Prot
  ENSP00000443427 ENTREZGENE
  ENSP00000443427.1 UniProtKB/Swiss-Prot
  ENSP00000445652 ENTREZGENE
  ENSP00000445652.1 UniProtKB/Swiss-Prot
  ENSP00000480966 ENTREZGENE
  ENSP00000480966.1 UniProtKB/Swiss-Prot
  ENSP00000504879 ENTREZGENE
  ENSP00000504879.1 UniProtKB/Swiss-Prot
  ENSP00000505646 ENTREZGENE
  ENSP00000505646.1 UniProtKB/Swiss-Prot
  ENSP00000506026.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000349767 ENTREZGENE
  ENST00000349767.6 UniProtKB/Swiss-Prot
  ENST00000393590.3 UniProtKB/Swiss-Prot
  ENST00000393591 ENTREZGENE
  ENST00000393591.5 UniProtKB/Swiss-Prot
  ENST00000393592 ENTREZGENE
  ENST00000393592.7 UniProtKB/Swiss-Prot
  ENST00000535931 UniProtKB/TrEMBL
  ENST00000535931.2 UniProtKB/Swiss-Prot
  ENST00000536225.2 UniProtKB/TrEMBL
  ENST00000538328 ENTREZGENE
  ENST00000538328.2 UniProtKB/Swiss-Prot
  ENST00000540124 ENTREZGENE
  ENST00000540124.6 UniProtKB/Swiss-Prot
  ENST00000540342 ENTREZGENE
  ENST00000540342.6 UniProtKB/Swiss-Prot
  ENST00000542092 ENTREZGENE
  ENST00000542092.5 UniProtKB/Swiss-Prot
  ENST00000544437 UniProtKB/TrEMBL
  ENST00000544437.6 UniProtKB/Swiss-Prot
  ENST00000618468 ENTREZGENE
  ENST00000618468.5 UniProtKB/Swiss-Prot
  ENST00000679753 ENTREZGENE
  ENST00000679753.1 UniProtKB/Swiss-Prot
  ENST00000680825.1 UniProtKB/TrEMBL
  ENST00000680955 ENTREZGENE
  ENST00000680955.1 UniProtKB/Swiss-Prot
GTEx ENSG00000171631 GTEx
HGNC ID HGNC:8543 ENTREZGENE
Human Proteome Map P2RY6 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y3_rcpt UniProtKB/TrEMBL
  P2Y6_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5031 ENTREZGENE
OMIM 602451 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32872 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y3PRNOCPTR UniProtKB/TrEMBL
  P2Y6PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R5I9 ENTREZGENE, UniProtKB/TrEMBL
  A0A7P0TA46_HUMAN UniProtKB/TrEMBL
  F5GX90_HUMAN UniProtKB/TrEMBL
  F5GYF3_HUMAN UniProtKB/TrEMBL
  F5H7H9_HUMAN UniProtKB/TrEMBL
  P2RY6_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q15754 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 P2RY6  pyrimidinergic receptor P2Y6  P2RY6  pyrimidinergic receptor P2Y, G-protein coupled, 6  Symbol and/or name change 5135510 APPROVED