Cyp2b19 (cytochrome P450, family 2, subfamily b, polypeptide 19) - Rat Genome Database

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Gene: Cyp2b19 (cytochrome P450, family 2, subfamily b, polypeptide 19) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
RGD ID: 736410
MGI Page MGI
Description: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPIIB19; cytochrome P450 2B19; Cytochrome P450 2B19 (CYPIIB19); cytochrome P450, 2b19
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,456,567 - 26,472,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,456,567 - 26,472,055 (+)EnsemblGRCm39 Ensembl
GRCm38726,757,142 - 26,772,630 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,757,142 - 26,772,630 (+)EnsemblGRCm38mm10GRCm38
MGSCv37727,542,206 - 27,557,649 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,465,947 - 26,481,390 (+)NCBIMGSCv36mm8
Celera721,341,874 - 21,357,577 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid. Keeney DS, etal., J Biol Chem. 1998 Apr 10;273(15):9279-84.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:9615220   PMID:9799616   PMID:9822682   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12840027   PMID:14630516   PMID:14681479   PMID:15680914  
PMID:16141072   PMID:16141073   PMID:17964055   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22083726   PMID:37660780  


Genomics

Variants

.
Variants in Cyp2b19
877 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:563
Count of miRNA genes:400
Interacting mature miRNAs:440
Transcripts:ENSMUST00000077855, ENSMUST00000132315, ENSMUST00000138018
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
D7Mit144  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38726,772,606 - 26,772,751UniSTSGRCm38
MGSCv37727,557,625 - 27,557,770UniSTSGRCm37
Celera721,357,553 - 21,357,698UniSTS
Cytogenetic Map7A3UniSTS
cM Map78.0UniSTS
Whitehead Genetic75.5UniSTS
Whitehead/MRC_RH7337.16UniSTS
Whitehead_YAC7 UniSTS
Cyp2b10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS
Cyp2b19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map715.44UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000077855   ⟹   ENSMUSP00000077021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,456,567 - 26,472,055 (+)Ensembl
GRCm38.p6 Ensembl726,757,142 - 26,772,630 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132315
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,456,588 - 26,465,059 (+)Ensembl
GRCm38.p6 Ensembl726,757,163 - 26,765,634 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,465,980 - 26,470,816 (+)Ensembl
GRCm38.p6 Ensembl726,766,555 - 26,771,391 (+)Ensembl
RefSeq Acc Id: NM_007814   ⟹   NP_031840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39726,456,567 - 26,472,055 (+)NCBI
GRCm38726,757,142 - 26,772,630 (+)NCBI
MGSCv37727,542,206 - 27,557,649 (+)RGD
Celera721,341,874 - 21,357,577 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031840 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC78770 (Get FASTA)   NCBI Sequence Viewer  
  AAI37966 (Get FASTA)   NCBI Sequence Viewer  
  AAI37967 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000077021
  ENSMUSP00000077021.7
GenBank Protein O55071 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031840   ⟸   NM_007814
- UniProtKB: B2RQK1 (UniProtKB/Swiss-Prot),   O55071 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000077021   ⟸   ENSMUST00000077855

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55071-F1-model_v2 AlphaFold O55071 1-492 view protein structure

Promoters
RGD ID:6892320
Promoter ID:EPDNEW_M9611
Type:multiple initiation site
Name:Cyp2b19_1
Description:Mus musculus cytochrome P450, family 2, subfamily b, polypeptide19 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38726,757,162 - 26,757,222EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107303 AgrOrtholog
Ensembl Genes ENSMUSG00000066704 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000077855 ENTREZGENE
  ENSMUST00000077855.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report mmu:13090 UniProtKB/Swiss-Prot
MGD MGI:107303 ENTREZGENE
NCBI Gene 13090 ENTREZGENE
PANTHER CYTOCHROME P450 2B19-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2b19 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2B UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt B2RQK1 ENTREZGENE
  CP2BJ_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RQK1 UniProtKB/Swiss-Prot