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Gene: PCSK2 (proprotein convertase subtilisin/kexin type 2) Homo sapiens
Symbol: PCSK2
Name: proprotein convertase subtilisin/kexin type 2
Description: Exhibits serine-type endopeptidase activity. Involved in insulin processing. Localizes to extracellular space; membrane; and nucleoplasm. Implicated in myocardial infarction and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KEX2-like endoprotease 2; NEC 2; NEC-2; NEC2; neuroendocrine convertase 2; PC2; prohormone convertase 2; proprotein convertase 2; SPC2; subtilisin-like prohormone convertases
Mus musculus (house mouse) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Canis lupus familiaris (dog) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)
Sus scrofa (pig) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Chlorocebus sabaeus (African green monkey) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Heterocephalus glaber (naked mole-rat) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2017,226,107 - 17,484,578 (+)EnsemblGRCh38hg38GRCh38
GRCh382017,226,107 - 17,484,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372017,206,752 - 17,465,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,155,631 - 17,413,223 (+)NCBINCBI36hg18NCBI36
Build 342017,155,630 - 17,413,223NCBI
Celera2017,282,082 - 17,539,671 (+)NCBI
Cytogenetic Map20p12.1NCBI
HuRef2017,169,857 - 17,428,162 (+)NCBIHuRef
CHM1_12017,206,780 - 17,465,251 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PCSK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736345
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.