CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) - Rat Genome Database

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Gene: CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) Homo sapiens
Analyze
Symbol: CNP
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
RGD ID: 736298
HGNC Page HGNC
Description: Predicted to have 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Localizes to several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome; INTERACTS WITH 2-hydroxypropanoic acid; acrolein; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP1; CNPase; HLD20
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1741,966,763 - 41,977,740 (+)EnsemblGRCh38hg38GRCh38
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,118,813 - 40,129,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
aniline  (ISO)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (EXP)
corticotropin  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
enniatin  (EXP)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
haloperidol  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
oxycodone  (ISO)
ozone  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (EXP)
rimonabant  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
SR 144528  (ISO)
sunitinib  (EXP)
Temsirolimus  (ISO)
tetrachloromethane  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Chen S, etal., PLoS One. 2011;6(8):e24293. Epub 2011 Aug 30.
2. Connor JR, etal., Sleep Med. 2011 Jun;12(6):614-9. Epub 2011 May 12.
3. Degano AL and Roth GA, J Neurosci Res. 2000 Jan 15;59(2):283-90.
4. Georgieva L, etal., Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12469-74. Epub 2006 Aug 4.
5. GOA_HUMAN data from the GO Consortium
6. Hagemeyer N, etal., EMBO Mol Med. 2012 Apr 4. doi: 10.1002/emmm.201200230.
7. Huang Z, etal., Brain Res. 2009 Dec 8;1301:100-9. Epub 2009 Sep 10.
8. Kooi EJ, etal., Neuropathol Appl Neurobiol. 2009 Jun;35(3):283-95. Epub 2008 Sep 17.
9. Lee JH, etal., Brain Res. 2007 Dec 14;1185:246-55. Epub 2007 Sep 20.
10. Lewohl JM, etal., Alcohol Clin Exp Res. 2005 Sep;29(9):1698-705.
11. Lin KY and Lai SC, J Comp Pathol. 2009 Nov;141(4):248-53. Epub 2009 Jul 9.
12. Lovato L, etal., Mol Cell Proteomics. 2008 Dec;7(12):2337-49. Epub 2008 Jul 31.
13. Peirce TR, etal., Arch Gen Psychiatry. 2006 Jan;63(1):18-24.
14. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. RGD automated import pipeline for gene-chemical interactions
16. Sajad M, etal., J Mol Neurosci. 2011 Mar;43(3):531-40. Epub 2010 Nov 25.
17. Svetlov SI, etal., J Trauma. 2010 Oct;69(4):795-804.
18. Tang F, etal., Neurosci Lett. 2007 Apr 12;416(2):113-6. Epub 2007 Jan 30.
19. Ulrich R, etal., Neuropathol Appl Neurobiol. 2008 Dec;34(6):603-20. Epub 2008 May 5.
20. Yao DL, etal., Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6190-4.
Additional References at PubMed
PMID:1315529   PMID:1322358   PMID:1360194   PMID:1385234   PMID:2161933   PMID:2164018   PMID:2835044   PMID:2995854   PMID:6328143   PMID:7821789   PMID:8392017   PMID:8921398  
PMID:9268698   PMID:10646504   PMID:11156964   PMID:11842207   PMID:11993850   PMID:12452325   PMID:12477932   PMID:12643545   PMID:12947117   PMID:14702039   PMID:15489334   PMID:15502338  
PMID:15713463   PMID:16103231   PMID:16343930   PMID:17010574   PMID:17081065   PMID:17150526   PMID:17215244   PMID:17500595   PMID:17964117   PMID:18289148   PMID:18482256   PMID:18496213  
PMID:19034380   PMID:19056867   PMID:19165527   PMID:19199708   PMID:19348671   PMID:19508346   PMID:19913121   PMID:19946888   PMID:20628086   PMID:21525035   PMID:21873635   PMID:22321011  
PMID:22589395   PMID:22678362   PMID:22810586   PMID:22926577   PMID:22954668   PMID:23032943   PMID:23084924   PMID:23376485   PMID:23533145   PMID:23667531   PMID:23891004   PMID:24260477  
PMID:24705354   PMID:24711643   PMID:24797263   PMID:24808540   PMID:25281560   PMID:25756610   PMID:25921289   PMID:25930075   PMID:25963833   PMID:26186194   PMID:26972000   PMID:27025967  
PMID:27173435   PMID:27637333   PMID:28031328   PMID:28514442   PMID:28515276   PMID:28675297   PMID:29467282   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29615496   PMID:29715546  
PMID:29844126   PMID:30166453   PMID:30194290   PMID:30209976   PMID:30355738   PMID:30471916   PMID:30581152   PMID:30619736   PMID:30833792   PMID:30940648   PMID:31090455   PMID:31091453  
PMID:31343991   PMID:31527615   PMID:31586073   PMID:31617266   PMID:31980649   PMID:32128616   PMID:32457219   PMID:32780723   PMID:32814053   PMID:32877691   PMID:33144569  


Genomics

Comparative Map Data
CNP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1741,966,763 - 41,977,740 (+)EnsemblGRCh38hg38GRCh38
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,118,813 - 40,129,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
Cnp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,465,765 - 100,472,565 (+)NCBIGRCm39mm39
GRCm39 Ensembl11100,465,730 - 100,482,555 (+)Ensembl
GRCm3811100,574,909 - 100,591,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,574,904 - 100,591,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,436,253 - 100,443,053 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611100,391,065 - 100,397,815 (+)NCBImm8
Celera11111,195,104 - 111,201,904 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Cnp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,511,164 - 85,517,723 (+)NCBI
Rnor_6.0 Ensembl1088,490,798 - 88,497,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01088,490,798 - 88,497,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,284,045 - 88,290,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,519,421 - 89,525,978 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,533,790 - 89,540,348 (+)NCBI
Celera1084,227,529 - 84,234,088 (+)NCBICelera
RH 3.4 Map10859.8RGD
Cytogenetic Map10q31NCBI
Cnp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,114,454 - 16,118,622 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,115,137 - 16,119,261 (+)NCBIChiLan1.0ChiLan1.0
CNP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,560,056 - 15,569,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,560,056 - 15,568,916 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,338,085 - 15,349,089 (-)NCBIMhudiblu_PPA_v0panPan3
CNP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,888,350 - 20,896,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,886,574 - 20,896,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,349,053 - 20,356,835 (-)NCBI
ROS_Cfam_1.0921,606,902 - 21,614,689 (-)NCBI
UMICH_Zoey_3.1920,392,407 - 20,400,181 (-)NCBI
UNSW_CanFamBas_1.0920,659,216 - 20,666,990 (-)NCBI
UU_Cfam_GSD_1.0920,762,355 - 20,770,140 (-)NCBI
LOC101962838
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,233,405 - 20,240,592 (-)NCBI
SpeTri2.0NW_00493649016,834,570 - 16,841,734 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,758,081 - 20,776,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,758,081 - 20,765,655 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,048,293 - 21,055,830 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103243434
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,288,583 - 64,296,940 (-)NCBI
ChlSab1.1 Ensembl1664,289,828 - 64,296,922 (-)Ensembl
Vero_WHO_p1.0NW_02366607735,106,165 - 35,114,853 (-)NCBI
Cnp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,856,455 - 1,861,142 (-)NCBI

Position Markers
WI-15279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,125,923 - 40,126,022UniSTSGRCh37
Build 361737,379,449 - 37,379,548RGDNCBI36
Celera1736,780,623 - 36,780,722RGD
Cytogenetic Map17q21UniSTS
HuRef1735,891,287 - 35,891,386UniSTS
GeneMap99-GB4 RH Map17309.32UniSTS
Whitehead-RH Map17343.6UniSTS
WI-15314  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,127,049 - 40,127,174UniSTSGRCh37
Build 361737,380,575 - 37,380,700RGDNCBI36
Celera1736,781,749 - 36,781,874RGD
Cytogenetic Map17q21UniSTS
HuRef1735,892,413 - 35,892,538UniSTS
GeneMap99-GB4 RH Map17316.37UniSTS
Whitehead-RH Map17339.5UniSTS
NCBI RH Map17352.4UniSTS
RH103542  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,121,038 - 40,121,167UniSTSGRCh37
Build 361737,374,564 - 37,374,693RGDNCBI36
Celera1736,775,737 - 36,775,866RGD
Cytogenetic Map17q21UniSTS
HuRef1735,886,402 - 35,886,531UniSTS
GeneMap99-GB4 RH Map17307.26UniSTS
G63900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,128,796 - 40,129,133UniSTSGRCh37
Build 361737,382,322 - 37,382,659RGDNCBI36
Celera1736,783,497 - 36,783,834RGD
Cytogenetic Map17q21UniSTS
Cytogenetic Map17q11.2UniSTS
HuRef1735,894,160 - 35,894,497UniSTS
D17S824E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,125,500 - 40,125,629UniSTSGRCh37
Build 361737,379,026 - 37,379,155RGDNCBI36
Celera1736,780,200 - 36,780,329RGD
Cytogenetic Map17q21UniSTS
HuRef1735,890,864 - 35,890,993UniSTS
SGC35787  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,125,977 - 40,126,184UniSTSGRCh37
Build 361737,379,503 - 37,379,710RGDNCBI36
Celera1736,780,677 - 36,780,884RGD
Cytogenetic Map17q21UniSTS
HuRef1735,891,341 - 35,891,548UniSTS
GeneMap99-GB4 RH Map17309.83UniSTS
Whitehead-RH Map17343.6UniSTS
G10619  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,126,235 - 40,126,411UniSTSGRCh37
Build 361737,379,761 - 37,379,937RGDNCBI36
Celera1736,780,935 - 36,781,111RGD
Cytogenetic Map17q21UniSTS
HuRef1735,891,599 - 35,891,775UniSTS
RH1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,126,842 - 40,127,092UniSTSGRCh37
Build 361737,380,368 - 37,380,618RGDNCBI36
Celera1736,781,542 - 36,781,792RGD
Cytogenetic Map17q21UniSTS
HuRef1735,892,206 - 35,892,456UniSTS
GeneMap99-GB4 RH Map17307.04UniSTS
NCBI RH Map17483.8UniSTS
CNP_534.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,125,712 - 40,126,583UniSTSGRCh37
Build 361737,379,238 - 37,380,109RGDNCBI36
Celera1736,780,412 - 36,781,283RGD
HuRef1735,891,076 - 35,891,947UniSTS
GDB:201802  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,125,051 - 40,125,492UniSTSGRCh37
Celera1736,779,751 - 36,780,192UniSTS
Cytogenetic Map17q21UniSTS
HuRef1735,890,415 - 35,890,856UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5707
Count of miRNA genes:1184
Interacting mature miRNAs:1550
Transcripts:ENST00000393888, ENST00000393892, ENST00000441615, ENST00000472031, ENST00000486438, ENST00000585452, ENST00000587679, ENST00000589772, ENST00000591072, ENST00000591945, ENST00000592105, ENST00000592446, ENST00000592861
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 78
Medium 2381 1894 1642 549 1347 391 3896 1362 3643 378 1441 1602 172 1204 2328 3
Low 58 1097 84 75 604 74 461 835 13 41 19 11 3 1 460 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001330216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011524340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB988051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY337437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000393888   ⟹   ENSP00000377466
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,815 - 41,975,176 (+)Ensembl
RefSeq Acc Id: ENST00000393892   ⟹   ENSP00000377470
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,795 - 41,977,740 (+)Ensembl
RefSeq Acc Id: ENST00000441615   ⟹   ENSP00000413104
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,882 - 41,968,557 (+)Ensembl
RefSeq Acc Id: ENST00000472031   ⟹   ENSP00000467641
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,763 - 41,974,228 (+)Ensembl
RefSeq Acc Id: ENST00000486438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,971,609 - 41,973,962 (+)Ensembl
RefSeq Acc Id: ENST00000585452   ⟹   ENSP00000468471
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,967,783 - 41,968,585 (+)Ensembl
RefSeq Acc Id: ENST00000587679   ⟹   ENSP00000468198
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,798 - 41,968,669 (+)Ensembl
RefSeq Acc Id: ENST00000589772   ⟹   ENSP00000466807
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,967,333 - 41,968,486 (+)Ensembl
RefSeq Acc Id: ENST00000591945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,795 - 41,968,175 (+)Ensembl
RefSeq Acc Id: ENST00000592105
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,971,288 - 41,973,817 (+)Ensembl
RefSeq Acc Id: ENST00000592446
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,966,798 - 41,968,503 (+)Ensembl
RefSeq Acc Id: ENST00000592861
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1741,970,281 - 41,971,797 (+)Ensembl
RefSeq Acc Id: NM_001330216   ⟹   NP_001317145
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,967,797 - 41,977,740 (+)NCBI
Sequence:
RefSeq Acc Id: NM_033133   ⟹   NP_149124
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,966,795 - 41,977,740 (+)NCBI
GRCh371740,118,737 - 40,129,754 (+)NCBI
Build 361737,372,285 - 37,383,280 (+)NCBI Archive
HuRef1735,884,123 - 35,895,118 (+)ENTREZGENE
CHM1_11740,354,523 - 40,365,518 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011524340   ⟹   XP_011522642
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,966,882 - 41,975,176 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_149124   ⟸   NM_033133
- Peptide Label: isoform 1
- UniProtKB: P09543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011522642   ⟸   XM_011524340
- Peptide Label: isoform X1
- UniProtKB: P09543 (UniProtKB/Swiss-Prot),   A0A024R1T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317145   ⟸   NM_001330216
- Peptide Label: isoform 2
- UniProtKB: P09543 (UniProtKB/Swiss-Prot),   A0A024R1T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000468471   ⟸   ENST00000585452
RefSeq Acc Id: ENSP00000413104   ⟸   ENST00000441615
RefSeq Acc Id: ENSP00000468198   ⟸   ENST00000587679
RefSeq Acc Id: ENSP00000466807   ⟸   ENST00000589772
RefSeq Acc Id: ENSP00000377466   ⟸   ENST00000393888
RefSeq Acc Id: ENSP00000377470   ⟸   ENST00000393892
RefSeq Acc Id: ENSP00000467641   ⟸   ENST00000472031

Promoters
RGD ID:6793879
Promoter ID:HG_KWN:26162
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_033133,   OTTHUMT00000257445,   OTTHUMT00000257446,   UC002HYK.1,   UC002HYM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,371,586 - 37,372,522 (+)MPROMDB
RGD ID:6852500
Promoter ID:EP74062
Type:initiation region
Name:HS_CNP
Description:2',3'-cyclic nucleotide 3' phosphodiesterase.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,372,350 - 37,372,410EPD
RGD ID:6814594
Promoter ID:HG_XEF:3393
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat,   K562,   Lymphoblastoid
Transcripts:NM_001035528,   NM_001092161,   NM_001146318,   NM_180993,   NM_205050
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,372,989 - 37,373,489 (+)MPROMDB
RGD ID:6793880
Promoter ID:HG_KWN:26163
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:UC002HYN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361737,376,536 - 37,377,877 (+)MPROMDB
RGD ID:7235039
Promoter ID:EPDNEW_H23265
Type:initiation region
Name:CNP_1
Description:2',3'-cyclic nucleotide 3' phosphodiesterase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381741,966,795 - 41,966,855EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
NM_001144766.2(DNAJC7):c.1042C>T (p.Arg348Trp) single nucleotide variant Malignant melanoma [RCV000071486] Chr17:41982276 [GRCh38]
Chr17:40134294 [GRCh37]
Chr17:37387820 [NCBI36]
Chr17:17q21.2
not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_033133.5(CNP):c.-77C>T single nucleotide variant Myopia 2, autosomal dominant [RCV001072107] Chr17:41966808 [GRCh38]
Chr17:40118826 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.-67C>T single nucleotide variant Myopia 2, autosomal dominant [RCV001072111] Chr17:41966818 [GRCh38]
Chr17:40118836 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.1057C>T (p.Arg353Trp) single nucleotide variant Marfanoid habitus and intellectual disability [RCV000850468] Chr17:41973715 [GRCh38]
Chr17:40125733 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_033133.5(CNP):c.1095C>T (p.Gly365=) single nucleotide variant not provided [RCV000890316] Chr17:41973753 [GRCh38]
Chr17:40125771 [GRCh37]
Chr17:17q21.2
benign
NM_033133.5(CNP):c.59A>C (p.Lys20Thr) single nucleotide variant Myopia 2, autosomal dominant [RCV001072104] Chr17:41968123 [GRCh38]
Chr17:40120141 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.1034G>A (p.Gly345Asp) single nucleotide variant Myopia 2, autosomal dominant [RCV001072108] Chr17:41973692 [GRCh38]
Chr17:40125710 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.59A>G (p.Lys20Arg) single nucleotide variant Myopia 2, autosomal dominant [RCV001072109] Chr17:41968123 [GRCh38]
Chr17:40120141 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.1015G>A (p.Val339Ile) single nucleotide variant Myopia 2, autosomal dominant [RCV001072110] Chr17:41973673 [GRCh38]
Chr17:40125691 [GRCh37]
Chr17:17q21.2
pathogenic
NM_033133.5(CNP):c.245C>T (p.Ser82Leu) single nucleotide variant Leukodystrophy, hypomyelinating, 20 [RCV001263540] Chr17:41968309 [GRCh38]
Chr17:40120327 [GRCh37]
Chr17:17q21.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2158 AgrOrtholog
COSMIC CNP COSMIC
Ensembl Genes ENSG00000173786 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000377466 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000377470 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000413104 UniProtKB/TrEMBL
  ENSP00000466807 UniProtKB/TrEMBL
  ENSP00000467641 UniProtKB/TrEMBL
  ENSP00000468198 UniProtKB/TrEMBL
  ENSP00000468471 UniProtKB/TrEMBL
Ensembl Transcript ENST00000393888 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000393892 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000441615 UniProtKB/TrEMBL
  ENST00000472031 UniProtKB/TrEMBL
  ENST00000585452 UniProtKB/TrEMBL
  ENST00000587679 UniProtKB/TrEMBL
  ENST00000589772 UniProtKB/TrEMBL
GTEx ENSG00000173786 GTEx
HGNC ID HGNC:2158 ENTREZGENE
Human Proteome Map CNP Human Proteome Map
InterPro CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNuc_Pdiesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1267 UniProtKB/Swiss-Prot
NCBI Gene 1267 ENTREZGENE
OMIM 123830 OMIM
  619071 OMIM
PANTHER PTHR10156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26680 PharmGKB
PIRSF CNPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55144 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R1T5 ENTREZGENE, UniProtKB/TrEMBL
  C9K0L8_HUMAN UniProtKB/TrEMBL
  CN37_HUMAN UniProtKB/Swiss-Prot
  K7EN66_HUMAN UniProtKB/TrEMBL
  K7EQ27_HUMAN UniProtKB/TrEMBL
  K7ERC4_HUMAN UniProtKB/TrEMBL
  K7ERZ0_HUMAN UniProtKB/TrEMBL
  P09543 ENTREZGENE