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Gene: CNP (2',3'-cyclic nucleotide 3' phosphodiesterase) Homo sapiens
Symbol: CNP
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Description: Predicted to have 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Localizes to several cellular components, including extracellular space; microtubule; and nucleoplasm. Implicated in multiple sclerosis and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome; INTERACTS WITH 2-hydroxypropanoic acid; all-trans-retinoic acid; amiodarone.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP1; CNPase
Mus musculus (house mouse) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)
Pan paniscus (bonobo/pygmy chimpanzee) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Canis lupus familiaris (dog) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)
Sus scrofa (pig) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Chlorocebus sabaeus (African green monkey) : CNP (2',3'-cyclic nucleotide 3' phosphodiesterase)
Heterocephalus glaber (naked mole-rat) : Cnp (2',3'-cyclic nucleotide 3' phosphodiesterase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CNP (Gene ID: 1267) and NPPC (Gene ID: 4880) share the CNP symbol/alias in common. CNP is a widely used alternative name for C-type natriuretic peptide (NPPC), which can be confused with the official symbol for 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP). [06 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1741,966,763 - 41,977,740 (+)EnsemblGRCh38hg38GRCh38
GRCh381741,966,795 - 41,977,740 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,118,737 - 40,129,754 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,372,285 - 37,383,280 (+)NCBINCBI36hg18NCBI36
Build 341737,372,284 - 37,383,280NCBI
Celera1736,773,458 - 36,784,455 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1735,884,123 - 35,895,118 (+)NCBIHuRef
CHM1_11740,354,523 - 40,365,518 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CNP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736298
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.