Nat8 (N-acetyltransferase 8 (GCN5-related)) - Rat Genome Database

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Gene: Nat8 (N-acetyltransferase 8 (GCN5-related)) Mus musculus
Analyze
Symbol: Nat8
Name: N-acetyltransferase 8 (GCN5-related)
RGD ID: 736259
MGI Page MGI
Description: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in gastrulation with mouth forming second. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be integral component of membrane. Orthologous to several human genes including NAT8 (N-acetyltransferase 8 (putative)); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610037O16Rik; acetyltransferase 2; ATase2; camello-like 4; camello-like protein 4; CCNAT; Cml; Cml4; cysteinyl-conjugate N-acetyltransferase; N-acetyltransferase 8; N-acetyltransferase 8 (GCN5-related, putative); probable N-acetyltransferase CML4
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,807,369 - 85,813,839 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,807,370 - 85,809,064 (-)Ensembl
GRCm38685,830,387 - 85,836,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,780,381 - 85,781,884 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,796,045 - 85,797,740 (-)NCBImm8
Celera687,767,874 - 87,769,374 (-)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arecoline  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlorohydrocarbon  (ISO)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
dichloroacetic acid  (EXP)
diethyl maleate  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
furan  (ISO)
indole-3-methanol  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methylmercury chloride  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
zoledronic acid  (ISO)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:25057902   PMID:31806660  


Genomics

Comparative Map Data
Nat8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,807,369 - 85,813,839 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,807,370 - 85,809,064 (-)Ensembl
GRCm38685,830,387 - 85,836,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,780,381 - 85,781,884 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,796,045 - 85,797,740 (-)NCBImm8
Celera687,767,874 - 87,769,374 (-)NCBICelera
Cytogenetic Map6C3NCBI
NAT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl273,640,723 - 73,642,422 (-)EnsemblGRCh38hg38GRCh38
GRCh38273,640,723 - 73,642,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,867,850 - 73,869,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,721,358 - 73,723,045 (-)NCBINCBI36hg18NCBI36
Build 34273,779,613 - 73,781,182NCBI
Celera273,718,675 - 73,720,362 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef273,602,763 - 73,604,450 (-)NCBIHuRef
CHM1_1273,798,615 - 73,800,302 (-)NCBICHM1_1
Nat8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,279,521 - 118,284,671 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4118,270,954 - 118,281,763 (-)Ensembl
Rnor_6.04117,525,963 - 117,527,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,101,688 - 182,103,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,001,277 - 120,002,055 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,245,757 - 120,246,536 (-)NCBI
Celera4107,259,757 - 107,260,535 (-)NCBICelera
Cytogenetic Map4q34NCBI
NAT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A75,189,613 - 75,191,198 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,189,726 - 75,190,409 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A73,702,173 - 73,703,763 (-)NCBIMhudiblu_PPA_v0panPan3
NAT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,285,915 - 49,288,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,929,557 - 48,932,108 (+)NCBI
ROS_Cfam_1.01750,148,044 - 50,150,636 (+)NCBI
UMICH_Zoey_3.11749,164,172 - 49,166,764 (+)NCBI
UNSW_CanFamBas_1.01749,231,560 - 49,234,152 (+)NCBI
UU_Cfam_GSD_1.01749,790,606 - 49,793,199 (+)NCBI
NAT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1369,250,326 - 69,254,079 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,452,154 - 72,453,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,550,087 - 33,552,301 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604578,547,713 - 78,549,293 (-)NCBIVero_WHO_p1.0
Nat8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476296,735 - 97,440 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
UniSTS:235483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,830,393 - 85,830,633UniSTSGRCm38
MGSCv37685,780,387 - 85,780,627UniSTSGRCm37
Celera687,767,880 - 87,768,120UniSTS
Cytogenetic Map6C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:139
Interacting mature miRNAs:145
Transcripts:ENSMUST00000032073
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032073   ⟹   ENSMUSP00000032073
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,807,370 - 85,809,064 (-)Ensembl
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)Ensembl
RefSeq Acc Id: NM_001362060   ⟹   NP_001348989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,813,839 (-)NCBI
GRCm38685,830,387 - 85,836,857 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023455   ⟹   NP_075944
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,809,261 (-)NCBI
GRCm38685,830,387 - 85,832,279 (-)NCBI
MGSCv37685,780,381 - 85,781,884 (-)RGD
Celera687,767,874 - 87,769,374 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506536   ⟹   XP_006506599
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,809,859 (-)NCBI
GRCm38685,830,387 - 85,832,877 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075944   ⟸   NM_023455
- UniProtKB: Q9JIY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506599   ⟸   XM_006506536
- Peptide Label: isoform X1
- UniProtKB: Q9JIY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001348989   ⟸   NM_001362060
RefSeq Acc Id: ENSMUSP00000032073   ⟸   ENSMUST00000032073
Protein Domains
N-acetyltransferase

Promoters
RGD ID:6839125
Promoter ID:MM_KWN:46700
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009CQH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,781,686 - 85,782,186 (-)MPROMDB
RGD ID:6890340
Promoter ID:EPDNEW_M8574
Type:multiple initiation site
Name:Nat8_1
Description:Mus musculus N-acetyltransferase 8 (GCN5-related) , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,831,831 - 85,831,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915646 AgrOrtholog
Ensembl Genes ENSMUSG00000030004 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000032073 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032073 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
KEGG Report mmu:68396 UniProtKB/Swiss-Prot
MGD MGI:1915646 ENTREZGENE
NCBI Gene 68396 ENTREZGENE
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Nat8 PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
UniProt NAT8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 Nat8  N-acetyltransferase 8 (GCN5-related)    N-acetyltransferase 8 (GCN5-related, putative)  Symbol and/or name change 5135510 APPROVED