Nat8 (N-acetyltransferase 8 (GCN5-related)) - Rat Genome Database

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Gene: Nat8 (N-acetyltransferase 8 (GCN5-related)) Mus musculus
Analyze
Symbol: Nat8
Name: N-acetyltransferase 8 (GCN5-related)
RGD ID: 736259
MGI Page MGI
Description: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in gastrulation with mouth forming second. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610037O16Rik; acetyltransferase 2; ATase2; camello-like 4; camello-like protein 4; CCNAT; Cml; Cml4; cysteinyl-conjugate N-acetyltransferase; N-acetyltransferase 8; N-acetyltransferase 8 (GCN5-related, putative); probable N-acetyltransferase CML4
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,807,369 - 85,813,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,807,370 - 85,809,064 (-)EnsemblGRCm39 Ensembl
GRCm38685,830,387 - 85,836,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,780,381 - 85,781,884 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,796,045 - 85,797,740 (-)NCBIMGSCv36mm8
Celera687,767,874 - 87,769,374 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
arecoline  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorohydrocarbon  (ISO)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
dichloroacetic acid  (EXP)
diethyl maleate  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
furan  (ISO)
indole-3-methanol  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methylmercury chloride  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, etal., Dev Biol 2001 Jun 15;234(2):483-96.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:25057902   PMID:31806660   PMID:33846551  


Genomics

Comparative Map Data
Nat8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,807,369 - 85,813,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,807,370 - 85,809,064 (-)EnsemblGRCm39 Ensembl
GRCm38685,830,387 - 85,836,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,780,381 - 85,781,884 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,796,045 - 85,797,740 (-)NCBIMGSCv36mm8
Celera687,767,874 - 87,769,374 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.49NCBI
NAT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,640,723 - 73,642,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,640,723 - 73,642,422 (-)EnsemblGRCh38hg38GRCh38
GRCh37273,867,850 - 73,869,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,721,358 - 73,723,045 (-)NCBINCBI36Build 36hg18NCBI36
Build 34273,779,613 - 73,781,182NCBI
Celera273,718,675 - 73,720,362 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef273,602,763 - 73,604,450 (-)NCBIHuRef
CHM1_1273,798,615 - 73,800,302 (-)NCBICHM1_1
T2T-CHM13v2.0273,653,777 - 73,655,476 (-)NCBIT2T-CHM13v2.0
Nat8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,836,986 - 119,837,764 (-)NCBIGRCr8
mRatBN7.24118,279,521 - 118,284,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4118,270,954 - 118,281,763 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4123,760,745 - 123,761,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04119,535,547 - 119,536,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04118,149,119 - 118,149,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04117,525,963 - 117,527,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,101,688 - 182,103,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,001,277 - 120,002,055 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14120,245,757 - 120,246,536 (-)NCBI
Celera4107,259,757 - 107,260,535 (-)NCBICelera
Cytogenetic Map4q34NCBI
NAT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,730,365 - 52,731,508 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,733,118 - 52,734,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A73,702,173 - 73,703,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,189,613 - 75,191,198 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,189,726 - 75,190,409 (-)Ensemblpanpan1.1panPan2
NAT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,285,915 - 49,288,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,929,557 - 48,932,108 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01750,148,044 - 50,150,636 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11749,164,172 - 49,166,764 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,231,560 - 49,234,152 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,790,606 - 49,793,199 (+)NCBIUU_Cfam_GSD_1.0
NAT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1369,250,326 - 69,254,079 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,452,154 - 72,453,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,550,087 - 33,552,301 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604578,547,713 - 78,549,293 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nat8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476296,735 - 97,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nat8
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:139
Interacting mature miRNAs:145
Transcripts:ENSMUST00000032073
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse

Markers in Region
UniSTS:235483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,830,393 - 85,830,633UniSTSGRCm38
MGSCv37685,780,387 - 85,780,627UniSTSGRCm37
Celera687,767,880 - 87,768,120UniSTS
Cytogenetic Map6C3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000032073   ⟹   ENSMUSP00000032073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,807,370 - 85,809,064 (-)Ensembl
GRCm38.p6 Ensembl685,830,388 - 85,832,082 (-)Ensembl
RefSeq Acc Id: NM_001362060   ⟹   NP_001348989
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,813,839 (-)NCBI
GRCm38685,830,387 - 85,836,857 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023455   ⟹   NP_075944
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,809,261 (-)NCBI
GRCm38685,830,387 - 85,832,279 (-)NCBI
MGSCv37685,780,381 - 85,781,884 (-)RGD
Celera687,767,874 - 87,769,374 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506536   ⟹   XP_006506599
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,807,369 - 85,809,859 (-)NCBI
GRCm38685,830,387 - 85,832,877 (-)NCBI
Sequence:
RefSeq Acc Id: NP_075944   ⟸   NM_023455
- UniProtKB: Q9JIY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506599   ⟸   XM_006506536
- Peptide Label: isoform X1
- UniProtKB: Q9JIY7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001348989   ⟸   NM_001362060
- UniProtKB: Q9JIY7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000032073   ⟸   ENSMUST00000032073
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIY7-F1-model_v2 AlphaFold Q9JIY7 1-227 view protein structure

Promoters
RGD ID:6839125
Promoter ID:MM_KWN:46700
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC009CQH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,781,686 - 85,782,186 (-)MPROMDB
RGD ID:6890340
Promoter ID:EPDNEW_M8574
Type:multiple initiation site
Name:Nat8_1
Description:Mus musculus N-acetyltransferase 8 (GCN5-related) , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,831,831 - 85,831,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915646 AgrOrtholog
Ensembl Genes ENSMUSG00000030004 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032073 ENTREZGENE
  ENSMUST00000032073.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.630.30 UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
KEGG Report mmu:68396 UniProtKB/Swiss-Prot
MGD MGI:1915646 ENTREZGENE
NCBI Gene 68396 ENTREZGENE
PANTHER GNAT FAMILY N-ACETYLTRANSFERASE UniProtKB/Swiss-Prot
  N-ACETYLTRANSFERASE 8 UniProtKB/Swiss-Prot
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Nat8 PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
UniProt NAT8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 Nat8  N-acetyltransferase 8 (GCN5-related)    N-acetyltransferase 8 (GCN5-related, putative)  Symbol and/or name change 5135510 APPROVED