GPR135 (G protein-coupled receptor 135) - Rat Genome Database

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Gene: GPR135 (G protein-coupled receptor 135) Homo sapiens
Analyze
Symbol: GPR135
Name: G protein-coupled receptor 135
RGD ID: 736248
HGNC Page HGNC:19991
Description: Enables arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 135; HUMNPIIY20; probable G-protein coupled receptor 135
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381459,452,783 - 59,465,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1459,429,022 - 59,465,380 (-)EnsemblGRCh38hg38GRCh38
GRCh371459,927,477 - 59,932,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361458,999,993 - 59,001,812 (-)NCBINCBI36Build 36hg18NCBI36
Build 341458,965,492 - 59,001,812NCBI
Celera1439,979,309 - 39,981,128 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1440,094,106 - 40,095,925 (-)NCBIHuRef
CHM1_11459,868,393 - 59,870,212 (-)NCBICHM1_1
T2T-CHM13v2.01453,659,699 - 53,672,299 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endosome  (IBA,IDA,IEA)
endosome membrane  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, etal., FEBS Lett 2003 Nov 20;554(3):381-8.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12679517   PMID:14702039   PMID:15489334   PMID:16169070   PMID:20198315   PMID:21873635   PMID:22632162   PMID:24705354   PMID:28722770   PMID:28827538   PMID:29507755  
PMID:30021884   PMID:31343991  


Genomics

Comparative Map Data
GPR135
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381459,452,783 - 59,465,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1459,429,022 - 59,465,380 (-)EnsemblGRCh38hg38GRCh38
GRCh371459,927,477 - 59,932,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361458,999,993 - 59,001,812 (-)NCBINCBI36Build 36hg18NCBI36
Build 341458,965,492 - 59,001,812NCBI
Celera1439,979,309 - 39,981,128 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1440,094,106 - 40,095,925 (-)NCBIHuRef
CHM1_11459,868,393 - 59,870,212 (-)NCBICHM1_1
T2T-CHM13v2.01453,659,699 - 53,672,299 (-)NCBIT2T-CHM13v2.0
Gpr135
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391272,114,748 - 72,117,875 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1272,114,750 - 72,117,899 (-)EnsemblGRCm39 Ensembl
GRCm381272,067,974 - 72,071,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1272,067,976 - 72,071,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv371273,170,605 - 73,171,978 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361272,988,202 - 72,989,575 (-)NCBIMGSCv36mm8
Celera1273,180,633 - 73,182,006 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.2NCBI
Gpr135
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8696,363,466 - 96,366,594 (-)NCBIGRCr8
mRatBN7.2690,627,533 - 90,630,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl690,629,178 - 90,630,551 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx690,999,916 - 91,001,289 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0691,299,380 - 91,300,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0690,738,936 - 90,740,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0694,816,976 - 94,818,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl694,816,976 - 94,818,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06104,261,635 - 104,263,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4694,262,988 - 94,264,361 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1694,266,443 - 94,267,817 (-)NCBI
Celera689,094,054 - 89,095,427 (-)NCBICelera
Cytogenetic Map6q24NCBI
Gpr135
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546613,188,710 - 13,192,314 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546613,188,710 - 13,194,054 (-)NCBIChiLan1.0ChiLan1.0
GPR135
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21560,594,838 - 60,603,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11459,811,352 - 59,819,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01440,064,817 - 40,071,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11458,329,664 - 58,332,815 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1458,331,046 - 58,332,449 (-)Ensemblpanpan1.1panPan2
GPR135
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1834,683,841 - 34,685,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha834,444,248 - 34,446,877 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0834,919,401 - 34,922,039 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl834,919,001 - 34,922,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1834,536,642 - 34,539,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0834,605,685 - 34,608,329 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0834,972,929 - 34,975,567 (-)NCBIUU_Cfam_GSD_1.0
Gpr135
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864070,377,446 - 70,378,904 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364953,813,078 - 3,814,256 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364953,812,825 - 3,814,252 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR135
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1188,580,947 - 188,582,434 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11188,580,016 - 188,582,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GPR135
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12436,693,214 - 36,695,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2436,694,048 - 36,695,547 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605324,947,818 - 24,950,265 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr135
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473441,641,813 - 41,643,929 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPR135
28 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q22.3-23.3(chr14:57041036-67208231)x1 copy number loss See cases [RCV000051521] Chr14:57041036..67208231 [GRCh38]
Chr14:57507754..67674948 [GRCh37]
Chr14:56577507..66744701 [NCBI36]
Chr14:14q22.3-23.3		 pathogenic
GRCh38/hg38 14q23.1(chr14:58146022-61273619)x1 copy number loss See cases [RCV000051522] Chr14:58146022..61273619 [GRCh38]
Chr14:58612740..61740337 [GRCh37]
Chr14:57682493..60810090 [NCBI36]
Chr14:14q23.1		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q23.1-23.2(chr14:57653413-64093528)x1 copy number loss See cases [RCV000138348] Chr14:57653413..64093528 [GRCh38]
Chr14:58120131..64560246 [GRCh37]
Chr14:57189884..63629999 [NCBI36]
Chr14:14q23.1-23.2		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_022571.6(GPR135):c.134G>C (p.Ser45Thr) single nucleotide variant Inborn genetic diseases [RCV003295330] Chr14:59465093 [GRCh38]
Chr14:59931811 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.647C>T (p.Pro216Leu) single nucleotide variant Inborn genetic diseases [RCV003255600] Chr14:59464580 [GRCh38]
Chr14:59931298 [GRCh37]
Chr14:14q23.1		 uncertain significance
GRCh37/hg19 14q23.1(chr14:59527587-60119877)x3 copy number gain not provided [RCV000683612] Chr14:59527587..60119877 [GRCh37]
Chr14:14q23.1		 uncertain significance
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3		 likely pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
GRCh37/hg19 14q22.3-23.2(chr14:57804997-63590203)x1 copy number loss not provided [RCV002472446] Chr14:57804997..63590203 [GRCh37]
Chr14:14q22.3-23.2		 likely pathogenic
NM_022571.6(GPR135):c.359G>A (p.Gly120Asp) single nucleotide variant Inborn genetic diseases [RCV003264771] Chr14:59464868 [GRCh38]
Chr14:59931586 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.76G>A (p.Ala26Thr) single nucleotide variant Inborn genetic diseases [RCV002841502] Chr14:59465151 [GRCh38]
Chr14:59931869 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.940G>A (p.Val314Met) single nucleotide variant Inborn genetic diseases [RCV002993368] Chr14:59464287 [GRCh38]
Chr14:59931005 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1154T>C (p.Val385Ala) single nucleotide variant Inborn genetic diseases [RCV002778094] Chr14:59464073 [GRCh38]
Chr14:59930791 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.728C>T (p.Pro243Leu) single nucleotide variant Inborn genetic diseases [RCV002818558] Chr14:59464499 [GRCh38]
Chr14:59931217 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1070G>A (p.Arg357Gln) single nucleotide variant Inborn genetic diseases [RCV002774111] Chr14:59464157 [GRCh38]
Chr14:59930875 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.367G>A (p.Ala123Thr) single nucleotide variant Inborn genetic diseases [RCV002660795] Chr14:59464860 [GRCh38]
Chr14:59931578 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.238G>A (p.Glu80Lys) single nucleotide variant Inborn genetic diseases [RCV002888017] Chr14:59464989 [GRCh38]
Chr14:59931707 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1028G>T (p.Cys343Phe) single nucleotide variant Inborn genetic diseases [RCV002760067] Chr14:59464199 [GRCh38]
Chr14:59930917 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.782G>T (p.Gly261Val) single nucleotide variant Inborn genetic diseases [RCV002893022] Chr14:59464445 [GRCh38]
Chr14:59931163 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1408T>C (p.Cys470Arg) single nucleotide variant Inborn genetic diseases [RCV002708772] Chr14:59463819 [GRCh38]
Chr14:59930537 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.881G>A (p.Cys294Tyr) single nucleotide variant Inborn genetic diseases [RCV002712622] Chr14:59464346 [GRCh38]
Chr14:59931064 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.487G>C (p.Asp163His) single nucleotide variant Inborn genetic diseases [RCV002916554] Chr14:59464740 [GRCh38]
Chr14:59931458 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1156A>G (p.Ile386Val) single nucleotide variant Inborn genetic diseases [RCV002956124] Chr14:59464071 [GRCh38]
Chr14:59930789 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.941T>C (p.Val314Ala) single nucleotide variant Inborn genetic diseases [RCV002964829] Chr14:59464286 [GRCh38]
Chr14:59931004 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.162C>A (p.Asn54Lys) single nucleotide variant Inborn genetic diseases [RCV002748032] Chr14:59465065 [GRCh38]
Chr14:59931783 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.62C>T (p.Ser21Phe) single nucleotide variant Inborn genetic diseases [RCV002714357] Chr14:59465165 [GRCh38]
Chr14:59931883 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.152C>A (p.Ala51Glu) single nucleotide variant Inborn genetic diseases [RCV002674174] Chr14:59465075 [GRCh38]
Chr14:59931793 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1300T>A (p.Tyr434Asn) single nucleotide variant Inborn genetic diseases [RCV002655364] Chr14:59463927 [GRCh38]
Chr14:59930645 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1445C>T (p.Thr482Ile) single nucleotide variant Inborn genetic diseases [RCV003297715] Chr14:59463782 [GRCh38]
Chr14:59930500 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1012G>A (p.Val338Ile) single nucleotide variant Inborn genetic diseases [RCV003198815] Chr14:59464215 [GRCh38]
Chr14:59930933 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1318G>A (p.Ala440Thr) single nucleotide variant Inborn genetic diseases [RCV003287228] Chr14:59463909 [GRCh38]
Chr14:59930627 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.520G>C (p.Ala174Pro) single nucleotide variant Inborn genetic diseases [RCV003343264] Chr14:59464707 [GRCh38]
Chr14:59931425 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.575C>T (p.Ser192Leu) single nucleotide variant Inborn genetic diseases [RCV003360218] Chr14:59464652 [GRCh38]
Chr14:59931370 [GRCh37]
Chr14:14q23.1		 uncertain significance
NM_022571.6(GPR135):c.1460C>A (p.Ser487Tyr) single nucleotide variant Inborn genetic diseases [RCV003344938] Chr14:59463767 [GRCh38]
Chr14:59930485 [GRCh37]
Chr14:14q23.1		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
GRCh37/hg19 14q22.3-24.1(chr14:57588965-68334517)x3 copy number gain not provided [RCV003485034] Chr14:57588965..68334517 [GRCh37]
Chr14:14q22.3-24.1		 likely pathogenic
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1		 pathogenic
GRCh37/hg19 14q22.3-23.2(chr14:55667390-64447598)x1 copy number loss not provided [RCV003483204] Chr14:55667390..64447598 [GRCh37]
Chr14:14q22.3-23.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1581
Count of miRNA genes:764
Interacting mature miRNAs:913
Transcripts:ENST00000395116, ENST00000481661
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH104192  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371459,930,421 - 59,930,545UniSTSGRCh37
Build 361459,000,174 - 59,000,298RGDNCBI36
Celera1439,979,490 - 39,979,614RGD
Cytogenetic Map14q23.1UniSTS
HuRef1440,094,287 - 40,094,411UniSTS
GeneMap99-GB4 RH Map14136.74UniSTS
D14S1226  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371459,930,611 - 59,930,721UniSTSGRCh37
Build 361459,000,364 - 59,000,474RGDNCBI36
Celera1439,979,680 - 39,979,790RGD
Cytogenetic Map14q23.1UniSTS
HuRef1440,094,477 - 40,094,587UniSTS
Whitehead-YAC Contig Map14 UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 38 17 1 5 3 28 2 369 9 1 5
Low 2298 2068 1530 442 1142 290 4156 1933 3458 355 1063 1574 164 1204 2630 4
Below cutoff 135 850 177 179 772 174 194 259 247 61 26 29 7 153

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017021599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054376614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB065563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL159140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY255588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY288418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX094623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000395116   ⟹   ENSP00000378548
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1459,460,759 - 59,465,380 (-)Ensembl
RefSeq Acc Id: ENST00000481661   ⟹   ENSP00000432696
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1459,429,022 - 59,465,341 (-)Ensembl
RefSeq Acc Id: NM_022571   ⟹   NP_072093
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,460,759 - 59,465,380 (-)NCBI
GRCh371459,930,240 - 59,932,059 (-)RGD
Build 361458,999,993 - 59,001,812 (-)NCBI Archive
Celera1439,979,309 - 39,981,128 (-)RGD
HuRef1440,094,106 - 40,095,925 (-)RGD
CHM1_11459,868,393 - 59,870,212 (-)NCBI
T2T-CHM13v2.01453,667,678 - 53,672,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017021596   ⟹   XP_016877085
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017021598   ⟹   XP_016877087
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017021599   ⟹   XP_016877088
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449693   ⟹   XP_024305461
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449694   ⟹   XP_024305462
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449695   ⟹   XP_024305463
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449696   ⟹   XP_024305464
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,452,783 - 59,465,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054376608   ⟹   XP_054232583
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376609   ⟹   XP_054232584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376610   ⟹   XP_054232585
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376611   ⟹   XP_054232586
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376612   ⟹   XP_054232587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376613   ⟹   XP_054232588
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
RefSeq Acc Id: XM_054376614   ⟹   XP_054232589
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01453,659,699 - 53,672,145 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072093   ⟸   NM_022571
- UniProtKB: Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot),   Q8IZ08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016877088   ⟸   XM_017021599
- Peptide Label: isoform X1
- UniProtKB: Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot),   Q8IZ08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016877087   ⟸   XM_017021598
- Peptide Label: isoform X1
- UniProtKB: Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot),   Q8IZ08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016877085   ⟸   XM_017021596
- Peptide Label: isoform X1
- UniProtKB: Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot),   Q8IZ08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305464   ⟸   XM_024449696
- Peptide Label: isoform X1
- UniProtKB: Q8IZ08 (UniProtKB/Swiss-Prot),   Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305463   ⟸   XM_024449695
- Peptide Label: isoform X1
- UniProtKB: Q8IZ08 (UniProtKB/Swiss-Prot),   Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305462   ⟸   XM_024449694
- Peptide Label: isoform X1
- UniProtKB: Q8IZ08 (UniProtKB/Swiss-Prot),   Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305461   ⟸   XM_024449693
- Peptide Label: isoform X1
- UniProtKB: Q8IZ08 (UniProtKB/Swiss-Prot),   Q86SM3 (UniProtKB/Swiss-Prot),   Q7Z604 (UniProtKB/Swiss-Prot),   Q8NH39 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000432696   ⟸   ENST00000481661
RefSeq Acc Id: ENSP00000378548   ⟸   ENST00000395116
RefSeq Acc Id: XP_054232589   ⟸   XM_054376614
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232587   ⟸   XM_054376612
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232588   ⟸   XM_054376613
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232586   ⟸   XM_054376611
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232584   ⟸   XM_054376609
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232583   ⟸   XM_054376608
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054232585   ⟸   XM_054376610
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8IZ08-F1-model_v2 AlphaFold Q8IZ08 1-494 view protein structure

Promoters
RGD ID:6791612
Promoter ID:HG_KWN:19492
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:ENST00000343189
Position:
Human AssemblyChrPosition (strand)Source
Build 361459,000,711 - 59,001,952 (-)MPROMDB
RGD ID:7227751
Promoter ID:EPDNEW_H19622
Type:initiation region
Name:GPR135_1
Description:G protein-coupled receptor 135
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381459,465,380 - 59,465,440EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19991 AgrOrtholog
COSMIC GPR135 COSMIC
Ensembl Genes ENSG00000181619 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000395116 ENTREZGENE
  ENST00000395116.2 UniProtKB/Swiss-Prot
  ENST00000481661 ENTREZGENE
  ENST00000481661.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000181619 GTEx
HGNC ID HGNC:19991 ENTREZGENE
Human Proteome Map GPR135 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report hsa:64582 UniProtKB/Swiss-Prot
NCBI Gene 64582 ENTREZGENE
OMIM 607970 OMIM
PANTHER G PROTEIN-COUPLED RECEPTOR UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTOR 135 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA134863427 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt GP135_HUMAN UniProtKB/Swiss-Prot
  Q7Z604 ENTREZGENE
  Q86SM3 ENTREZGENE
  Q8IZ08 ENTREZGENE
  Q8NH39 ENTREZGENE
UniProt Secondary Q7Z604 UniProtKB/Swiss-Prot
  Q86SM3 UniProtKB/Swiss-Prot
  Q8NH39 UniProtKB/Swiss-Prot