Zfp386 (zinc finger protein 386 (Kruppel-like)) - Rat Genome Database

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Gene: Zfp386 (zinc finger protein 386 (Kruppel-like)) Mus musculus
Analyze
Symbol: Zfp386
Name: zinc finger protein 386 (Kruppel-like)
RGD ID: 736215
MGI Page MGI
Description: Enables chromatin binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human ZNF519 (zinc finger protein 519).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KIAA4205; Kruppel associated box (KRAB) zinc finger 1; kruppel-like protein; Kzf1; mKIAA4205
RGD Orthologs
Human
Rat
Bonobo
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,011,334 - 116,026,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,011,344 - 116,026,980 (+)EnsemblGRCm39 Ensembl
GRCm3812116,047,714 - 116,063,231 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,047,724 - 116,063,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712117,285,935 - 117,299,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,248,381 - 110,261,342 (+)NCBIMGSCv36mm8
MGSCv3612116,495,575 - 116,508,405 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12477932   PMID:12520002   PMID:15226823   PMID:15522233   PMID:16141072   PMID:16141073  
PMID:17967808   PMID:18287559   PMID:18973680   PMID:20059953   PMID:20412781   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Zfp386
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912116,011,334 - 116,026,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12116,011,344 - 116,026,980 (+)EnsemblGRCm39 Ensembl
GRCm3812116,047,714 - 116,063,231 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12116,047,724 - 116,063,360 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712117,285,935 - 117,299,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,248,381 - 110,261,342 (+)NCBIMGSCv36mm8
MGSCv3612116,495,575 - 116,508,405 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1262.59NCBI
ZNF519
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381814,071,121 - 14,132,435 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1814,057,457 - 14,132,490 (-)EnsemblGRCh38hg38GRCh38
GRCh371814,071,120 - 14,132,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361814,094,724 - 14,122,429 (-)NCBINCBI36Build 36hg18NCBI36
Build 341814,094,723 - 14,122,429NCBI
Celera1813,958,163 - 14,006,658 (-)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1814,030,183 - 14,086,706 (-)NCBIHuRef
CHM1_11814,075,972 - 14,132,482 (-)NCBICHM1_1
T2T-CHM13v2.01814,233,972 - 14,295,283 (-)NCBIT2T-CHM13v2.0
Zfp386
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86143,109,563 - 143,124,266 (+)NCBIGRCr8
mRatBN7.26136,966,547 - 136,984,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6136,966,586 - 136,983,441 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6140,401,926 - 140,416,581 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06137,026,431 - 137,041,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06137,574,276 - 137,588,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06143,901,239 - 143,915,953 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6143,901,280 - 143,917,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06152,840,202 - 152,870,895 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46143,311,722 - 143,326,401 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16143,317,934 - 143,332,580 (+)NCBI
Celera6134,633,475 - 134,647,999 (+)NCBICelera
Cytogenetic Map6q33NCBI
ZNF519
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21723,910,579 - 23,971,979 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,603,175 - 9,634,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v018189,977 - 247,868 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1182,407,349 - 2,416,671 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC100526059
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1842,129,872 - 42,516,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2844,206,692 - 44,228,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Zfp386
588 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:820
Count of miRNA genes:521
Interacting mature miRNAs:601
Transcripts:ENSMUST00000073551, ENSMUST00000182566, ENSMUST00000182883, ENSMUST00000183125
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse
15092083Igly5_mIgG glycosylation 5, GP20 (mouse)12113373605117830647Mouse
15092084Igly1_mIgG glycosylation 1, GP1 (mouse)12114429496117830647Mouse
15092086Igly3_mIgG glycosylation 3, GP16 (mouse)12114429496117830647Mouse
15092087Igly4_mIgG glycosylation 4, GP17a (mouse)12114429496118423781Mouse

Markers in Region
PMC150727P12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812116,061,177 - 116,061,316UniSTSGRCm38
MGSCv3712117,299,645 - 117,299,784UniSTSGRCm37
Cytogenetic Map12F2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC160990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC243430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF175222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE652367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BN000872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF723896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH467273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ140586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ172693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK392620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN534929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000073551   ⟹   ENSMUSP00000073241
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,011,344 - 116,024,212 (+)Ensembl
GRCm38.p6 Ensembl12116,047,724 - 116,060,592 (+)Ensembl
RefSeq Acc Id: ENSMUST00000182566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,011,384 - 116,018,736 (+)Ensembl
GRCm38.p6 Ensembl12116,047,764 - 116,055,116 (+)Ensembl
RefSeq Acc Id: ENSMUST00000182883
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,011,449 - 116,015,245 (+)Ensembl
GRCm38.p6 Ensembl12116,047,829 - 116,051,625 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183125   ⟹   ENSMUSP00000138305
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12116,011,396 - 116,026,980 (+)Ensembl
GRCm38.p6 Ensembl12116,047,776 - 116,063,360 (+)Ensembl
RefSeq Acc Id: NM_001004066   ⟹   NP_001004066
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,011,344 - 116,026,829 (+)NCBI
GRCm3812116,047,724 - 116,063,209 (+)NCBI
MGSCv3712117,285,935 - 117,299,065 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286214   ⟹   NP_001273143
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,011,344 - 116,026,829 (+)NCBI
GRCm3812116,047,724 - 116,063,209 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019565   ⟹   NP_062511
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,011,344 - 116,026,829 (+)NCBI
GRCm3812116,047,724 - 116,063,209 (+)NCBI
MGSCv3712117,285,935 - 117,299,065 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244150   ⟹   XP_011242452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,011,334 - 116,026,851 (+)NCBI
GRCm3812116,047,714 - 116,063,231 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157539   ⟹   XP_036013432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912116,011,334 - 116,026,851 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001004066   ⟸   NM_001004066
- Peptide Label: isoform a
- UniProtKB: Q1WWJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062511   ⟸   NM_019565
- Peptide Label: isoform b
- UniProtKB: Q3TN43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273143   ⟸   NM_001286214
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: XP_011242452   ⟸   XM_011244150
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000138305   ⟸   ENSMUST00000183125
RefSeq Acc Id: ENSMUSP00000073241   ⟸   ENSMUST00000073551
RefSeq Acc Id: XP_036013432   ⟸   XM_036157539
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1WWJ5-F1-model_v2 AlphaFold Q1WWJ5 1-626 view protein structure

Promoters
RGD ID:8679456
Promoter ID:EPDNEW_M17758
Type:initiation region
Name:Zfp386_1
Description:Mus musculus zinc finger protein 386 (Kruppel-like) , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812116,047,753 - 116,047,813EPDNEW
RGD ID:6823207
Promoter ID:MM_KWN:13067
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000077866,   NM_019565,   UC007PHA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612117,285,666 - 117,286,337 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930708 AgrOrtholog
Ensembl Genes ENSMUSG00000042063 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073551 ENTREZGENE
  ENSMUST00000073551.6 UniProtKB/TrEMBL
  ENSMUST00000183125 ENTREZGENE
  ENSMUST00000183125.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:56220 UniProtKB/TrEMBL
MGD MGI:1930708 ENTREZGENE
NCBI Gene 56220 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 11 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp386 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt Q1WWJ5 ENTREZGENE, UniProtKB/TrEMBL
  Q3TN43 ENTREZGENE, UniProtKB/TrEMBL
  Q5DTH6_MOUSE UniProtKB/TrEMBL
  Q99KB9_MOUSE UniProtKB/TrEMBL
  Q9QZP7_MOUSE UniProtKB/TrEMBL