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Gene: Capn3 (calpain 3) Mus musculus
Symbol: Capn3
Name: calpain 3
Description: Exhibits calcium-dependent cysteine-type endopeptidase activity; metal ion binding activity; and molecular adaptor activity. Involved in several processes, including G1 to G0 transition involved in cell differentiation; regulation of transcription, DNA-templated; and sarcomere organization. Localizes to the cytosol; plasma membrane; and protein-containing complex. Used to study autosomal recessive limb-girdle muscular dystrophy type 2A. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Is expressed in several structures, including brain; eye; heart; and musculature. Orthologous to human CAPN3 (calpain 3); INTERACTS WITH bis(2-chloroethyl) sulfide; carbon nanotube; chrysene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323605; calcium-activated neutral proteinase 3; calpain L3; calpain p94; calpain-3; CANP 3; Capa-3; Capa3; Lp82; muscle-specific calcium-activated neutral protease 3; p94; skeletal muscle specific calpain p94
Homo sapiens (human) : CAPN3 (calpain 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Capn3 (calpain 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Capn3 (calpain 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CAPN3 (calpain 3)
Canis lupus familiaris (dog) : CAPN3 (calpain 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Capn3 (calpain 3)
Sus scrofa (pig) : CAPN3 (calpain 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2120,463,572 - 120,504,918 (+)Ensembl
GRCm38 Ensembl2120,456,019 - 120,504,913 (+)Ensembl
GRCm382120,463,593 - 120,504,919 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372120,289,329 - 120,330,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv362120,155,314 - 120,195,940 (+)NCBImm8
Celera2121,617,948 - 121,659,023 (+)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map260.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Capn3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736171
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.