APOC4 (apolipoprotein C4) - Rat Genome Database

Name: APOC4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: APOC4 (apolipoprotein C4) Homo sapiens

Analyze

Symbol:

APOC4

Name:

apolipoprotein C4

RGD ID:

736043

HGNC Page

HGNC

Description:

Predicted to have lipid transporter activity. Involved in positive regulation of sequestering of triglyceride and triglyceride homeostasis. Localizes to high-density lipoprotein particle and very-low-density lipoprotein particle.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

APO-CIV; APOC-IV; apolipoprotein C-IV

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Apoc4 (apolipoprotein C-IV)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Apoc4 (apolipoprotein C4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Apoc4 (apolipoprotein C4)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	APOC4 (apolipoprotein C4)	NCBI	Ortholog
Canis lupus familiaris (dog):	APOC4 (apolipoprotein C4)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Apoc4 (apolipoprotein C4)	NCBI	Ortholog
Sus scrofa (pig):	APOC4 (apolipoprotein C4)	HGNC	Ensembl, Inparanoid, NCBI, OrthoDB
Chlorocebus sabaeus (African green monkey):	APOC4 (apolipoprotein C4)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Apoc4 (apolipoprotein C4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Apoc4 (apolipoprotein C-IV)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	apoc4 (apolipoprotein C-IV)	Alliance	DIOPT (ZFIN)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	44,942,237 - 44,945,496 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	44,942,237 - 44,945,496 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	45,445,494 - 45,448,753 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	50,137,335 - 50,140,591 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	50,137,334 - 50,140,591	NCBI
Celera	19	42,249,817 - 42,253,073 (+)	NCBI
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	41,875,522 - 41,879,312 (+)	NCBI		HuRef
CHM1_1	19	45,448,327 - 45,451,585 (+)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

4-hydroxyphenyl retinamide (EXP)

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

aflatoxin B1 (ISO)

ammonium chloride (ISO)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

chenodeoxycholic acid (EXP)

chlorpromazine (EXP)

clofibrate (ISO)

cobalt dichloride (ISO)

cyclosporin A (EXP)

decabromodiphenyl ether (ISO)

farnesol (EXP)

fumonisin B1 (ISO)

furan (ISO)

GW 4064 (EXP)

GW 7647 (EXP)

lithocholic acid (ISO)

methylmercury chloride (EXP)

oleic acid (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

phenformin (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP)

rotenone (ISO)

sarin (EXP)

tetrachloromethane (ISO)

thioacetamide (ISO)

valdecoxib (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular receptor signaling pathway (TAS)

lipid metabolic process (TAS)

lipid transport (IEA)

positive regulation of sequestering of triglyceride (IBA,IMP)

triglyceride homeostasis (IBA,IMP)

very-low-density lipoprotein particle assembly (TAS)

very-low-density lipoprotein particle clearance (TAS)

Cellular Component

extracellular region (TAS)

high-density lipoprotein particle (IBA,IDA)

very-low-density lipoprotein particle (IBA,IDA,IMP,ISO)

Molecular Function

lipid transporter activity (TAS)

protein binding (IPI)

References

References - curated


1.	GOA_HUMAN data from the GO Consortium
2.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8530039	PMID:8827523	PMID:8910501	PMID:10996355	PMID:11752456	PMID:12032151	PMID:12477932	PMID:12700345	PMID:15489334	PMID:16335952	PMID:16344560	PMID:16763159
PMID:17154273	PMID:18193043	PMID:18193044	PMID:18802019	PMID:18809223	PMID:19060906	PMID:19197348	PMID:19336475	PMID:19913121	PMID:20331378	PMID:20430392	PMID:20498921
PMID:20571754	PMID:20602615	PMID:20628086	PMID:20714348	PMID:20855565	PMID:20864672	PMID:20972250	PMID:21103663	PMID:21873635	PMID:21943158	PMID:25378659	PMID:26129832
PMID:32296183

Genomics

Candidate Gene Status

APOC4 is a candidate Gene for QTL BW139_H

Comparative Map Data

APOC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	44,942,237 - 44,945,496 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	44,942,237 - 44,945,496 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	45,445,494 - 45,448,753 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	50,137,335 - 50,140,591 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	50,137,334 - 50,140,591	NCBI
Celera	19	42,249,817 - 42,253,073 (+)	NCBI
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	41,875,522 - 41,879,312 (+)	NCBI		HuRef
CHM1_1	19	45,448,327 - 45,451,585 (+)	NCBI		CHM1_1

Apoc4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	19,412,009 - 19,415,385 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	19,412,008 - 19,415,404 (-)	Ensembl
GRCm38	7	19,678,084 - 19,681,460 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	19,678,083 - 19,681,479 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	20,263,443 - 20,266,765 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	18,836,616 - 18,839,938 (-)	NCBI			mm8
Celera	7	17,084,177 - 17,087,500 (-)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	9.94	NCBI

Apoc4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	79,335,745 - 79,339,942 (-)	NCBI
Rnor_6.0 Ensembl	1	80,595,326 - 80,599,572 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	80,595,339 - 80,599,525 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	81,860,928 - 81,865,003 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	78,985,350 - 78,989,564 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	79,063,617 - 79,067,655 (+)	NCBI
Celera	1	73,795,049 - 73,799,140 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Apoc4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955555	2,018,327 - 2,018,828 (+)	NCBI	ChiLan1.0	ChiLan1.0

APOC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	50,495,239 - 50,498,194 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	19	41,889,099 - 41,892,546 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

APOC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	1	110,507,489 - 110,509,647 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	1	110,507,449 - 110,509,684 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Apoc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936706	1,528,187 - 1,530,028 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APOC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	51,400,909 - 51,403,719 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	47,282,628 - 47,285,470 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APOC4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	38,391,454 - 38,406,692 (+)	NCBI
ChlSab1.1 Ensembl	6	38,398,471 - 38,406,697 (+)	Ensembl

Position Markers

RH46551

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	45,448,503 - 45,448,695	UniSTS	GRCh37
Build 36	19	50,140,343 - 50,140,535	RGD	NCBI36
Celera	19	42,252,825 - 42,253,017	RGD
Cytogenetic Map	19	q13.2	UniSTS
HuRef	19	41,879,062 - 41,879,254	UniSTS
GeneMap99-GB4 RH Map	19	250.55	UniSTS

RH18398

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	19	45,448,563 - 45,448,746	UniSTS	GRCh37
Build 36	19	50,140,403 - 50,140,586	RGD	NCBI36
Celera	19	42,252,885 - 42,253,068	RGD
Cytogenetic Map	19	q	UniSTS
Cytogenetic Map	19	q13.2	UniSTS
HuRef	19	41,879,122 - 41,879,305	UniSTS
GeneMap99-GB4 RH Map	19	250.75	UniSTS
NCBI RH Map	19	484.8	UniSTS

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	571
Count of miRNA genes:	453
Interacting mature miRNAs:	489
Transcripts:	ENST00000591600, ENST00000592954
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

High

Medium

227

226

Low

162

301

222

107

480

124

266

Below cutoff

1032

1041

687

231

547

129

1996

854

2295

721

666

103

657

1307

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_008837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC011481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AV690709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY422953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DB185657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF371377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF371378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC250943	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC311132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MT073872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U32576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000591600 ⟹ ENSP00000466444

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	19	44,942,274 - 44,945,016 (+)	Ensembl

RefSeq Acc Id:

ENST00000592954 ⟹ ENSP00000468236

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	19	44,942,237 - 44,945,496 (+)	Ensembl

RefSeq Acc Id:

NM_001646 ⟹ NP_001637

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	44,942,237 - 44,945,496 (+)	NCBI
GRCh37	19	45,445,495 - 45,448,753 (+)	ENTREZGENE
Build 36	19	50,137,335 - 50,140,591 (+)	NCBI Archive
HuRef	19	41,875,522 - 41,879,312 (+)	ENTREZGENE
CHM1_1	19	45,448,327 - 45,451,585 (+)	NCBI

Sequence:

show sequence

GAGTTGAGCACAGAGGGACAGAGGCACGGAACCCCCAGAAATGTCCCTCCTCAGAAACAGGCTC
CAGGCCCTGCCTGCCCTGTGCCTCTGCGTGCTGGTCCTGGCCTGCATTGGGGCATGCCAGCCAG
AGGCCCAGGAAGGAACCCTGAGCCCCCCACCAAAGCTAAAGATGAGTCGCTGGAGCCTGGTGAG
GGGCAGGATGAAGGAGCTGCTGGAGACAGTGGTGAACAGGACCAGAGACGGGTGGCAATGGTTC
TGGAGCCCGAGCACCTTCCGGGGCTTCATGCAGACCTACTATGACGACCACCTGAGGGACCTGG
GTCCGCTCACCAAGGCCTGGTTCCTCGAATCCAAAGACAGCCTCTTGAAGAAGACCCACAGCCT
GTGCCCCAGGCTTGTCTGTGGGGACAAGGACCAGGGTTAAAATGTTCATAAAAGCCAGGTGTGG
TTGTGGCGGGTGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTAGGATGATGGCTTGAGCCCA
GGAGTTCGAGACCAGCCTGGGCAACACAGCGAGATCTCTTGGGGGTAAAACAAAAAGAAAAAAA
AAAGTTCATACTTCTCCAATAAATAAAGTCTCACCTGTGAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001637	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA91653	(Get FASTA)	NCBI Sequence Viewer
	AAH20723	(Get FASTA)	NCBI Sequence Viewer
	AAQ91812	(Get FASTA)	NCBI Sequence Viewer
	ABQ40074	(Get FASTA)	NCBI Sequence Viewer
	ABQ40075	(Get FASTA)	NCBI Sequence Viewer
	CBJ05769	(Get FASTA)	NCBI Sequence Viewer
	CBJ21221	(Get FASTA)	NCBI Sequence Viewer
	EAW57310	(Get FASTA)	NCBI Sequence Viewer
	P55056	(Get FASTA)	NCBI Sequence Viewer
	QPM65716	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001637 ⟸ NM_001646
- Peptide Label:	precursor
- UniProtKB:	P55056 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSLLRNRLQALPALCLCVLVLACIGACQPEAQEGTLSPPPKLKMSRWSLVRGRMKELLETVVNR TRDGWQWFWSPSTFRGFMQTYYDDHLRDLGPLTKAWFLESKDSLLKKTHSLCPRLVCGDKDQG hide sequence

RefSeq Acc Id:

ENSP00000466444 ⟸ ENST00000591600

RefSeq Acc Id:

ENSP00000468236 ⟸ ENST00000592954

Promoters

RGD ID:

7240363

Promoter ID:

EPDNEW_H25928

Type:

initiation region

Name:

APOC4_1

Description:

apolipoprotein C4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	19	44,942,274 - 44,942,334	EPDNEW

RGD ID:

6814628

Promoter ID:

HG_XEF:4133

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

K562

Transcripts:

NM_001082365, NM_007385

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	19	50,138,846 - 50,139,346 (+)	MPROMDB

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1	copy number loss	See cases [RCV000240182]	Chr19:43013365..47241534 [GRCh37] Chr19:19q13.2-13.32	pathogenic
GRCh37/hg19 19q13.32(chr19:45284576-45978239)x3	copy number gain	See cases [RCV000239782]	Chr19:45284576..45978239 [GRCh37] Chr19:19q13.32	uncertain significance
GRCh37/hg19 19q13.31-13.32(chr19:44300416-45639540)x1	copy number loss	See cases [RCV000512107]	Chr19:44300416..45639540 [GRCh37] Chr19:19q13.31-13.32	uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)	copy number gain	See cases [RCV000512296]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3	copy number gain	See cases [RCV000511289]	Chr19:260912..58956888 [GRCh37] Chr19:19p13.3-q13.43	pathogenic\|uncertain significance
GRCh37/hg19 19q13.32(chr19:45338895-45618902)x3	copy number gain	not provided [RCV000752710]	Chr19:45338895..45618902 [GRCh37] Chr19:19q13.32	benign
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3	copy number gain	not provided [RCV000752439]	Chr19:68029..59110290 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3	copy number gain	not provided [RCV000752444]	Chr19:260912..59097160 [GRCh37] Chr19:19p13.3-q13.43	pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3	copy number gain	not provided [RCV001007050]	Chr19:44738088..53621561 [GRCh37] Chr19:19q13.31-13.42	pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3	copy number gain	not provided [RCV000845733]	Chr19:28271106..49213832 [GRCh37] Chr19:19q11-13.33	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:611	AgrOrtholog
COSMIC	APOC4	COSMIC
Ensembl Genes	ENSG00000267467	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000466444	UniProtKB/TrEMBL
	ENSP00000468236	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000591600	UniProtKB/TrEMBL
	ENST00000592954	ENTREZGENE, UniProtKB/Swiss-Prot
GTEx	ENSG00000267467	GTEx
HGNC ID	HGNC:611	ENTREZGENE
Human Proteome Map	APOC4	Human Proteome Map
InterPro	APOC4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:346	UniProtKB/Swiss-Prot
NCBI Gene	346	ENTREZGENE
OMIM	600745	OMIM
PANTHER	PTHR32288	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	APOC4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA54	PharmGKB
UniProt	A5YAK2_HUMAN	UniProtKB/TrEMBL
	APOC4_HUMAN	UniProtKB/Swiss-Prot
	K7EMC3_HUMAN	UniProtKB/TrEMBL
	P55056	ENTREZGENE
UniProt Secondary	B3KWY6	UniProtKB/Swiss-Prot
	Q53YY8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-03	APOC4	apolipoprotein C4		apolipoprotein C-IV	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)