Asic5 (acid-sensing (proton-gated) ion channel family member 5) - Rat Genome Database

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Gene: Asic5 (acid-sensing (proton-gated) ion channel family member 5) Mus musculus
Analyze
Symbol: Asic5
Name: acid-sensing (proton-gated) ion channel family member 5
RGD ID: 736019
MGI Page MGI
Description: Exhibits proton channel activity and sodium channel activity. Involved in sodium ion transmembrane transport. Predicted to localize to integral component of plasma membrane. Orthologous to human ASIC5 (acid sensing ion channel subunit family member 5); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Acc; Accn5; acid-sensing ion channel 5; amiloride-sensitive cation channel 5; amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive Na+ channel; amiloride-sensitive sodium channel; BL; Blinac; brain-liver-intestine amiloride-sensitive Na(+) channel; brain-liver-intestine amiloride-sensitive sodium channel; Inac
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,889,600 - 81,928,540 (+)NCBIGRCm39mm39
GRCm39 Ensembl381,889,597 - 81,928,540 (+)Ensembl
GRCm38381,982,293 - 82,021,233 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,982,290 - 82,021,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv37381,800,844 - 81,825,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv36382,082,849 - 82,107,160 (+)NCBImm8
Celera382,022,407 - 82,046,104 (+)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:16141072   PMID:16141073   PMID:16707424   PMID:20656685   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600  
PMID:24663811   PMID:32034189  


Genomics

Comparative Map Data
Asic5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39381,889,600 - 81,928,540 (+)NCBIGRCm39mm39
GRCm39 Ensembl381,889,597 - 81,928,540 (+)Ensembl
GRCm38381,982,293 - 82,021,233 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,982,290 - 82,021,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv37381,800,844 - 81,825,155 (+)NCBIGRCm37mm9NCBIm37
MGSCv36382,082,849 - 82,107,160 (+)NCBImm8
Celera382,022,407 - 82,046,104 (+)NCBICelera
Cytogenetic Map3E3NCBI
ASIC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4155,829,729 - 155,866,277 (-)EnsemblGRCh38hg38GRCh38
GRCh384155,829,699 - 155,867,303 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,750,881 - 156,787,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364156,970,331 - 157,006,875 (-)NCBINCBI36hg18NCBI36
Build 344157,108,485 - 157,145,030NCBI
Celera4154,082,485 - 154,119,021 (-)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,489,804 - 152,526,264 (-)NCBIHuRef
CHM1_14156,728,541 - 156,765,056 (-)NCBICHM1_1
Asic5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22167,307,984 - 167,336,812 (+)NCBI
Rnor_6.0 Ensembl2180,936,688 - 180,964,365 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02180,935,392 - 180,964,365 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02200,343,769 - 200,372,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42173,632,309 - 173,662,245 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12173,582,414 - 173,612,351 (+)NCBI
Celera2161,337,695 - 161,366,476 (+)NCBICelera
Cytogenetic Map2q34NCBI
Asic5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547111,262,216 - 11,287,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547111,262,213 - 11,287,720 (+)NCBIChiLan1.0ChiLan1.0
ASIC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14160,012,564 - 160,048,763 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,012,564 - 160,048,763 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04148,195,680 - 148,232,042 (-)NCBIMhudiblu_PPA_v0panPan3
ASIC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11553,343,244 - 53,376,328 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1553,343,907 - 53,377,347 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1553,678,867 - 53,711,918 (-)NCBI
ROS_Cfam_1.01554,050,367 - 54,083,462 (-)NCBI
UMICH_Zoey_3.11553,303,775 - 53,336,887 (-)NCBI
UNSW_CanFamBas_1.01553,413,177 - 53,446,093 (-)NCBI
UU_Cfam_GSD_1.01553,727,107 - 53,760,202 (-)NCBI
Asic5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530137,035,723 - 37,063,163 (+)NCBI
SpeTri2.0NW_0049365762,483,715 - 2,510,037 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASIC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl844,646,814 - 44,674,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1844,646,451 - 44,674,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2846,642,042 - 46,670,075 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASIC5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17102,400,785 - 102,470,174 (-)NCBI
ChlSab1.1 Ensembl7102,401,405 - 102,438,308 (-)Ensembl
Asic5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248482,421,380 - 2,448,626 (+)NCBI

Position Markers
D3Mit229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38382,019,057 - 82,019,156UniSTSGRCm38
MGSCv37381,822,979 - 81,823,078UniSTSGRCm37
Celera382,043,949 - 82,044,048UniSTS
Cytogenetic Map3E-F1UniSTS
cM Map338.3UniSTS
Whitehead Genetic328.4UniSTS
Whitehead_YAC3 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4945016083450160Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34958758483587697Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34958758483587697Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35271817686718412Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35271817686718412Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35271817686718412Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35301585087015850Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:107
Interacting mature miRNAs:116
Transcripts:ENSMUST00000029641, ENSMUST00000107736, ENSMUST00000142889
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029641   ⟹   ENSMUSP00000029641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl381,996,922 - 82,021,233 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107736   ⟹   ENSMUSP00000103364
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl381,999,461 - 82,021,228 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142889
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl381,982,290 - 81,999,703 (+)Ensembl
RefSeq Acc Id: NM_021370   ⟹   NP_067345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39381,904,229 - 81,928,540 (+)NCBI
GRCm38381,996,922 - 82,021,233 (+)NCBI
MGSCv37381,800,844 - 81,825,155 (+)RGD
Celera382,022,407 - 82,046,104 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501821   ⟹   XP_006501884
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39381,889,600 - 81,928,536 (+)NCBI
GRCm38381,982,293 - 82,021,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501823   ⟹   XP_006501886
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39381,897,249 - 81,928,536 (+)NCBI
GRCm38381,989,942 - 82,021,229 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501825   ⟹   XP_006501888
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39381,889,600 - 81,928,536 (+)NCBI
GRCm38381,982,293 - 82,021,229 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067345   ⟸   NM_021370
- UniProtKB: Q9R0Y1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501888   ⟸   XM_006501825
- Peptide Label: isoform X2
- UniProtKB: D3Z0S5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501884   ⟸   XM_006501821
- Peptide Label: isoform X1
- UniProtKB: Q9R0Y1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501886   ⟸   XM_006501823
- Peptide Label: isoform X1
- UniProtKB: Q9R0Y1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029641   ⟸   ENSMUST00000029641
RefSeq Acc Id: ENSMUSP00000103364   ⟸   ENSMUST00000107736


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929259 AgrOrtholog
Ensembl Genes ENSMUSG00000028008 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029641 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000103364 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029641 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000107736 ENTREZGENE, UniProtKB/TrEMBL
InterPro ENaC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58170 UniProtKB/Swiss-Prot
MGD MGI:1929259 ENTREZGENE
NCBI Gene 58170 ENTREZGENE
PANTHER PTHR11690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asic5 PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ASIC5_MOUSE UniProtKB/Swiss-Prot
  D3Z0S5 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0Y1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-25 Asic5  acid-sensing (proton-gated) ion channel family member 5  Accn5  amiloride-sensitive cation channel 5, intestinal  Symbol and/or name change 5135510 APPROVED