OXTR (oxytocin receptor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: OXTR (oxytocin receptor) Homo sapiens
Analyze
Symbol: OXTR
Name: oxytocin receptor
RGD ID: 736017
HGNC Page HGNC
Description: Predicted to have oxytocin receptor activity; peptide binding activity; and vasopressin receptor activity. Predicted to be involved in several processes, including maternal process involved in parturition; positive regulation of cold-induced thermogenesis; and positive regulation of vasoconstriction. Predicted to localize to integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: OT-R
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl38,750,381 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl38,750,408 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh3838,750,381 - 8,769,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3738,792,067 - 8,811,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,767,094 - 8,786,300 (-)NCBINCBI36hg18NCBI36
Build 3438,767,093 - 8,786,300NCBI
Celera38,726,881 - 8,746,086 (-)NCBI
Cytogenetic Map3p25.3NCBI
HuRef38,726,158 - 8,745,365 (-)NCBIHuRef
CHM1_138,742,513 - 8,761,719 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway  (TAS)
digestive tract development  (IEA,ISO)
eating behavior  (IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
estrous cycle  (IEA,ISO)
female pregnancy  (IBA,ISO)
G protein-coupled receptor signaling pathway  (IBA,IEA,ISO,TAS)
heart development  (IEA,ISO)
lactation  (TAS)
maternal behavior  (IEA,ISO)
maternal process involved in parturition  (IBA,ISO)
memory  (IEA,ISO)
muscle contraction  (TAS)
negative regulation of gastric acid secretion  (IEA,ISO)
positive regulation of blood pressure  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of norepinephrine secretion  (IEA,ISO)
positive regulation of penile erection  (IEA,ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
positive regulation of uterine smooth muscle contraction  (IEA,ISO)
positive regulation of vasoconstriction  (IBA)
regulation of digestive system process  (ISO)
regulation of systemic arterial blood pressure by vasopressin  (IBA)
response to amphetamine  (IEA,ISO)
response to anoxia  (IEA,ISO)
response to cocaine  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to drug  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to steroid hormone  (ISO)
sleep  (IEA,ISO)
social behavior  (IEA,ISO)
sperm ejaculation  (IEA,ISO)
suckling behavior  (IEA,ISO)
telencephalon development  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:1313946   PMID:7607693   PMID:7798245   PMID:7921229   PMID:8077313   PMID:8593829   PMID:8593830   PMID:9283088   PMID:9433921   PMID:10027615   PMID:10453463   PMID:10698266  
PMID:10858434   PMID:10910058   PMID:11140838   PMID:11279203   PMID:11955056   PMID:12126740   PMID:12161007   PMID:12166628   PMID:12270111   PMID:12477932   PMID:12810550   PMID:12843193  
PMID:12955084   PMID:14664707   PMID:14691010   PMID:14749664   PMID:15035619   PMID:15044599   PMID:15089975   PMID:15089977   PMID:15093695   PMID:15452121   PMID:15591449   PMID:15705593  
PMID:15831296   PMID:15992526   PMID:16042376   PMID:16333859   PMID:16754659   PMID:16888077   PMID:16966388   PMID:17148753   PMID:17383819   PMID:17492653   PMID:17726073   PMID:17728669  
PMID:17893705   PMID:17939166   PMID:17952758   PMID:18082926   PMID:18207134   PMID:18312604   PMID:19001515   PMID:19015103   PMID:19086053   PMID:19126785   PMID:19336370   PMID:19347709  
PMID:19376182   PMID:19423652   PMID:19461999   PMID:19515497   PMID:19598235   PMID:19777562   PMID:19845972   PMID:19934046   PMID:19943975   PMID:20094064   PMID:20096818   PMID:20097922  
PMID:20196918   PMID:20303388   PMID:20347913   PMID:20400491   PMID:20413116   PMID:20436377   PMID:20452482   PMID:20488544   PMID:20547007   PMID:20547038   PMID:20585395   PMID:20647384  
PMID:20670427   PMID:20673868   PMID:20708845   PMID:20711752   PMID:20724662   PMID:20832055   PMID:20926803   PMID:21090345   PMID:21208749   PMID:21561435   PMID:21734268   PMID:21873635  
PMID:21876222   PMID:21896752   PMID:21934640   PMID:21963428   PMID:21964067   PMID:21984889   PMID:22015110   PMID:22064162   PMID:22084107   PMID:22123970   PMID:22146101   PMID:22212599  
PMID:22294460   PMID:22296985   PMID:22336563   PMID:22357335   PMID:22372486   PMID:22421562   PMID:22457427   PMID:22487732   PMID:22510359   PMID:22563705   PMID:22651577   PMID:22763666  
PMID:22809402   PMID:22882465   PMID:22892716   PMID:22986294   PMID:22999795   PMID:23040540   PMID:23089921   PMID:23219106   PMID:23252931   PMID:23284802   PMID:23354128   PMID:23355275  
PMID:23470776   PMID:23547247   PMID:23562248   PMID:23637833   PMID:23653389   PMID:23678036   PMID:23684879   PMID:23708061   PMID:23731038   PMID:23838880   PMID:23863476   PMID:23889750  
PMID:23915847   PMID:23921259   PMID:23946005   PMID:23974948   PMID:24002032   PMID:24059750   PMID:24120094   PMID:24128365   PMID:24209975   PMID:24223720   PMID:24295535   PMID:24367110  
PMID:24393355   PMID:24454713   PMID:24458227   PMID:24523928   PMID:24618689   PMID:24621820   PMID:24660771   PMID:24703166   PMID:24722188   PMID:24749639   PMID:24814480   PMID:24836510  
PMID:24916666   PMID:25001970   PMID:25003328   PMID:25047302   PMID:25092245   PMID:25199917   PMID:25244972   PMID:25262417   PMID:25309987   PMID:25326040   PMID:25403479   PMID:25419912  
PMID:25476609   PMID:25563749   PMID:25564674   PMID:25593022   PMID:25622005   PMID:25627343   PMID:25637390   PMID:25640833   PMID:25646574   PMID:25675509   PMID:25680993   PMID:25687563  
PMID:25773927   PMID:25890851   PMID:25935637   PMID:25968600   PMID:25977357   PMID:26061800   PMID:26106053   PMID:26110343   PMID:26121678   PMID:26178189   PMID:26228411   PMID:26241486  
PMID:26365303   PMID:26389606   PMID:26390829   PMID:26406593   PMID:26444016   PMID:26477647   PMID:26488131   PMID:26506050   PMID:26599592   PMID:26738630   PMID:26787430   PMID:26788924  
PMID:26822448   PMID:26857197   PMID:26858213   PMID:26903384   PMID:26903639   PMID:26911439   PMID:26998571   PMID:27015428   PMID:27036876   PMID:27107296   PMID:27108164   PMID:27109357  
PMID:27110446   PMID:27132494   PMID:27292275   PMID:27309964   PMID:27323309   PMID:27343933   PMID:27421662   PMID:27467763   PMID:27520745   PMID:27543885   PMID:27620964   PMID:27673556  
PMID:27693815   PMID:27716573   PMID:27743766   PMID:27798253   PMID:27818356   PMID:27842184   PMID:27862641   PMID:27872764   PMID:27903255   PMID:28017919   PMID:28024273   PMID:28049501  
PMID:28049625   PMID:28126018   PMID:28150062   PMID:28298427   PMID:28303421   PMID:28322981   PMID:28341538   PMID:28343138   PMID:28353027   PMID:28442360   PMID:28456503   PMID:28471218  
PMID:28472899   PMID:28478728   PMID:28499211   PMID:28526450   PMID:28530679   PMID:28566712   PMID:28687839   PMID:28694300   PMID:28715704   PMID:28785027   PMID:28815558   PMID:28890000  
PMID:28915380   PMID:28951495   PMID:28963465   PMID:29027364   PMID:29033100   PMID:29125397   PMID:29162179   PMID:29190530   PMID:29306689   PMID:29353531   PMID:29355918   PMID:29410310  
PMID:29428512   PMID:29505762   PMID:29513137   PMID:29524392   PMID:29580902   PMID:29673618   PMID:29680729   PMID:29843655   PMID:29851255   PMID:29858823   PMID:29860184   PMID:29885487  
PMID:29890447   PMID:29897293   PMID:29900533   PMID:29907738   PMID:29912955   PMID:29927293   PMID:29958244   PMID:30243577   PMID:30257007   PMID:30308385   PMID:30311451   PMID:30384146  
PMID:30415783   PMID:30489130   PMID:30496762   PMID:30592969   PMID:30605805   PMID:30624029   PMID:30633779   PMID:30688485   PMID:30801661   PMID:30818381   PMID:30858011   PMID:30918622  
PMID:30928624   PMID:30990880   PMID:31025834   PMID:31030321   PMID:31070227   PMID:31071720   PMID:31098723   PMID:31118457   PMID:31138298   PMID:31202819   PMID:31220321   PMID:31233509  
PMID:31282733   PMID:31291229   PMID:31326852   PMID:31415827   PMID:31493633   PMID:31521905   PMID:31530830   PMID:31587084   PMID:31718582   PMID:31771350   PMID:31919036   PMID:32444796  
PMID:32535602   PMID:32553369   PMID:32580785   PMID:32795360   PMID:32957930   PMID:33022913   PMID:33253216   PMID:33362272  


Genomics

Comparative Map Data
OXTR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl38,750,381 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl38,750,408 - 8,769,628 (-)EnsemblGRCh38hg38GRCh38
GRCh3838,750,381 - 8,769,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3738,792,067 - 8,811,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,767,094 - 8,786,300 (-)NCBINCBI36hg18NCBI36
Build 3438,767,093 - 8,786,300NCBI
Celera38,726,881 - 8,746,086 (-)NCBI
Cytogenetic Map3p25.3NCBI
HuRef38,726,158 - 8,745,365 (-)NCBIHuRef
CHM1_138,742,513 - 8,761,719 (-)NCBICHM1_1
Oxtr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,450,644 - 112,467,997 (-)NCBIGRCm39mm39
GRCm39 Ensembl6112,450,644 - 112,466,904 (-)Ensembl
GRCm386112,473,683 - 112,491,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,473,683 - 112,489,943 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,423,678 - 112,439,802 (-)NCBIGRCm37mm9NCBIm37
MGSCv366112,439,461 - 112,455,585 (-)NCBImm8
Celera6114,311,708 - 114,327,999 (-)NCBICelera
Cytogenetic Map6E3NCBI
Oxtr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24145,598,549 - 145,614,674 (-)NCBI
Rnor_6.0 Ensembl4144,403,358 - 144,416,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04144,399,326 - 144,417,598 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04207,701,360 - 207,717,840 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,314,089 - 148,326,797 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14148,558,929 - 148,571,638 (-)NCBI
Celera4134,168,869 - 134,184,999 (-)NCBICelera
Cytogenetic Map4q41NCBI
Oxtr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561337,902 - 354,336 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955561340,387 - 354,499 (-)NCBIChiLan1.0ChiLan1.0
OXTR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.138,962,454 - 8,963,730 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v038,701,344 - 8,721,706 (-)NCBIMhudiblu_PPA_v0panPan3
OXTR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,358,797 - 9,382,308 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,358,916 - 9,378,343 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,392,409 - 9,411,729 (+)NCBI
ROS_Cfam_1.0209,388,927 - 9,412,408 (+)NCBI
UMICH_Zoey_3.1209,110,306 - 9,130,001 (+)NCBI
UNSW_CanFamBas_1.0209,455,823 - 9,475,105 (+)NCBI
UU_Cfam_GSD_1.0209,429,314 - 9,449,013 (+)NCBI
Oxtr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,650,853 - 14,668,467 (-)NCBI
SpeTri2.0NW_0049366024,241,743 - 4,259,866 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXTR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,134,057 - 65,153,489 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,134,055 - 65,155,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,415,345 - 72,436,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OXTR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,746,108 - 44,764,501 (-)NCBI
ChlSab1.1 Ensembl2244,742,419 - 44,763,243 (-)Ensembl
Oxtr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247313,367,645 - 3,384,815 (-)NCBI

Position Markers
STS-X64878  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,794,603 - 8,794,741UniSTSGRCh37
Build 3638,769,603 - 8,769,741RGDNCBI36
Celera38,729,390 - 8,729,528RGD
Cytogenetic Map3p25UniSTS
HuRef38,728,669 - 8,728,807UniSTS
GeneMap99-GB4 RH Map342.74UniSTS
D3S18  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,791,711 - 8,791,888UniSTSGRCh37
Build 3638,766,711 - 8,766,888RGDNCBI36
Celera38,726,498 - 8,726,675RGD
Cytogenetic Map3p25UniSTS
HuRef38,725,775 - 8,725,952UniSTS
GDB:606394  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,793,763 - 8,794,040UniSTSGRCh37
Build 3638,768,763 - 8,769,040RGDNCBI36
Celera38,728,550 - 8,728,827RGD
Cytogenetic Map3p25UniSTS
HuRef38,727,827 - 8,728,106UniSTS
PMC170950P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,809,186 - 8,809,575UniSTSGRCh37
Build 3638,784,186 - 8,784,575RGDNCBI36
Celera38,743,972 - 8,744,361RGD
Cytogenetic Map3p25UniSTS
HuRef38,743,251 - 8,743,640UniSTS
D3S4539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,793,877 - 8,794,112UniSTSGRCh37
Build 3638,768,877 - 8,769,112RGDNCBI36
Celera38,728,664 - 8,728,899RGD
Cytogenetic Map3p25UniSTS
HuRef38,727,941 - 8,728,178UniSTS
D3S4163  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3738,794,271 - 8,794,589UniSTSGRCh37
Build 3638,769,271 - 8,769,589RGDNCBI36
Celera38,729,058 - 8,729,376RGD
Cytogenetic Map3p25UniSTS
HuRef38,728,337 - 8,728,655UniSTS
GeneMap99-G3 RH Map3337.0UniSTS
OXTR  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef38,728,653 - 8,728,753UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1635
Count of miRNA genes:943
Interacting mature miRNAs:1111
Transcripts:ENST00000316793, ENST00000431493, ENST00000449615, ENST00000474615
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 2
Medium 20 31 23 19 353 20 15 8 244 16 136 67 4 2
Low 797 968 744 134 503 108 1220 480 3140 217 1065 1038 35 179 837 3
Below cutoff 1612 1921 945 458 1015 325 3104 1690 329 180 247 501 132 1025 1936 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC068312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY389507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF070741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ535048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY798268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X64878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X80282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000316793   ⟹   ENSP00000324270
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl38,750,408 - 8,769,617 (-)Ensembl
RefSeq Acc Id: ENST00000431493   ⟹   ENSP00000414828
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl38,768,058 - 8,769,628 (-)Ensembl
RefSeq Acc Id: ENST00000449615   ⟹   ENSP00000389587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl38,767,912 - 8,768,677 (-)Ensembl
RefSeq Acc Id: ENST00000474615
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl38,768,443 - 8,769,613 (-)Ensembl
RefSeq Acc Id: NM_000916   ⟹   NP_000907
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,750,381 - 8,769,613 (-)NCBI
GRCh3738,792,094 - 8,811,300 (-)ENTREZGENE
Build 3638,767,094 - 8,786,300 (-)NCBI Archive
HuRef38,726,158 - 8,745,365 (-)ENTREZGENE
CHM1_138,742,513 - 8,761,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354653   ⟹   NP_001341582
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,750,381 - 8,769,613 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354654   ⟹   NP_001341583
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,750,381 - 8,769,613 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354655   ⟹   NP_001341584
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,750,381 - 8,769,232 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001354656   ⟹   NP_001341585
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,750,381 - 8,768,731 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000907   ⟸   NM_000916
- UniProtKB: P30559 (UniProtKB/Swiss-Prot),   B2R9L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001341582   ⟸   NM_001354653
- Sequence:
RefSeq Acc Id: NP_001341583   ⟸   NM_001354654
- Sequence:
RefSeq Acc Id: NP_001341584   ⟸   NM_001354655
- Sequence:
RefSeq Acc Id: NP_001341585   ⟸   NM_001354656
- Sequence:
RefSeq Acc Id: ENSP00000414828   ⟸   ENST00000431493
RefSeq Acc Id: ENSP00000324270   ⟸   ENST00000316793
RefSeq Acc Id: ENSP00000389587   ⟸   ENST00000449615
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6863448
Promoter ID:EPDNEW_H4889
Type:initiation region
Name:OXTR_2
Description:oxytocin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4890  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,768,425 - 8,768,485EPDNEW
RGD ID:6863450
Promoter ID:EPDNEW_H4890
Type:multiple initiation site
Name:OXTR_1
Description:oxytocin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4889  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3838,769,613 - 8,769,673EPDNEW
RGD ID:6801387
Promoter ID:HG_KWN:43575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000314042
Position:
Human AssemblyChrPosition (strand)Source
Build 3638,784,991 - 8,785,542 (-)MPROMDB
RGD ID:6801386
Promoter ID:HG_KWN:43576
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:OTTHUMT00000207061,   OTTHUMT00000314040,   OTTHUMT00000314041
Position:
Human AssemblyChrPosition (strand)Source
Build 3638,785,869 - 8,786,369 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p26.3-25.3(chr3:63843-9507969)x1 copy number loss See cases [RCV000051476] Chr3:63843..9507969 [GRCh38]
Chr3:105526..9549653 [GRCh37]
Chr3:80526..9524653 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.1-25.3(chr3:7400936-9450451)x1 copy number loss See cases [RCV000051479] Chr3:7400936..9450451 [GRCh38]
Chr3:7442623..9492135 [GRCh37]
Chr3:7417623..9467135 [NCBI36]
Chr3:3p26.1-25.3
pathogenic
GRCh38/hg38 3p25.3-25.2(chr3:8581778-12015238)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051480]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051480]|See cases [RCV000051480] Chr3:8581778..12015238 [GRCh38]
Chr3:8623464..12056738 [GRCh37]
Chr3:8598464..12031738 [NCBI36]
Chr3:3p25.3-25.2
pathogenic
GRCh38/hg38 3p26.1-25.3(chr3:7975734-9038133)x3 copy number gain See cases [RCV000051434] Chr3:7975734..9038133 [GRCh38]
Chr3:8017421..9079817 [GRCh37]
Chr3:7992421..9054817 [NCBI36]
Chr3:3p26.1-25.3
uncertain significance
GRCh38/hg38 3p26.3-25.3(chr3:52266-11089569)x1 copy number loss See cases [RCV000051447] Chr3:52266..11089569 [GRCh38]
Chr3:93949..11131255 [GRCh37]
Chr3:68949..11106255 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-22.2(chr3:52266-37148076)x3 copy number gain See cases [RCV000051097] Chr3:52266..37148076 [GRCh38]
Chr3:93949..37189567 [GRCh37]
Chr3:68949..37164571 [NCBI36]
Chr3:3p26.3-22.2
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:52066-20280127)x3 copy number gain See cases [RCV000051690] Chr3:52066..20280127 [GRCh38]
Chr3:93749..20321619 [GRCh37]
Chr3:68749..20296623 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p26.3-24.1(chr3:52266-29248782)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051718]|See cases [RCV000051718] Chr3:52266..29248782 [GRCh38]
Chr3:93949..29290273 [GRCh37]
Chr3:68949..29265277 [NCBI36]
Chr3:3p26.3-24.1
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:63843-19510600)x3 copy number gain See cases [RCV000051719] Chr3:63843..19510600 [GRCh38]
Chr3:105526..19552092 [GRCh37]
Chr3:80526..19527096 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p26.1-25.3(chr3:7401136-8995777)x3 copy number gain See cases [RCV000133877] Chr3:7401136..8995777 [GRCh38]
Chr3:7442823..9037461 [GRCh37]
Chr3:7417823..9012461 [NCBI36]
Chr3:3p26.1-25.3
uncertain significance
GRCh38/hg38 3p26.1-25.3(chr3:8038727-11240931)x4 copy number gain See cases [RCV000135641] Chr3:8038727..11240931 [GRCh38]
Chr3:8080414..11282617 [GRCh37]
Chr3:8055414..11257617 [NCBI36]
Chr3:3p26.1-25.3
likely pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:52266-9450310)x1 copy number loss See cases [RCV000137109] Chr3:52266..9450310 [GRCh38]
Chr3:93949..9491994 [GRCh37]
Chr3:68949..9466994 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.1-25.2(chr3:7975734-12636917)x3 copy number gain See cases [RCV000137309] Chr3:7975734..12636917 [GRCh38]
Chr3:8017421..12678416 [GRCh37]
Chr3:7992421..12653416 [NCBI36]
Chr3:3p26.1-25.2
likely pathogenic
GRCh38/hg38 3p26.3-25.2(chr3:32241-12681483)x1 copy number loss See cases [RCV000138143] Chr3:32241..12681483 [GRCh38]
Chr3:73914..12722982 [GRCh37]
Chr3:48914..12697982 [NCBI36]
Chr3:3p26.3-25.2
pathogenic
GRCh38/hg38 3p26.3-24.1(chr3:32241-30064208)x3 copy number gain See cases [RCV000138004] Chr3:32241..30064208 [GRCh38]
Chr3:73914..30105699 [GRCh37]
Chr3:48914..30080703 [NCBI36]
Chr3:3p26.3-24.1
pathogenic
GRCh38/hg38 3p26.3-24.3(chr3:32241-20334387)x3 copy number gain See cases [RCV000137941] Chr3:32241..20334387 [GRCh38]
Chr3:73914..20375879 [GRCh37]
Chr3:48914..20350883 [NCBI36]
Chr3:3p26.3-24.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:32241-11379835)x1 copy number loss See cases [RCV000138376] Chr3:32241..11379835 [GRCh38]
Chr3:73914..11421309 [GRCh37]
Chr3:48914..11396309 [NCBI36]
Chr3:3p26.3-25.3
pathogenic|likely benign
GRCh38/hg38 3p26.3-25.3(chr3:32241-9469506)x1 copy number loss See cases [RCV000139253] Chr3:32241..9469506 [GRCh38]
Chr3:73914..9511190 [GRCh37]
Chr3:48914..9486190 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-25.1(chr3:32241-13613818)x3 copy number gain See cases [RCV000138946] Chr3:32241..13613818 [GRCh38]
Chr3:73914..13655318 [GRCh37]
Chr3:48914..13630319 [NCBI36]
Chr3:3p26.3-25.1
pathogenic
GRCh38/hg38 3p25.3(chr3:8320124-9395968)x1 copy number loss See cases [RCV000140519] Chr3:8320124..9395968 [GRCh38]
Chr3:8361812..9437652 [GRCh37]
Chr3:8336812..9412652 [NCBI36]
Chr3:3p25.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:32241-9574994)x1 copy number loss See cases [RCV000140239] Chr3:32241..9574994 [GRCh38]
Chr3:73914..9616678 [GRCh37]
Chr3:48914..9591678 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:32241-9066287)x1 copy number loss See cases [RCV000140848] Chr3:32241..9066287 [GRCh38]
Chr3:73914..9107971 [GRCh37]
Chr3:48914..9082971 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3 copy number gain See cases [RCV000141810] Chr3:53308..41381521 [GRCh38]
Chr3:94991..41423012 [GRCh37]
Chr3:69991..41398016 [NCBI36]
Chr3:3p26.3-22.1
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:20213-11221602)x1 copy number loss See cases [RCV000141731] Chr3:20213..11221602 [GRCh38]
Chr3:61891..11263288 [GRCh37]
Chr3:36891..11238288 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:20213-9362037)x1 copy number loss See cases [RCV000142284] Chr3:20213..9362037 [GRCh38]
Chr3:61891..9403721 [GRCh37]
Chr3:36891..9378721 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:32241-10323124)x1 copy number loss See cases [RCV000143325] Chr3:32241..10323124 [GRCh38]
Chr3:73914..10364808 [GRCh37]
Chr3:48914..10339808 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:32241-10631310)x1 copy number loss See cases [RCV000143173] Chr3:32241..10631310 [GRCh38]
Chr3:73914..10672995 [GRCh37]
Chr3:48914..10647995 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh38/hg38 3p26.1-25.1(chr3:7356110-14360442)x3 copy number gain See cases [RCV000143766] Chr3:7356110..14360442 [GRCh38]
Chr3:7397797..14401942 [GRCh37]
Chr3:7372797..14376946 [NCBI36]
Chr3:3p26.1-25.1
pathogenic
GRCh38/hg38 3p26.3-25.3(chr3:688897-11051142)x1 copy number loss See cases [RCV000143706] Chr3:688897..11051142 [GRCh38]
Chr3:730581..11092828 [GRCh37]
Chr3:705581..11067828 [NCBI36]
Chr3:3p26.3-25.3
pathogenic
GRCh37/hg19 3p26.3-24.2(chr3:61891-24432821)x3 copy number gain See cases [RCV000447247] Chr3:61891..24432821 [GRCh37]
Chr3:3p26.3-24.2
pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-36710181)x3 copy number gain See cases [RCV000448528] Chr3:61891..36710181 [GRCh37]
Chr3:3p26.3-22.2
pathogenic
GRCh37/hg19 3p26.1-25.3(chr3:6842555-10153209)x1 copy number loss See cases [RCV000448839] Chr3:6842555..10153209 [GRCh37]
Chr3:3p26.1-25.3
pathogenic
GRCh37/hg19 3p26.3-22.3(chr3:61891-33958201)x3 copy number gain See cases [RCV000510429] Chr3:61891..33958201 [GRCh37]
Chr3:3p26.3-22.3
pathogenic
GRCh37/hg19 3p26.3-22.2(chr3:61891-37459464)x3 copy number gain See cases [RCV000511463] Chr3:61891..37459464 [GRCh37]
Chr3:3p26.3-22.2
pathogenic
GRCh37/hg19 3p26.1-25.3(chr3:7349315-9047066)x3 copy number gain See cases [RCV000511091] Chr3:7349315..9047066 [GRCh37]
Chr3:3p26.1-25.3
uncertain significance
GRCh37/hg19 3p26.3-25.2(chr3:61891-12575409)x1 copy number loss See cases [RCV000511155] Chr3:61891..12575409 [GRCh37]
Chr3:3p26.3-25.2
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p25.3(chr3:8716167-9005190)x1 copy number loss not provided [RCV000682239] Chr3:8716167..9005190 [GRCh37]
Chr3:3p25.3
uncertain significance
GRCh37/hg19 3p26.3-25.3(chr3:61891-10104842)x1 copy number loss not provided [RCV000682180] Chr3:61891..10104842 [GRCh37]
Chr3:3p26.3-25.3
pathogenic
GRCh37/hg19 3p26.3-24.3(chr3:1897972-19519085)x3 copy number gain not provided [RCV000682215] Chr3:1897972..19519085 [GRCh37]
Chr3:3p26.3-24.3
pathogenic
GRCh37/hg19 3p26.1-24.3(chr3:5173870-16760262)x3 copy number gain not provided [RCV000682233] Chr3:5173870..16760262 [GRCh37]
Chr3:3p26.1-24.3
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_000916.3(OXTR):c.360G>T (p.Val120=) single nucleotide variant not provided [RCV000900318] Chr3:8767828 [GRCh38]
Chr3:8809514 [GRCh37]
Chr3:3p25.3
likely benign
NM_000916.3(OXTR):c.1015G>A (p.Glu339Lys) single nucleotide variant not provided [RCV000950098] Chr3:8753132 [GRCh38]
Chr3:8794818 [GRCh37]
Chr3:3p25.3
benign
Single allele deletion Neurodevelopmental disorder [RCV000787442] Chr3:36016..9307855 [GRCh37]
Chr3:3p26.3-25.3
likely pathogenic
NM_000916.3(OXTR):c.1104G>A (p.Ser368=) single nucleotide variant not provided [RCV000896744] Chr3:8753043 [GRCh38]
Chr3:8794729 [GRCh37]
Chr3:3p25.3
benign
NM_000916.3(OXTR):c.515T>C (p.Val172Ala) single nucleotide variant not provided [RCV000946712] Chr3:8767673 [GRCh38]
Chr3:8809359 [GRCh37]
Chr3:3p25.3
benign
NM_000916.3(OXTR):c.616C>G (p.Leu206Val) single nucleotide variant not provided [RCV000973327] Chr3:8767572 [GRCh38]
Chr3:8809258 [GRCh37]
Chr3:3p25.3
benign
NM_000916.3(OXTR):c.65G>A (p.Gly22Glu) single nucleotide variant not provided [RCV000997975] Chr3:8768123 [GRCh38]
Chr3:8809809 [GRCh37]
Chr3:3p25.3
uncertain significance
NM_000916.3(OXTR):c.351C>T (p.Tyr117=) single nucleotide variant not provided [RCV000961430] Chr3:8767837 [GRCh38]
Chr3:8809523 [GRCh37]
Chr3:3p25.3
benign
NM_000916.3(OXTR):c.1068C>A (p.Arg356=) single nucleotide variant not provided [RCV000888508] Chr3:8753079 [GRCh38]
Chr3:8794765 [GRCh37]
Chr3:3p25.3
benign
NM_000916.3(OXTR):c.705C>A (p.Thr235=) single nucleotide variant not provided [RCV000931542] Chr3:8767483 [GRCh38]
Chr3:8809169 [GRCh37]
Chr3:3p25.3
likely benign
GRCh37/hg19 3p26.1-25.3(chr3:7172720-9545741)x3 copy number gain not provided [RCV001005411] Chr3:7172720..9545741 [GRCh37]
Chr3:3p26.1-25.3
uncertain significance
GRCh37/hg19 3p25.3(chr3:8736661-8889809)x1 copy number loss not provided [RCV001005412] Chr3:8736661..8889809 [GRCh37]
Chr3:3p25.3
uncertain significance
GRCh37/hg19 3p26.3-25.3(chr3:61891-10287825)x1 copy number loss not provided [RCV001007530] Chr3:61891..10287825 [GRCh37]
Chr3:3p26.3-25.3
pathogenic
NC_000003.11:g.(?_8775553)_(9730776_?)dup duplication Long QT syndrome [RCV001033330] Chr3:8775553..9730776 [GRCh37]
Chr3:3p25.3
uncertain significance
GRCh37/hg19 3p25.3(chr3:8745819-9043663)x3 copy number gain not provided [RCV001259807] Chr3:8745819..9043663 [GRCh37]
Chr3:3p25.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8529 AgrOrtholog
COSMIC OXTR COSMIC
Ensembl Genes ENSG00000180914 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000324270 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000389587 UniProtKB/TrEMBL
  ENSP00000414828 UniProtKB/TrEMBL
Ensembl Transcript ENST00000316793 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000431493 UniProtKB/TrEMBL
  ENST00000449615 UniProtKB/TrEMBL
GTEx ENSG00000180914 GTEx
HGNC ID HGNC:8529 ENTREZGENE
Human Proteome Map OXTR Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxytocn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasoprsn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5021 ENTREZGENE
OMIM 167055 OMIM
PANTHER PTHR24241:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32858 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OXYTOCINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VASOPRESSINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0T1J2_HUMAN UniProtKB/TrEMBL
  B2R9L7 ENTREZGENE, UniProtKB/TrEMBL
  C9JN09_HUMAN UniProtKB/TrEMBL
  C9JQC4_HUMAN UniProtKB/TrEMBL
  L8E6Y2_HUMAN UniProtKB/TrEMBL
  OXYR_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  X5DRH4_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q15071 UniProtKB/Swiss-Prot