CPQ (carboxypeptidase Q) - Rat Genome Database

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Gene: CPQ (carboxypeptidase Q) Homo sapiens
Analyze
Symbol: CPQ
Name: carboxypeptidase Q
RGD ID: 736012
HGNC Page HGNC
Description: Exhibits metallodipeptidase activity and protein homodimerization activity. Involved in peptide catabolic process and proteolysis. Localizes to Golgi apparatus and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aminopeptidase; blood plasma glutamate carboxypeptidase; LDP; lysosomal dipeptidase; PGCP; plasma glutamate carboxypeptidase; Ser-Met dipeptidase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl896,645,242 - 97,149,654 (+)EnsemblGRCh38hg38GRCh38
GRCh38896,645,242 - 97,143,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37897,657,470 - 98,155,729 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36897,726,675 - 98,224,900 (+)NCBINCBI36hg18NCBI36
Build 34897,726,674 - 98,224,898NCBI
Celera893,843,723 - 94,341,990 (+)NCBI
Cytogenetic Map8q22.1NCBI
HuRef892,862,971 - 93,361,718 (+)NCBIHuRef
CHM1_1897,697,957 - 98,196,225 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-acetylaminofluorene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
butanal  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
dicrotophos  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glyphosate  (ISO)
L-ethionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
methapyrilene  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nimesulide  (ISO)
O-methyleugenol  (EXP)
omeprazole  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
progesterone  (EXP)
propanal  (EXP)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10206990   PMID:12477932   PMID:12591738   PMID:12675526   PMID:16303743   PMID:16344560   PMID:17214548   PMID:20201926   PMID:20379614   PMID:20551380   PMID:20802479   PMID:21873635  
PMID:23376485   PMID:23533145   PMID:23725790   PMID:23728906   PMID:27806330   PMID:29196255   PMID:30997501  


Genomics

Comparative Map Data
CPQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl896,645,242 - 97,149,654 (+)EnsemblGRCh38hg38GRCh38
GRCh38896,645,242 - 97,143,501 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37897,657,470 - 98,155,729 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36897,726,675 - 98,224,900 (+)NCBINCBI36hg18NCBI36
Build 34897,726,674 - 98,224,898NCBI
Celera893,843,723 - 94,341,990 (+)NCBI
Cytogenetic Map8q22.1NCBI
HuRef892,862,971 - 93,361,718 (+)NCBIHuRef
CHM1_1897,697,957 - 98,196,225 (+)NCBICHM1_1
Cpq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391533,083,275 - 33,594,698 (+)NCBIGRCm39mm39
GRCm39 Ensembl1533,083,275 - 33,594,698 (+)Ensembl
GRCm381533,083,129 - 33,594,552 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1533,083,129 - 33,594,552 (+)EnsemblGRCm38mm10GRCm38
MGSCv371533,012,884 - 33,524,307 (+)NCBIGRCm37mm9NCBIm37
MGSCv361533,027,787 - 33,539,093 (+)NCBImm8
Celera1533,743,973 - 34,239,581 (+)NCBICelera
Cytogenetic Map15B3.1NCBI
Cpq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2764,264,025 - 64,830,867 (+)NCBI
Rnor_6.0 Ensembl771,709,157 - 72,167,417 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0771,709,174 - 72,167,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0771,880,847 - 71,975,396 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0772,004,374 - 72,338,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4768,430,069 - 68,900,500 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1768,450,798 - 68,921,230 (+)NCBI
Celera761,386,725 - 61,844,888 (+)NCBICelera
Cytogenetic Map7q22NCBI
Cpq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541712,585,722 - 13,024,655 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541712,585,829 - 13,020,935 (+)NCBIChiLan1.0ChiLan1.0
CPQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1895,461,027 - 95,974,029 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl895,599,177 - 95,974,029 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0893,264,536 - 93,883,201 (+)NCBIMhudiblu_PPA_v0panPan3
CPQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12941,058,641 - 41,461,567 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2941,058,306 - 41,461,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02941,286,374 - 41,655,798 (+)NCBI
UMICH_Zoey_3.12941,328,033 - 41,695,262 (+)NCBI
UNSW_CanFamBas_1.02941,296,426 - 41,666,684 (+)NCBI
UU_Cfam_GSD_1.02941,790,780 - 42,130,099 (+)NCBI
Cpq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530338,063,459 - 38,513,392 (-)NCBI
SpeTri2.0NW_00493647045,489,562 - 45,848,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl439,480,676 - 39,967,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1439,492,663 - 39,855,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2442,482,480 - 42,670,723 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2442,758,536 - 42,938,686 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPQ
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1891,604,736 - 92,095,671 (+)NCBI
ChlSab1.1 Ensembl891,738,987 - 92,097,126 (+)Ensembl
Cpq
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247633,943,816 - 4,482,111 (+)NCBI

Position Markers
WI-15529  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,991,129 - 97,991,260UniSTSGRCh37
Build 36898,060,305 - 98,060,436RGDNCBI36
Celera894,177,391 - 94,177,522RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,197,083 - 93,197,214UniSTS
GeneMap99-GB4 RH Map8440.32UniSTS
Whitehead-RH Map8581.2UniSTS
RH92662  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,981,298 - 97,981,470UniSTSGRCh37
Build 36898,050,474 - 98,050,646RGDNCBI36
Celera894,167,549 - 94,167,721RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,187,238 - 93,187,410UniSTS
GeneMap99-GB4 RH Map8442.54UniSTS
RH122258  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,782,340 - 97,782,616UniSTSGRCh37
Build 36897,851,516 - 97,851,792RGDNCBI36
Celera893,968,588 - 93,968,864RGD
Cytogenetic Map8q22.2UniSTS
HuRef892,987,876 - 92,988,152UniSTS
G59464  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,875,141 - 97,875,331UniSTSGRCh37
Build 36897,944,317 - 97,944,507RGDNCBI36
Celera894,061,385 - 94,061,575RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,080,665 - 93,080,855UniSTS
SHGC-108118  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,073,035 - 98,073,330UniSTSGRCh37
Build 36898,142,211 - 98,142,506RGDNCBI36
Celera894,259,306 - 94,259,601RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,279,000 - 93,279,295UniSTS
TNG Radiation Hybrid Map848271.0UniSTS
SHGC-143008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,042,543 - 98,042,817UniSTSGRCh37
Build 36898,111,719 - 98,111,993RGDNCBI36
Celera894,228,818 - 94,229,092RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,248,507 - 93,248,781UniSTS
TNG Radiation Hybrid Map848251.0UniSTS
SHGC-112347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,037,588 - 98,037,891UniSTSGRCh37
Build 36898,106,764 - 98,107,067RGDNCBI36
Celera894,223,863 - 94,224,166RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,243,552 - 93,243,855UniSTS
SHGC-142280  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,671,898 - 97,672,238UniSTSGRCh37
Build 36897,741,074 - 97,741,414RGDNCBI36
Celera893,858,122 - 93,858,462RGD
Cytogenetic Map8q22.2UniSTS
HuRef892,877,409 - 92,877,749UniSTS
TNG Radiation Hybrid Map866151.0UniSTS
WI-22073  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,964,214 - 97,964,494UniSTSGRCh37
Build 36898,033,390 - 98,033,670RGDNCBI36
Celera894,150,460 - 94,150,740RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,170,151 - 93,170,431UniSTS
GeneMap99-GB4 RH Map8442.04UniSTS
Whitehead-RH Map8581.1UniSTS
NCBI RH Map81127.0UniSTS
D8S1377E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,155,505 - 98,155,646UniSTSGRCh37
Build 36898,224,681 - 98,224,822RGDNCBI36
Celera894,341,773 - 94,341,914RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,361,492 - 93,361,633UniSTS
GeneMap99-GB4 RH Map8441.24UniSTS
NCBI RH Map8996.5UniSTS
AFM198ZF10  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,874,424 - 97,874,629UniSTSGRCh37
Build 36897,943,600 - 97,943,805RGDNCBI36
Celera894,060,668 - 94,060,873RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,079,948 - 93,080,153UniSTS
Whitehead-YAC Contig Map8 UniSTS
D8S1512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,155,492 - 98,155,669UniSTSGRCh37
Build 36898,224,668 - 98,224,845RGDNCBI36
Celera894,341,760 - 94,341,937RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,361,479 - 93,361,656UniSTS
GeneMap99-GB4 RH Map8440.02UniSTS
Whitehead-RH Map8581.2UniSTS
Whitehead-YAC Contig Map8 UniSTS
NCBI RH Map81216.1UniSTS
D7S2217  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,817,548 - 97,817,751UniSTSGRCh37
Build 36897,886,724 - 97,886,927RGDNCBI36
Celera894,003,796 - 94,003,999RGD
Cytogenetic Map8q22.2UniSTS
HuRef893,023,074 - 93,023,277UniSTS
Whitehead-RH Map8579.4UniSTS
Whitehead-YAC Contig Map8 UniSTS
NCBI RH Map81215.1UniSTS
G54714  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37897,875,140 - 97,875,339UniSTSGRCh37
Celera894,061,384 - 94,061,583UniSTS
Cytogenetic Map8q22.2UniSTS
HuRef893,080,664 - 93,080,863UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1225
Count of miRNA genes:665
Interacting mature miRNAs:745
Transcripts:ENST00000220763, ENST00000517742, ENST00000519484, ENST00000519900, ENST00000521142, ENST00000522617, ENST00000525310, ENST00000529551, ENST00000532528
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2158 2624 1553 454 1309 340 3185 1077 1975 379 1106 1418 116 1203 1933 2
Low 220 360 170 168 267 122 1168 1097 1707 37 321 141 52 1 855
Below cutoff 40 1 287 2 1 16 11 19 26 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA492294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC010859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF119386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF445505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA699663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000220763   ⟹   ENSP00000220763
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,645,242 - 97,143,501 (+)Ensembl
RefSeq Acc Id: ENST00000517742   ⟹   ENSP00000429146
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,645,375 - 96,835,097 (+)Ensembl
RefSeq Acc Id: ENST00000519484   ⟹   ENSP00000431114
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,760,974 - 96,785,310 (+)Ensembl
RefSeq Acc Id: ENST00000519900   ⟹   ENSP00000431024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,645,371 - 96,785,292 (+)Ensembl
RefSeq Acc Id: ENST00000521142   ⟹   ENSP00000429934
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,761,240 - 96,785,287 (+)Ensembl
RefSeq Acc Id: ENST00000522617   ⟹   ENSP00000429134
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl897,029,469 - 97,149,654 (+)Ensembl
RefSeq Acc Id: ENST00000525310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl896,732,292 - 96,785,328 (+)Ensembl
RefSeq Acc Id: ENST00000529551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl897,055,527 - 97,092,936 (+)Ensembl
RefSeq Acc Id: ENST00000532528
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl897,055,527 - 97,092,710 (+)Ensembl
RefSeq Acc Id: NM_016134   ⟹   NP_057218
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38896,645,242 - 97,143,501 (+)NCBI
GRCh37897,657,455 - 98,155,731 (+)NCBI
Build 36897,726,675 - 98,224,900 (+)NCBI Archive
Celera893,843,723 - 94,341,990 (+)RGD
HuRef892,862,971 - 93,361,718 (+)NCBI
CHM1_1897,697,957 - 98,196,225 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057218   ⟸   NM_016134
- Peptide Label: preproprotein
- UniProtKB: Q9Y646 (UniProtKB/Swiss-Prot),   A0A024R9B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000429146   ⟸   ENST00000517742
RefSeq Acc Id: ENSP00000431114   ⟸   ENST00000519484
RefSeq Acc Id: ENSP00000431024   ⟸   ENST00000519900
RefSeq Acc Id: ENSP00000429934   ⟸   ENST00000521142
RefSeq Acc Id: ENSP00000429134   ⟸   ENST00000522617
RefSeq Acc Id: ENSP00000220763   ⟸   ENST00000220763
Protein Domains
Peptidase_M28

Promoters
RGD ID:7213833
Promoter ID:EPDNEW_H12662
Type:initiation region
Name:CPQ_1
Description:carboxypeptidase Q
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38896,645,310 - 96,645,370EPDNEW
RGD ID:6806934
Promoter ID:HG_KWN:61759
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_016134
Position:
Human AssemblyChrPosition (strand)Source
Build 36897,725,986 - 97,726,922 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1(chr8:92755532-97792132)x1 copy number loss See cases [RCV000054278] Chr8:92755532..97792132 [GRCh38]
Chr8:93767760..98804360 [GRCh37]
Chr8:93836936..98873536 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q22.1(chr8:96065893-97276981)x1 copy number loss See cases [RCV000054279] Chr8:96065893..97276981 [GRCh38]
Chr8:97078121..98289209 [GRCh37]
Chr8:97147297..98358385 [NCBI36]
Chr8:8q22.1
pathogenic
NM_016134.3(CPQ):c.-34-730A>C single nucleotide variant Lung cancer [RCV000107908] Chr8:96784134 [GRCh38]
Chr8:97796362 [GRCh37]
Chr8:8q22.1
uncertain significance
NM_016134.3(CPQ):c.434-16653G>C single nucleotide variant Lung cancer [RCV000107909] Chr8:96818320 [GRCh38]
Chr8:97830548 [GRCh37]
Chr8:8q22.1
uncertain significance
NM_016134.3(CPQ):c.849+1996C>A single nucleotide variant Lung cancer [RCV000107910] Chr8:96882001 [GRCh38]
Chr8:97894229 [GRCh37]
Chr8:8q22.1
uncertain significance
NM_016134.3(CPQ):c.850-26468T>G single nucleotide variant Lung cancer [RCV000107911] Chr8:96939467 [GRCh38]
Chr8:97951695 [GRCh37]
Chr8:8q22.1
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_016134.4(CPQ):c.1dup (p.Met1fs) duplication not specified [RCV000484729] Chr8:96784889..96784890 [GRCh38]
Chr8:97797117..97797118 [GRCh37]
Chr8:8q22.1
likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:96468763-98522743)x1 copy number loss not provided [RCV000683017] Chr8:96468763..98522743 [GRCh37]
Chr8:8q22.1
uncertain significance
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
t(8;11)(q22;q23)dn translocation not specified [RCV000714252] Chr8:98018338..98025939 [GRCh37]
Chr11:116274486..116274490 [GRCh37]
Chr11:11q23.3
Chr8:8q22.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_016134.4(CPQ):c.990G>A (p.Leu330=) single nucleotide variant not provided [RCV000880732] Chr8:97029431 [GRCh38]
Chr8:98041659 [GRCh37]
Chr8:8q22.1
benign
NM_016134.4(CPQ):c.433+8T>C single nucleotide variant not provided [RCV000883874] Chr8:96785338 [GRCh38]
Chr8:97797566 [GRCh37]
Chr8:8q22.1
benign
NM_016134.4(CPQ):c.452T>C (p.Leu151Pro) single nucleotide variant not provided [RCV000883875] Chr8:96834991 [GRCh38]
Chr8:97847219 [GRCh37]
Chr8:8q22.1
benign
NM_016134.4(CPQ):c.163_167dup (p.Tyr56Ter) duplication not provided [RCV000906362] Chr8:96785059..96785060 [GRCh38]
Chr8:97797287..97797288 [GRCh37]
Chr8:8q22.1
likely benign
GRCh37/hg19 8q22.1(chr8:97154645-98155535)x3 copy number gain Leri pleonosteosis [RCV000856633] Chr8:97154645..98155535 [GRCh37]
Chr8:8q22.1
pathogenic
NM_016134.4(CPQ):c.413G>A (p.Ser138Asn) single nucleotide variant not provided [RCV000962339] Chr8:96785310 [GRCh38]
Chr8:97797538 [GRCh37]
Chr8:8q22.1
benign
NM_016134.4(CPQ):c.274T>G (p.Tyr92Asp) single nucleotide variant not provided [RCV000967848] Chr8:96785171 [GRCh38]
Chr8:97797399 [GRCh37]
Chr8:8q22.1
benign
GRCh37/hg19 8q22.1(chr8:97656087-98126625)x1 copy number loss not provided [RCV001006123] Chr8:97656087..98126625 [GRCh37]
Chr8:8q22.1
uncertain significance
GRCh37/hg19 8q22.1(chr8:97830138-97887447)x1 copy number loss not provided [RCV001006124] Chr8:97830138..97887447 [GRCh37]
Chr8:8q22.1
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_016134.4(CPQ):c.610A>G (p.Ile204Val) single nucleotide variant not provided [RCV000969541] Chr8:96835149 [GRCh38]
Chr8:97847377 [GRCh37]
Chr8:8q22.1
benign
NM_016134.4(CPQ):c.985C>A (p.Arg329=) single nucleotide variant not provided [RCV000957888] Chr8:97029426 [GRCh38]
Chr8:98041654 [GRCh37]
Chr8:8q22.1
benign
GRCh37/hg19 8q22.1(chr8:96646399-98973327)x3 copy number gain not provided [RCV001006122] Chr8:96646399..98973327 [GRCh37]
Chr8:8q22.1
likely pathogenic
GRCh37/hg19 8q22.1(chr8:95803280-97802022)x3 copy number gain not provided [RCV001259019] Chr8:95803280..97802022 [GRCh37]
Chr8:8q22.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16910 AgrOrtholog
COSMIC CPQ COSMIC
Ensembl Genes ENSG00000104324 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220763 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429134 UniProtKB/TrEMBL
  ENSP00000429146 UniProtKB/TrEMBL
  ENSP00000429934 UniProtKB/TrEMBL
  ENSP00000431024 UniProtKB/TrEMBL
  ENSP00000431114 UniProtKB/TrEMBL
Ensembl Transcript ENST00000220763 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517742 UniProtKB/TrEMBL
  ENST00000519484 UniProtKB/TrEMBL
  ENST00000519900 UniProtKB/TrEMBL
  ENST00000521142 UniProtKB/TrEMBL
  ENST00000522617 UniProtKB/TrEMBL
GTEx ENSG00000104324 GTEx
HGNC ID HGNC:16910 ENTREZGENE
Human Proteome Map CPQ Human Proteome Map
InterPro CPQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10404 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10404 ENTREZGENE
OMIM 618754 OMIM
PANTHER PTHR12053 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166048947 PharmGKB
UniProt A0A024R9B8 ENTREZGENE, UniProtKB/TrEMBL
  CBPQ_HUMAN UniProtKB/Swiss-Prot
  E5RH35_HUMAN UniProtKB/TrEMBL
  E5RJA8_HUMAN UniProtKB/TrEMBL
  E5RJP8_HUMAN UniProtKB/TrEMBL
  E5RJZ7_HUMAN UniProtKB/TrEMBL
  H0YBB7_HUMAN UniProtKB/TrEMBL
  Q9Y646 ENTREZGENE
UniProt Secondary B2RD88 UniProtKB/Swiss-Prot
  Q8NBZ1 UniProtKB/Swiss-Prot
  Q9UNM8 UniProtKB/Swiss-Prot
  Q9Y5X6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-01 CPQ  carboxypeptidase Q  PGCP  plasma glutamate carboxypeptidase  Symbol and/or name change 5135510 APPROVED