Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IL1RAPL1 (interleukin 1 receptor accessory protein like 1) Homo sapiens
Symbol: IL1RAPL1
Name: interleukin 1 receptor accessory protein like 1
Description: Predicted to have signaling receptor binding activity and voltage-gated calcium channel activity. Involved in negative regulation of exocytosis; regulation of synapse organization; and trans-synaptic signaling by trans-synaptic complex. Localizes to the glutamatergic synapse and plasma membrane. Implicated in intellectual disability and non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IL-1-RAPL-1; IL-1RAPL-1; IL1R8; IL1RAPL; IL1RAPL-1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; mental retardation, X-linked 21; MRX10; MRX21; MRX34; oligophrenin-4; OPHN4; three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX28,587,446 - 29,956,718 (+)Ensembl
GRCh38X28,587,446 - 29,956,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X28,605,681 - 29,974,467 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X28,515,480 - 29,884,761 (+)NCBINCBI36hg18NCBI36
Build 34X28,365,215 - 29,734,493NCBI
CeleraX32,732,824 - 34,100,946 (+)NCBI
Cytogenetic MapXp21.3-p21.2NCBI
HuRefX26,346,333 - 27,710,305 (+)NCBIHuRef
CHM1_1X28,636,125 - 30,004,681 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL1RAPL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735979
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.