Slit3 (slit guidance ligand 3) - Rat Genome Database

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Gene: Slit3 (slit guidance ligand 3) Mus musculus
Analyze
Symbol: Slit3
Name: slit guidance ligand 3
RGD ID: 735860
MGI Page MGI
Description: Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: b2b2362.1Clo; Sl; Slil2; slit homolog 3 (Drosophila); slit homolog 3 protein; slit-3; Slit1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,012,283 - 35,599,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,012,051 - 35,599,334 (+)EnsemblGRCm39 Ensembl
GRCm381135,121,456 - 35,708,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,121,224 - 35,708,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,934,958 - 35,522,009 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,964,879 - 35,551,735 (+)NCBIMGSCv36mm8
Celera1138,900,451 - 39,489,864 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1120.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acetaldehyde  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chlormequat chloride  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
daunorubicin  (ISO)
dexamethasone  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
flusilazole  (EXP)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
panobinostat  (ISO)
parathion  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. Doi T, etal., J Pediatr Surg. 2009 Nov;44(11):2092-5. doi: 10.1016/j.jpedsurg.2009.02.068.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, etal., Eur J Neurosci. 2005 Nov;22(9):2134-44.
Additional References at PubMed
PMID:8889548   PMID:10102269   PMID:10349621   PMID:10349636   PMID:10433822   PMID:10864954   PMID:10864955   PMID:11042159   PMID:11076861   PMID:11520671   PMID:11748150   PMID:12141424  
PMID:12477932   PMID:12520002   PMID:12609596   PMID:12702769   PMID:12954717   PMID:14550534   PMID:14610273   PMID:14621295   PMID:15091338   PMID:15162513   PMID:15226823   PMID:15511637  
PMID:16141072   PMID:16141073   PMID:16284245   PMID:16291793   PMID:16439476   PMID:16602821   PMID:16715082   PMID:16828733   PMID:16854408   PMID:17306799   PMID:17581972   PMID:17715346  
PMID:18287559   PMID:18345009   PMID:18547144   PMID:18562598   PMID:18617019   PMID:18829537   PMID:18842816   PMID:19325248   PMID:19563800   PMID:19700621   PMID:19741192   PMID:19906969  
PMID:20231872   PMID:20498081   PMID:20606719   PMID:20631173   PMID:20696379   PMID:20941780   PMID:20947829   PMID:21078908   PMID:21267068   PMID:21664580   PMID:21688288   PMID:21873635  
PMID:22306607   PMID:22349628   PMID:22399681   PMID:22696295   PMID:22806432   PMID:22981605   PMID:23161783   PMID:23255421   PMID:23307742   PMID:23328398   PMID:23534961   PMID:23536828  
PMID:23821580   PMID:23884932   PMID:24006456   PMID:24065825   PMID:24355925   PMID:24741061   PMID:24952961   PMID:25056828   PMID:25325980   PMID:25456121   PMID:25485759   PMID:25490618  
PMID:25691540   PMID:25807483   PMID:25810521   PMID:25843547   PMID:26257608   PMID:26743624   PMID:27819291   PMID:28234971   PMID:29031500   PMID:29229150   PMID:29343636   PMID:29504949  
PMID:29623926   PMID:29764562   PMID:29785024   PMID:29961574   PMID:30389141   PMID:30392794   PMID:30483073   PMID:30504829   PMID:30819894   PMID:32325033   PMID:32470195   PMID:32553152  
PMID:32644051   PMID:32857951   PMID:33347679   PMID:34249921   PMID:34423586   PMID:34782792   PMID:35343246   PMID:37497580   PMID:37596575   PMID:37830982  


Genomics

Comparative Map Data
Slit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,012,283 - 35,599,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,012,051 - 35,599,334 (+)EnsemblGRCm39 Ensembl
GRCm381135,121,456 - 35,708,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,121,224 - 35,708,507 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,934,958 - 35,522,009 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,964,879 - 35,551,735 (+)NCBIMGSCv36mm8
Celera1138,900,451 - 39,489,864 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1120.29NCBI
SLIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,661,740 - 169,301,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,661,740 - 169,301,139 (-)EnsemblGRCh38hg38GRCh38
GRCh375168,088,745 - 168,728,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,025,857 - 168,660,554 (-)NCBINCBI36Build 36hg18NCBI36
Build 345168,025,856 - 168,660,554NCBI
Celera5164,128,856 - 164,759,439 (-)NCBICelera
Cytogenetic Map5q34-q35.1NCBI
HuRef5163,187,021 - 163,825,867 (-)NCBIHuRef
CHM1_15167,521,662 - 168,160,538 (-)NCBICHM1_1
T2T-CHM13v2.05169,196,497 - 169,836,714 (-)NCBIT2T-CHM13v2.0
Slit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,075,929 - 20,660,704 (+)NCBIGRCr8
mRatBN7.21019,571,798 - 20,156,634 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1019,571,684 - 20,156,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1024,327,438 - 24,913,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01023,815,979 - 24,401,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,295,723 - 19,880,358 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01019,924,200 - 20,517,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,320,878 - 20,518,518 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01019,801,599 - 20,392,415 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,983,166 - 20,576,689 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11020,098,220 - 20,577,738 (+)NCBI
Celera1019,201,522 - 19,782,964 (+)NCBICelera
Cytogenetic Map10q12NCBI
Slit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540821,722,632 - 22,322,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540821,719,487 - 22,322,958 (-)NCBIChiLan1.0ChiLan1.0
SLIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24163,822,402 - 164,461,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15161,966,392 - 162,604,913 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05164,029,432 - 164,664,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15170,793,386 - 171,425,236 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5170,793,731 - 171,425,242 (-)Ensemblpanpan1.1panPan2
SLIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1442,506,680 - 43,099,053 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl442,508,426 - 43,094,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha442,466,027 - 43,055,860 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0442,928,562 - 43,521,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl442,928,887 - 43,516,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1442,700,926 - 43,290,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0442,893,778 - 43,485,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0443,399,255 - 43,991,187 (+)NCBIUU_Cfam_GSD_1.0
Slit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721396,574,901 - 97,136,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936622565,346 - 752,299 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936622191,165 - 756,552 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1654,553,426 - 55,220,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11654,551,536 - 55,221,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21659,123,810 - 59,790,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12370,890,096 - 71,524,002 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2370,885,737 - 71,106,703 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660347,156,377 - 7,794,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473320,683,814 - 21,291,088 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473320,683,680 - 21,293,663 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slit3
20692 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:539
Count of miRNA genes:399
Interacting mature miRNAs:465
Transcripts:ENSMUST00000069837, ENSMUST00000124438, ENSMUST00000153098, ENSMUST00000156571
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300607Tnbs2_mtri-nitrobenzene sulfonic acid susceptible 2 (mouse)Not determined112489805235126680Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
10043922Alcw9_malcohol withdrawal 9 (mouse)Not determined113557861644065931Mouse
1301718Pbw3_mpentobarbital withdrawal QTL 3 (mouse)Not determined113557861644065931Mouse
1558769Zolw1_mzolpidem withdrawal 1 (mouse)Not determined113557861644065931Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse

Markers in Region
BE197067  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,711,774 - 35,711,919UniSTSGRCm38
MGSCv371135,525,276 - 35,525,421UniSTSGRCm37
Celera1139,493,125 - 39,493,270UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11475.38UniSTS
C87259  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,295,754 - 35,296,003UniSTSGRCm38
MGSCv371135,109,256 - 35,109,505UniSTSGRCm37
Celera1139,075,371 - 39,075,620UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11479.46UniSTS
D11Mit186  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,235,729 - 35,235,853UniSTSGRCm38
MGSCv371135,049,231 - 35,049,355UniSTSGRCm37
Celera1139,015,342 - 39,015,466UniSTS
Cytogenetic Map11A5UniSTS
cM Map1117.0UniSTS
Whitehead Genetic1114.2UniSTS
D11Mit231.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,687,641 - 35,687,792UniSTSGRCm38
MGSCv371135,501,143 - 35,501,294UniSTSGRCm37
Celera1139,469,323 - 39,469,474UniSTS
Cytogenetic Map11A5UniSTS
cM Map1117.0UniSTS
cM Map11 UniSTS
Whitehead Genetic1114.2UniSTS
Slit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map11 UniSTS
D11Dcr6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,687,789 - 35,687,889UniSTSGRCm38
MGSCv371135,501,291 - 35,501,391UniSTSGRCm37
Celera1139,469,471 - 39,469,583UniSTS
Cytogenetic Map11A5UniSTS
cM Map11 UniSTS
UniSTS:236552  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,711,807 - 35,711,907UniSTSGRCm38
MGSCv371135,525,309 - 35,525,409UniSTSGRCm37
Celera1139,493,158 - 39,493,258UniSTS
Cytogenetic Map11A5UniSTS
MT3692  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,687,789 - 35,687,889UniSTSGRCm38
MGSCv371135,501,291 - 35,501,391UniSTSGRCm37
Celera1139,469,471 - 39,469,583UniSTS
Cytogenetic Map11A5UniSTS
cM Map1117.0UniSTS
Whitehead Genetic1114.2UniSTS
Whitehead/MRC_RH11475.38UniSTS
UniSTS:224405  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,178,530 - 35,178,632UniSTSGRCm38
MGSCv371134,992,032 - 34,992,134UniSTSGRCm37
Cytogenetic Map11A5UniSTS
AU048637  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,156,363 - 35,156,568UniSTSGRCm38
MGSCv371134,969,865 - 34,970,070UniSTSGRCm37
Celera1138,935,585 - 38,935,788UniSTS
Cytogenetic Map11A5UniSTS
Slit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
Slit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
Slit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map11 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000069837   ⟹   ENSMUSP00000066857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,012,051 - 35,599,334 (+)Ensembl
GRCm38.p6 Ensembl1135,121,224 - 35,708,507 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,435,512 - 35,503,463 (+)Ensembl
GRCm38.p6 Ensembl1135,544,685 - 35,612,636 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153098
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,068,610 - 35,400,955 (+)Ensembl
GRCm38.p6 Ensembl1135,177,783 - 35,510,128 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,062,456 - 35,126,034 (+)Ensembl
GRCm38.p6 Ensembl1135,171,629 - 35,235,207 (+)Ensembl
RefSeq Acc Id: NM_011412   ⟹   NP_035542
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,012,283 - 35,599,334 (+)NCBI
GRCm381135,121,456 - 35,708,507 (+)ENTREZGENE
MGSCv371134,934,958 - 35,522,009 (+)RGD
Celera1138,900,451 - 39,489,864 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035542 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD19349 (Get FASTA)   NCBI Sequence Viewer  
  AAD44760 (Get FASTA)   NCBI Sequence Viewer  
  AAI50781 (Get FASTA)   NCBI Sequence Viewer  
  BAC98033 (Get FASTA)   NCBI Sequence Viewer  
  BAE27826 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000066857
  ENSMUSP00000066857.4
GenBank Protein Q9WVB4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035542   ⟸   NM_011412
- Peptide Label: precursor
- UniProtKB: B1ATW4 (UniProtKB/Swiss-Prot),   Q9WVB4 (UniProtKB/Swiss-Prot),   B2RX06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000066857   ⟸   ENSMUST00000069837
Protein Domains
CTCK   EGF-like   Laminin G   Laminin G-like   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVB4-F1-model_v2 AlphaFold Q9WVB4 1-1523 view protein structure

Promoters
RGD ID:6822160
Promoter ID:MM_KWN:6943
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1
Transcripts:ENSMUST00000069837
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361134,934,419 - 34,934,919 (+)MPROMDB
RGD ID:8674294
Promoter ID:EPDNEW_M15177
Type:initiation region
Name:Slit3_1
Description:Mus musculus slit guidance ligand 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,121,480 - 35,121,540EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1315202 AgrOrtholog
Ensembl Genes ENSMUSG00000056427 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000069837 ENTREZGENE
  ENSMUST00000069837.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20564 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1315202 ENTREZGENE
NCBI Gene 20564 ENTREZGENE
PANTHER SLIT HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT HOMOLOG 3 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slit3 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CTCK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_RI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1ATW4 ENTREZGENE
  B2RX06 ENTREZGENE, UniProtKB/TrEMBL
  Q3UHN1_MOUSE UniProtKB/TrEMBL
  Q6ZQ39_MOUSE UniProtKB/TrEMBL
  Q9WVB4 ENTREZGENE
  Q9Z0Y6_MOUSE UniProtKB/TrEMBL
  SLIT3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B1ATW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Slit3  slit guidance ligand 3    slit homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED