LIN7C (lin-7 homolog C, crumbs cell polarity complex component) - Rat Genome Database

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Gene: LIN7C (lin-7 homolog C, crumbs cell polarity complex component) Homo sapiens
Analyze
Symbol: LIN7C
Name: lin-7 homolog C, crumbs cell polarity complex component
RGD ID: 735828
HGNC Page HGNC:17789
Description: Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ11215; lin-7 homolog C; LIN-7 protein 3; LIN-7-C; LIN-7C; MALS-3; MALS3; mammalian lin-seven protein 3; veli-3; VELI3; vertebrate lin-7 homolog 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,494,418 - 27,506,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,494,418 - 27,506,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,515,965 - 27,528,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,472,699 - 27,484,879 (-)NCBINCBI36Build 36hg18NCBI36
Build 341127,472,699 - 27,484,879NCBI
Celera1127,661,655 - 27,674,034 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,214,688 - 27,227,063 (-)NCBIHuRef
CHM1_11127,515,302 - 27,527,664 (-)NCBICHM1_1
T2T-CHM13v2.01127,634,869 - 27,647,239 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:10341223   PMID:12006486   PMID:12477932   PMID:14596909   PMID:14702039   PMID:14960569   PMID:15024025   PMID:16147993   PMID:16192275   PMID:16344560   PMID:17110338  
PMID:17237226   PMID:17942893   PMID:17987659   PMID:18286632   PMID:18543122   PMID:18854154   PMID:19322201   PMID:19615732   PMID:20215397   PMID:20702775   PMID:21145499   PMID:21873635  
PMID:22119785   PMID:22504420   PMID:23201090   PMID:23376485   PMID:24255178   PMID:24366813   PMID:24945404   PMID:24961284   PMID:25796446   PMID:25852190   PMID:26053890   PMID:26186194  
PMID:26496610   PMID:26549023   PMID:26638075   PMID:26673895   PMID:26933062   PMID:27684187   PMID:28298427   PMID:28514442   PMID:28675297   PMID:28700943   PMID:28720576   PMID:29509190  
PMID:29568061   PMID:29997244   PMID:30344098   PMID:31048545   PMID:31182584   PMID:31527615   PMID:31822558   PMID:31980649   PMID:32203420   PMID:32296183   PMID:32687490   PMID:32707033  
PMID:32929329   PMID:33417871   PMID:33545068   PMID:33961781   PMID:35013218   PMID:35271311   PMID:35384245   PMID:35446349   PMID:35559673   PMID:35944360   PMID:36215168   PMID:36517590  
PMID:38113892   PMID:38117590  


Genomics

Comparative Map Data
LIN7C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,494,418 - 27,506,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,494,418 - 27,506,769 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,515,965 - 27,528,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,472,699 - 27,484,879 (-)NCBINCBI36Build 36hg18NCBI36
Build 341127,472,699 - 27,484,879NCBI
Celera1127,661,655 - 27,674,034 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,214,688 - 27,227,063 (-)NCBIHuRef
CHM1_11127,515,302 - 27,527,664 (-)NCBICHM1_1
T2T-CHM13v2.01127,634,869 - 27,647,239 (-)NCBIT2T-CHM13v2.0
Lin7c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,721,205 - 109,731,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,721,198 - 109,731,348 (+)EnsemblGRCm39 Ensembl
GRCm382109,890,878 - 109,900,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,890,853 - 109,901,003 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,731,035 - 109,741,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,691,717 - 109,701,776 (+)NCBIMGSCv36mm8
Celera2111,051,913 - 111,061,966 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
Lin7c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,859,425 - 116,872,363 (+)NCBIGRCr8
mRatBN7.2396,406,800 - 96,417,779 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,406,813 - 96,417,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx399,967,159 - 99,974,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,566,119 - 108,573,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,329,474 - 106,336,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,010,923 - 101,018,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,010,899 - 101,018,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,611,032 - 107,618,344 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,327,942 - 95,335,254 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,224,369 - 95,231,682 (+)NCBI
Celera395,431,335 - 95,438,647 (+)NCBICelera
Cytogenetic Map3q34NCBI
Lin7c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,650,106 - 6,658,817 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,650,539 - 6,658,811 (-)NCBIChiLan1.0ChiLan1.0
LIN7C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,705,210 - 29,717,388 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,705,738 - 29,717,917 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,458,735 - 27,471,068 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,361,291 - 27,373,440 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,361,301 - 27,373,440 (-)Ensemblpanpan1.1panPan2
LIN7C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12148,061,446 - 48,071,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2148,064,929 - 48,071,429 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,559,133 - 47,569,202 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02149,209,214 - 49,215,684 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2149,205,598 - 49,215,634 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02148,358,900 - 48,368,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,950,090 - 48,960,165 (-)NCBIUU_Cfam_GSD_1.0
Lin7c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,572,620 - 36,582,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,727,435 - 5,737,924 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,727,463 - 5,736,696 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIN7C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,845,208 - 32,856,322 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,844,928 - 32,855,166 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,428,346 - 35,438,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIN7C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,598,442 - 37,610,568 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,598,475 - 37,606,392 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038134,908,426 - 134,920,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lin7c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,161,179 - 17,167,073 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476617,159,205 - 17,167,119 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LIN7C
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p14.3-12(chr11:22550115-38199159)x1 copy number loss See cases [RCV000052648] Chr11:22550115..38199159 [GRCh38]
Chr11:22571661..38220709 [GRCh37]
Chr11:22528237..38177285 [NCBI36]
Chr11:11p14.3-12		 pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13		 pathogenic
NM_018362.3(LIN7C):c.37+1342A>G single nucleotide variant Lung cancer [RCV000109970] Chr11:27505374 [GRCh38]
Chr11:27526921 [GRCh37]
Chr11:11p14.1		 uncertain significance
GRCh38/hg38 11p14.2-13(chr11:26368962-35252976)x1 copy number loss See cases [RCV000135295] Chr11:26368962..35252976 [GRCh38]
Chr11:26390509..35274523 [GRCh37]
Chr11:26347085..35231099 [NCBI36]
Chr11:11p14.2-13		 pathogenic
GRCh38/hg38 11p14.3-13(chr11:24595399-31096539)x3 copy number gain See cases [RCV000134877] Chr11:24595399..31096539 [GRCh38]
Chr11:24616945..31118086 [GRCh37]
Chr11:24573521..31074662 [NCBI36]
Chr11:11p14.3-13		 pathogenic
GRCh38/hg38 11p14.3-14.1(chr11:23024064-27978597)x1 copy number loss See cases [RCV000137723] Chr11:23024064..27978597 [GRCh38]
Chr11:23045610..28000144 [GRCh37]
Chr11:23002186..27956720 [NCBI36]
Chr11:11p14.3-14.1		 likely pathogenic
GRCh38/hg38 11p15.1-13(chr11:20079474-34463996)x1 copy number loss See cases [RCV000142499] Chr11:20079474..34463996 [GRCh38]
Chr11:20101020..34485543 [GRCh37]
Chr11:20057596..34442119 [NCBI36]
Chr11:11p15.1-13		 pathogenic
GRCh37/hg19 11p14.1(chr11:27407012-28000144)x3 copy number gain See cases [RCV000240429] Chr11:27407012..28000144 [GRCh37]
Chr11:11p14.1		 uncertain significance
GRCh37/hg19 11p15.1-13(chr11:18536224-31923308)x1 copy number loss Aniridia 1 [RCV000420782] Chr11:18536224..31923308 [GRCh37]
Chr11:11p15.1-13		 pathogenic
GRCh37/hg19 11p15.1-13(chr11:21586131-33168232)x1 copy number loss Wilms tumor, aniridia, genitourinary anomalies, intellectual disability, and obesity syndrome [RCV000435400] Chr11:21586131..33168232 [GRCh37]
Chr11:11p15.1-13		 pathogenic
GRCh37/hg19 11p14.2-11.12(chr11:26574629-50508019)x3 copy number gain See cases [RCV000448603] Chr11:26574629..50508019 [GRCh37]
Chr11:11p14.2-11.12		 pathogenic
GRCh37/hg19 11p14.3-13(chr11:25771208-35614978)x1 copy number loss See cases [RCV000512014] Chr11:25771208..35614978 [GRCh37]
Chr11:11p14.3-13		 pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_018362.4(LIN7C):c.548C>T (p.Ser183Leu) single nucleotide variant Inborn genetic diseases [RCV003274995] Chr11:27498695 [GRCh38]
Chr11:27520242 [GRCh37]
Chr11:11p14.1		 uncertain significance
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p14.3-14.1(chr11:25090108-28909131)x3 copy number gain not provided [RCV000683363] Chr11:25090108..28909131 [GRCh37]
Chr11:11p14.3-14.1		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p14.3-12(chr11:24469451-37524085)x1 copy number loss not provided [RCV000737457] Chr11:24469451..37524085 [GRCh37]
Chr11:11p14.3-12		 pathogenic
GRCh37/hg19 11p14.3-13(chr11:25196998-34196484)x1 copy number loss not provided [RCV000737466] Chr11:25196998..34196484 [GRCh37]
Chr11:11p14.3-13		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p14.2-13(chr11:27154853-33302474)x1 copy number loss not provided [RCV000749997] Chr11:27154853..33302474 [GRCh37]
Chr11:11p14.2-13		 pathogenic
GRCh37/hg19 11p14.3-13(chr11:22079154-35597645)x1 copy number loss not provided [RCV000849589] Chr11:22079154..35597645 [GRCh37]
Chr11:11p14.3-13		 pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13		 pathogenic
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13		 pathogenic
GRCh37/hg19 11p15.2-14.1(chr11:13970757-27565888)x3 copy number gain not provided [RCV001006388] Chr11:13970757..27565888 [GRCh37]
Chr11:11p15.2-14.1		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p14.1(chr11:27382897-29172035)x1 copy number loss See cases [RCV002292391] Chr11:27382897..29172035 [GRCh37]
Chr11:11p14.1		 uncertain significance
GRCh37/hg19 11p14.1(chr11:27340839-27572771)x1 copy number loss not provided [RCV002474961] Chr11:27340839..27572771 [GRCh37]
Chr11:11p14.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2698
Count of miRNA genes:754
Interacting mature miRNAs:876
Transcripts:ENST00000278193, ENST00000524596
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-17417  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371127,515,975 - 27,516,124UniSTSGRCh37
Build 361127,472,551 - 27,472,700RGDNCBI36
Celera1127,661,665 - 27,661,814RGD
Cytogenetic Map11p14UniSTS
HuRef1127,214,698 - 27,214,847UniSTS
GeneMap99-GB4 RH Map11104.49UniSTS
Whitehead-RH Map1194.0UniSTS
D11S1220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371127,516,240 - 27,516,419UniSTSGRCh37
Build 361127,472,816 - 27,472,995RGDNCBI36
Celera1127,661,930 - 27,662,109RGD
Cytogenetic Map11p14UniSTS
HuRef1127,214,963 - 27,215,142UniSTS
GeneMap99-GB4 RH Map11104.55UniSTS
A006U38  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371127,517,782 - 27,517,929UniSTSGRCh37
Build 361127,474,358 - 27,474,505RGDNCBI36
Celera1127,663,472 - 27,663,619RGD
Cytogenetic Map11p14UniSTS
HuRef1127,216,505 - 27,216,652UniSTS
GeneMap99-GB4 RH Map11103.43UniSTS
D11S4549  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371127,524,767 - 27,524,904UniSTSGRCh37
Build 361127,481,343 - 27,481,480RGDNCBI36
Celera1127,670,475 - 27,670,612RGD
Cytogenetic Map11p14UniSTS
HuRef1127,223,504 - 27,223,641UniSTS
Stanford-G3 RH Map111268.0UniSTS
NCBI RH Map11169.8UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
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Cytogenetic Map12p13UniSTS
Cytogenetic Map3q28UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic MapXq22.2UniSTS
Cytogenetic Map7p12.3UniSTS
Cytogenetic Map7p15.1UniSTS
Cytogenetic Map2q37.2UniSTS
Cytogenetic Map18q22.3UniSTS
Cytogenetic Map14q32.13UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map20q13.2-q13.3UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map14q32.2UniSTS
Cytogenetic Map13q13.3UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q23.3UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map8p12-p11UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map7p11.1UniSTS
Cytogenetic Map1q31-q32UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map3p21.32UniSTS
Cytogenetic Map2p24.2UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map6q24.1UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map17q11-q21UniSTS
Cytogenetic Map12q23UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map17q24-q25UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map8q12.3UniSTS
Cytogenetic Map5q21.2UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map4q35.2UniSTS
Cytogenetic Map3p26.1UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map2q21.2UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p11.3UniSTS
Cytogenetic Map17q11.1UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q32-q34UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map2p15-p13UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map6q23-q24UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1652 1127 1530 491 1029 369 2987 670 2017 315 1072 1521 138 1 879 1682 6 2
Low 787 1832 196 133 890 96 1370 1527 1717 103 388 92 37 325 1106
Below cutoff 32 32 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000278193   ⟹   ENSP00000278193
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1127,494,418 - 27,506,769 (-)Ensembl
RefSeq Acc Id: ENST00000524596   ⟹   ENSP00000435353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1127,494,898 - 27,506,769 (-)Ensembl
RefSeq Acc Id: NM_018362   ⟹   NP_060832
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381127,494,418 - 27,506,769 (-)NCBI
GRCh371127,515,965 - 27,528,326 (-)ENTREZGENE
Build 361127,472,699 - 27,484,879 (-)NCBI Archive
HuRef1127,214,688 - 27,227,063 (-)ENTREZGENE
CHM1_11127,515,302 - 27,527,664 (-)NCBI
T2T-CHM13v2.01127,634,869 - 27,647,239 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_060832   ⟸   NM_018362
- UniProtKB: Q9NUP9 (UniProtKB/Swiss-Prot),   Q53FX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000435353   ⟸   ENST00000524596
RefSeq Acc Id: ENSP00000278193   ⟸   ENST00000278193
Protein Domains
L27   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NUP9-F1-model_v2 AlphaFold Q9NUP9 1-197 view protein structure

Promoters
RGD ID:6789939
Promoter ID:HG_KWN:12518
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_018362,   UC001MRM.1,   UC001MRN.1,   UC001MRO.1,   UC001MRP.1,   UC001MRQ.2,   UC001MRR.2,   UC009YII.1,   UC009YIJ.1,   UC009YIK.1,   UC009YIL.1,   UC009YIM.1,   UC009YIN.1,   UC009YIO.1,   UC009YIP.1,   UC009YIQ.1,   UC009YIR.1,   UC009YIS.1,   UC009YIT.1,   UC009YIU.1,   UC009YIV.1,   UC009YIW.1,   UC009YIX.1,   UC009YIY.1,   UC009YIZ.1,   UC009YJA.1,   UC009YJB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361127,484,586 - 27,485,087 (+)MPROMDB
RGD ID:7219897
Promoter ID:EPDNEW_H15694
Type:initiation region
Name:LIN7C_1
Description:lin-7 homolog C, crumbs cell polarity complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381127,506,767 - 27,506,827EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17789 AgrOrtholog
COSMIC LIN7C COSMIC
Ensembl Genes ENSG00000148943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000278193 ENTREZGENE
  ENST00000278193.7 UniProtKB/Swiss-Prot
  ENST00000524596.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000148943 GTEx
HGNC ID HGNC:17789 ENTREZGENE
Human Proteome Map LIN7C Human Proteome Map
InterPro L27_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIN7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55327 UniProtKB/Swiss-Prot
NCBI Gene 55327 ENTREZGENE
OMIM 612332 OMIM
PANTHER PROTEIN LIN-7 HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN LIN-7 HOMOLOG C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134891786 PharmGKB
PIRSF Lin-7_homologue UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V1D4_HUMAN UniProtKB/TrEMBL
  LIN7C_HUMAN UniProtKB/Swiss-Prot
  Q53FX5 ENTREZGENE, UniProtKB/TrEMBL
  Q9NUP9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 LIN7C  lin-7 homolog C, crumbs cell polarity complex component    lin-7 homolog C (C. elegans)  Symbol and/or name change 5135510 APPROVED