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Gene: PAM (peptidylglycine alpha-amidating monooxygenase) Homo sapiens
Symbol: PAM
Name: peptidylglycine alpha-amidating monooxygenase
Description: Exhibits peptidylamidoglycolate lyase activity; peptidylglycine monooxygenase activity; and zinc ion binding activity. Involved in peptide amidation. Localizes to the extracellular exosome and membrane. Biomarker of prostate adenocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: PAL; pancreatic peptidylglycine alpha-amidating monooxygenase; peptidyl alpha-amidating enzyme; peptidyl-alpha-hydroxyglycine alpha-amidating lyase; peptidyl-glycine alpha-amidating monooxygenase; peptidylamidoglycolate lyase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-hydroxylating monooxygenase; PHM
Mus musculus (house mouse) : Pam (peptidylglycine alpha-amidating monooxygenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pam (peptidylglycine alpha-amidating monooxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pam (peptidylglycine alpha-amidating monooxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : PAM (peptidylglycine alpha-amidating monooxygenase)
Canis lupus familiaris (dog) : PAM (peptidylglycine alpha-amidating monooxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pam (peptidylglycine alpha-amidating monooxygenase)
Sus scrofa (pig) : PAM (peptidylglycine alpha-amidating monooxygenase)
Chlorocebus sabaeus (green monkey) : PAM (peptidylglycine alpha-amidating monooxygenase)
Heterocephalus glaber (naked mole-rat) : Pam (peptidylglycine alpha-amidating monooxygenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5102,753,981 - 103,031,105 (+)Ensembl
GRCh385102,754,783 - 103,031,105 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375102,201,527 - 102,366,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365102,229,426 - 102,393,316 (+)NCBINCBI36hg18NCBI36
Build 345102,229,425 - 102,393,315NCBI
Celera598,149,342 - 98,314,632 (+)NCBI
Cytogenetic Map5q21.1NCBI
HuRef597,382,969 - 97,548,060 (+)NCBIHuRef
CHM1_15101,523,097 - 101,799,441 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PAM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735807
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.