YKT6 (YKT6 v-SNARE homolog) - Rat Genome Database

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Gene: YKT6 (YKT6 v-SNARE homolog) Homo sapiens
Analyze
Symbol: YKT6
Name: YKT6 v-SNARE homolog
RGD ID: 735770
HGNC Page HGNC:16959
Description: Enables SNAP receptor activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde transport, endosome to Golgi; and vesicle docking involved in exocytosis. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and endosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: prenylated snare protein; R-SNARE; SNARE protein Ykt6; synaptobrevin homolog YKT6; YKT6 v-SNARE homolog (S. cerevisiae); YKT6 v-SNARE protein; YKT6, S. cerevisiae, homolog of
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC442272  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,200,978 - 44,214,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,200,959 - 44,214,294 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,240,577 - 44,253,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,207,103 - 44,220,418 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,013,817 - 44,027,132NCBI
Celera744,338,544 - 44,351,859 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,125,857 - 44,139,172 (+)NCBIHuRef
CHM1_1744,244,442 - 44,257,752 (+)NCBICHM1_1
T2T-CHM13v2.0744,359,565 - 44,372,881 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,280,084 - 44,293,399 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:9211930   PMID:11474112   PMID:11884350   PMID:11927603   PMID:12388752   PMID:12477932   PMID:12690205   PMID:14607937   PMID:14702039   PMID:15044687   PMID:15215310  
PMID:15479160   PMID:15489334   PMID:15544955   PMID:16344560   PMID:16354670   PMID:16821082   PMID:17643375   PMID:18029348   PMID:21873635   PMID:22412018   PMID:22939629   PMID:23376485  
PMID:23824909   PMID:25416956   PMID:25468996   PMID:26186194   PMID:26344197   PMID:26638075   PMID:26760575   PMID:27285987   PMID:27634302   PMID:28380382   PMID:28514442   PMID:29395067  
PMID:29568061   PMID:29789439   PMID:30010460   PMID:30021884   PMID:30194290   PMID:30442766   PMID:30639242   PMID:31056421   PMID:31177093   PMID:31452512   PMID:31536960   PMID:31648898  
PMID:31678930   PMID:31732153   PMID:31871319   PMID:32128853   PMID:32513696   PMID:32550891   PMID:32687490   PMID:32877691   PMID:33239621   PMID:33845483   PMID:33916271   PMID:33957083  
PMID:33961781   PMID:34079125   PMID:34221701   PMID:34369648   PMID:34373451   PMID:34396876   PMID:34432599   PMID:34672954   PMID:34709727   PMID:35063084   PMID:35241646   PMID:35271311  
PMID:35384245   PMID:35545034   PMID:35844135   PMID:36215168   PMID:36237976   PMID:37058019   PMID:37232246   PMID:37381005   PMID:37774976   PMID:37827155   PMID:37931956   PMID:38117590  
PMID:38340317  


Genomics

Comparative Map Data
YKT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,200,978 - 44,214,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,200,959 - 44,214,294 (+)EnsemblGRCh38hg38GRCh38
GRCh37744,240,577 - 44,253,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,207,103 - 44,220,418 (+)NCBINCBI36Build 36hg18NCBI36
Build 34744,013,817 - 44,027,132NCBI
Celera744,338,544 - 44,351,859 (+)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,125,857 - 44,139,172 (+)NCBIHuRef
CHM1_1744,244,442 - 44,257,752 (+)NCBICHM1_1
T2T-CHM13v2.0744,359,565 - 44,372,881 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,280,084 - 44,293,399 (+)NCBI
Ykt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,905,779 - 5,917,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,905,693 - 5,917,780 (+)EnsemblGRCm39 Ensembl
GRCm38115,955,758 - 5,967,780 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,955,693 - 5,967,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,855,761 - 5,867,783 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,855,835 - 5,867,783 (+)NCBIMGSCv36mm8
Celera116,447,816 - 6,459,840 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.89NCBI
Ykt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,041,393 - 85,057,347 (+)NCBIGRCr8
mRatBN7.21480,832,187 - 80,843,394 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,832,187 - 80,843,385 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,234,395 - 85,243,714 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,474,492 - 86,483,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,923,806 - 82,933,125 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,196,018 - 86,207,057 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,195,892 - 86,205,712 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,880,204 - 86,889,524 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,619,828 - 86,629,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,638,972 - 86,648,293 (+)NCBI
Celera1479,716,098 - 79,725,418 (+)NCBICelera
Cytogenetic Map14q21NCBI
Ykt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,763,982 - 7,776,153 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,764,125 - 7,776,429 (-)NCBIChiLan1.0ChiLan1.0
YKT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,111,738 - 49,125,662 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,436,478 - 97,450,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,915,181 - 44,928,001 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,975,782 - 44,996,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,982,748 - 44,994,183 (+)Ensemblpanpan1.1panPan2
YKT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,131,031 - 2,140,443 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,721,412 - 14,730,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,721,419 - 14,730,907 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,352,875 - 14,362,275 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,333,138 - 14,342,549 (-)NCBIUU_Cfam_GSD_1.0
Ykt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,954,485 - 99,967,329 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,166,153 - 19,179,719 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,166,225 - 19,179,060 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YKT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,960,113 - 50,971,384 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,961,451 - 50,971,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,855,334 - 55,865,266 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YKT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,454,126 - 14,467,452 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,452,968 - 14,467,417 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,048,115 - 8,061,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ykt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,832,114 - 7,845,149 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,832,436 - 7,844,416 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in YKT6
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p13-12.3(chr7:44193369-46558381)x1 copy number loss See cases [RCV000052316] Chr7:44193369..46558381 [GRCh38]
Chr7:44232968..46597979 [GRCh37]
Chr7:44199493..46564504 [NCBI36]
Chr7:7p13-12.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:39814159-45749735)x1 copy number loss See cases [RCV000053132] Chr7:39814159..45749735 [GRCh38]
Chr7:39853758..45789334 [GRCh37]
Chr7:39820283..45755859 [NCBI36]
Chr7:7p14.1-12.3		 pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 copy number loss See cases [RCV000136092] Chr7:40534157..56107122 [GRCh38]
Chr7:40573756..56174815 [GRCh37]
Chr7:40540281..56142309 [NCBI36]
Chr7:7p14.1-11.2		 pathogenic
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 copy number loss See cases [RCV000136904] Chr7:40020598..50543500 [GRCh38]
Chr7:40060197..50611198 [GRCh37]
Chr7:40026722..50578692 [NCBI36]
Chr7:7p14.1-12.1		 pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3		 pathogenic
GRCh38/hg38 7p14.1-13(chr7:39063400-45363096)x1 copy number loss See cases [RCV000137305] Chr7:39063400..45363096 [GRCh38]
Chr7:39103000..45402695 [GRCh37]
Chr7:39069525..45369220 [NCBI36]
Chr7:7p14.1-13		 pathogenic
GRCh38/hg38 7p14.1-13(chr7:38177999-45304100)x1 copy number loss See cases [RCV000142297] Chr7:38177999..45304100 [GRCh38]
Chr7:38217601..45343699 [GRCh37]
Chr7:38184126..45310224 [NCBI36]
Chr7:7p14.1-13		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p13(chr7:43884184-44297732)x3 copy number gain not provided [RCV000584852] Chr7:43884184..44297732 [GRCh37]
Chr7:7p13		 likely benign
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 copy number loss See cases [RCV000446941] Chr7:40350383..47034422 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
GRCh37/hg19 7p14.3-13(chr7:32911003-44576005)x1 copy number loss See cases [RCV000446955] Chr7:32911003..44576005 [GRCh37]
Chr7:7p14.3-13		 pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 copy number gain See cases [RCV000512091] Chr7:11048840..52863626 [GRCh37]
Chr7:7p21.3-12.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NC_000007.13:g.(?_44153173)_(44365020_?)dup duplication not provided [RCV003105675] Chr7:44153173..44365020 [GRCh37]
Chr7:7p13		 uncertain significance
NC_000007.13:g.(?_43810758)_(44747598_?)del deletion not provided [RCV003105673] Chr7:43810758..44747598 [GRCh37]
Chr7:7p13		 uncertain significance
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p14.1-12.3(chr7:41124364-47945566) copy number loss Syndactyly [RCV001352654] Chr7:41124364..47945566 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
GRCh37/hg19 7p13-12.2(chr7:43341583-50171623) copy number loss Intracranial hemorrhage [RCV001352658] Chr7:43341583..50171623 [GRCh37]
Chr7:7p13-12.2		 pathogenic
GRCh37/hg19 7p14.1-12.2(chr7:40778439-50228656) copy number loss not specified [RCV002053688] Chr7:40778439..50228656 [GRCh37]
Chr7:7p14.1-12.2		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
NM_006555.4(YKT6):c.19A>G (p.Ser7Gly) single nucleotide variant Inborn genetic diseases [RCV003260813] Chr7:44201154 [GRCh38]
Chr7:44240753 [GRCh37]
Chr7:7p13		 uncertain significance
NM_006555.4(YKT6):c.523G>A (p.Glu175Lys) single nucleotide variant Inborn genetic diseases [RCV002907222] Chr7:44211086 [GRCh38]
Chr7:44250685 [GRCh37]
Chr7:7p13		 uncertain significance
NM_006555.4(YKT6):c.464A>C (p.Asn155Thr) single nucleotide variant Inborn genetic diseases [RCV002753444] Chr7:44211027 [GRCh38]
Chr7:44250626 [GRCh37]
Chr7:7p13		 uncertain significance
NM_006555.4(YKT6):c.191A>G (p.Tyr64Cys) single nucleotide variant Inborn genetic diseases [RCV002688216] Chr7:44206388 [GRCh38]
Chr7:44245987 [GRCh37]
Chr7:7p13		 uncertain significance
NM_006555.4(YKT6):c.184C>A (p.Gln62Lys) single nucleotide variant Inborn genetic diseases [RCV003375020] Chr7:44204647 [GRCh38]
Chr7:44244246 [GRCh37]
Chr7:7p13		 uncertain significance
GRCh37/hg19 7p14.1-12.3(chr7:42516660-46202495)x1 copy number loss not provided [RCV003482956] Chr7:42516660..46202495 [GRCh37]
Chr7:7p14.1-12.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2457
Count of miRNA genes:958
Interacting mature miRNAs:1158
Transcripts:ENST00000223369, ENST00000421621, ENST00000424864, ENST00000447123, ENST00000463014, ENST00000478411, ENST00000496112
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:594252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,253,797 - 44,253,884UniSTSGRCh37
Build 36744,220,322 - 44,220,409RGDNCBI36
Celera744,351,763 - 44,351,850RGD
Cytogenetic Map7p15.1UniSTS
HuRef744,139,076 - 44,139,163UniSTS
CRA_TCAGchr7v2744,293,303 - 44,293,390UniSTS
RH12548  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376159,342,963 - 159,343,095UniSTSGRCh37
Build 366159,262,951 - 159,263,083RGDNCBI36
Celera6159,990,827 - 159,990,959RGD
Cytogenetic Map7p15.1UniSTS
Cytogenetic Map6q25.3UniSTS
HuRef6156,814,038 - 156,814,170UniSTS
GeneMap99-GB4 RH Map6616.89UniSTS
NCBI RH Map61624.5UniSTS
YKT6_9161  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,253,229 - 44,254,090UniSTSGRCh37
Build 36744,219,754 - 44,220,615RGDNCBI36
Celera744,351,195 - 44,352,056RGD
HuRef744,138,508 - 44,139,369UniSTS
CRA_TCAGchr7v2744,292,735 - 44,293,596UniSTS
STS-AA037832  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,253,612 - 44,253,862UniSTSGRCh37
Build 36744,220,137 - 44,220,387RGDNCBI36
Celera744,351,578 - 44,351,828RGD
Cytogenetic Map7p15.1UniSTS
HuRef744,138,891 - 44,139,141UniSTS
CRA_TCAGchr7v2744,293,118 - 44,293,368UniSTS
GeneMap99-GB4 RH Map7208.79UniSTS
NCBI RH Map7654.4UniSTS
D7S2060E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37744,252,683 - 44,252,860UniSTSGRCh37
Build 36744,219,208 - 44,219,385RGDNCBI36
Celera744,350,649 - 44,350,826RGD
Cytogenetic Map7p15.1UniSTS
HuRef744,137,962 - 44,138,139UniSTS
CRA_TCAGchr7v2744,292,189 - 44,292,366UniSTS
TNG Radiation Hybrid Map721537.0UniSTS
Stanford-G3 RH Map71930.0UniSTS
NCBI RH Map7657.0UniSTS
GeneMap99-G3 RH Map71930.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2439 2791 1639 537 1815 378 4357 2130 3728 416 1460 1613 175 1 1204 2788 6 2
Low 200 87 87 136 87 67 6 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054328423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054357103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU130339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000223369   ⟹   ENSP00000223369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,978 - 44,214,294 (+)Ensembl
RefSeq Acc Id: ENST00000421621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,206,407 - 44,214,264 (+)Ensembl
RefSeq Acc Id: ENST00000424864   ⟹   ENSP00000412414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,208,136 - 44,212,613 (+)Ensembl
RefSeq Acc Id: ENST00000447123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,972 - 44,212,538 (+)Ensembl
RefSeq Acc Id: ENST00000463014
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,207,333 - 44,208,580 (+)Ensembl
RefSeq Acc Id: ENST00000478411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,978 - 44,214,269 (+)Ensembl
RefSeq Acc Id: ENST00000496112   ⟹   ENSP00000420805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,968 - 44,212,889 (+)Ensembl
RefSeq Acc Id: ENST00000677090   ⟹   ENSP00000504160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,201,012 - 44,212,595 (+)Ensembl
RefSeq Acc Id: ENST00000677436   ⟹   ENSP00000503560
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,983 - 44,214,276 (+)Ensembl
RefSeq Acc Id: ENST00000677851   ⟹   ENSP00000503746
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,978 - 44,214,166 (+)Ensembl
RefSeq Acc Id: ENST00000678359   ⟹   ENSP00000503337
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,972 - 44,214,259 (+)Ensembl
RefSeq Acc Id: ENST00000678497   ⟹   ENSP00000503381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,966 - 44,214,166 (+)Ensembl
RefSeq Acc Id: ENST00000679020   ⟹   ENSP00000504623
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,959 - 44,213,876 (+)Ensembl
RefSeq Acc Id: ENST00000679209   ⟹   ENSP00000504364
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,978 - 44,214,264 (+)Ensembl
RefSeq Acc Id: ENST00000679310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl744,200,978 - 44,214,166 (+)Ensembl
RefSeq Acc Id: NM_001363678   ⟹   NP_001350607
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,200,978 - 44,214,294 (+)NCBI
T2T-CHM13v2.0744,359,565 - 44,372,881 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001410874   ⟹   NP_001397803
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,200,978 - 44,214,294 (+)NCBI
T2T-CHM13v2.0744,359,565 - 44,372,881 (+)NCBI
RefSeq Acc Id: NM_006555   ⟹   NP_006546
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,200,978 - 44,214,294 (+)NCBI
GRCh37744,240,577 - 44,253,893 (+)NCBI
Build 36744,207,103 - 44,220,418 (+)NCBI Archive
HuRef744,125,857 - 44,139,172 (+)ENTREZGENE
CHM1_1744,244,442 - 44,257,752 (+)NCBI
T2T-CHM13v2.0744,359,565 - 44,372,881 (+)NCBI
CRA_TCAGchr7v2744,280,084 - 44,293,399 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_054328423   ⟹   XP_054184398
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,200,978 - 44,211,608 (+)NCBI
RefSeq Acc Id: XM_054357103   ⟹   XP_054213078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0744,359,565 - 44,370,195 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_006546   ⟸   NM_006555
- Peptide Label: isoform 1
- UniProtKB: Q6FGU9 (UniProtKB/Swiss-Prot),   Q53F01 (UniProtKB/Swiss-Prot),   B4DR94 (UniProtKB/Swiss-Prot),   Q6IB15 (UniProtKB/Swiss-Prot),   O15498 (UniProtKB/Swiss-Prot),   A4D2J0 (UniProtKB/TrEMBL),   B5BU81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350607   ⟸   NM_001363678
- Peptide Label: isoform 2
- UniProtKB: B5BU81 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000412414   ⟸   ENST00000424864
RefSeq Acc Id: ENSP00000420805   ⟸   ENST00000496112
RefSeq Acc Id: ENSP00000223369   ⟸   ENST00000223369
RefSeq Acc Id: ENSP00000504160   ⟸   ENST00000677090
RefSeq Acc Id: ENSP00000503560   ⟸   ENST00000677436
RefSeq Acc Id: ENSP00000503746   ⟸   ENST00000677851
RefSeq Acc Id: ENSP00000503381   ⟸   ENST00000678497
RefSeq Acc Id: ENSP00000503337   ⟸   ENST00000678359
RefSeq Acc Id: ENSP00000504364   ⟸   ENST00000679209
RefSeq Acc Id: ENSP00000504623   ⟸   ENST00000679020
RefSeq Acc Id: NP_001397803   ⟸   NM_001410874
- Peptide Label: isoform 3
- UniProtKB: A0A7I2V4L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054184398   ⟸   XM_054328423
- Peptide Label: isoform X1
- UniProtKB: A0A7I2V4L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054213078   ⟸   XM_054357103
- Peptide Label: isoform X1
- UniProtKB: A0A7I2V4L6 (UniProtKB/TrEMBL)
Protein Domains
Longin   v-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15498-F1-model_v2 AlphaFold O15498 1-198 view protein structure

Promoters
RGD ID:7210507
Promoter ID:EPDNEW_H10999
Type:initiation region
Name:YKT6_1
Description:YKT6 v-SNARE homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38744,200,980 - 44,201,040EPDNEW
RGD ID:6806412
Promoter ID:HG_KWN:57227
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006555,   OTTHUMT00000343171,   OTTHUMT00000343173
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,206,879 - 44,207,379 (+)MPROMDB
RGD ID:6806413
Promoter ID:HG_KWN:57230
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC010KYB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36744,216,851 - 44,217,351 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16959 AgrOrtholog
COSMIC YKT6 COSMIC
Ensembl Genes ENSG00000106636 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000223369 ENTREZGENE
  ENST00000223369.3 UniProtKB/Swiss-Prot
  ENST00000424864.1 UniProtKB/TrEMBL
  ENST00000496112 ENTREZGENE
  ENST00000496112.5 UniProtKB/Swiss-Prot
  ENST00000677090 ENTREZGENE
  ENST00000677090.1 UniProtKB/TrEMBL
  ENST00000677436.1 UniProtKB/TrEMBL
  ENST00000677851.1 UniProtKB/TrEMBL
  ENST00000678359.1 UniProtKB/TrEMBL
  ENST00000678497.1 UniProtKB/TrEMBL
  ENST00000679020.1 UniProtKB/Swiss-Prot
  ENST00000679209.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Longin domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000106636 GTEx
HGNC ID HGNC:16959 ENTREZGENE
Human Proteome Map YKT6 Human Proteome Map
InterPro Longin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Longin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  R-SNARE_YKT6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10652 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10652 ENTREZGENE
OMIM 606209 OMIM
PANTHER SYNAPTOBREVIN HOMOLOG YKT6 UniProtKB/Swiss-Prot
  SYNAPTOBREVIN HOMOLOG YKT6 UniProtKB/Swiss-Prot
  SYNAPTOBREVIN HOMOLOG YKT6 UniProtKB/TrEMBL
  SYNAPTOBREVIN HOMOLOG YKT6 UniProtKB/TrEMBL
Pfam Longin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptobrevin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA145007308 PharmGKB
PROSITE LONGIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Longin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7I2V3A1_HUMAN UniProtKB/TrEMBL
  A0A7I2V3S2_HUMAN UniProtKB/TrEMBL
  A0A7I2V3V7_HUMAN UniProtKB/TrEMBL
  A0A7I2V4L6 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V530_HUMAN UniProtKB/TrEMBL
  A4D2J0 ENTREZGENE, UniProtKB/TrEMBL
  B4DR94 ENTREZGENE
  B5BU81 ENTREZGENE, UniProtKB/TrEMBL
  H7C3K7_HUMAN UniProtKB/TrEMBL
  O15498 ENTREZGENE
  Q53F01 ENTREZGENE
  Q6FGU9 ENTREZGENE
  Q6IB15 ENTREZGENE
  YKT6_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B4DR94 UniProtKB/Swiss-Prot
  Q53F01 UniProtKB/Swiss-Prot
  Q6FGU9 UniProtKB/Swiss-Prot
  Q6IB15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-14 YKT6  YKT6 v-SNARE homolog  YKT6  YKT6 v-SNARE homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED