MEP1A (meprin A subunit alpha) - Rat Genome Database

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Gene: MEP1A (meprin A subunit alpha) Homo sapiens
Analyze
Symbol: MEP1A
Name: meprin A subunit alpha
RGD ID: 735747
HGNC Page HGNC
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Part of meprin A complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bA268F1.1 (meprin A alpha (PABA peptide hydrolase)); endopeptidase-2; meprin 1 alpha; meprin A, alpha (PABA peptide hydrolase); N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; PABA peptide hydrolase; PPH alpha; PPHA
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: MEP1AP1   MEP1AP2   MEP1AP3   MEP1AP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl646,793,389 - 46,839,778 (+)EnsemblGRCh38hg38GRCh38
GRCh38646,793,384 - 46,845,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37646,761,126 - 46,807,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,869,053 - 46,915,478 (+)NCBINCBI36hg18NCBI36
Build 34646,869,085 - 46,915,473NCBI
Celera648,313,551 - 48,359,899 (+)NCBI
Cytogenetic Map6p12.3NCBI
HuRef646,484,757 - 46,530,783 (+)NCBIHuRef
CHM1_1646,764,471 - 46,810,789 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1939172   PMID:7340337   PMID:7774936   PMID:8063866   PMID:8125298   PMID:8262185   PMID:8660687   PMID:8760356   PMID:9288916   PMID:9914532   PMID:10348167   PMID:10620696  
PMID:10898933   PMID:11267665   PMID:11278902   PMID:11301339   PMID:11487543   PMID:12189145   PMID:12477932   PMID:12556482   PMID:16159877   PMID:16344560   PMID:16378686   PMID:17195012  
PMID:19262505   PMID:20631730   PMID:20806899   PMID:21873635   PMID:22096485   PMID:22326557   PMID:22923609   PMID:23123160   PMID:24388959   PMID:24474695   PMID:26354767   PMID:27378469  
PMID:27999200   PMID:28502593  


Genomics

Comparative Map Data
MEP1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl646,793,389 - 46,839,778 (+)EnsemblGRCh38hg38GRCh38
GRCh38646,793,384 - 46,845,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37646,761,126 - 46,807,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36646,869,053 - 46,915,478 (+)NCBINCBI36hg18NCBI36
Build 34646,869,085 - 46,915,473NCBI
Celera648,313,551 - 48,359,899 (+)NCBI
Cytogenetic Map6p12.3NCBI
HuRef646,484,757 - 46,530,783 (+)NCBIHuRef
CHM1_1646,764,471 - 46,810,789 (+)NCBICHM1_1
Mep1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,785,215 - 43,815,034 (-)NCBIGRCm39mm39
GRCm39 Ensembl1743,785,215 - 43,813,703 (-)Ensembl
GRCm381743,474,324 - 43,504,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,474,324 - 43,502,812 (-)EnsemblGRCm38mm10GRCm38
MGSCv371743,611,278 - 43,639,722 (-)NCBIGRCm37mm9NCBIm37
MGSCv361742,938,373 - 42,967,156 (-)NCBImm8
Celera1746,896,845 - 46,925,249 (-)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.73NCBI
Mep1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2917,474,634 - 17,504,147 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl917,474,619 - 17,504,147 (+)Ensembl
Rnor_6.0920,048,163 - 20,077,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,048,121 - 20,077,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,925,181 - 18,953,891 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,170,762 - 13,201,094 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1913,168,083 - 13,198,416 (+)NCBI
Celera915,197,113 - 15,224,494 (+)NCBICelera
Cytogenetic Map9q13NCBI
Mep1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543711,602,113 - 11,636,144 (+)NCBIChiLan1.0ChiLan1.0
MEP1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1647,647,721 - 47,690,331 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,647,721 - 47,691,070 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0646,382,105 - 46,425,300 (+)NCBIMhudiblu_PPA_v0panPan3
MEP1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,966,215 - 15,004,069 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,966,209 - 15,003,867 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,997,039 - 15,035,329 (+)NCBI
ROS_Cfam_1.01215,465,854 - 15,500,412 (+)NCBI
ROS_Cfam_1.0 Ensembl1215,465,839 - 15,500,421 (+)Ensembl
UMICH_Zoey_3.11214,981,007 - 15,015,182 (+)NCBI
UNSW_CanFamBas_1.01215,070,190 - 15,108,254 (+)NCBI
UU_Cfam_GSD_1.01215,216,475 - 15,254,182 (+)NCBI
Mep1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,406,962 - 50,445,654 (+)NCBI
SpeTri2.0NW_00493647613,514,965 - 13,553,209 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEP1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1741,587,698 - 41,625,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,248,938 - 48,286,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEP1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,439,415 - 25,479,092 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,439,442 - 25,473,681 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604446,813,671 - 46,854,220 (+)NCBIVero_WHO_p1.0
Mep1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475413,845,949 - 13,865,792 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
STS-M82962  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37646,807,173 - 46,807,435UniSTSGRCh37
Build 36646,915,132 - 46,915,394RGDNCBI36
Celera648,359,553 - 48,359,815RGD
Cytogenetic Map6p12-p11UniSTS
HuRef646,530,437 - 46,530,699UniSTS
GeneMap99-GB4 RH Map6179.69UniSTS
NCBI RH Map6693.7UniSTS
D6S2059  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p12-p11UniSTS
GeneMap99-G3 RH Map62703.0UniSTS
RH65261  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p12-p11UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:425
Count of miRNA genes:265
Interacting mature miRNAs:282
Transcripts:ENST00000230588
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 15 12
Medium 471 30 29 123 29 1 3 2 4 1 1
Low 279 9 50 45 173 44 31 9 97 10 374 42 4 16 12 2
Below cutoff 888 1212 947 330 603 234 2107 826 2504 130 589 916 100 736 1168 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF478685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL161618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA432559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M82962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000230588   ⟹   ENSP00000230588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl646,793,389 - 46,839,778 (+)Ensembl
RefSeq Acc Id: ENST00000611727   ⟹   ENSP00000480465
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl646,793,391 - 46,839,166 (+)Ensembl
RefSeq Acc Id: ENST00000680229   ⟹   ENSP00000505289
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl646,793,391 - 46,839,166 (+)Ensembl
RefSeq Acc Id: ENST00000680769
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl646,793,391 - 46,839,155 (+)Ensembl
RefSeq Acc Id: NM_005588   ⟹   NP_005579
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,793,389 - 46,839,778 (+)NCBI
GRCh37646,761,094 - 46,807,519 (+)ENTREZGENE
Build 36646,869,053 - 46,915,478 (+)NCBI Archive
HuRef646,484,757 - 46,530,783 (+)ENTREZGENE
CHM1_1646,764,471 - 46,810,789 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514628   ⟹   XP_011512930
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,793,384 - 46,839,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011514629   ⟹   XP_011512931
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,793,386 - 46,845,987 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005579   ⟸   NM_005588
- Peptide Label: precursor
- UniProtKB: Q16819 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011512931   ⟸   XM_011514629
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011512930   ⟸   XM_011514628
- Peptide Label: isoform X1
- UniProtKB: B7ZL91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000480465   ⟸   ENST00000611727
RefSeq Acc Id: ENSP00000230588   ⟸   ENST00000230588
RefSeq Acc Id: ENSP00000505289   ⟸   ENST00000680229
Protein Domains
EGF-like   MAM   MATH   Peptidase M12A

Promoters
RGD ID:7208265
Promoter ID:EPDNEW_H9876
Type:multiple initiation site
Name:MEP1A_1
Description:meprin A subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,793,389 - 46,793,449EPDNEW
RGD ID:6851448
Promoter ID:EP73525
Type:single initiation site
Name:HS_MEP1A
Description:Meprin A, alpha (PABA peptide hydrolase).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36646,869,085 - 46,869,145EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.1-12.3(chr6:44985760-47986838)x3 copy number gain See cases [RCV000135580] Chr6:44985760..47986838 [GRCh38]
Chr6:44953497..47954574 [GRCh37]
Chr6:45061475..48062533 [NCBI36]
Chr6:6p21.1-12.3
likely pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1
pathogenic|uncertain significance
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320)x1 copy number loss See cases [RCV000446897] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p12.3(chr6:46717940-46925746)x3 copy number gain not provided [RCV000682667] Chr6:46717940..46925746 [GRCh37]
Chr6:6p12.3
likely benign
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_005588.3(MEP1A):c.1152T>C (p.Asp384=) single nucleotide variant not provided [RCV000918306] Chr6:46833081 [GRCh38]
Chr6:46800818 [GRCh37]
Chr6:6p12.3
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7015 AgrOrtholog
COSMIC MEP1A COSMIC
Ensembl Genes ENSG00000112818 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000230588 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000480465 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000505289 UniProtKB/TrEMBL
Ensembl Transcript ENST00000230588 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000611727 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000680229 UniProtKB/TrEMBL
Gene3D-CATH 2.60.210.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000112818 GTEx
HGNC ID HGNC:7015 ENTREZGENE
Human Proteome Map MEP1A Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH/TRAF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Meprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Meprin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMP_meprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4224 UniProtKB/Swiss-Prot
NCBI Gene 4224 ENTREZGENE
OMIM 600388 OMIM
PANTHER PTHR10127:SF824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Astacin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30749 PharmGKB
PIRSF Meprin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ASTACIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7P0Z478_HUMAN UniProtKB/TrEMBL
  B7ZL91 ENTREZGENE, UniProtKB/TrEMBL
  MEP1A_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RRM4 UniProtKB/Swiss-Prot
  B0AZP9 UniProtKB/Swiss-Prot
  B2RCS2 UniProtKB/Swiss-Prot
  Q8TDC9 UniProtKB/Swiss-Prot
  Q9H1R1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 MEP1A  meprin A subunit alpha    meprin A, alpha (PABA peptide hydrolase)  Symbol and/or name change 5135510 APPROVED