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Gene: Man2a1 (mannosidase 2, alpha 1) Mus musculus
Symbol: Man2a1
Name: mannosidase 2, alpha 1
Description: Exhibits hydrolase activity, hydrolyzing N-glycosyl compounds and mannosidase activity. Involved in several processes, including N-glycan processing; animal organ development; and respiratory gaseous exchange by respiratory system. Localizes to the Golgi membrane; cis-Golgi network; and extracellular space. Used to study congenital dyserythropoietic anemia and systemic lupus erythematosus. Is expressed in adrenal gland; gland; and white fat. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1); PARTICIPATES IN N-linked glycan biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-mannosidase 2; AMan II; golgi alpha-mannosidase II; man II; Mana-2; Mana2; mannosidase alpha class 2A member 1; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase; Map-2
Homo sapiens (human) : MAN2A1 (mannosidase alpha class 2A member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Man2a1 (mannosidase, alpha, class 2A, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Man2a1 (mannosidase alpha class 2A member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAN2A1 (mannosidase alpha class 2A member 1)
Canis lupus familiaris (dog) : MAN2A1 (mannosidase alpha class 2A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Man2a1 (mannosidase alpha class 2A member 1)
Sus scrofa (pig) : MAN2A1 (mannosidase alpha class 2A member 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1764,600,736 - 64,755,110 (+)Ensembl
GRCm381764,600,688 - 64,755,110 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371764,950,989 - 65,104,450 (+)NCBIGRCm37mm9NCBIm37
MGSCv361764,497,940 - 64,651,401 (+)NCBImm8
Celera1768,918,943 - 69,071,751 (+)NCBICelera
Cytogenetic Map17 E1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Man2a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735706
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.