SCT (secretin) - Rat Genome Database
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Gene: SCT (secretin) Homo sapiens
Analyze
Symbol: SCT
Name: secretin
RGD ID: 735506
HGNC Page HGNC
Description: Exhibits G protein-coupled receptor binding activity. Predicted to be involved in several processes, including cellular water homeostasis; dentate gyrus development; and regulation of secretion. Predicted to localize to extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: prepro-secretin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11626,309 - 627,181 (-)EnsemblGRCh38hg38GRCh38
GRCh3811626,095 - 627,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711626,309 - 627,181 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3711626,313 - 627,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611616,313 - 617,173 (-)NCBINCBI36hg18NCBI36
Build 3411616,312 - 617,173NCBI
Celera11691,460 - 692,319 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11441,591 - 442,452 (-)NCBIHuRef
CHM1_111625,322 - 626,221 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5,6,7,8-tetrahydrobiopterin  (EXP)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
arsenous acid  (EXP)
BAPTA  (ISO)
Benzamil  (EXP)
bethanechol  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbachol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
copper(II) sulfate  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dopamine  (EXP)
flavonoids  (ISO)
folic acid  (ISO)
gamma-aminobutyric acid  (ISO)
genistein  (ISO)
Goe 6976  (ISO)
homovanillic acid  (EXP)
lead diacetate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
Nicardipine  (ISO)
omega-conotoxin GVIA  (ISO)
paracetamol  (EXP,ISO)
Pentagastrin  (EXP)
pirinixic acid  (EXP)
potassium atom  (EXP)
potassium chloride  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
sapropterin  (EXP)
sodium atom  (EXP)
tacrolimus hydrate  (ISO)
tetrodotoxin  (ISO)
titanium dioxide  (ISO)
triclosan  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:7612008   PMID:7782300   PMID:8579602   PMID:9440501   PMID:10576771   PMID:10764961   PMID:10807420   PMID:11060443   PMID:11278902   PMID:11814635   PMID:12036966   PMID:12133828  
PMID:12160732   PMID:15118068   PMID:15610158   PMID:15706223   PMID:16888194   PMID:16888198   PMID:16992627   PMID:18240029   PMID:18280672   PMID:18566919   PMID:18577758   PMID:19239625  
PMID:19372104   PMID:19904746   PMID:20398908   PMID:21597914   PMID:21851058   PMID:21873635   PMID:22964305   PMID:23064014   PMID:23233532   PMID:25332973   PMID:32296183  


Genomics

Comparative Map Data
SCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11626,309 - 627,181 (-)EnsemblGRCh38hg38GRCh38
GRCh3811626,095 - 627,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711626,309 - 627,181 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3711626,313 - 627,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611616,313 - 617,173 (-)NCBINCBI36hg18NCBI36
Build 3411616,312 - 617,173NCBI
Celera11691,460 - 692,319 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11441,591 - 442,452 (-)NCBIHuRef
CHM1_111625,322 - 626,221 (-)NCBICHM1_1
Sct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,858,242 - 140,859,082 (-)NCBIGRCm39mm39
GRCm387141,278,329 - 141,279,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,278,330 - 141,279,133 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,464,237 - 148,465,030 (-)NCBIGRCm37mm9NCBIm37
MGSCv367141,129,650 - 141,130,426 (-)NCBImm8
Celera7141,072,071 - 141,072,883 (-)NCBICelera
Cytogenetic Map7F5NCBI
Sct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21196,382,941 - 196,383,635 (-)NCBI
Rnor_6.0 Ensembl1214,264,754 - 214,265,668 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01214,264,865 - 214,277,437 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01221,182,403 - 221,191,992 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,472,250 - 201,472,944 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,623,164 - 201,623,978 (-)NCBI
Celera1194,016,798 - 194,017,492 (-)NCBICelera
Cytogenetic Map1q41NCBI
Sct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,433,969 - 11,434,574 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,433,857 - 11,434,662 (+)NCBIChiLan1.0ChiLan1.0
SCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111661,461 - 662,008 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011632,073 - 634,296 (-)NCBIMhudiblu_PPA_v0panPan3
SCT
(Canis lupus familiaris - dog)
No map positions available.
Sct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936888459,168 - 459,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2383,799 - 384,642 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12382,783 - 385,082 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22289,564 - 290,744 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11444,487 - 445,535 (-)NCBI
ChlSab1.1 Ensembl1444,601 - 445,339 (-)Ensembl
Sct
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,841,994 - 21,842,754 (+)NCBI

Position Markers
UniSTS:481377  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711626,381 - 627,173UniSTSGRCh37
Celera11691,528 - 692,319UniSTS
HuRef11441,659 - 442,452UniSTS
UniSTS:484039  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711626,334 - 627,169UniSTSGRCh37
Celera11691,481 - 692,315UniSTS
HuRef11441,612 - 442,448UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:347
Interacting mature miRNAs:393
Transcripts:ENST00000176195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 21 5 21 4 36 4 135 119 18 3 78 24 116
Low 1753 913 1059 211 859 185 1471 1287 1385 197 973 1165 36 117 1062 2
Below cutoff 583 1452 475 292 466 193 2011 650 1841 169 309 335 100 682 1236 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000176195   ⟹   ENSP00000176195
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11626,309 - 627,181 (-)Ensembl
RefSeq Acc Id: NM_021920   ⟹   NP_068739
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811626,309 - 627,181 (-)NCBI
GRCh3711626,313 - 627,173 (-)ENTREZGENE
Build 3611616,313 - 617,173 (-)NCBI Archive
HuRef11441,591 - 442,452 (-)ENTREZGENE
CHM1_111625,322 - 626,221 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018109   ⟹   XP_016873598
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811626,095 - 627,692 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068739 (Get FASTA)   NCBI Sequence Viewer  
  XP_016873598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31443 (Get FASTA)   NCBI Sequence Viewer  
  EAX02368 (Get FASTA)   NCBI Sequence Viewer  
  P09683 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_068739   ⟸   NM_021920
- Peptide Label: preproprotein
- UniProtKB: P09683 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016873598   ⟸   XM_017018109
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000176195   ⟸   ENST00000176195

Promoters
RGD ID:7219183
Promoter ID:EPDNEW_H15338
Type:initiation region
Name:SCT_1
Description:secretin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15339  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811627,181 - 627,241EPDNEW
RGD ID:7219187
Promoter ID:EPDNEW_H15339
Type:multiple initiation site
Name:SCT_2
Description:secretin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15338  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811628,649 - 628,709EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.4(chr11:196966-3377077)x3 copy number gain See cases [RCV000050947] Chr11:196966..3377077 [GRCh38]
Chr11:196966..3398307 [GRCh37]
Chr11:186966..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:218365-3377077)x3 copy number gain See cases [RCV000053614] Chr11:218365..3377077 [GRCh38]
Chr11:218365..3398307 [GRCh37]
Chr11:208365..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3624139)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|See cases [RCV000053592] Chr11:196966..3624139 [GRCh38]
Chr11:196966..3645369 [GRCh37]
Chr11:186966..3601945 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5(chr11:196855-2116185)x3 copy number gain See cases [RCV000142923] Chr11:196855..2116185 [GRCh38]
Chr11:196855..2137415 [GRCh37]
Chr11:186855..2093991 [NCBI36]
Chr11:11p15.5
pathogenic
GRCh37/hg19 11p15.5(chr11:532230-699463)x3 copy number gain See cases [RCV000240134] Chr11:532230..699463 [GRCh37]
Chr11:11p15.5
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:193187-5291338)x3 copy number gain See cases [RCV000446036] Chr11:193187..5291338 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-6644927)x3 copy number gain See cases [RCV000449417] Chr11:230615..6644927 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5(chr11:532230-699404)x3 copy number gain See cases [RCV000445988] Chr11:532230..699404 [GRCh37]
Chr11:11p15.5
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3 copy number gain not provided [RCV000683369] Chr11:230615..9704511 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5(chr11:381754-821676)x3 copy number gain not provided [RCV000749876] Chr11:381754..821676 [GRCh37]
Chr11:11p15.5
benign
GRCh37/hg19 11p15.5(chr11:556531-927020)x3 copy number gain not provided [RCV000749890] Chr11:556531..927020 [GRCh37]
Chr11:11p15.5
benign
NC_000011.9:g.(?_612625)_(2193840_?)dup duplication Immunodeficiency 39 [RCV001033372] Chr11:612625..2193840 [GRCh37]
Chr11:11p15.5
uncertain significance
NC_000011.9:g.(?_532616)_(2906985_?)dup duplication Neuronal ceroid lipofuscinosis [RCV001032557] Chr11:532616..2906985 [GRCh37]
Chr11:11p15.5-15.4
uncertain significance
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Russell-Silver syndrome [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
NM_021920.4(SCT):c.123G>A (p.Arg41=) single nucleotide variant not provided [RCV000894610] Chr11:626938 [GRCh38]
Chr11:626938 [GRCh37]
Chr11:11p15.5
likely benign
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
NC_000011.10:g.(?_532616)_(795026_?)dup duplication Infantile epileptic dyskinetic encephalopathy [RCV001031133] Chr11:532616..795026 [GRCh37]
Chr11:11p15.5
uncertain significance
GRCh37/hg19 11p15.5(chr11:230615-1150353)x3 copy number gain not provided [RCV001259592] Chr11:230615..1150353 [GRCh37]
Chr11:11p15.5
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:230615-4851537)x3 copy number gain See cases [RCV001263059] Chr11:230615..4851537 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:210300-8664358)x3 copy number gain Russell-Silver syndrome [RCV001263222] Chr11:210300..8664358 [GRCh37]
Chr11:11p15.5-15.4
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10607 AgrOrtholog
COSMIC SCT COSMIC
Ensembl Genes ENSG00000070031 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000274473 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000176195 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000483559 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000176195 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000622382 UniProtKB/Swiss-Prot
GTEx ENSG00000070031 GTEx
  ENSG00000274473 GTEx
HGNC ID HGNC:10607 ENTREZGENE
Human Proteome Map SCT Human Proteome Map
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot
  Prosecretin UniProtKB/Swiss-Prot
KEGG Report hsa:6343 UniProtKB/Swiss-Prot
NCBI Gene 6343 ENTREZGENE
OMIM 182099 OMIM
PANTHER PTHR17378 UniProtKB/Swiss-Prot
Pfam Hormone_2 UniProtKB/Swiss-Prot
PharmGKB PA35017 PharmGKB
PROSITE GLUCAGON UniProtKB/Swiss-Prot
SMART GLUCA UniProtKB/Swiss-Prot
UniProt P09683 ENTREZGENE, UniProtKB/Swiss-Prot