ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) - Rat Genome Database

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Gene: ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) Homo sapiens
Analyze
Symbol: ADH4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
RGD ID: 735489
HGNC Page HGNC:252
Description: Enables several functions, including oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; retinoid binding activity; and zinc ion binding activity. Involved in cellular aldehyde metabolic process; fatty acid omega-oxidation; and primary alcohol metabolic process. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADH-2; alcohol dehydrogenase 4; alcohol dehydrogenase class II pi chain; aldehyde reductase; all-trans-retinol dehydrogenase [NAD(+)] ADH4; epididymis secretory protein Li 4; HEL-S-4
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,123,658 - 99,144,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl499,123,657 - 99,157,792 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,044,809 - 100,065,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,263,855 - 100,284,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,401,812 - 100,423,028NCBI
Celera497,342,359 - 97,362,981 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,782,906 - 95,803,527 (-)NCBIHuRef
CHM1_14100,021,522 - 100,042,141 (-)NCBICHM1_1
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
atazanavir sulfate  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
chloroethene  (ISO)
cimetidine  (EXP)
clofibrate  (ISO)
copper(II) sulfate  (EXP,ISO)
cyclosporin A  (EXP)
cyhalothrin  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dicrotophos  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (EXP)
fenofibrate  (EXP)
fipronil  (ISO)
flutamide  (ISO)
fomepizole  (EXP)
formaldehyde  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
indometacin  (EXP)
L-ethionine  (ISO)
Lasiocarpine  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
metformin  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nefazodone  (EXP,ISO)
niclosamide  (EXP)
O-methyleugenol  (EXP)
omeprazole  (ISO)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
propan-2-ol  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rotenone  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
Sunset Yellow FCF  (EXP)
tartrazine  (EXP)
tebuconazole  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IDA,TAS)
nucleoplasm  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9982   PMID:1362387   PMID:1889753   PMID:3036213   PMID:3466164   PMID:8032153   PMID:9570155   PMID:10407146   PMID:10514444   PMID:11009184   PMID:11279029   PMID:11752456  
PMID:11900616   PMID:11916005   PMID:11964133   PMID:11997393   PMID:12477932   PMID:12631290   PMID:14745297   PMID:15028279   PMID:15369820   PMID:15489334   PMID:15863808   PMID:16081420  
PMID:16220108   PMID:16237392   PMID:16787387   PMID:17069770   PMID:17207965   PMID:17279314   PMID:18029348   PMID:18331377   PMID:18801187   PMID:18996923   PMID:19182438   PMID:19193628  
PMID:19343046   PMID:19687126   PMID:19861527   PMID:19874574   PMID:19898482   PMID:19925625   PMID:20363298   PMID:20453000   PMID:20462248   PMID:20626721   PMID:20634891   PMID:20800603  
PMID:21184752   PMID:21480392   PMID:21635275   PMID:21832049   PMID:21873635   PMID:21988832   PMID:22044940   PMID:22147505   PMID:22232963   PMID:22960999   PMID:23456092   PMID:23468174  
PMID:24051444   PMID:24469609   PMID:24625756   PMID:26039424   PMID:29318394   PMID:31682009   PMID:31753913   PMID:31768945   PMID:32296183   PMID:33556337   PMID:35437765   PMID:35944360  
PMID:36553522  


Genomics

Comparative Map Data
ADH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,123,658 - 99,144,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl499,123,657 - 99,157,792 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,044,809 - 100,065,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,263,855 - 100,284,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,401,812 - 100,423,028NCBI
Celera497,342,359 - 97,362,981 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,782,906 - 95,803,527 (-)NCBIHuRef
CHM1_14100,021,522 - 100,042,141 (-)NCBICHM1_1
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBIT2T-CHM13v2.0
Adh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,121,217 - 138,138,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,121,227 - 138,136,653 (+)EnsemblGRCm39 Ensembl
GRCm383138,415,456 - 138,432,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,415,466 - 138,430,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,078,461 - 138,093,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,352,896 - 138,368,279 (+)NCBIMGSCv36mm8
Celera3144,836,181 - 144,853,583 (+)NCBICelera
Cytogenetic Map3G3NCBI
Adh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22226,948,717 - 226,966,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,697,253 - 234,715,474 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02232,596,984 - 232,615,201 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02227,461,666 - 227,479,885 (+)NCBIRnor_WKY
Rnor_6.02243,702,035 - 243,720,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,237,059 - 262,254,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,952,313 - 235,970,671 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,939,028 - 235,957,343 (+)NCBI
Celera2219,105,553 - 219,122,791 (+)NCBICelera
Cytogenetic Map2q44NCBI
ADH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14102,186,670 - 102,206,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,183,956 - 102,206,923 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0491,522,444 - 91,543,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,282,526 - 21,299,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBIUU_Cfam_GSD_1.0
ADH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,225,656 - 121,261,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,409,996 - 130,434,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,226,787 - 47,248,518 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,226,191 - 47,248,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,658,415 - 25,678,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ADH4
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q23(chr4:97972342-100038125)x3 copy number gain See cases [RCV000051632] Chr4:97972342..100038125 [GRCh38]
Chr4:98893493..100959282 [GRCh37]
Chr4:99112516..101178305 [NCBI36]
Chr4:4q23
uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
NM_000670.3(ADH4):c.419G>A (p.Gly140Glu) single nucleotide variant Malignant melanoma [RCV000060883] Chr4:99136629 [GRCh38]
Chr4:100057780 [GRCh37]
Chr4:100276803 [NCBI36]
Chr4:4q23
not provided
NM_000670.3(ADH4):c.42C>T (p.Ile14=) single nucleotide variant Malignant melanoma [RCV000060884] Chr4:99142757 [GRCh38]
Chr4:100063908 [GRCh37]
Chr4:100282931 [NCBI36]
Chr4:4q23
not provided
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24
pathogenic
GRCh38/hg38 4q22.1-24(chr4:92610413-101521991)x1 copy number loss See cases [RCV000140412] Chr4:92610413..101521991 [GRCh38]
Chr4:93531564..102443148 [GRCh37]
Chr4:93750587..102662171 [NCBI36]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1 copy number loss See cases [RCV000445741] Chr4:85805268..103678797 [GRCh37]
Chr4:4q21.23-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.1-24(chr4:92201567-103043808)x1 copy number loss See cases [RCV000511194] Chr4:92201567..103043808 [GRCh37]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q23(chr4:99687168-100200509)x3 copy number gain not provided [RCV000743861] Chr4:99687168..100200509 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4q23(chr4:99687168-100202078)x3 copy number gain not provided [RCV000743862] Chr4:99687168..100202078 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_000670.5(ADH4):c.51dup (p.Ala18fs) duplication CIC-DUX Sarcoma [RCV000993829] Chr4:99142747..99142748 [GRCh38]
Chr4:100063898..100063899 [GRCh37]
Chr4:4q23
not provided
GRCh37/hg19 4q22.2-24(chr4:94692345-101308220)x1 copy number loss not provided [RCV001259285] Chr4:94692345..101308220 [GRCh37]
Chr4:4q22.2-24
likely pathogenic
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3 copy number gain not provided [RCV001827745] Chr4:95490755..109977216 [GRCh37]
Chr4:4q22.3-25
likely pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
GRCh37/hg19 4q23(chr4:99835828-100089147) copy number loss not specified [RCV002053445] Chr4:99835828..100089147 [GRCh37]
Chr4:4q23
uncertain significance
GRCh37/hg19 4q23(chr4:99918661-100046008)x1 copy number loss not provided [RCV002473926] Chr4:99918661..100046008 [GRCh37]
Chr4:4q23
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2381
Count of miRNA genes:793
Interacting mature miRNAs:895
Transcripts:ENST00000265512, ENST00000423445, ENST00000503416, ENST00000503944, ENST00000504125, ENST00000504581, ENST00000504894, ENST00000505590, ENST00000506705, ENST00000508393, ENST00000509471, ENST00000512499
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-X56411  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,065,442 - 100,065,606UniSTSGRCh37
Build 364100,284,465 - 100,284,629RGDNCBI36
Celera497,362,974 - 97,363,138RGD
Cytogenetic Map4q22UniSTS
HuRef495,803,520 - 95,803,684UniSTS
GeneMap99-GB4 RH Map4490.71UniSTS
NCBI RH Map41161.2UniSTS
SHGC-35298  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,045,318 - 100,045,526UniSTSGRCh37
Build 364100,264,341 - 100,264,549RGDNCBI36
Celera497,342,845 - 97,343,053RGD
Cytogenetic Map4q22UniSTS
HuRef495,783,392 - 95,783,600UniSTS
TNG Radiation Hybrid Map460945.0UniSTS
GeneMap99-GB4 RH Map4494.02UniSTS
Whitehead-RH Map4533.9UniSTS
NCBI RH Map41143.3UniSTS
GeneMap99-G3 RH Map45531.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 154 154 154
Medium 121 83 261 266 35 256 39 110 5 7 24 7 10 50 19
Low 1217 1050 478 162 345 34 2048 955 494 87 653 427 128 828 1260
Below cutoff 987 1392 720 29 714 5 2061 946 1875 185 586 898 28 322 1455 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP002026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV658711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV659353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV659364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY974245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD014080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU668317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265512   ⟹   ENSP00000265512
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,123,658 - 99,144,297 (-)Ensembl
RefSeq Acc Id: ENST00000503416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,131,652 - 99,142,811 (-)Ensembl
RefSeq Acc Id: ENST00000503944
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,136,537 - 99,143,206 (-)Ensembl
RefSeq Acc Id: ENST00000504125   ⟹   ENSP00000427525
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,131,674 - 99,144,268 (-)Ensembl
RefSeq Acc Id: ENST00000504581
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,141,639 - 99,157,792 (-)Ensembl
RefSeq Acc Id: ENST00000504894   ⟹   ENSP00000427261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,139,143 - 99,144,297 (-)Ensembl
RefSeq Acc Id: ENST00000505590   ⟹   ENSP00000425416
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,124,379 - 99,144,276 (-)Ensembl
RefSeq Acc Id: ENST00000506705   ⟹   ENSP00000426667
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,126,594 - 99,144,276 (-)Ensembl
RefSeq Acc Id: ENST00000508393   ⟹   ENSP00000424630
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,123,657 - 99,144,297 (-)Ensembl
RefSeq Acc Id: ENST00000509471   ⟹   ENSP00000424583
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,124,364 - 99,136,537 (-)Ensembl
RefSeq Acc Id: ENST00000512499   ⟹   ENSP00000423571
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,131,631 - 99,144,238 (-)Ensembl
RefSeq Acc Id: ENST00000629236   ⟹   ENSP00000486450
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,123,667 - 99,144,281 (-)Ensembl
RefSeq Acc Id: NM_000670   ⟹   NP_000661
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,123,658 - 99,144,297 (-)NCBI
GRCh374100,044,832 - 100,065,449 (-)ENTREZGENE
Build 364100,263,855 - 100,284,472 (-)NCBI Archive
HuRef495,782,906 - 95,803,527 (-)ENTREZGENE
CHM1_14100,021,498 - 100,042,141 (-)NCBI
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001306171   ⟹   NP_001293100
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,123,658 - 99,144,297 (-)NCBI
CHM1_14100,021,498 - 100,042,141 (-)NCBI
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001306172   ⟹   NP_001293101
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,123,658 - 99,144,297 (-)NCBI
CHM1_14100,021,498 - 100,042,141 (-)NCBI
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000661   ⟸   NM_000670
- Peptide Label: isoform 2
- UniProtKB: Q8TCD7 (UniProtKB/Swiss-Prot),   P08319 (UniProtKB/Swiss-Prot),   V9HVX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001293101   ⟸   NM_001306172
- Peptide Label: isoform 1
- UniProtKB: P08319 (UniProtKB/Swiss-Prot),   V9HVX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001293100   ⟸   NM_001306171
- Peptide Label: isoform 1
- UniProtKB: P08319 (UniProtKB/Swiss-Prot),   V9HVX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000427525   ⟸   ENST00000504125
RefSeq Acc Id: ENSP00000427261   ⟸   ENST00000504894
RefSeq Acc Id: ENSP00000425416   ⟸   ENST00000505590
RefSeq Acc Id: ENSP00000426667   ⟸   ENST00000506705
RefSeq Acc Id: ENSP00000424630   ⟸   ENST00000508393
RefSeq Acc Id: ENSP00000424583   ⟸   ENST00000509471
RefSeq Acc Id: ENSP00000486450   ⟸   ENST00000629236
RefSeq Acc Id: ENSP00000423571   ⟸   ENST00000512499
RefSeq Acc Id: ENSP00000265512   ⟸   ENST00000265512
Protein Domains
ADH_N   ADH_zinc_N   Enoyl reductase (ER)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08319-F1-model_v2 AlphaFold P08319 1-380 view protein structure

Promoters
RGD ID:6868088
Promoter ID:EPDNEW_H7209
Type:initiation region
Name:ADH4_1
Description:alcohol dehydrogenase 4 , pi polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,144,297 - 99,144,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:252 AgrOrtholog
COSMIC ADH4 COSMIC
Ensembl Genes ENSG00000198099 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000265512 ENTREZGENE
  ENSP00000265512.7 UniProtKB/Swiss-Prot
  ENSP00000423571.1 UniProtKB/TrEMBL
  ENSP00000424583.1 UniProtKB/TrEMBL
  ENSP00000424630 ENTREZGENE
  ENSP00000424630.1 UniProtKB/Swiss-Prot
  ENSP00000425416 ENTREZGENE
  ENSP00000425416.1 UniProtKB/Swiss-Prot
  ENSP00000426667.1 UniProtKB/TrEMBL
  ENSP00000427261.1 UniProtKB/TrEMBL
  ENSP00000427525.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000265512 ENTREZGENE
  ENST00000265512.12 UniProtKB/Swiss-Prot
  ENST00000504125.1 UniProtKB/TrEMBL
  ENST00000504894.1 UniProtKB/TrEMBL
  ENST00000505590 ENTREZGENE
  ENST00000505590.5 UniProtKB/Swiss-Prot
  ENST00000506705.5 UniProtKB/TrEMBL
  ENST00000508393 ENTREZGENE
  ENST00000508393.5 UniProtKB/Swiss-Prot
  ENST00000509471.5 UniProtKB/TrEMBL
  ENST00000512499.5 UniProtKB/TrEMBL
GTEx ENSG00000198099 GTEx
HGNC ID HGNC:252 ENTREZGENE
Human Proteome Map ADH4 Human Proteome Map
InterPro ADH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc_ADH_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:127 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 127 ENTREZGENE
OMIM 103740 OMIM
PANTHER PTHR43880:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADH4 RGD, PharmGKB
PROSITE ADH_ZINC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RDF8_HUMAN UniProtKB/TrEMBL
  ADH4_HUMAN UniProtKB/Swiss-Prot
  D6R9K8_HUMAN UniProtKB/TrEMBL
  D6RF43_HUMAN UniProtKB/TrEMBL
  D6RIB1_HUMAN UniProtKB/TrEMBL
  H0Y9N0_HUMAN UniProtKB/TrEMBL
  P08319 ENTREZGENE
  Q8TCD7 ENTREZGENE
  V9HVX7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A8K470 UniProtKB/Swiss-Prot
  B4DIE7 UniProtKB/Swiss-Prot
  C9J4A9 UniProtKB/Swiss-Prot
  Q8TCD7 UniProtKB/Swiss-Prot