Symbol:
GGH
Name:
gamma-glutamyl hydrolase
Description:
Exhibits gamma-glutamyl-peptidase activity. Predicted to be involved in tetrahydrofolylpolyglutamate metabolic process. Localizes to the extracellular space.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
conjugase; folylpolygammaglutamyl hydrolase; gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); GH
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Ggh (gamma-glutamyl hydrolase) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Ggh (gamma-glutamyl hydrolase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Ggh (gamma-glutamyl hydrolase) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
GGH (gamma-glutamyl hydrolase) NCBI
Ortholog
Canis lupus familiaris (dog):
GGH (gamma-glutamyl hydrolase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ggh (gamma-glutamyl hydrolase) NCBI
Ortholog
Sus scrofa (pig):
GGH (gamma-glutamyl hydrolase) HGNC
NCBI
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Ggh (gamma-glutamyl hydrolase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Ggh (gamma-glutamyl hydrolase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
zgc:171566
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
ggh (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
l(3)72Dp
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
l(3)72Dr
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 8 63,015,079 - 63,038,806 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 8 63,927,638 - 63,951,610 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 8 64,090,192 - 64,113,940 (-) NCBI NCBI36 hg18 NCBI36 Build 34 8 64,090,194 - 64,113,940 NCBI Celera 8 59,917,838 - 59,941,813 (-) NCBI Cytogenetic Map 8 q12.3 NCBI HuRef 8 59,415,504 - 59,439,479 (-) NCBI HuRef CHM1_1 8 63,980,633 - 64,004,623 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GGH mRNA CTD PMID:19619570 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of GGH mRNA CTD PMID:16474171 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GGH mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of GGH mRNA CTD PMID:19619570 more ... 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of GGH mRNA CTD PMID:21179406 3H-1,2-dithiole-3-thione decreases expression ISO RGD:2682 6480464 1, 2-dithiol-3-thione results in decreased expression of GGH mRNA CTD PMID:19162173 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO RGD:2682 6480464 Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 6-propyl-2-thiouracil affects expression ISO RGD:2682 6480464 Propylthiouracil affects the expression of GGH mRNA CTD PMID:19483382 amiodarone affects expression ISO RGD:2682 6480464 Amiodarone affects the expression of GGH mRNA CTD PMID:19483382 ammonium chloride affects expression ISO RGD:2682 6480464 Ammonium Chloride affects the expression of GGH mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:2682 6480464 Amphetamine results in increased expression of GGH mRNA CTD PMID:30779732 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GGH mRNA CTD PMID:25258189 azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of GGH mRNA CTD PMID:22623647 benzbromarone affects expression ISO RGD:2682 6480464 Benzbromarone affects the expression of GGH mRNA CTD PMID:19483382 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of GGH mRNA CTD PMID:17879257 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GGH mRNA CTD PMID:16474171 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of GGH mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GGH mRNA CTD PMID:29275510 bisphenol A affects expression ISO RGD:2682 6480464 bisphenol A affects the expression of GGH mRNA CTD PMID:25181051 cadmium dichloride decreases methylation ISO RGD:2682 6480464 Cadmium Chloride results in decreased methylation of GGH promoter CTD PMID:22457795 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of GGH mRNA CTD PMID:21592394 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of GGH mRNA CTD PMID:21592394 choline multiple interactions ISO RGD:10636 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene CTD PMID:20938992 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of GGH mRNA CTD PMID:27594783 clofibrate affects expression ISO RGD:2682 6480464 Clofibrate affects the expression of GGH mRNA CTD PMID:19483382 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of GGH mRNA CTD PMID:19549813 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression EXP 6480464 Coumestrol results in increased expression of GGH mRNA CTD PMID:19167446 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of GGH mRNA CTD PMID:20106945 , PMID:25562108 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of GGH mRNA CTD PMID:25258189 dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of GGH mRNA CTD PMID:28302478 diuron increases expression ISO RGD:2682 6480464 Diuron results in increased expression of GGH mRNA CTD PMID:21551480 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of GGH mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GGH protein CTD PMID:23301498 folic acid affects expression EXP 6480464 Folic Acid affects the expression of GGH mRNA CTD PMID:17311948 folic acid decreases expression EXP 6480464 Folic Acid deficiency results in decreased expression of GGH mRNA, Folic Acid deficiency results in decreased expression of GGH protein CTD PMID:18499665 folic acid multiple interactions ISO RGD:10636 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene CTD PMID:20938992 folic acid increases hydrolysis ISO RGD:2682 6480464 GGH protein results in increased hydrolysis of Folic Acid CTD PMID:17449573 folic acid multiple interactions ISO RGD:2682 6480464 4-hydroxymercuribenzoate inhibits the reaction [GGH protein results in increased hydrolysis of Folic Acid] CTD PMID:17449573 genistein increases expression EXP 6480464 Genistein results in increased expression of GGH mRNA CTD PMID:16474171 gentamycin increases expression ISO RGD:2682 6480464 Gentamicins results in increased expression of GGH mRNA CTD PMID:22061828 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of GGH mRNA CTD PMID:21179406 L-ethionine affects expression ISO RGD:2682 6480464 Ethionine affects the expression of GGH mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:10636 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GGH gene CTD PMID:20938992 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of GGH mRNA CTD PMID:23897011 methotrexate affects response to substance EXP 6480464 GGH gene polymorphism affects the susceptibility to Methotrexate CTD PMID:21219404 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of GGH mRNA CTD PMID:28001369 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:10636 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of GGH mRNA CTD PMID:22401849 N-nitrosodimethylamine increases expression ISO RGD:2682 6480464 Dimethylnitrosamine results in increased expression of GGH mRNA CTD PMID:25380136 nefazodone increases expression ISO RGD:2682 6480464 nefazodone results in increased expression of GGH mRNA CTD PMID:24136188 nimesulide increases expression ISO RGD:2682 6480464 nimesulide results in increased expression of GGH mRNA CTD PMID:24136188 omeprazole affects expression ISO RGD:2682 6480464 Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of GGH mRNA CTD PMID:22230336 pemetrexed affects response to substance EXP 6480464 GGH protein affects the susceptibility to Pemetrexed CTD PMID:17575230 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:2682 6480464 perfluorooctane sulfonic acid results in decreased expression of GGH mRNA CTD PMID:18692542 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of GGH mRNA CTD PMID:27153767 phenethyl isothiocyanate increases expression ISO RGD:2682 6480464 phenethyl isothiocyanate results in increased expression of GGH mRNA CTD PMID:17616710 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of GGH mRNA CTD PMID:19159669 pirinixic acid affects expression ISO RGD:2682 6480464 pirinixic acid affects the expression of GGH mRNA CTD PMID:19483382 platinum affects response to substance EXP 6480464 GGH gene polymorphism affects the susceptibility to Platinum CTD PMID:18851872 platinum(0) affects response to substance EXP 6480464 GGH gene polymorphism affects the susceptibility to Platinum CTD PMID:18851872 quercetin increases expression ISO RGD:2682 6480464 Quercetin results in increased expression of GGH mRNA CTD PMID:26432773 resveratrol multiple interactions EXP 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of GGH mRNA CTD PMID:19167446 silicon dioxide affects secretion EXP 6480464 Silicon Dioxide analog affects the secretion of GGH protein CTD PMID:25895662 Soman decreases expression ISO RGD:2682 6480464 Soman results in decreased expression of GGH mRNA CTD PMID:19281266 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of GGH mRNA CTD PMID:21592394 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of GGH mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:10636 6480464 Carbon Tetrachloride results in increased expression of GGH mRNA CTD PMID:27339419 tetrahydropalmatine increases expression EXP 6480464 tetrahydropalmatine results in increased expression of GGH protein CTD PMID:20109541 thioacetamide affects expression ISO RGD:2682 6480464 Thioacetamide affects the expression of GGH mRNA CTD PMID:19483382 tris(2-butoxyethyl) phosphate affects expression EXP 6480464 tris(2-butoxyethyl) phosphate affects the expression of GGH mRNA CTD PMID:29024780 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of GGH mRNA CTD PMID:22378314 valdecoxib increases expression ISO RGD:2682 6480464 valdecoxib results in increased expression of GGH mRNA CTD PMID:24136188 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of GGH mRNA CTD PMID:25979313 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of GGH mRNA CTD PMID:23179753 , PMID:27188386 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of GGH mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
