RAMP2 (receptor activity modifying protein 2) - Rat Genome Database

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Gene: RAMP2 (receptor activity modifying protein 2) Homo sapiens
Analyze
Symbol: RAMP2
Name: receptor activity modifying protein 2
RGD ID: 735315
HGNC Page HGNC:9844
Description: Enables adrenomedullin binding activity and adrenomedullin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel morphogenesis; and cell-cell junction assembly. Located in cell surface; cytoplasm; and plasma membrane. Part of adrenomedullin receptor complex. Implicated in hypertension. Biomarker of colorectal cancer and hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity-modifying protein 2; receptor (calcitonin) activity modifying protein 2; receptor (G protein-coupled) activity modifying protein 2; receptor activity-modifying protein 2; receptor-activity-modifying protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,761,227 - 42,763,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,758,447 - 42,763,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,913,245 - 40,915,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,166,738 - 38,168,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,166,737 - 38,168,580NCBI
Celera1737,569,491 - 37,571,338 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,678,311 - 36,680,158 (+)NCBIHuRef
CHM1_11741,148,776 - 41,150,623 (+)NCBICHM1_1
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diethyl malate  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ethylparaben  (EXP)
fenofibrate  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
pirinixic acid  (ISO)
resveratrol  (EXP)
rimonabant  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sunitinib  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
urethane  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. Dai K, etal., Oncogene. 2020 Feb;39(9):1914-1930. doi: 10.1038/s41388-019-1112-z. Epub 2019 Nov 21.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension.] Gong YS, etal., Sheng Li Xue Bao. 2007 Apr 25;59(2):210-4.
4. Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9. Hikosaka T, etal., Peptides. 2011 Sep;32(9):1825-31. doi: 10.1016/j.peptides.2011.07.012. Epub 2011 Aug 3.
5. The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats. Hiragushi K, etal., Kidney Int. 2004 Feb;65(2):540-50.
6. The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis. Hwang IS, etal., Regul Pept. 2006 Jul 15;135(1-2):69-77. Epub 2006 May 19.
7. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Jia YX, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):117-23. Epub 2006 Aug 17.
8. Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension. Makino Y, etal., J Clin Endocrinol Metab. 2001 Oct;86(10):5079-82.
9. Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation. Man SY, etal., Neuropeptides. 2007 Jun;41(3):177-87. Epub 2007 Mar 1.
10. Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy. Nagae T, etal., Biochem Biophys Res Commun 2000 Apr 2;270(1):89-93.
11. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi T, etal., Hypertension 2003 Mar;41(3):512-8.
12. Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo. Nouguer├Ęde E, etal., Cancer Med. 2013 Apr;2(2):196-207. doi: 10.1002/cam4.51. Epub 2013 Jan 29.
13. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat. Pan ChS, etal., Basic Res Cardiol. 2006 May;101(3):193-203. Epub 2006 Feb 6.
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Association study of calcitonin-receptor-like receptor gene in essential hypertension. Sano M, etal., Am J Hypertens. 2005 Mar;18(3):403-8.
16. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy. Yoshihara F, etal., Regul Pept. 2005 Apr 15;127(1-3):239-44.
17. [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats] Yu XM, etal., Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):496-500.
Additional References at PubMed
PMID:9620797   PMID:10217420   PMID:10354609   PMID:10767413   PMID:10882736   PMID:11060459   PMID:11387328   PMID:11591721   PMID:11754963   PMID:11804624   PMID:11973435   PMID:12036966  
PMID:12093471   PMID:12419522   PMID:12446722   PMID:12477932   PMID:12565884   PMID:14722252   PMID:15245870   PMID:15300632   PMID:15489334   PMID:15613468   PMID:16410241   PMID:16531504  
PMID:16912219   PMID:16964401   PMID:17671114   PMID:18097473   PMID:18240029   PMID:18577758   PMID:18593822   PMID:18835256   PMID:19210874   PMID:19913121   PMID:20074556   PMID:20596610  
PMID:20628086   PMID:21873635   PMID:22102369   PMID:22500019   PMID:24169318   PMID:24199627   PMID:24505304   PMID:24831942   PMID:25982113   PMID:26198634   PMID:27013657   PMID:28586439  
PMID:28614667   PMID:28904253   PMID:30115739   PMID:30631154   PMID:30826286   PMID:31150417   PMID:32296183   PMID:33385343   PMID:33961781   PMID:34271220   PMID:38279501  


Genomics

Comparative Map Data
RAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,761,227 - 42,763,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,758,447 - 42,763,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371740,913,245 - 40,915,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,166,738 - 38,168,585 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,166,737 - 38,168,580NCBI
Celera1737,569,491 - 37,571,338 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,678,311 - 36,680,158 (+)NCBIHuRef
CHM1_11741,148,776 - 41,150,623 (+)NCBICHM1_1
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBIT2T-CHM13v2.0
Ramp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,137,160 - 101,139,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,136,854 - 101,150,372 (+)EnsemblGRCm39 Ensembl
GRCm3811101,246,334 - 101,248,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,246,028 - 101,259,546 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,107,648 - 101,109,564 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,062,424 - 101,064,340 (+)NCBIMGSCv36mm8
Celera11112,542,561 - 112,544,477 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.47NCBI
Ramp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,689,148 - 86,690,956 (+)NCBIGRCr8
mRatBN7.21086,187,366 - 86,190,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,188,812 - 86,231,829 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,226,790 - 91,228,598 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,701,301 - 90,703,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,094,462 - 86,096,270 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,166,170 - 89,168,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,166,890 - 89,168,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,965,679 - 88,967,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,275,463 - 90,277,242NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,289,832 - 90,291,611NCBI
Cytogenetic Map10q31NCBI
Ramp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,584,742 - 16,586,093 (+)NCBIChiLan1.0ChiLan1.0
RAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,222,750 - 22,225,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,112,840 - 24,115,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,554,888 - 14,557,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,779,666 - 14,781,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,779,666 - 14,781,481 (-)Ensemblpanpan1.1panPan2
RAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,250,711 - 20,252,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,712,023 - 19,713,795 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,969,093 - 20,970,865 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,969,095 - 20,971,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,753,999 - 19,755,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,020,208 - 20,021,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,122,921 - 20,124,693 (-)NCBIUU_Cfam_GSD_1.0
Ramp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,593,351 - 19,595,280 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,479,650 - 17,482,716 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,479,899 - 17,481,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,092,196 - 20,094,469 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,092,204 - 20,094,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,346,948 - 20,349,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,526,915 - 63,529,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,526,305 - 63,528,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,320,238 - 34,322,154 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ramp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,435,121 - 1,436,421 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAMP2
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
NM_005854.3(RAMP2):c.420C>T (p.Asp140=) single nucleotide variant not provided [RCV000927207] Chr17:42762744 [GRCh38]
Chr17:40914762 [GRCh37]
Chr17:17q21.2
likely benign
NM_005854.3(RAMP2):c.31G>T (p.Gly11Cys) single nucleotide variant not specified [RCV004140701] Chr17:42761292 [GRCh38]
Chr17:40913310 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.16G>A (p.Val6Met) single nucleotide variant not specified [RCV004190548] Chr17:42761277 [GRCh38]
Chr17:40913295 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.170C>T (p.Thr57Met) single nucleotide variant not specified [RCV004168168] Chr17:42762361 [GRCh38]
Chr17:40914379 [GRCh37]
Chr17:17q21.2
likely benign
NM_005854.3(RAMP2):c.446T>C (p.Met149Thr) single nucleotide variant not specified [RCV004159449] Chr17:42762770 [GRCh38]
Chr17:40914788 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.37C>G (p.Arg13Gly) single nucleotide variant not specified [RCV004099339] Chr17:42761298 [GRCh38]
Chr17:40913316 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.25G>A (p.Ala9Thr) single nucleotide variant not specified [RCV004333699] Chr17:42761286 [GRCh38]
Chr17:40913304 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.40C>T (p.Leu14Phe) single nucleotide variant not specified [RCV004276218] Chr17:42761301 [GRCh38]
Chr17:40913319 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.375G>C (p.Gln125His) single nucleotide variant not specified [RCV004336118] Chr17:42762699 [GRCh38]
Chr17:40914717 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.410C>G (p.Thr137Ser) single nucleotide variant not specified [RCV004358422] Chr17:42762734 [GRCh38]
Chr17:40914752 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.52C>G (p.Arg18Gly) single nucleotide variant not specified [RCV004445743] Chr17:42761313 [GRCh38]
Chr17:40913331 [GRCh37]
Chr17:17q21.2
uncertain significance
NM_005854.3(RAMP2):c.97+8C>T single nucleotide variant RAMP2-related disorder [RCV003902120] Chr17:42761366 [GRCh38]
Chr17:40913384 [GRCh37]
Chr17:17q21.2
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1847
Count of miRNA genes:603
Interacting mature miRNAs:686
Transcripts:ENST00000253796, ENST00000587142, ENST00000588576, ENST00000588928, ENST00000589683, ENST00000591972
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-N93656  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,914,875 - 40,915,029UniSTSGRCh37
Build 361738,168,401 - 38,168,555RGDNCBI36
Celera1737,571,154 - 37,571,308RGD
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q12-q21.1UniSTS
HuRef1736,679,974 - 36,680,128UniSTS
GeneMap99-GB4 RH Map17303.84UniSTS
NCBI RH Map17352.4UniSTS
RAMP2_3760  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371740,914,692 - 40,915,146UniSTSGRCh37
Build 361738,168,218 - 38,168,672RGDNCBI36
Celera1737,570,971 - 37,571,425RGD
HuRef1736,679,791 - 36,680,245UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2
Medium 2281 2159 1409 349 535 189 4158 2079 3373 352 1326 1428 161 1204 2670 1
Low 73 393 305 270 608 268 180 104 333 45 92 104 9 1 118 2 2
Below cutoff 31 369 3 1 522 2 9 5 20 2 23 40 3 1

Sequence


RefSeq Acc Id: ENST00000253796   ⟹   ENSP00000253796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,761,227 - 42,763,041 (+)Ensembl
RefSeq Acc Id: ENST00000587142   ⟹   ENSP00000466455
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,761,258 - 42,762,854 (+)Ensembl
RefSeq Acc Id: ENST00000588576   ⟹   ENSP00000465725
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,761,258 - 42,763,002 (+)Ensembl
RefSeq Acc Id: ENST00000588928   ⟹   ENSP00000466980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,760,805 - 42,762,698 (+)Ensembl
RefSeq Acc Id: ENST00000589683   ⟹   ENSP00000467463
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,760,775 - 42,763,041 (+)Ensembl
RefSeq Acc Id: ENST00000591972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1742,758,447 - 42,761,899 (+)Ensembl
RefSeq Acc Id: NM_005854   ⟹   NP_005845
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,761,227 - 42,763,041 (+)NCBI
GRCh371740,913,145 - 40,915,063 (+)NCBI
Build 361738,166,738 - 38,168,585 (+)NCBI Archive
HuRef1736,678,311 - 36,680,158 (+)ENTREZGENE
CHM1_11741,148,776 - 41,150,623 (+)NCBI
T2T-CHM13v2.01743,618,368 - 43,620,182 (+)NCBI
Sequence:
RefSeq Acc Id: NP_005845   ⟸   NM_005854
- Peptide Label: precursor
- UniProtKB: K7EMD3 (UniProtKB/Swiss-Prot),   A7L9S6 (UniProtKB/Swiss-Prot),   Q8N1F2 (UniProtKB/Swiss-Prot),   O60895 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000253796   ⟸   ENST00000253796
RefSeq Acc Id: ENSP00000466455   ⟸   ENST00000587142
RefSeq Acc Id: ENSP00000466980   ⟸   ENST00000588928
RefSeq Acc Id: ENSP00000465725   ⟸   ENST00000588576
RefSeq Acc Id: ENSP00000467463   ⟸   ENST00000589683

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O60895-F1-model_v2 AlphaFold O60895 1-175 view protein structure

Promoters
RGD ID:7235127
Promoter ID:EPDNEW_H23309
Type:initiation region
Name:RAMP2_1
Description:receptor activity modifying protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381742,761,227 - 42,761,287EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9844 AgrOrtholog
COSMIC RAMP2 COSMIC
Ensembl Genes ENSG00000131477 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000253796 ENTREZGENE
  ENST00000253796.10 UniProtKB/Swiss-Prot
  ENST00000587142.5 UniProtKB/Swiss-Prot
  ENST00000588576.1 UniProtKB/TrEMBL
  ENST00000588928.1 UniProtKB/TrEMBL
  ENST00000589683.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000131477 GTEx
HGNC ID HGNC:9844 ENTREZGENE
Human Proteome Map RAMP2 Human Proteome Map
InterPro RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAMP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10266 UniProtKB/Swiss-Prot
NCBI Gene 10266 ENTREZGENE
OMIM 605154 OMIM
PANTHER PTHR14076 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RAMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34203 PharmGKB
UniProt A7L9S6 ENTREZGENE
  K7EKQ3_HUMAN UniProtKB/TrEMBL
  K7EMD3 ENTREZGENE
  K7ENJ8_HUMAN UniProtKB/TrEMBL
  K7EPN3_HUMAN UniProtKB/TrEMBL
  O60895 ENTREZGENE
  Q8N1F2 ENTREZGENE
  RAMP2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A7L9S6 UniProtKB/Swiss-Prot
  K7EMD3 UniProtKB/Swiss-Prot
  Q8N1F2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 RAMP2  receptor activity modifying protein 2  RAMP2  receptor (G protein-coupled) activity modifying protein 2  Symbol and/or name change 5135510 APPROVED