Mcpt2 (mast cell protease 2) - Rat Genome Database

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Gene: Mcpt2 (mast cell protease 2) Mus musculus
Analyze
No known orthologs.
Symbol: Mcpt2
Name: mast cell protease 2
RGD ID: 735288
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in cytoplasm; extracellular space; and intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mcp-; Mcp-2; MMCP-; MMCP-2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,259,041 - 56,282,092 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,279,498 - 56,282,099 (+)EnsemblGRCm39 Ensembl
GRCm381456,021,584 - 56,044,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,042,041 - 56,044,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,660,960 - 56,663,471 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,996,194 - 54,998,705 (+)NCBIMGSCv36mm8
Celera1453,847,333 - 53,849,844 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1372640   PMID:1569097   PMID:1688433   PMID:1995638   PMID:7959952   PMID:8098710   PMID:8917549   PMID:9094993   PMID:9360993   PMID:9541598   PMID:9600738   PMID:10349636  
PMID:10737774   PMID:11042159   PMID:11076861   PMID:11141502   PMID:11217851   PMID:11973313   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16393974   PMID:16807745   PMID:16807746  
PMID:19801677   PMID:21267068   PMID:21873635   PMID:32005755  


Genomics

Variants

.
Variants in Mcpt2
787 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:107
Interacting mature miRNAs:107
Transcripts:ENSMUST00000015576
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015576   ⟹   ENSMUSP00000015576
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1456,279,498 - 56,282,099 (+)Ensembl
GRCm38.p6 Ensembl1456,042,041 - 56,044,642 (+)Ensembl
RefSeq Acc Id: NM_008571   ⟹   NP_032597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391456,279,580 - 56,282,090 (+)NCBI
GRCm381456,042,123 - 56,044,634 (+)NCBI
MGSCv371456,660,960 - 56,663,471 (+)RGD
Celera1453,847,333 - 53,849,844 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011244980   ⟹   XP_011243282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391456,259,041 - 56,282,092 (+)NCBI
GRCm381456,021,584 - 56,044,635 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032597   ⟸   NM_008571
- Peptide Label: precursor
- UniProtKB: P15119 (UniProtKB/Swiss-Prot),   Q541U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243282   ⟸   XM_011244980
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000015576   ⟸   ENSMUST00000015576
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15119-F1-model_v2 AlphaFold P15119 1-244 view protein structure

Promoters
RGD ID:8682494
Promoter ID:EPDNEW_M19278
Type:multiple initiation site
Name:Mcpt2_1
Description:Mus musculus mast cell protease 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381456,042,115 - 56,042,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96938 AgrOrtholog
Ensembl Genes ENSMUSG00000022226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000015576 ENTREZGENE
  ENSMUST00000015576.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17225 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96938 ENTREZGENE
NCBI Gene 17225 ENTREZGENE
PANTHER CHYMASE 2, MAST CELL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mcpt2 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MCPT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q541U2 ENTREZGENE, UniProtKB/TrEMBL