Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | renal cell carcinoma | | ISO | UNC5C (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21600761 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | renal cell carcinoma | | ISO | UNC5C (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21600761 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | Rat neurological mutations cerebellar vermis defect and hobble are caused by mutations in the netrin-1 receptor gene Unc5h3. | Kuramoto T, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):103-8. |
4. | Rat mutations cvd and hob with cerebellar malformations map to chromosome 2. | Kuwamura M, etal., Exp Anim 2004 Jan;53(1):21-6. |
5. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
6. | GOA pipeline | RGD automated data pipeline |
7. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:1401878 | PMID:9126743 | PMID:9389662 | PMID:9550145 | PMID:10818148 | PMID:10964959 | PMID:11387206 | PMID:18077458 | PMID:18479186 | PMID:22685302 | PMID:23144223 | PMID:25419706 |
PMID:27068745 | PMID:28483977 |
Unc5c (Rattus norvegicus - Norway rat) |
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UNC5C (Homo sapiens - human) |
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Unc5c (Mus musculus - house mouse) |
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Unc5c (Chinchilla lanigera - long-tailed chinchilla) |
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UNC5C (Pan paniscus - bonobo/pygmy chimpanzee) |
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UNC5C (Canis lupus familiaris - dog) |
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Unc5c (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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UNC5C (Sus scrofa - pig) |
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UNC5C (Chlorocebus sabaeus - green monkey) |
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Unc5c (Heterocephalus glaber - naked mole-rat) |
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Variants in Unc5c
2378 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D2Rat296 |
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RH138265 |
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AU049740 |
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Unc5c |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 4 | 8 | 2 | 3 | 2 | 48 | 12 | 13 | 2 | ||||
Low | 2 | 28 | 17 | 7 | 16 | 7 | 6 | 6 | 26 | 21 | 24 | 9 | 6 |
Below cutoff | 1 | 11 | 27 | 27 | 27 | 2 | 4 | 2 | 4 | 2 |
RefSeq Transcripts | NM_001415084 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_199407 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039102727 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039102728 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039102729 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB118026 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473952 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000002 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000050330 ⟹ ENSRNOP00000050380 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000082287 ⟹ ENSRNOP00000068741 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000093785 ⟹ ENSRNOP00000095040 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000106798 ⟹ ENSRNOP00000090774 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000108186 ⟹ ENSRNOP00000089543 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000116804 ⟹ ENSRNOP00000087486 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000120185 ⟹ ENSRNOP00000088490 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001415084 ⟹ NP_001402013 | ||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_199407 ⟹ NP_955439 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039102727 ⟹ XP_038958655 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039102728 ⟹ XP_038958656 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039102729 ⟹ XP_038958657 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_001402013 | (Get FASTA) | NCBI Sequence Viewer |
NP_955439 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038958655 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038958656 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038958657 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | BAD05181 | (Get FASTA) | NCBI Sequence Viewer |
EDL82340 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000050380.6 | ||
ENSRNOP00000068741.2 | |||
ENSRNOP00000087486 | |||
ENSRNOP00000087486.1 | |||
ENSRNOP00000088490.1 | |||
ENSRNOP00000089543 | |||
ENSRNOP00000089543.1 | |||
ENSRNOP00000090774 | |||
ENSRNOP00000090774.1 | |||
ENSRNOP00000095040.1 | |||
ENSRNOP00055033097 | |||
ENSRNOP00060000498 | |||
ENSRNOP00065034044 | |||
GenBank Protein | Q761X5 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_955439 ⟸ NM_199407 |
- Peptide Label: | isoform 2 precursor |
- UniProtKB: | Q761X5 (UniProtKB/Swiss-Prot), A0A8I6AAJ4 (UniProtKB/TrEMBL), A6HW54 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000068741 ⟸ ENSRNOT00000082287 |
RefSeq Acc Id: | ENSRNOP00000050380 ⟸ ENSRNOT00000050330 |
RefSeq Acc Id: | XP_038958655 ⟸ XM_039102727 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I6GH52 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038958656 ⟸ XM_039102728 |
- Peptide Label: | isoform X2 |
- UniProtKB: | F1LM73 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038958657 ⟸ XM_039102729 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A0A8I6A7B2 (UniProtKB/TrEMBL), F1LM73 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000088490 ⟸ ENSRNOT00000120185 |
RefSeq Acc Id: | ENSRNOP00000087486 ⟸ ENSRNOT00000116804 |
RefSeq Acc Id: | ENSRNOP00000095040 ⟸ ENSRNOT00000093785 |
RefSeq Acc Id: | ENSRNOP00000089543 ⟸ ENSRNOT00000108186 |
RefSeq Acc Id: | ENSRNOP00000090774 ⟸ ENSRNOT00000106798 |
RefSeq Acc Id: | NP_001402013 ⟸ NM_001415084 |
- Peptide Label: | isoform 1 precursor |
- UniProtKB: | Q761X5 (UniProtKB/Swiss-Prot), A0A8I6AEG2 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q761X5-F1-model_v2 | AlphaFold | Q761X5 | 1-931 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:735109 | AgrOrtholog |
BioCyc Gene | G2FUF-51003 | BioCyc |
Ensembl Genes | ENSRNOG00000029071 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
ENSRNOG00055023546 | UniProtKB/Swiss-Prot | |
ENSRNOG00060000911 | UniProtKB/Swiss-Prot | |
ENSRNOG00065023936 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000050330.6 | UniProtKB/TrEMBL |
ENSRNOT00000082287.2 | UniProtKB/TrEMBL | |
ENSRNOT00000093785.1 | UniProtKB/TrEMBL | |
ENSRNOT00000106798 | ENTREZGENE | |
ENSRNOT00000106798.1 | UniProtKB/TrEMBL | |
ENSRNOT00000108186 | ENTREZGENE | |
ENSRNOT00000108186.1 | UniProtKB/TrEMBL | |
ENSRNOT00000116804.1 | UniProtKB/TrEMBL | |
ENSRNOT00000120185.1 | UniProtKB/TrEMBL | |
ENSRNOT00055040747 | UniProtKB/Swiss-Prot | |
ENSRNOT00060001211 | UniProtKB/Swiss-Prot | |
ENSRNOT00065041654 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 1.10.533.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
2.20.100.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
2.60.220.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
2.60.40.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | DEATH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Death_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Death_UNC5C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig-like_fold | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_I-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ig_sub2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TSP1_rpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TSP1_rpt_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UNC5 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UPA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZU5_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:362049 | UniProtKB/Swiss-Prot |
NCBI Gene | 362049 | ENTREZGENE |
PANTHER | NETRIN RECEPTOR UNC5C | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR12582 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Death | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
I-set | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TSP_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UPA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZU5 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Unc5c | PhenoGen |
PRINTS | TSP1REPEAT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | IG_LIKE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TSP1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZU5 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000029071 | RatGTEx |
ENSRNOG00055023546 | RatGTEx | |
ENSRNOG00060000911 | RatGTEx | |
ENSRNOG00065023936 | RatGTEx | |
SMART | DEATH | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IGc2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00409 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TSP1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZU5 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF47986 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF48726 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF82895 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A0G2JTK0_RAT | UniProtKB/TrEMBL |
A0A8I6A7B2 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6AAJ4 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6AEG2 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6APK1_RAT | UniProtKB/TrEMBL | |
A0A8I6GH52 | ENTREZGENE, UniProtKB/TrEMBL | |
A6HW54 | ENTREZGENE, UniProtKB/TrEMBL | |
F1LM73 | ENTREZGENE, UniProtKB/TrEMBL | |
Q761X5 | ENTREZGENE, UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-06-26 | Unc5c | unc-5 netrin receptor C | Unc5c | unc-5 homolog C (C. elegans) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2004-09-10 | Unc5c | unc-5 homolog C (C. elegans) | Symbol and Name status set to approved | 1299863 | APPROVED |