Nradd (neurotrophin receptor associated death domain) - Rat Genome Database
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Gene: Nradd (neurotrophin receptor associated death domain) Mus musculus
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Symbol: Nradd
Name: neurotrophin receptor associated death domain
RGD ID: 734424
MGI Page MGI
Description: Predicted to have several functions, including death receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in Rho protein signal transduction and positive regulation of cell death. Localizes to lamellipodium; membrane; and nuclear envelope lumen. Is expressed in medulla oblongata and medulla oblongata basal plate mantle layer. Orthologous to human NRADDP (neurotrophin receptor associated death domain, pseudogene); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[b]fluoranthene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2610311B09Rik; BB104149; death domain containing membrane protein NRADD; death domain-containing membrane protein NRADD; neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein; NR; NRDD; NRH2; PL; PLAIDD
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,450,203 - 110,453,461 (-)NCBIGRCm39mm39
GRCm389110,621,135 - 110,624,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,523,639 - 110,526,897 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,465,951 - 110,469,209 (-)NCBImm8
Celera9110,351,068 - 110,354,326 (-)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15028767   PMID:15280425   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693  
PMID:19407813   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23935974   PMID:25093680   PMID:25443284   PMID:27775873  


Genomics

Comparative Map Data
Nradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,450,203 - 110,453,461 (-)NCBIGRCm39mm39
GRCm389110,621,135 - 110,624,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,523,639 - 110,526,897 (-)NCBIGRCm37mm9NCBIm37
MGSCv369110,465,951 - 110,469,209 (-)NCBImm8
Celera9110,351,068 - 110,354,326 (-)NCBICelera
Cytogenetic Map9F2NCBI
NRADDP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl347,010,824 - 47,013,465 (+)EnsemblGRCh38hg38GRCh38
GRCh38347,011,542 - 47,013,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37347,053,032 - 47,054,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36347,028,036 - 47,029,961 (+)NCBINCBI36hg18NCBI36
Celera346,991,549 - 46,993,474 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef347,096,136 - 47,098,062 (+)NCBIHuRef
CHM1_1347,003,417 - 47,005,342 (+)NCBICHM1_1
Nradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08118,890,402 - 118,893,712 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,890,399 - 118,893,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,231,589 - 118,234,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,002,319 - 115,005,292 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,021,773 - 115,024,747 (-)NCBI
Celera8109,884,040 - 109,887,013 (-)NCBICelera
Cytogenetic Map8q32NCBI

Position Markers
BB104149  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,621,139 - 110,621,258UniSTSGRCm38
MGSCv379110,523,643 - 110,523,762UniSTSGRCm37
Celera9110,351,072 - 110,351,191UniSTS
Cytogenetic Map9F2UniSTS
Whitehead/MRC_RH91129.04UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:181
Interacting mature miRNAs:193
Transcripts:ENSMUST00000035069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035069   ⟹   ENSMUSP00000035069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196735   ⟹   ENSMUSP00000143785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,621,508 - 110,623,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196876   ⟹   ENSMUSP00000142925
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,621,885 - 110,624,378 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,622,580 - 110,624,431 (-)Ensembl
RefSeq Acc Id: NM_026012   ⟹   NP_080288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,450,203 - 110,453,461 (-)NCBI
GRCm389110,621,135 - 110,624,393 (-)NCBI
MGSCv379110,523,639 - 110,526,897 (-)RGD
Celera9110,351,068 - 110,354,326 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080288   ⟸   NM_026012
- UniProtKB: Q8CJ26 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035069   ⟸   ENSMUST00000035069
RefSeq Acc Id: ENSMUSP00000142925   ⟸   ENSMUST00000196876
RefSeq Acc Id: ENSMUSP00000143785   ⟸   ENSMUST00000196735
Protein Domains
Death   TNFR_16_TM

Promoters
RGD ID:6844883
Promoter ID:MM_KWN:58920
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,526,781 - 110,527,687 (-)MPROMDB
RGD ID:8671008
Promoter ID:EPDNEW_M13535
Type:initiation region
Name:Nradd_1
Description:Mus musculus neurotrophin receptor associated death domain ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,624,399 - 110,624,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914419 AgrOrtholog
Ensembl Genes ENSMUSG00000032491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142925 UniProtKB/TrEMBL
  ENSMUSP00000143785 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035069 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000196735 UniProtKB/TrEMBL
  ENSMUST00000196876 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67169 UniProtKB/Swiss-Prot
MGD MGI:1914419 ENTREZGENE
NCBI Gene 67169 ENTREZGENE
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nradd PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.46680 ENTREZGENE
UniProt A0A0G2JEW0_MOUSE UniProtKB/TrEMBL
  A0A0G2JH13_MOUSE UniProtKB/TrEMBL
  NRADD_MOUSE UniProtKB/Swiss-Prot
  Q8CHQ4_MOUSE UniProtKB/TrEMBL
  Q8CJ26 ENTREZGENE
  Q9CVM2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TVC1 UniProtKB/Swiss-Prot