Nradd (neurotrophin receptor associated death domain) - Rat Genome Database

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Gene: Nradd (neurotrophin receptor associated death domain) Mus musculus
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Symbol: Nradd
Name: neurotrophin receptor associated death domain
RGD ID: 734424
MGI Page MGI
Description: Predicted to enable several functions, including coreceptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in Rho protein signal transduction. Predicted to act upstream of or within apoptotic process. Located in lamellipodium; membrane; and nuclear envelope lumen. Is expressed in dorsal root ganglion; medulla oblongata; retina layer; and spinal cord. Orthologous to human NRADDP (neurotrophin receptor associated death domain, pseudogene).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2610311B09Rik; BB104149; death domain containing membrane protein NRADD; death domain-containing membrane protein NRADD; neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein; NR; NRDD; NRH2; PL; PLAIDD
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,450,203 - 110,453,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,450,203 - 110,453,520 (-)EnsemblGRCm39 Ensembl
GRCm389110,621,135 - 110,624,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,523,639 - 110,526,897 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,465,951 - 110,469,209 (-)NCBIMGSCv36mm8
Celera9110,351,068 - 110,354,326 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. Wang X, etal., Cell Death Differ 2003 May;10(5):580-91.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15028767   PMID:15280425   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693  
PMID:19407813   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23935974   PMID:25093680   PMID:25443284   PMID:27775873  


Genomics

Comparative Map Data
Nradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,450,203 - 110,453,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,450,203 - 110,453,520 (-)EnsemblGRCm39 Ensembl
GRCm389110,621,135 - 110,624,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,523,639 - 110,526,897 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,465,951 - 110,469,209 (-)NCBIMGSCv36mm8
Celera9110,351,068 - 110,354,326 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.26NCBI
NRADDP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38347,011,542 - 47,013,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl347,011,542 - 47,013,146 (+)EnsemblGRCh38hg38GRCh38
GRCh37347,053,032 - 47,054,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36347,028,036 - 47,029,961 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,991,549 - 46,993,474 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef347,096,136 - 47,098,062 (+)NCBIHuRef
CHM1_1347,003,417 - 47,005,342 (+)NCBICHM1_1
T2T-CHM13v2.0347,027,905 - 47,029,830 (+)NCBIT2T-CHM13v2.0
Nradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,478,055 - 119,481,336 (-)NCBIGRCr8
mRatBN7.28110,599,667 - 110,603,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,599,667 - 110,603,149 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,214,649 - 116,217,623 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,413,844 - 114,416,818 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,256,643 - 112,259,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,890,402 - 118,893,712 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,890,399 - 118,893,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,231,589 - 118,234,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,002,319 - 115,005,292 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,021,773 - 115,024,747 (-)NCBI
Celera8109,884,040 - 109,887,013 (-)NCBICelera
Cytogenetic Map8q32NCBI

Variants

.
Variants in Nradd
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:181
Interacting mature miRNAs:193
Transcripts:ENSMUST00000035069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse

Markers in Region
BB104149  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389110,621,139 - 110,621,258UniSTSGRCm38
MGSCv379110,523,643 - 110,523,762UniSTSGRCm37
Celera9110,351,072 - 110,351,191UniSTS
Cytogenetic Map9F2UniSTS
Whitehead/MRC_RH91129.04UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000035069   ⟹   ENSMUSP00000035069
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,450,203 - 110,453,520 (-)Ensembl
GRCm38.p6 Ensembl9110,621,135 - 110,624,452 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196735   ⟹   ENSMUSP00000143785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,450,576 - 110,452,390 (-)Ensembl
GRCm38.p6 Ensembl9110,621,508 - 110,623,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000196876   ⟹   ENSMUSP00000142925
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,450,953 - 110,453,446 (-)Ensembl
GRCm38.p6 Ensembl9110,621,885 - 110,624,378 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,451,648 - 110,453,499 (-)Ensembl
GRCm38.p6 Ensembl9110,622,580 - 110,624,431 (-)Ensembl
RefSeq Acc Id: NM_026012   ⟹   NP_080288
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,450,203 - 110,453,461 (-)NCBI
GRCm389110,621,135 - 110,624,393 (-)NCBI
MGSCv379110,523,639 - 110,526,897 (-)RGD
Celera9110,351,068 - 110,354,326 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080288   ⟸   NM_026012
- UniProtKB: Q3TVC1 (UniProtKB/Swiss-Prot),   Q8CJ26 (UniProtKB/Swiss-Prot),   A0A0G2JH13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035069   ⟸   ENSMUST00000035069
RefSeq Acc Id: ENSMUSP00000142925   ⟸   ENSMUST00000196876
RefSeq Acc Id: ENSMUSP00000143785   ⟸   ENSMUST00000196735
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJ26-F1-model_v2 AlphaFold Q8CJ26 1-228 view protein structure

Promoters
RGD ID:6844883
Promoter ID:MM_KWN:58920
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,526,781 - 110,527,687 (-)MPROMDB
RGD ID:8671008
Promoter ID:EPDNEW_M13535
Type:initiation region
Name:Nradd_1
Description:Mus musculus neurotrophin receptor associated death domain ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,624,399 - 110,624,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914419 AgrOrtholog
Ensembl Genes ENSMUSG00000032491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035069 ENTREZGENE
  ENSMUST00000035069.14 UniProtKB/Swiss-Prot
  ENSMUST00000196735.2 UniProtKB/TrEMBL
  ENSMUST00000196876.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67169 UniProtKB/Swiss-Prot
MGD MGI:1914419 ENTREZGENE
NCBI Gene 67169 ENTREZGENE
PANTHER DEATH DOMAIN-CONTAINING MEMBRANE PROTEIN NRADD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_16_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nradd PhenoGen
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JEW0_MOUSE UniProtKB/TrEMBL
  A0A0G2JH13 ENTREZGENE, UniProtKB/TrEMBL
  NRADD_MOUSE UniProtKB/Swiss-Prot
  Q3TVC1 ENTREZGENE
  Q8CHQ4_MOUSE UniProtKB/TrEMBL
  Q8CJ26 ENTREZGENE
  Q9CVM2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TVC1 UniProtKB/Swiss-Prot