Adap2 (ArfGAP with dual PH domains 2) - Rat Genome Database
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Gene: Adap2 (ArfGAP with dual PH domains 2) Mus musculus
Analyze
Symbol: Adap2
Name: ArfGAP with dual PH domains 2
RGD ID: 734307
MGI Page MGI
Description: Is expressed in several structures, including brain; future brain; heart; inner ear; and limb bud. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: arf-GAP with dual PH domain-containing protein 2; Cent; Centa2; centaurin, alpha 2; centaurin-alpha-2; cnt-a2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,044,869 - 80,071,449 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,044,931 - 80,069,784 (+)Ensembl
GRCm381180,154,044 - 80,178,827 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,154,105 - 80,178,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv371179,967,664 - 79,992,329 (+)NCBIGRCm37mm9NCBIm37
MGSCv361179,970,357 - 79,995,022 (+)NCBImm8
Celera1189,790,391 - 89,815,051 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
1. MGD data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12696059   PMID:14610273   PMID:15489334   PMID:16138909   PMID:16141072   PMID:16141073  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:24711647   PMID:32325033  


Genomics

Comparative Map Data
Adap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,044,869 - 80,071,449 (+)NCBIGRCm39mm39
GRCm39 Ensembl1180,044,931 - 80,069,784 (+)Ensembl
GRCm381180,154,044 - 80,178,827 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,154,105 - 80,178,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv371179,967,664 - 79,992,329 (+)NCBIGRCm37mm9NCBIm37
MGSCv361179,970,357 - 79,995,022 (+)NCBImm8
Celera1189,790,391 - 89,815,051 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.56NCBI
ADAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1730,906,344 - 30,959,322 (+)EnsemblGRCh38hg38GRCh38
GRCh381730,921,904 - 30,959,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371729,248,963 - 29,286,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361726,272,880 - 26,310,337 (+)NCBINCBI36hg18NCBI36
Build 341726,273,058 - 26,310,335NCBI
Celera1726,169,680 - 26,207,134 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1725,459,432 - 25,496,890 (+)NCBIHuRef
CHM1_11729,311,315 - 29,348,777 (+)NCBICHM1_1
Adap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21065,138,006 - 65,166,147 (+)NCBI
Rnor_6.0 Ensembl1067,494,984 - 67,526,426 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01067,494,851 - 67,527,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01067,153,666 - 67,166,063 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01067,176,542 - 67,184,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41068,360,450 - 68,390,279 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11068,374,072 - 68,403,895 (+)NCBI
Celera1064,100,093 - 64,126,867 (+)NCBICelera
Cytogenetic Map10q25NCBI
Adap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554817,068,219 - 7,094,184 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554817,068,217 - 7,094,946 (+)NCBIChiLan1.0ChiLan1.0
ADAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11725,371,444 - 25,408,751 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1725,371,444 - 25,408,751 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01725,881,050 - 25,920,260 (-)NCBIMhudiblu_PPA_v0panPan3
ADAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl940,819,425 - 40,845,517 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1940,801,120 - 40,845,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365382,767,489 - 2,790,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,817,664 - 42,849,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11242,817,683 - 42,864,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,622,709 - 44,663,307 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,623,548 - 25,658,891 (+)NCBI
ChlSab1.1 Ensembl1625,623,786 - 25,657,029 (+)Ensembl
Adap2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624875174,272 - 203,501 (+)NCBI

Position Markers
Centa2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
cM Map1147.24UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117384671582178599Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117768304780855532Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:345
Count of miRNA genes:291
Interacting mature miRNAs:314
Transcripts:ENSMUST00000021050, ENSMUST00000134118
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021050   ⟹   ENSMUSP00000021050
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,154,105 - 80,178,958 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134118   ⟹   ENSMUSP00000130731
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,154,116 - 80,165,776 (+)Ensembl
RefSeq Acc Id: NM_172133   ⟹   NP_742145
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,044,988 - 80,069,653 (+)NCBI
GRCm381180,154,162 - 80,178,827 (+)NCBI
MGSCv371179,967,664 - 79,992,329 (+)RGD
Celera1189,790,391 - 89,815,051 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156583   ⟹   XP_036012476
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,047,587 - 80,071,449 (+)NCBI
RefSeq Acc Id: XM_036156584   ⟹   XP_036012477
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,044,869 - 80,064,907 (+)NCBI
RefSeq Acc Id: XR_004936920
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,044,869 - 80,064,948 (+)NCBI
RefSeq Acc Id: XR_004936921
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,044,869 - 80,071,449 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_742145   ⟸   NM_172133
- UniProtKB: Q8R2V5 (UniProtKB/Swiss-Prot),   Q5SSK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000130731   ⟸   ENSMUST00000134118
RefSeq Acc Id: ENSMUSP00000021050   ⟸   ENSMUST00000021050
RefSeq Acc Id: XP_036012477   ⟸   XM_036156584
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036012476   ⟸   XM_036156583
- Peptide Label: isoform X1
Protein Domains
Arf-GAP   PH

Promoters
RGD ID:6820305
Promoter ID:MM_KWN:8796
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000000630,   OTTMUST00000000631,   UC007KLL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361179,967,384 - 79,967,884 (+)MPROMDB
RGD ID:8675788
Promoter ID:EPDNEW_M15925
Type:initiation region
Name:Adap2_1
Description:Mus musculus ArfGAP with dual PH domains 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,154,118 - 80,154,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2663075 AgrOrtholog
Ensembl Genes ENSMUSG00000020709 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021050 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000130731 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021050 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000134118 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARFGAP/RecO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH1_ADAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH2_ADAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2663075 ENTREZGENE
NCBI Gene 216991 ENTREZGENE
Pfam ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adap2 PhenoGen
PRINTS REVINTRACTNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARFGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ArfGap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57863 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADAP2_MOUSE UniProtKB/Swiss-Prot
  E9QAL8_MOUSE UniProtKB/TrEMBL
  Q3V340_MOUSE UniProtKB/TrEMBL
  Q5SSK2 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2V5 ENTREZGENE