PTPN21 (protein tyrosine phosphatase non-receptor type 21) - Rat Genome Database

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Gene: PTPN21 (protein tyrosine phosphatase non-receptor type 21) Homo sapiens
Analyze
Symbol: PTPN21
Name: protein tyrosine phosphatase non-receptor type 21
RGD ID: 734205
HGNC Page HGNC
Description: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21); protein tyrosine phosphatase D1; protein-tyrosine phosphatase D1; PTPD1; PTPRL10; tyrosine-protein phosphatase non-receptor type 21
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1488,465,778 - 88,555,007 (-)EnsemblGRCh38hg38GRCh38
GRCh381488,465,778 - 88,555,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371488,932,122 - 89,021,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361488,001,875 - 88,090,876 (-)NCBINCBI36hg18NCBI36
Build 341488,003,869 - 88,090,876NCBI
Celera1468,977,718 - 69,066,716 (-)NCBI
Cytogenetic Map14q31.3NCBI
HuRef1469,102,423 - 69,191,405 (-)NCBIHuRef
CHM1_11488,869,992 - 88,958,966 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
Enterolactone  (EXP)
entinostat  (EXP)
fenamidone  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
genistein  (ISO)
lead diacetate  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methylphenidate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
undecane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:7519780   PMID:7838537   PMID:8889548   PMID:9685376   PMID:10585123   PMID:11013262   PMID:12477932   PMID:15143158   PMID:16344560   PMID:16918960   PMID:18223254   PMID:19000305  
PMID:20923765   PMID:21752600   PMID:21873635   PMID:22810586   PMID:25062045   PMID:25681686   PMID:26186194   PMID:27432908   PMID:27880917   PMID:28514442   PMID:28675297   PMID:29987050  
PMID:30472188   PMID:31217419   PMID:31340145   PMID:31898344   PMID:32296183   PMID:33431714   PMID:33961781  


Genomics

Comparative Map Data
PTPN21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1488,465,778 - 88,555,007 (-)EnsemblGRCh38hg38GRCh38
GRCh381488,465,778 - 88,555,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371488,932,122 - 89,021,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361488,001,875 - 88,090,876 (-)NCBINCBI36hg18NCBI36
Build 341488,003,869 - 88,090,876NCBI
Celera1468,977,718 - 69,066,716 (-)NCBI
Cytogenetic Map14q31.3NCBI
HuRef1469,102,423 - 69,191,405 (-)NCBIHuRef
CHM1_11488,869,992 - 88,958,966 (-)NCBICHM1_1
Ptpn21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,643,000 - 98,703,664 (-)NCBIGRCm39mm39
GRCm39 Ensembl1298,643,000 - 98,703,664 (-)Ensembl
GRCm381298,676,741 - 98,737,613 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,676,741 - 98,737,405 (-)EnsemblGRCm38mm10GRCm38
MGSCv371299,914,951 - 99,975,615 (-)NCBIGRCm37mm9NCBIm37
MGSCv361299,077,792 - 99,135,644 (-)NCBImm8
Celera1299,901,870 - 99,962,936 (-)NCBICelera
Cytogenetic Map12ENCBI
Ptpn21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26117,933,066 - 117,998,095 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl6117,933,066 - 117,998,095 (-)Ensembl
Rnor_6.06122,656,500 - 122,721,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,656,500 - 122,721,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06131,870,742 - 131,942,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46122,840,062 - 122,910,939 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16122,843,808 - 122,914,686 (-)NCBI
Celera6115,494,945 - 115,557,718 (-)NCBICelera
Cytogenetic Map6q32NCBI
Ptpn21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543811,090,044 - 11,153,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543811,087,906 - 11,162,592 (-)NCBIChiLan1.0ChiLan1.0
PTPN21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11488,444,261 - 88,528,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1488,444,261 - 88,528,951 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01469,085,843 - 69,174,659 (-)NCBIMhudiblu_PPA_v0panPan3
PTPN21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,707,192 - 59,783,185 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,708,972 - 59,782,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha859,285,172 - 59,364,633 (-)NCBI
ROS_Cfam_1.0859,976,521 - 60,056,056 (-)NCBI
ROS_Cfam_1.0 Ensembl859,976,546 - 60,051,844 (-)Ensembl
UMICH_Zoey_3.1859,655,290 - 59,735,083 (-)NCBI
UNSW_CanFamBas_1.0859,701,218 - 59,780,673 (-)NCBI
UU_Cfam_GSD_1.0860,034,791 - 60,114,624 (-)NCBI
Ptpn21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,072,021 - 16,147,382 (+)NCBI
SpeTri2.0NW_00493648815,922,624 - 15,996,997 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7110,373,528 - 110,453,813 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17110,374,915 - 110,453,820 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,869,832 - 116,952,531 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12466,102,081 - 66,191,918 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2466,101,788 - 66,187,987 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605353,464,502 - 53,552,903 (-)NCBIVero_WHO_p1.0
Ptpn21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473413,801,739 - 13,866,825 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH70921  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,934,339 - 88,934,605UniSTSGRCh37
Build 361488,004,092 - 88,004,358RGDNCBI36
Celera1468,979,932 - 68,980,198RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,104,637 - 69,104,903UniSTS
GeneMap99-GB4 RH Map14234.46UniSTS
SHGC-35706  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,932,187 - 88,932,388UniSTSGRCh37
Build 361488,001,940 - 88,002,141RGDNCBI36
Celera1468,977,783 - 68,977,984RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,102,488 - 69,102,689UniSTS
GeneMap99-G3 RH Map143625.0UniSTS
RH91423  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,932,205 - 88,932,363UniSTSGRCh37
Build 361488,001,958 - 88,002,116RGDNCBI36
Celera1468,977,801 - 68,977,959RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,102,506 - 69,102,664UniSTS
GeneMap99-GB4 RH Map14233.63UniSTS
G35383  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,949,701 - 88,949,810UniSTSGRCh37
Build 361488,019,454 - 88,019,563RGDNCBI36
Celera1468,995,294 - 68,995,403RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,119,999 - 69,120,108UniSTS
G35957  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371489,011,006 - 89,011,152UniSTSGRCh37
Build 361488,080,759 - 88,080,905RGDNCBI36
Celera1469,056,598 - 69,056,744RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,181,293 - 69,181,439UniSTS
D14S1322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,934,322 - 88,934,462UniSTSGRCh37
Build 361488,004,075 - 88,004,215RGDNCBI36
Celera1468,979,915 - 68,980,055RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,104,620 - 69,104,760UniSTS
GeneMap99-G3 RH Map143630.0UniSTS
G36125  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,961,528 - 88,961,680UniSTSGRCh37
Build 361488,031,281 - 88,031,433RGDNCBI36
Celera1469,007,122 - 69,007,274RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,131,828 - 69,131,980UniSTS
D14S1347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371488,932,205 - 88,932,353UniSTSGRCh37
Build 361488,001,958 - 88,002,106RGDNCBI36
Celera1468,977,801 - 68,977,949RGD
Cytogenetic Map14q31.3UniSTS
HuRef1469,102,506 - 69,102,654UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4227
Count of miRNA genes:1246
Interacting mature miRNAs:1600
Transcripts:ENST00000328736, ENST00000536337, ENST00000553531, ENST00000554178, ENST00000554270, ENST00000554628, ENST00000555243, ENST00000556564, ENST00000557249
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1838 1726 777 109 84 38 3426 1065 866 154 1242 1387 81 1010 2035 3
Low 593 507 942 512 504 425 929 1120 2841 264 206 213 90 194 753 2
Below cutoff 698 1 1 997 1 5 2 2 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_046949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006720011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011536369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI800682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM930068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA860560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000328736   ⟹   ENSP00000330276
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,465,778 - 88,550,622 (-)Ensembl
RefSeq Acc Id: ENST00000536337   ⟹   ENSP00000443951
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,467,955 - 88,550,530 (-)Ensembl
RefSeq Acc Id: ENST00000553531   ⟹   ENSP00000450847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,467,770 - 88,469,616 (-)Ensembl
RefSeq Acc Id: ENST00000554178
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,512,318 - 88,550,619 (-)Ensembl
RefSeq Acc Id: ENST00000554270
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,467,955 - 88,550,530 (-)Ensembl
RefSeq Acc Id: ENST00000554628
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,492,900 - 88,551,489 (-)Ensembl
RefSeq Acc Id: ENST00000555243   ⟹   ENSP00000451401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,504,425 - 88,551,460 (-)Ensembl
RefSeq Acc Id: ENST00000556564   ⟹   ENSP00000452414
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,465,778 - 88,555,007 (-)Ensembl
RefSeq Acc Id: ENST00000557249
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1488,469,965 - 88,473,932 (-)Ensembl
RefSeq Acc Id: NM_007039   ⟹   NP_008970
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,778 - 88,555,007 (-)NCBI
GRCh371488,932,122 - 89,021,123 (-)RGD
Build 361488,001,875 - 88,090,876 (-)NCBI Archive
Celera1468,977,718 - 69,066,716 (-)RGD
HuRef1469,102,423 - 69,191,405 (-)ENTREZGENE
CHM1_11488,869,992 - 88,958,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005267287   ⟹   XP_005267344
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,552,126 (-)NCBI
GRCh371488,932,122 - 89,021,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006720011   ⟹   XP_006720074
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,554,719 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536367   ⟹   XP_011534669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,552,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536368   ⟹   XP_011534670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,526,041 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011536369   ⟹   XP_011534671
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,550,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020938   ⟹   XP_016876427
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,552,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020939   ⟹   XP_016876428
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,465,954 - 88,517,181 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_008970   ⟸   NM_007039
- UniProtKB: Q16825 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005267344   ⟸   XM_005267287
- Peptide Label: isoform X1
- UniProtKB: Q16825 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006720074   ⟸   XM_006720011
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011534669   ⟸   XM_011536367
- Peptide Label: isoform X1
- UniProtKB: Q16825 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534671   ⟸   XM_011536369
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011534670   ⟸   XM_011536368
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016876427   ⟸   XM_017020938
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016876428   ⟸   XM_017020939
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000451401   ⟸   ENST00000555243
RefSeq Acc Id: ENSP00000452414   ⟸   ENST00000556564
RefSeq Acc Id: ENSP00000443951   ⟸   ENST00000536337
RefSeq Acc Id: ENSP00000330276   ⟸   ENST00000328736
RefSeq Acc Id: ENSP00000450847   ⟸   ENST00000553531
Promoters
RGD ID:6791825
Promoter ID:HG_KWN:19951
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid
Transcripts:ENST00000328736
Position:
Human AssemblyChrPosition (strand)Source
Build 361488,086,681 - 88,087,682 (-)MPROMDB
RGD ID:6791826
Promoter ID:HG_KWN:19952
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:UC010ATF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361488,087,399 - 88,087,899 (-)MPROMDB
RGD ID:6791827
Promoter ID:HG_KWN:19953
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_007039
Position:
Human AssemblyChrPosition (strand)Source
Build 361488,090,649 - 88,091,149 (-)MPROMDB
RGD ID:7228325
Promoter ID:EPDNEW_H19908
Type:initiation region
Name:PTPN21_2
Description:protein tyrosine phosphatase, non-receptor type 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19909  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,551,504 - 88,551,564EPDNEW
RGD ID:7228327
Promoter ID:EPDNEW_H19909
Type:initiation region
Name:PTPN21_1
Description:protein tyrosine phosphatase, non-receptor type 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19908  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381488,554,774 - 88,554,834EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
NM_007039.3(PTPN21):c.97G>A (p.Glu33Lys) single nucleotide variant Malignant melanoma [RCV000070637] Chr14:88550321 [GRCh38]
Chr14:89016665 [GRCh37]
Chr14:88086418 [NCBI36]
Chr14:14q31.3
not provided
NM_007039.3(PTPN21):c.229T>G (p.Trp77Gly) single nucleotide variant Malignant melanoma [RCV000062805] Chr14:88517213 [GRCh38]
Chr14:88983557 [GRCh37]
Chr14:88053310 [NCBI36]
Chr14:14q31.3
not provided
NM_007039.4(PTPN21):c.94A>C (p.Asn32His) single nucleotide variant Malignant tumor of prostate [RCV000149190] Chr14:88550324 [GRCh38]
Chr14:89016668 [GRCh37]
Chr14:14q31.3
uncertain significance
GRCh38/hg38 14q31.3(chr14:87746480-88540154)x3 copy number gain See cases [RCV000133861] Chr14:87746480..88540154 [GRCh38]
Chr14:88212824..89006498 [GRCh37]
Chr14:87282577..88076251 [NCBI36]
Chr14:14q31.3
uncertain significance
NM_007039.3:c.1756G>C single nucleotide variant Malignant melanoma of skin [RCV000149758] Chr14:14q31.3 not provided
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q31.3(chr14:88463741-88715010)x1 copy number loss See cases [RCV000136929] Chr14:88463741..88715010 [GRCh38]
Chr14:88930085..89181354 [GRCh37]
Chr14:87999838..88251107 [NCBI36]
Chr14:14q31.3
uncertain significance
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
NM_007039.3(PTPN21):c.829G>A (p.Glu277Lys) single nucleotide variant Malignant melanoma of skin [RCV000149757] Chr14:88497226 [GRCh38]
Chr14:88963570 [GRCh37]
not provided
NM_007039.3(PTPN21):c.2224G>A (p.Asp742Asn) single nucleotide variant Malignant melanoma of skin [RCV000149759] Chr14:88479207 [GRCh38]
Chr14:88945551 [GRCh37]
not provided
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q31.3(chr14:88865689-89340231)x1 copy number loss See cases [RCV000510258] Chr14:88865689..89340231 [GRCh37]
Chr14:14q31.3
uncertain significance
GRCh37/hg19 14q31.3(chr14:88123942-88970366)x1 copy number loss See cases [RCV000511774] Chr14:88123942..88970366 [GRCh37]
Chr14:14q31.3
uncertain significance
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33
pathogenic
GRCh37/hg19 14q31.2-32.2(chr14:84783137-96908198)x1 copy number loss not provided [RCV000683625] Chr14:84783137..96908198 [GRCh37]
Chr14:14q31.2-32.2
pathogenic
GRCh37/hg19 14q31.2-32.2(chr14:84783523-96907490)x1 copy number loss Deletion syndrome [RCV001004048] Chr14:84783523..96907490 [GRCh37]
Chr14:14q31.2-32.2
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
NM_007039.4(PTPN21):c.2262C>T (p.Pro754=) single nucleotide variant not provided [RCV000947587] Chr14:88479169 [GRCh38]
Chr14:88945513 [GRCh37]
Chr14:14q31.3
benign
NM_007039.4(PTPN21):c.1800C>G (p.His600Gln) single nucleotide variant not provided [RCV000947588] Chr14:88479631 [GRCh38]
Chr14:88945975 [GRCh37]
Chr14:14q31.3
benign
NM_007039.4(PTPN21):c.3296G>A (p.Ser1099Asn) single nucleotide variant not provided [RCV000947586] Chr14:88469016 [GRCh38]
Chr14:88935360 [GRCh37]
Chr14:14q31.3
benign
GRCh37/hg19 14q31.3(chr14:88843652-89040286)x3 copy number gain not provided [RCV000849822] Chr14:88843652..89040286 [GRCh37]
Chr14:14q31.3
uncertain significance
NC_000014.8:g.(?_88852143)_(89343774_?)dup duplication Bardet-Biedl syndrome [RCV000800032] Chr14:88385799..88877430 [GRCh38]
Chr14:88852143..89343774 [GRCh37]
Chr14:14q31.3
uncertain significance
GRCh37/hg19 14q24.3-32.11(chr14:77274990-89803137)x1 copy number loss not provided [RCV000847566] Chr14:77274990..89803137 [GRCh37]
Chr14:14q24.3-32.11
pathogenic
NM_007039.4(PTPN21):c.2356C>G (p.Pro786Ala) single nucleotide variant not provided [RCV000910312] Chr14:88479075 [GRCh38]
Chr14:88945419 [GRCh37]
Chr14:14q31.3
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9651 AgrOrtholog
COSMIC PTPN21 COSMIC
Ensembl Genes ENSG00000070778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000330276 UniProtKB/Swiss-Prot
  ENSP00000443951 UniProtKB/TrEMBL
  ENSP00000450847 UniProtKB/TrEMBL
  ENSP00000451401 UniProtKB/TrEMBL
  ENSP00000452414 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000328736 UniProtKB/Swiss-Prot
  ENST00000536337 UniProtKB/TrEMBL
  ENST00000553531 UniProtKB/TrEMBL
  ENST00000555243 UniProtKB/TrEMBL
  ENST00000556564 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000070778 GTEx
HGNC ID HGNC:9651 ENTREZGENE
Human Proteome Map PTPN21 Human Proteome Map
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_non-rcpt_14/21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPN14/21_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11099 UniProtKB/Swiss-Prot
NCBI Gene 11099 ENTREZGENE
OMIM 603271 OMIM
Pfam FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33994 PharmGKB
PIRSF Tyr-Ptase_nr14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V1Q9_HUMAN UniProtKB/TrEMBL
  G3V3S6_HUMAN UniProtKB/TrEMBL
  H0YJ59_HUMAN UniProtKB/TrEMBL
  PTN21_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q8WX29_HUMAN UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN21  protein tyrosine phosphatase non-receptor type 21    protein tyrosine phosphatase, non-receptor type 21  Symbol and/or name change 5135510 APPROVED
2011-09-01 PTPN21  protein tyrosine phosphatase, non-receptor type 21  PTPN21  protein tyrosine phosphatase, non-receptor type 21  Symbol and/or name change 5135510 APPROVED