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Gene: PTPN6 (protein tyrosine phosphatase non-receptor type 6) Homo sapiens
Symbol: PTPN6
Name: protein tyrosine phosphatase non-receptor type 6
RGD ID: 734188
Description: Exhibits several functions, including phosphorylation-dependent protein binding activity; phosphotyrosine residue binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including cellular protein modification process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of protein phosphorylation. Localizes to cytoplasm; nuclear lumen; and protein-containing complex. Biomarker of anogenital venereal wart and cervical cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HCP; HCPH; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein-tyrosine phosphatase 1C; protein-tyrosine phosphatase SHP-1; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; tyrosine-protein phosphatase non-receptor type 6
Mus musculus (house mouse) : Ptpn6 (protein tyrosine phosphatase, non-receptor type 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpn6 (protein tyrosine phosphatase, non-receptor type 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Canis lupus familiaris (dog) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
Sus scrofa (pig) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Chlorocebus sabaeus (African green monkey) : PTPN6 (protein tyrosine phosphatase non-receptor type 6)
Heterocephalus glaber (naked mole-rat) : Ptpn6 (protein tyrosine phosphatase non-receptor type 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl126,946,468 - 6,961,316 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,946,577 - 6,961,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,055,740 - 7,070,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,926,001 - 6,940,740 (+)NCBINCBI36hg18NCBI36
Build 34126,930,762 - 6,940,740NCBI
Celera128,674,361 - 8,691,497 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,911,844 - 6,928,943 (+)NCBIHuRef
CHM1_1127,054,727 - 7,069,431 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPN6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734188
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.