Rhoq (ras homolog family member Q) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rhoq (ras homolog family member Q) Mus musculus
Analyze
Symbol: Rhoq
Name: ras homolog family member Q
RGD ID: 734158
MGI Page MGI
Description: Predicted to enable several functions, including GBD domain binding activity; GTP binding activity; and profilin binding activity. Involved in cellular response to insulin stimulus; cortical actin cytoskeleton organization; and negative regulation of protein localization to plasma membrane. Acts upstream of or within regulation of cell shape. Located in membrane raft. Is expressed in telencephalon. Orthologous to human RHOQ (ras homolog family member Q); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ar; Arhq; ras homolog gene family, member Q; ras-like protein TC10; ras-related GTP-binding protein TC10; rho-related GTP-binding protein RhoQ; small GTPase Tc10; Tc10; TC10A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,270,539 - 87,307,497 (+)NCBIGRCm39mm39
GRCm39 Ensembl1787,270,510 - 87,307,497 (+)Ensembl
GRCm381786,963,111 - 87,000,069 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,963,082 - 87,000,069 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,362,451 - 87,399,409 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,871,437 - 86,908,395 (+)NCBImm8
MGSCv361786,286,620 - 86,323,731 (+)NCBImm8
Celera1791,341,979 - 91,379,066 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fumonisin B1  (EXP)
gadodiamide hydrate  (ISO)
genistein  (ISO)
isobutanol  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
Soman  (ISO)
succimer  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vitamin E  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10490598   PMID:10967094   PMID:11162552   PMID:11309621   PMID:11821390   PMID:12215429   PMID:12456725   PMID:12477932   PMID:12529401   PMID:12773384   PMID:14734537  
PMID:15489334   PMID:15782199   PMID:16525015   PMID:16602821   PMID:17008399   PMID:18434594   PMID:18948252   PMID:21873635   PMID:24154525   PMID:25211221   PMID:26410627   PMID:28747344  
PMID:29891904   PMID:33156548  


Genomics

Comparative Map Data
Rhoq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,270,539 - 87,307,497 (+)NCBIGRCm39mm39
GRCm39 Ensembl1787,270,510 - 87,307,497 (+)Ensembl
GRCm381786,963,111 - 87,000,069 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,963,082 - 87,000,069 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,362,451 - 87,399,409 (+)NCBIGRCm37mm9NCBIm37
MGSCv361786,871,437 - 86,908,395 (+)NCBImm8
MGSCv361786,286,620 - 86,323,731 (+)NCBImm8
Celera1791,341,979 - 91,379,066 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
RHOQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl246,541,806 - 46,584,688 (+)EnsemblGRCh38hg38GRCh38
GRCh38246,542,409 - 46,584,688 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37246,769,629 - 46,811,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,623,371 - 46,665,331 (+)NCBINCBI36hg18NCBI36
Build 34246,681,525 - 46,721,071NCBI
Celera246,608,550 - 46,650,502 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef246,508,355 - 46,549,243 (+)NCBIHuRef
CHM1_1246,700,205 - 46,742,118 (+)NCBICHM1_1
Rhoq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.267,613,632 - 7,652,047 (-)NCBImRatBN7.2
Rnor_6.0610,533,151 - 10,568,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,533,151 - 10,568,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,521,668 - 20,557,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,414,042 - 10,449,472 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1610,414,041 - 10,449,471 (+)NCBI
Celera67,350,412 - 7,385,836 (-)NCBICelera
Cytogenetic Map6q12NCBI
Rhoq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,457,757 - 13,495,221 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,457,757 - 13,495,221 (+)NCBIChiLan1.0ChiLan1.0
RHOQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A47,589,343 - 47,629,200 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A46,657,884 - 46,698,604 (+)NCBIMhudiblu_PPA_v0panPan3
RHOQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,766,623 - 48,807,198 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,768,191 - 48,804,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,621,692 - 48,661,408 (+)NCBI
ROS_Cfam_1.01049,638,479 - 49,678,182 (+)NCBI
UMICH_Zoey_3.11049,346,518 - 49,386,173 (+)NCBI
UNSW_CanFamBas_1.01049,636,763 - 49,676,458 (+)NCBI
UU_Cfam_GSD_1.01049,819,868 - 49,859,560 (+)NCBI
Rhoq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,265,228 - 34,298,999 (-)NCBI
SpeTri2.0NW_0049365085,692,482 - 5,727,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,973,622 - 94,012,580 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1393,970,545 - 94,012,660 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,054,930 - 100,097,052 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,605,881 - 60,648,444 (-)NCBI
ChlSab1.1 Ensembl1460,608,998 - 60,648,193 (-)Ensembl
Vero_WHO_p1.0NW_02366604551,197,579 - 51,238,229 (+)NCBI
Rhoq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473827,997,493 - 28,031,840 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175680065690800808Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175680065690800808Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175680065690800808Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175680065690800808Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175680065690800808Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175680065690800808Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175722744793199751Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5728209491282202Mouse
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176199358194987271Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176199358194987271Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176357811994987271Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176490750994987271Mouse
14928308Manh82_mmandible shape 82 (mouse)176600781494987271Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176863389194987271Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177039377094987271Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177039377094987271Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177039377094987271Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177039377094987271Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177308770494987271Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177308770494987271Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7380065693199751Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177428209490087842Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177428209490087842Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178050000091100000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1171
Count of miRNA genes:637
Interacting mature miRNAs:781
Transcripts:ENSMUST00000024956, ENSMUST00000139344
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000024956   ⟹   ENSMUSP00000024956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,270,510 - 87,307,497 (+)Ensembl
GRCm38.p6 Ensembl1786,963,082 - 87,000,069 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139344   ⟹   ENSMUSP00000116780
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,270,720 - 87,302,526 (+)Ensembl
GRCm38.p6 Ensembl1786,963,292 - 86,995,098 (+)Ensembl
RefSeq Acc Id: ENSMUST00000234309   ⟹   ENSMUSP00000157092
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,302,023 - 87,304,856 (+)Ensembl
GRCm38.p6 Ensembl1786,994,595 - 86,997,428 (+)Ensembl
RefSeq Acc Id: NM_145491   ⟹   NP_663466
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391787,270,539 - 87,307,497 (+)NCBI
GRCm381786,963,111 - 87,000,069 (+)NCBI
MGSCv371787,362,451 - 87,399,409 (+)RGD
Celera1791,341,979 - 91,379,066 (+)RGD
cM Map17 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_663466 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH48813 (Get FASTA)   NCBI Sequence Viewer  
  AAH56363 (Get FASTA)   NCBI Sequence Viewer  
  BAB91068 (Get FASTA)   NCBI Sequence Viewer  
  EDL38618 (Get FASTA)   NCBI Sequence Viewer  
  Q8R527 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_663466   ⟸   NM_145491
- UniProtKB: Q8R527 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000116780   ⟸   ENSMUST00000139344
RefSeq Acc Id: ENSMUSP00000024956   ⟸   ENSMUST00000024956
RefSeq Acc Id: ENSMUSP00000157092   ⟸   ENSMUST00000234309

Promoters
RGD ID:13676934
Promoter ID:EPDNEW_M22616
Type:initiation region
Name:Rhoq_2
Description:Mus musculus ras homolog family member Q , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22617  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381786,963,084 - 86,963,144EPDNEW
RGD ID:13676936
Promoter ID:EPDNEW_M22617
Type:initiation region
Name:Rhoq_1
Description:Mus musculus ras homolog family member Q , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22616  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381786,963,295 - 86,963,355EPDNEW
RGD ID:6828564
Promoter ID:MM_KWN:24382
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000059651,   OTTMUST00000059652
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,361,666 - 87,362,712 (+)MPROMDB
RGD ID:6847449
Promoter ID:MM_ACW:23844
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:RHOQ.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,363,756 - 87,364,256 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931553 AgrOrtholog
Ensembl Genes ENSMUSG00000024143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000024956 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116780 UniProtKB/TrEMBL
  ENSMUSP00000157092 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024956 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000139344 UniProtKB/TrEMBL
  ENSMUST00000234309 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104215 UniProtKB/Swiss-Prot
MGD MGI:1931553 ENTREZGENE
NCBI Gene 104215 ENTREZGENE
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhoq PhenoGen
PROSITE RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EHR0_MOUSE UniProtKB/TrEMBL
  D3Z3L1_MOUSE UniProtKB/TrEMBL
  Q8R527 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q7TNC0 UniProtKB/Swiss-Prot
  Q80VH4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Rhoq  ras homolog family member Q    ras homolog gene family, member Q  Symbol and/or name change 5135510 APPROVED