Rtn4r (reticulon 4 receptor) - Rat Genome Database

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Gene: Rtn4r (reticulon 4 receptor) Mus musculus
Analyze
Symbol: Rtn4r
Name: reticulon 4 receptor
RGD ID: 734084
MGI Page MGI
Description: Enables chondroitin sulfate binding activity; heparin binding activity; and neuregulin receptor activity. Involved in several processes, including corpus callosum development; negative regulation of neuron projection development; and neuronal signal transduction. Acts upstream of or within axonogenesis. Located in several cellular components, including axonal growth cone; dendritic shaft; and neuronal cell body. Is expressed in several structures, including cardiovascular system; forelimb bud; intestine; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: N; Ng; NgR; NgR1; nogo receptor; Nogo-66 receptor; nogo66 receptor-1; NOGOR; reticulon-4 receptor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,945,506 - 17,970,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,945,506 - 17,970,272 (+)EnsemblGRCm39 Ensembl
GRCm381618,127,642 - 18,152,408 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,127,642 - 18,152,408 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,127,799 - 18,152,501 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,041,269 - 18,065,971 (+)NCBIMGSCv36mm8
Celera1618,700,292 - 18,725,154 (+)NCBICelera
Cytogenetic Map16A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11201742   PMID:11777918   PMID:11891768   PMID:12089450   PMID:12097502   PMID:12378589   PMID:12477932   PMID:12764110   PMID:12839991   PMID:14614146   PMID:14664809  
PMID:15121177   PMID:15489334   PMID:15504325   PMID:15647357   PMID:15866044   PMID:16092935   PMID:16195464   PMID:16407455   PMID:16452662   PMID:16602821   PMID:17122049   PMID:17329206  
PMID:17470639   PMID:17572674   PMID:18043741   PMID:18182498   PMID:18214994   PMID:18334965   PMID:18337405   PMID:18411262   PMID:18632947   PMID:18775783   PMID:19052207   PMID:19158290  
PMID:19243684   PMID:19367338   PMID:19400741   PMID:19439611   PMID:19500648   PMID:19833111   PMID:19889996   PMID:19915139   PMID:20093372   PMID:20351248   PMID:20562862   PMID:20573699  
PMID:20809785   PMID:20844138   PMID:21057507   PMID:21267068   PMID:21454605   PMID:21491433   PMID:21645550   PMID:21677750   PMID:21768085   PMID:21817055   PMID:21821099   PMID:21873635  
PMID:21906273   PMID:22096481   PMID:22162062   PMID:22260793   PMID:22281491   PMID:22325200   PMID:22406547   PMID:22728374   PMID:22923615   PMID:22964785   PMID:22967270   PMID:23045690  
PMID:23055483   PMID:23223298   PMID:23473316   PMID:23829864   PMID:24194600   PMID:24339996   PMID:24449409   PMID:24594926   PMID:24741044   PMID:24860456   PMID:24922571   PMID:24952961  
PMID:25034269   PMID:25164659   PMID:25386856   PMID:25632122   PMID:25662716   PMID:26083872   PMID:26335717   PMID:26367446   PMID:26472557   PMID:26472924   PMID:26586827   PMID:26838771  
PMID:27138950   PMID:27166169   PMID:27339102   PMID:27798181   PMID:27956620   PMID:28000762   PMID:28297672   PMID:28827698   PMID:28935984   PMID:29024660   PMID:29196321   PMID:29615517  
PMID:29768445   PMID:29887305   PMID:30225353   PMID:30226403   PMID:30612149   PMID:30787106   PMID:30804090   PMID:31061088   PMID:32201946   PMID:32325033   PMID:33536561   PMID:35353001  


Genomics

Comparative Map Data
Rtn4r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,945,506 - 17,970,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,945,506 - 17,970,272 (+)EnsemblGRCm39 Ensembl
GRCm381618,127,642 - 18,152,408 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,127,642 - 18,152,408 (+)EnsemblGRCm38mm10GRCm38
MGSCv371618,127,799 - 18,152,501 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,041,269 - 18,065,971 (+)NCBIMGSCv36mm8
Celera1618,700,292 - 18,725,154 (+)NCBICelera
Cytogenetic Map16A3NCBI
RTN4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,241,415 - 20,268,318 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2220,241,415 - 20,283,246 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,228,938 - 20,255,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,608,938 - 18,635,816 (-)NCBINCBI36Build 36hg18NCBI36
Celera224,079,624 - 4,107,575 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,848,286 - 3,849,983 (-)NCBIHuRef
CHM1_12220,228,468 - 20,255,665 (-)NCBICHM1_1
T2T-CHM13v2.02220,621,207 - 20,649,434 (-)NCBIT2T-CHM13v2.0
Rtn4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,844,585 - 82,869,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,844,309 - 82,869,466 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,572,958 - 91,597,436 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01184,234,074 - 84,258,552 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01183,287,699 - 83,312,175 (-)NCBIRnor_WKY
Rnor_6.01186,992,665 - 87,017,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,992,399 - 87,017,115 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,085,449 - 90,109,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,839,082 - 84,863,508 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11184,879,678 - 84,904,105 (-)NCBI
Celera1181,620,565 - 81,644,966 (-)NCBICelera
Cytogenetic Map11q23NCBI
Rtn4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,866,398 - 17,891,820 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,866,508 - 17,891,803 (+)NCBIChiLan1.0ChiLan1.0
RTN4R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12218,673,548 - 18,675,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2218,673,548 - 18,680,017 (-)Ensemblpanpan1.1panPan2
RTN4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,109,991 - 29,117,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,113,428 - 29,115,918 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,049,600 - 29,074,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,493,710 - 30,518,771 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,493,543 - 30,518,786 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,542,789 - 28,567,865 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,168,179 - 28,193,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,252,843 - 29,277,947 (+)NCBIUU_Cfam_GSD_1.0
Rtn4r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118138,598,174 - 138,623,308 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366194,130,748 - 4,155,894 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366194,130,757 - 4,155,885 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTN4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,579,046 - 51,602,968 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,579,043 - 51,603,180 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21455,216,090 - 55,240,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RTN4R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,469,854 - 5,497,858 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660851,437,876 - 1,466,276 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rtn4r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747829,850 - 855,991 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624747829,947 - 855,942 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:162
Interacting mature miRNAs:179
Transcripts:ENSMUST00000059589
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse

Markers in Region
Rtn4r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371618,151,862 - 18,152,392UniSTSGRCm37
Celera1618,724,515 - 18,725,045UniSTS
Cytogenetic Map16B1UniSTS
cM Map16 UniSTS
Rtn4r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381618,151,769 - 18,152,299UniSTSGRCm38
MGSCv371618,151,862 - 18,152,392UniSTSGRCm37
Celera1618,724,515 - 18,725,045UniSTS
Cytogenetic Map16B1UniSTS
cM Map16 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000059589   ⟹   ENSMUSP00000062924
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,945,506 - 17,970,272 (+)Ensembl
GRCm38.p6 Ensembl1618,127,642 - 18,152,408 (+)Ensembl
RefSeq Acc Id: NM_022982   ⟹   NP_075358
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,945,506 - 17,970,272 (+)NCBI
GRCm381618,127,642 - 18,152,408 (+)NCBI
MGSCv371618,127,799 - 18,152,501 (+)RGD
Celera1618,700,292 - 18,725,154 (+)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075358   ⟸   NM_022982
- Peptide Label: precursor
- UniProtKB: Q80WQ1 (UniProtKB/Swiss-Prot),   Q99PI8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062924   ⟸   ENSMUST00000059589
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PI8-F1-model_v2 AlphaFold Q99PI8 1-473 view protein structure

Promoters
RGD ID:8685718
Promoter ID:EPDNEW_M20859
Type:initiation region
Name:Rtn4r_1
Description:Mus musculus reticulon 4 receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381618,127,676 - 18,127,736EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136886 AgrOrtholog
Ensembl Genes ENSMUSG00000043811 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000062924 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059589 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:65079 UniProtKB/Swiss-Prot
MGD MGI:2136886 ENTREZGENE
NCBI Gene 65079 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot
PhenoGen Rtn4r PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
SMART LRR_TYP UniProtKB/Swiss-Prot
UniProt Q80WQ1 ENTREZGENE
  Q99PI8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q80WQ1 UniProtKB/Swiss-Prot