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Gene: Cyth2 (cytohesin 2) Mus musculus
Symbol: Cyth2
Name: cytohesin 2
Description: Exhibits ARF guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Predicted to be involved in negative regulation of dendrite development and regulation of cell adhesion. Localizes to the bicellular tight junction. Orthologous to human CYTH2 (cytohesin 2); PARTICIPATES IN Arf family mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[b]fluoranthene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ARF nucleotide-binding site opener; ARNO; CLM2; cytohesin-2; mSec7-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; Pscd2; SEC7 homolog B
Homo sapiens (human) : CYTH2 (cytohesin 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyth2 (cytohesin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cyth2 (cytohesin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CYTH2 (cytohesin 2)
Canis lupus familiaris (dog) : CYTH2 (cytohesin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cyth2 (cytohesin 2)
Sus scrofa (pig) : CYTH2 (cytohesin 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38745,806,637 - 45,814,322 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37753,062,007 - 53,069,686 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,674,679 - 45,682,328 (-)NCBImm8
Celera741,270,769 - 41,278,444 (-)NCBICelera
Cytogenetic Map7 B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyth2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734081
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.