Fzd9 (frizzled class receptor 9) - Rat Genome Database

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Gene: Fzd9 (frizzled class receptor 9) Mus musculus
Analyze
Symbol: Fzd9
Name: frizzled class receptor 9
RGD ID: 734068
MGI Page MGI
Description: Enables Wnt receptor activity. Involved in several processes, including bone regeneration; negative regulation of skeletal muscle acetylcholine-gated channel clustering; and positive regulation of bone mineralization. Acts upstream of or within B cell differentiation; learning or memory; and neuroblast proliferation. Located in filopodium membrane and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; gonad; sensory organ; and skeleton. Used to study Williams-Beuren syndrome. Orthologous to human FZD9 (frizzled class receptor 9).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: frizzled homolog 9; frizzled-9; fz-9; Fz9; mFz3; mfz9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,277,792 - 135,279,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,277,792 - 135,280,084 (-)EnsemblGRCm39 Ensembl
GRCm385135,248,938 - 135,251,047 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,248,938 - 135,251,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,724,808 - 135,726,917 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,533,564 - 135,535,674 (-)NCBIMGSCv36mm8
Celera5132,260,609 - 132,262,718 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C and Merrick BA, Differentiation. 2008 Jan 2;.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
10. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, etal., Genomics 2000 Oct 1;69(1):1-13.
Additional References at PubMed
PMID:8889548   PMID:10198163   PMID:10349636   PMID:10559494   PMID:10575226   PMID:11042159   PMID:11076861   PMID:11334716   PMID:11335128   PMID:11440986   PMID:11455436   PMID:11685582  
PMID:11779826   PMID:12412008   PMID:12812787   PMID:15226823   PMID:15245425   PMID:15342465   PMID:15354291   PMID:15472464   PMID:15572594   PMID:15800025   PMID:15858069   PMID:15930120  
PMID:15939089   PMID:16141072   PMID:16141073   PMID:16510140   PMID:16602821   PMID:16783635   PMID:17064353   PMID:17145500   PMID:17576136   PMID:17582687   PMID:17804636   PMID:18351662  
PMID:18351675   PMID:18364260   PMID:18635608   PMID:18800919   PMID:19179304   PMID:19285468   PMID:19562671   PMID:19716861   PMID:21041481   PMID:21267068   PMID:21325536   PMID:21402791  
PMID:21731673   PMID:21873635   PMID:24151333   PMID:24391920   PMID:24860427   PMID:24952961   PMID:27402827   PMID:28813421   PMID:31351040   PMID:32404924   PMID:32511952   PMID:33141892  
PMID:33653688   PMID:34759273   PMID:35707728  


Genomics

Comparative Map Data
Fzd9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,277,792 - 135,279,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,277,792 - 135,280,084 (-)EnsemblGRCm39 Ensembl
GRCm385135,248,938 - 135,251,047 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,248,938 - 135,251,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,724,808 - 135,726,917 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,533,564 - 135,535,674 (-)NCBIMGSCv36mm8
Celera5132,260,609 - 132,262,718 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.08NCBI
FZD9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,433,778 - 73,436,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl773,433,778 - 73,436,120 (+)EnsemblGRCh38hg38GRCh38
GRCh37772,848,108 - 72,850,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,486,045 - 72,488,386 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,292,963 - 72,295,149NCBI
Celera768,326,020 - 68,328,361 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef768,729,438 - 68,731,779 (+)NCBIHuRef
CHM1_1772,993,577 - 72,995,918 (+)NCBICHM1_1
T2T-CHM13v2.0774,634,272 - 74,636,614 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,181,181 - 72,183,522 (+)NCBI
Fzd9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,427,084 - 21,429,398 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,427,084 - 21,429,398 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,568,651 - 22,570,965 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01223,180,980 - 23,183,294 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01222,247,456 - 22,249,770 (+)NCBIRnor_WKY
Rnor_6.01224,473,981 - 24,476,295 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,473,981 - 24,476,295 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,471,284 - 26,473,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,581,510 - 22,583,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,572,254 - 22,574,569 (+)NCBI
Celera1223,189,657 - 23,191,971 (+)NCBICelera
Cytogenetic Map12q12NCBI
Fzd9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,246,324 - 14,247,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,245,994 - 14,247,551 (-)NCBIChiLan1.0ChiLan1.0
FZD9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1780,588,167 - 80,590,337 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,588,167 - 80,590,337 (+)Ensemblpanpan1.1panPan2
FZD9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,782,394 - 6,784,565 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,782,774 - 6,784,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,479,582 - 8,481,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,597,879 - 6,600,019 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,598,235 - 6,600,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,573,034 - 6,575,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,535,346 - 6,537,484 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,698,260 - 6,700,400 (-)NCBIUU_Cfam_GSD_1.0
Fzd9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,326,748 - 131,328,721 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365432,707,846 - 2,709,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,754,783 - 10,757,147 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,753,294 - 10,762,812 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,454,083 - 10,460,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FZD9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,621,434 - 9,623,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,621,770 - 9,623,545 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,849,337 - 6,851,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,323,817 - 14,325,601 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,323,445 - 14,325,616 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,249,465 - 135,249,733UniSTSGRCm38
MGSCv375135,725,335 - 135,725,603UniSTSGRCm37
Celera5132,261,136 - 132,261,404UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,249,465 - 135,249,719UniSTSGRCm38
MGSCv375135,725,335 - 135,725,589UniSTSGRCm37
Celera5132,261,136 - 132,261,390UniSTS
Cytogenetic Map5G2UniSTS
cM Map575.0UniSTS
Fzd10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,249,606 - 135,249,784UniSTSGRCm38
MGSCv375135,725,476 - 135,725,654UniSTSGRCm37
Celera5132,261,277 - 132,261,455UniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map5G2UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,249,606 - 135,249,784UniSTSGRCm38
MGSCv375135,725,476 - 135,725,654UniSTSGRCm37
Celera5132,261,277 - 132,261,455UniSTS
Cytogenetic Map5G2UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,249,003 - 135,249,484UniSTSGRCm38
MGSCv375135,724,873 - 135,725,354UniSTSGRCm37
Celera5132,260,674 - 132,261,155UniSTS
Cytogenetic Map5G2UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
Fzd9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:168
Interacting mature miRNAs:195
Transcripts:ENSMUST00000062572
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062572   ⟹   ENSMUSP00000053551
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,277,792 - 135,280,084 (-)Ensembl
GRCm38.p6 Ensembl5135,248,938 - 135,251,230 (-)Ensembl
RefSeq Acc Id: NM_010246   ⟹   NP_034376
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395135,277,792 - 135,279,901 (-)NCBI
GRCm385135,248,938 - 135,251,047 (-)ENTREZGENE
MGSCv375135,724,808 - 135,726,917 (-)RGD
Celera5132,260,609 - 132,262,718 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034376   ⟸   NM_010246
- Peptide Label: precursor
- UniProtKB: Q9R2B3 (UniProtKB/Swiss-Prot),   Q9R216 (UniProtKB/Swiss-Prot),   A0A8C6MUP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000053551   ⟸   ENSMUST00000062572
Protein Domains
FZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R216-F1-model_v2 AlphaFold Q9R216 1-592 view protein structure

Promoters
RGD ID:6888314
Promoter ID:EPDNEW_M7608
Type:initiation region
Name:Fzd9_1
Description:Mus musculus frizzled class receptor 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385135,251,001 - 135,251,061EPDNEW
RGD ID:6837546
Promoter ID:MM_KWN:44348
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver
Transcripts:NM_010246
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365135,725,261 - 135,727,142 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1313278 AgrOrtholog
Ensembl Genes ENSMUSG00000049551 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000053551 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062572 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  FZ9_CRD UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
KEGG Report mmu:14371 UniProtKB/Swiss-Prot
MGD MGI:1313278 ENTREZGENE
NCBI Gene 14371 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
Pfam Frizzled UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PhenoGen Fzd9 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
SMART FRI UniProtKB/Swiss-Prot
  Frizzled UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot
UniProt A0A8C6MUP0 ENTREZGENE
  FZD9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R2B3 ENTREZGENE
UniProt Secondary O35494 UniProtKB/Swiss-Prot
  Q9CX16 UniProtKB/Swiss-Prot
  Q9R2B3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Fzd9  frizzled class receptor 9    frizzled homolog 9 (Drosophila)  Symbol and/or name change 5135510 APPROVED