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Gene: NPAS4 (neuronal PAS domain protein 4) Homo sapiens
Symbol: NPAS4
Name: neuronal PAS domain protein 4
RGD ID: 734007
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHe79; class E basic helix-loop-helix protein 79; HLH-PAS transcription factor NXF; Le-PAS; neuronal PAS domain-containing protein 4; neuronal PAS4; NXF; PAS domain-containing protein 10; PASD10
Mus musculus (house mouse) : Npas4 (neuronal PAS domain protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Npas4 (neuronal PAS domain protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npas4 (neuronal PAS domain protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NPAS4 (neuronal PAS domain protein 4)
Canis lupus familiaris (dog) : NPAS4 (neuronal PAS domain protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npas4 (neuronal PAS domain protein 4)
Sus scrofa (pig) : NPAS4 (neuronal PAS domain protein 4)
Chlorocebus sabaeus (African green monkey) : NPAS4 (neuronal PAS domain protein 4)
Heterocephalus glaber (naked mole-rat) : Npas4 (neuronal PAS domain protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1166,421,004 - 66,426,707 (+)EnsemblGRCh38hg38GRCh38
GRCh381166,408,922 - 66,426,707 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,188,475 - 66,194,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,945,051 - 65,950,753 (+)NCBINCBI36hg18NCBI36
Build 341165,945,050 - 65,950,753NCBI
Celera1163,508,508 - 63,514,210 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1162,516,143 - 62,521,845 (+)NCBIHuRef
CHM1_11166,072,529 - 66,078,231 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NPAS4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734007
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.