Reg3a (regenerating islet-derived 3 alpha) - Rat Genome Database
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Gene: Reg3a (regenerating islet-derived 3 alpha) Mus musculus
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Symbol: Reg3a
Name: regenerating islet-derived 3 alpha
RGD ID: 733989
MGI Page MGI
Description: Is expressed in gut and pancreas. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AV063448; generating islet-derived, mouse homolog 3 alpha; islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; reg III-alpha; REG-3-alpha; regenerating islet-derived protein 3-alpha; regenerating islet-derived protein III-alpha; RegIII (alpha)
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,357,692 - 78,360,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,357,692 - 78,360,810 (+)Ensembl
GRCm38678,380,709 - 78,383,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,380,709 - 78,383,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,330,703 - 78,333,833 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,310,218 - 78,313,348 (+)NCBImm8
Celera680,403,904 - 80,407,034 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:9055810   PMID:10349636   PMID:10767532   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17936263   PMID:19343564   PMID:21410322   PMID:21873635  
PMID:21979939   PMID:22727489   PMID:25938566   PMID:26683606   PMID:28774595  


Genomics

Comparative Map Data
Reg3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,357,692 - 78,360,822 (+)NCBIGRCm39mm39
GRCm39 Ensembl678,357,692 - 78,360,810 (+)Ensembl
GRCm38678,380,709 - 78,383,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,380,709 - 78,383,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,330,703 - 78,333,833 (+)NCBIGRCm37mm9NCBIm37
MGSCv36678,310,218 - 78,313,348 (+)NCBImm8
Celera680,403,904 - 80,407,034 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.76NCBI
Reg3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24110,872,398 - 110,875,157 (+)NCBI
Rnor_6.0 Ensembl4109,477,920 - 109,480,659 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04109,477,893 - 109,480,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04174,183,721 - 174,186,487 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,366,001 - 112,368,767 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14112,610,508 - 112,613,239 (+)NCBI
Celera499,904,353 - 99,907,119 (+)NCBICelera
Cytogenetic Map4q33NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:235
Interacting mature miRNAs:248
Transcripts:ENSMUST00000101272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000101272   ⟹   ENSMUSP00000098829
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl678,380,709 - 78,383,827 (+)Ensembl
RefSeq Acc Id: NM_011259   ⟹   NP_035389
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39678,357,692 - 78,360,822 (+)NCBI
GRCm38678,380,709 - 78,383,839 (+)ENTREZGENE
MGSCv37678,330,703 - 78,333,833 (+)RGD
Celera680,403,904 - 80,407,034 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035389   ⟸   NM_011259
- Peptide Label: precursor
- UniProtKB: O09037 (UniProtKB/Swiss-Prot),   Q794C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098829   ⟸   ENSMUST00000101272
Protein Domains
C-type lectin

Promoters
RGD ID:6890066
Promoter ID:EPDNEW_M8483
Type:initiation region
Name:Reg3a_1
Description:Mus musculus regenerating islet-derived 3 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8484  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,380,755 - 78,380,815EPDNEW
RGD ID:6890068
Promoter ID:EPDNEW_M8484
Type:multiple initiation site
Name:Reg3a_2
Description:Mus musculus regenerating islet-derived 3 alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8483  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38678,381,070 - 78,381,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109408 AgrOrtholog
Ensembl Genes ENSMUSG00000079516 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098829 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000101272 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19694 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109408 ENTREZGENE
NCBI Gene 19694 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg3a PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O09037 ENTREZGENE
  Q794C6 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQE4_MOUSE UniProtKB/TrEMBL
  Q9CVF4_MOUSE UniProtKB/TrEMBL
  REG3A_MOUSE UniProtKB/Swiss-Prot