Hes5 (hes family bHLH transcription factor 5) - Rat Genome Database

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Gene: Hes5 (hes family bHLH transcription factor 5) Mus musculus
Analyze
Symbol: Hes5
Name: hes family bHLH transcription factor 5
RGD ID: 733924
MGI Page MGI
Description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of cell differentiation; nephron morphogenesis; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including nervous system development; regulation of nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; paraxial mesenchyme; sensory organ; and urinary system. Orthologous to human HES5 (hes family bHLH transcription factor 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHb3; bHLHb38; hairy and enhancer of split 5; hairy and enhancer of split 5 (Drosophila); transcription factor HES-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,042,358 - 155,046,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,045,380 - 155,046,828 (+)EnsemblGRCm39 Ensembl
GRCm384154,960,626 - 154,962,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,960,923 - 154,962,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,335,032 - 154,336,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,804,723 - 153,806,171 (+)NCBIMGSCv36mm8
Celera4157,232,968 - 157,234,416 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
carbamazepine  (EXP)
CHIR 99021  (EXP,ISO)
clofibrate  (EXP)
cortisol  (ISO)
crocidolite asbestos  (EXP)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
iron dichloride  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(ethylene)  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
thyroxine  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IBA)
astrocyte differentiation  (IDA)
BMP signaling pathway  (IGI)
brain development  (IMP)
camera-type eye development  (IMP)
cartilage development  (IMP,ISO)
cell adhesion  (IGI)
cell differentiation  (IEA)
cell maturation  (IGI)
central nervous system myelination  (IMP)
chondrocyte differentiation  (IMP)
comma-shaped body morphogenesis  (IEP)
establishment of epithelial cell polarity  (IGI)
forebrain radial glial cell differentiation  (ISO)
glial cell fate commitment  (IMP)
inner ear auditory receptor cell differentiation  (IGI)
inner ear receptor cell stereocilium organization  (IGI)
metanephric nephron tubule morphogenesis  (IEP)
negative regulation of astrocyte differentiation  (IDA)
negative regulation of DNA-templated transcription  (IMP,ISO)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (IGI,IMP)
negative regulation of inner ear receptor cell differentiation  (IMP)
negative regulation of neuron differentiation  (IGI,IMP)
negative regulation of oligodendrocyte differentiation  (IDA,IMP)
negative regulation of pro-B cell differentiation  (ISO)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IGI,IMP,ISO)
nervous system development  (IEA)
neural tube development  (IGI)
neuron differentiation  (IGI,IMP,ISO)
neuronal stem cell population maintenance  (IMP,ISO)
Notch signaling pathway  (IDA,IMP,ISO,NAS,TAS)
oligodendrocyte development  (IMP)
oligodendrocyte differentiation  (IMP)
positive regulation of BMP signaling pathway  (IGI)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of Notch signaling pathway  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (IDA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IGI)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
protein-containing complex assembly  (IDA)
regulation of cell differentiation  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IGI)
regulation of myelination  (IMP)
regulation of neurogenesis  (IBA,IGI)
regulation of neuron differentiation  (IGI)
regulation of transcription by RNA polymerase II  (IBA)
S-shaped body morphogenesis  (IEP)
smoothened signaling pathway  (IDA)
specification of loop of Henle identity  (IEP)
telencephalon development  (IGI)

Cellular Component
nucleoplasm  (TAS)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal ependyma morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal nasal placode morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurohypophysis morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal pituitary diverticulum morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pituitary gland morphology  (IAGP)
abnormal pituitary infundibular stalk morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent choroid plexus  (IAGP)
absent oligodendrocytes  (IAGP)
absent optic vesicle  (IAGP)
absent pituitary intermediate lobe  (IAGP)
decreased embryo size  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
increased Cajal-Retzius cell number  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased somatotroph cell number  (IAGP)
increased vestibular hair cell number  (IAGP)
neuron hypertrophy  (IAGP)
pituitary gland hypoplasia  (IAGP)
premature neuronal precursor differentiation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Chenn A and Walsh CA, Science 2002 Jul 19;297(5580):365-9.
2. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
Additional References at PubMed
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Genomics

Comparative Map Data
Hes5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,042,358 - 155,046,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,045,380 - 155,046,828 (+)EnsemblGRCm39 Ensembl
GRCm384154,960,626 - 154,962,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,960,923 - 154,962,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,335,032 - 154,336,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364153,804,723 - 153,806,171 (+)NCBIMGSCv36mm8
Celera4157,232,968 - 157,234,416 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.01NCBI
HES5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,528,745 - 2,530,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,528,745 - 2,530,263 (-)EnsemblGRCh38hg38GRCh38
GRCh3712,460,184 - 2,461,702 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,450,044 - 2,451,544 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412,492,347 - 2,493,846NCBI
Celera1124,288 - 125,788 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,739,123 - 1,740,623 (-)NCBIHuRef
CHM1_112,446,941 - 2,448,441 (-)NCBICHM1_1
T2T-CHM13v2.011,970,389 - 1,971,907 (-)NCBIT2T-CHM13v2.0
Hes5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,804,511 - 170,807,988 (+)NCBIGRCr8
mRatBN7.25165,522,138 - 165,523,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,227,682 - 168,228,449 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,049,096 - 170,049,863 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,011,628 - 170,012,395 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,364,421 - 172,365,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,820,392 - 175,821,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,763,869 - 171,764,636 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15171,774,363 - 171,775,131 (+)NCBI
Celera5163,728,713 - 163,729,480 (+)NCBICelera
Cytogenetic Map5q36NCBI
Hes5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,700,162 - 8,701,748 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,700,212 - 8,701,581 (+)NCBIChiLan1.0ChiLan1.0
HES5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,717,334 - 225,719,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,377,907 - 224,379,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,261,260 - 1,263,128 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HES5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,387,961 - 57,389,412 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,388,674 - 57,389,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0557,592,177 - 57,593,619 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,592,171 - 57,593,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,583,534 - 57,584,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,475,854 - 57,477,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,865,566 - 57,867,005 (-)NCBIUU_Cfam_GSD_1.0
Hes5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,418,080 - 28,419,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,046,613 - 1,047,950 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,045,496 - 1,047,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,408,956 - 64,410,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,409,110 - 64,410,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HES5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,023,750 - 129,028,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,027,370 - 129,028,065 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605433,373,940 - 33,375,505 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,516,189 - 7,518,734 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,516,279 - 7,517,654 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hes5
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:330
Interacting mature miRNAs:368
Transcripts:ENSMUST00000049621, ENSMUST00000151480
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse

Markers in Region
UniSTS:235116  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,962,077 - 154,962,339UniSTSGRCm38
MGSCv374154,336,186 - 154,336,448UniSTSGRCm37
Celera4157,234,122 - 157,234,384UniSTS
Cytogenetic Map4E2UniSTS
cM Map481.5UniSTS
Hes5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,961,004 - 154,961,533UniSTSGRCm38
MGSCv374154,335,113 - 154,335,642UniSTSGRCm37
Celera4157,233,049 - 157,233,578UniSTS
Cytogenetic Map4E2UniSTS
cM Map481.5UniSTS
UniSTS:484887  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,960,971 - 154,961,919UniSTSGRCm38
MGSCv374154,335,080 - 154,336,028UniSTSGRCm37
Celera4157,233,016 - 157,233,964UniSTS
Cytogenetic Map4E2UniSTS
cM Map481.5UniSTS
Hes5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
Hes5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,961,932 - 154,962,187UniSTSGRCm38
MGSCv374154,336,041 - 154,336,296UniSTSGRCm37
Celera4157,233,977 - 157,234,232UniSTS
Cytogenetic Map4E2UniSTS
Hes5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,960,902 - 154,961,049UniSTSGRCm38
MGSCv374154,335,011 - 154,335,158UniSTSGRCm37
Celera4157,232,947 - 157,233,094UniSTS
Cytogenetic Map4E2UniSTS
Hes5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384154,960,920 - 154,961,049UniSTSGRCm38
MGSCv374154,335,029 - 154,335,158UniSTSGRCm37
Celera4157,232,965 - 157,233,094UniSTS
Cytogenetic Map4E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000049621   ⟹   ENSMUSP00000051118
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4155,045,380 - 155,046,828 (+)Ensembl
GRCm38.p6 Ensembl4154,960,923 - 154,962,371 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4155,045,428 - 155,045,863 (+)Ensembl
GRCm38.p6 Ensembl4154,960,971 - 154,961,406 (+)Ensembl
RefSeq Acc Id: NM_001370755   ⟹   NP_001357684
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,045,380 - 155,046,828 (+)NCBI
GRCm384154,960,923 - 154,962,371 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010419   ⟹   NP_034549
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,045,380 - 155,046,828 (+)NCBI
GRCm384154,960,923 - 154,962,371 (+)NCBI
MGSCv374154,335,032 - 154,336,480 (+)RGD
Celera4157,232,968 - 157,234,416 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538562   ⟹   XP_006538625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394155,042,358 - 155,046,829 (+)NCBI
GRCm384154,960,626 - 154,962,372 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034549   ⟸   NM_010419
- Peptide Label: isoform 1
- UniProtKB: Q8BVI1 (UniProtKB/Swiss-Prot),   P70120 (UniProtKB/Swiss-Prot),   Q499J8 (UniProtKB/TrEMBL),   Q3U0U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538625   ⟸   XM_006538562
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001357684   ⟸   NM_001370755
- Peptide Label: isoform 2
- UniProtKB: Q3U0U9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000051118   ⟸   ENSMUST00000049621
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70120-F1-model_v2 AlphaFold P70120 1-167 view protein structure

Promoters
RGD ID:6835465
Promoter ID:MM_KWN:41116
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:ENSMUST00000049621,   OTTMUST00000024352,   OTTMUST00000024353
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364154,334,826 - 154,335,326 (+)MPROMDB
RGD ID:6885752
Promoter ID:EPDNEW_M6327
Type:initiation region
Name:Hes5_1
Description:Mus musculus hes family bHLH transcription factor 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384154,960,969 - 154,961,029EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104876 AgrOrtholog
Ensembl Genes ENSMUSG00000048001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049621 ENTREZGENE
  ENSMUST00000049621.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HES_HEY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orange_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15208 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104876 ENTREZGENE
NCBI Gene 15208 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR HES-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hes5 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ORANGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HES5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U0U9 ENTREZGENE, UniProtKB/TrEMBL
  Q499J8 ENTREZGENE, UniProtKB/TrEMBL
  Q8BVI1 ENTREZGENE
UniProt Secondary Q8BVI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Hes5  hes family bHLH transcription factor 5    hairy and enhancer of split 5 (Drosophila)  Symbol and/or name change 5135510 APPROVED