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Gene: CDK12 (cyclin dependent kinase 12) Homo sapiens
Symbol: CDK12
Name: cyclin dependent kinase 12
Description: Exhibits RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Localizes to cyclin K-CDK12 complex and nuclear speck; PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; aflatoxin B1; benzo[a]pyrene diol epoxide I.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; hCDK12; KIAA0904; protein kinase for splicing component
Mus musculus (house mouse) : Cdk12 (cyclin-dependent kinase 12)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdk12 (cyclin-dependent kinase 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk12 (cyclin dependent kinase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK12 (cyclin dependent kinase 12)
Canis lupus familiaris (dog) : CDK12 (cyclin dependent kinase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk12 (cyclin dependent kinase 12)
Sus scrofa (pig) : CDK12 (cyclin dependent kinase 12)
Chlorocebus sabaeus (African green monkey) : CDK12 (cyclin dependent kinase 12)
Heterocephalus glaber (naked mole-rat) : Cdk12 (cyclin dependent kinase 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1739,461,486 - 39,564,907 (+)EnsemblGRCh38hg38GRCh38
GRCh381739,461,486 - 39,567,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,617,739 - 37,721,398 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,871,265 - 34,944,326 (+)NCBINCBI36hg18NCBI36
Celera1734,278,706 - 34,351,410 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,411,094 - 33,484,358 (+)NCBIHuRef
CHM1_11737,853,958 - 37,926,678 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDK12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733880
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.