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Gene: Pax4 (paired box 4) Mus musculus
Symbol: Pax4
Name: paired box 4
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; foregut-midgut junction; and urinary system. Human ortholog(s) of this gene implicated in diabetic ketoacidosis; maturity-onset diabetes of the young type 9; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human PAX4 (paired box 4); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: paired box gene 4; paired box protein Pax-4; Pax-4
Homo sapiens (human) : PAX4 (paired box 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pax4 (paired box 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pax4 (paired box 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PAX4 (paired box 4)
Canis lupus familiaris (dog) : PAX4 (paired box 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pax4 (paired box 4)
Sus scrofa (pig) : PAX4 (paired box 4)
Chlorocebus sabaeus (African green monkey) : PAX4 (paired box 4)
Heterocephalus glaber (naked mole-rat) : Pax4 (paired box 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl628,442,334 - 28,449,353 (-)EnsemblGRCm38mm10GRCm38
GRCm38628,442,334 - 28,449,340 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37628,392,334 - 28,399,340 (-)NCBIGRCm37mm9NCBIm37
MGSCv36628,392,350 - 28,399,285 (-)NCBImm8
Celera628,449,374 - 28,456,380 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map611.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pax4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733722
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.