Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase)

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Gene: Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase) Mus musculus

Analyze

Symbol:

Hmgcl

Name:

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

RGD ID:

733717

MGI Page

MGI

Description:

Predicted to enable several functions, including fatty-acyl-CoA binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in alimentary system; cranium; and liver. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-hydroxy-3-methylglutarate-CoA lyase; AW476067; HL; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1)	HGNC	OrthoDB
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG10399	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LYS20	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Saccharomyces cerevisiae (baker's yeast):	LYS21	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	Y71G12B.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	135,673,745 - 135,689,979 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	4	135,673,759 - 135,689,928 (+)	Ensembl
GRCm38	4	135,946,448 - 135,962,668 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	135,946,448 - 135,962,617 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	135,502,368 - 135,518,532 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	4	135,218,521 - 135,234,689 (+)	NCBI			mm8
Celera	4	134,147,609 - 134,163,748 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	68.14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

amino acid metabolic disorder (ISO)

Experimental Diabetes Mellitus (ISO)

galactose epimerase deficiency (ISO)

genetic disease (ISO)

Long-Chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (EXP)

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

acetamide (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

aristolochic acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

C60 fullerene (ISO)

cadmium atom (EXP)

carbon nanotube (EXP)

CGP 52608 (ISO)

cisplatin (ISO)

clofibrate (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dinophysistoxin 1 (ISO)

dioxygen (EXP)

doxorubicin (EXP,ISO)

ethyl methanesulfonate (ISO)

finasteride (ISO)

fipronil (ISO)

flutamide (ISO)

folic acid (EXP)

formaldehyde (ISO)

furan (ISO)

genistein (ISO)

gentamycin (ISO)

hydralazine (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP)

quercetin (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (ISO)

trichloroethene (ISO)

triptonide (EXP)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (ISO)

ketone body biosynthetic process (IBA,ISO)

leucine catabolic process (IBA)

lipid metabolic process (IBA,ISO)

liver development (ISO)

mitochondrion organization (IMP)

response to fatty acid (ISO)

response to nutrient (ISO)

response to starvation (ISO)

Cellular Component

mitochondrial inner membrane (HDA)

mitochondrion (HDA,IBA,IDA,ISO)

peroxisome (ISO)

protein-containing complex (ISO)

Molecular Function

carboxylic acid binding (ISO)

catalytic activity (IEA)

fatty-acyl-CoA binding (ISO)

hydroxymethylglutaryl-CoA lyase activity (IBA,ISO)

lyase activity (IEA)

magnesium ion binding (ISO)

manganese ion binding (ISO)

metal ion binding (ISO)

oxo-acid-lyase activity (IEA)

structural molecule activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

butanoate metabolic pathway (IEA,ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

ketone bodies metabolic pathway (IEA,ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

succinyl-CoA:3-oxoacid transferase deficiency pathway (ISO)

valine, leucine and isoleucine degradation pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal gluconeogenesis (IAGP)

abnormal heart morphology (IAGP)

abnormal hepatocyte morphology (IAGP)

abnormal hepatocyte physiology (IAGP)

abnormal mitochondrial morphology (IAGP)

abnormal placenta morphology (IAGP)

decreased embryo size (IAGP)

embryonic lethality during organogenesis, incomplete penetrance (IAGP)

hypoglycemia (IAGP)

increased circulating ammonia level (IAGP)

increased circulating carnitine level (IAGP)

lethargy (IAGP)

premature death (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.	Mitchell GA, etal., J Biol Chem. 1993 Feb 25;268(6):4376-81.
3.	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
4.	Cerebral ketone body metabolism.	Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	Molecular genetics of HMG-CoA lyase deficiency.	Pie J, etal., Mol Genet Metab. 2007 Nov;92(3):198-209. Epub 2007 Aug 9.
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.	Williamson DH, etal., Biochem J. 1968 Jul;108(3):353-61.

Additional References at PubMed

PMID:7873878	PMID:8102917	PMID:8617516	PMID:9003443	PMID:9680378	PMID:9817922	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932
PMID:12855751	PMID:12865426	PMID:14610273	PMID:14681479	PMID:15782199	PMID:16141072	PMID:16141073	PMID:16916647	PMID:18614015	PMID:21267068	PMID:21873635	PMID:22496890
PMID:23375831	PMID:23861731	PMID:26767982	PMID:27689697	PMID:28378742	PMID:28380375	PMID:30550785	PMID:32325033

Genomics

Comparative Map Data

Hmgcl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	135,673,745 - 135,689,979 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	4	135,673,759 - 135,689,928 (+)	Ensembl
GRCm38	4	135,946,448 - 135,962,668 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	135,946,448 - 135,962,617 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	135,502,368 - 135,518,532 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	4	135,218,521 - 135,234,689 (+)	NCBI			mm8
Celera	4	134,147,609 - 134,163,748 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	68.14	NCBI

HMGCL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	23,801,885 - 23,825,429 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	23,801,885 - 23,838,620 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	24,128,375 - 24,151,919 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	24,000,954 - 24,024,536 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	23,873,682 - 23,897,218	NCBI
Celera	1	22,457,935 - 22,481,518 (-)	NCBI
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	22,379,944 - 22,403,530 (-)	NCBI		HuRef
CHM1_1	1	24,241,156 - 24,264,719 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	23,636,860 - 23,660,403 (-)	NCBI

Hmgcl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	148,178,203 - 148,192,072 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	5	148,178,252 - 148,192,068 (+)	Ensembl
Rnor_6.0	5	154,294,841 - 154,308,582 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	154,294,806 - 154,308,640 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	158,059,692 - 158,073,433 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	154,730,232 - 154,743,974 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	5	154,740,270 - 154,754,013 (+)	NCBI
Celera	5	146,585,153 - 146,598,872 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Hmgcl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	3,720,103 - 3,735,192 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	3,720,103 - 3,734,730 (-)	NCBI	ChiLan1.0	ChiLan1.0

HMGCL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	23,977,723 - 24,016,262 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	23,977,723 - 24,001,150 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	22,993,489 - 23,017,307 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

HMGCL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	75,688,736 - 75,703,095 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	75,688,827 - 75,702,965 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	72,258,838 - 72,273,447 (+)	NCBI
ROS_Cfam_1.0	2	76,248,035 - 76,262,645 (+)	NCBI
ROS_Cfam_1.0 Ensembl	2	76,248,094 - 76,262,650 (+)	Ensembl
UMICH_Zoey_3.1	2	73,070,389 - 73,084,998 (+)	NCBI
UNSW_CanFamBas_1.0	2	74,077,019 - 74,091,642 (+)	NCBI
UU_Cfam_GSD_1.0	2	75,082,631 - 75,097,245 (+)	NCBI

Hmgcl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	43,130,437 - 43,146,341 (-)	NCBI
SpeTri2.0	NW_004936474	8,955,216 - 8,971,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HMGCL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	81,611,422 - 81,630,429 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	81,611,516 - 81,630,454 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	75,396,399 - 75,415,349 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HMGCL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	108,846,313 - 108,883,702 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	20	108,860,613 - 108,884,473 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666033	7,451,331 - 7,475,377 (-)	NCBI	Vero_WHO_p1.0

Hmgcl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	8,348,724 - 8,363,220 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624764	8,349,288 - 8,363,178 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

AW476067

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	135,962,174 - 135,962,296	UniSTS	GRCm38
MGSCv37	4	135,518,089 - 135,518,211	UniSTS	GRCm37
Celera	4	134,163,305 - 134,163,427	UniSTS
Cytogenetic Map	4	D3	UniSTS
cM Map	4	65.6	UniSTS
Whitehead/MRC_RH	4	1795.25	UniSTS

Hmgcl

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	4	D3	UniSTS
cM Map	4	65.6	UniSTS

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11567249	Elorr3_m	ethanol induced loss of righting response 3 (mouse)					4	3722677	156268235	Mouse
1357895	Ctrcts_m	cataract severity (mouse)			Not determined		4	45709925	138342753	Mouse
26884437	Sklq13_m	skull length QTL 13, 16 week (mouse)					4	57700000	155684457	Mouse
25314312	Syncl2_m	synaptonemal complex length 2 (mouse)					4	65718237	146584457	Mouse
26884445	Sklq7_m	skull length QTL 7, 10 week (mouse)					4	68018237	150884457	Mouse
4141623	W6q13_m	weight 6 weeks QTL 13 (mouse)			Not determined			88982069	140468203	Mouse
4141549	W10q10_m	weight 10 weeks QTL 10 (mouse)			Not determined			88982069	140468203	Mouse
4141093	W3q17_m	weight 3 weeks QTL 17 (mouse)			Not determined			88982069	140468203	Mouse
39128212	Lwq21_m	liver weight QTL 21 (mouse)					4	88982069	140468203	Mouse
1301823	Bmd7_m	bone mineral density 7 (mouse)			Not determined		4	88982069	151654550	Mouse
13208562	Wght7_m	weight 7 (mouse)					4	90888237	148084457	Mouse
1301815	Sles2_m	systemic lupus erythmatosus suppressor 2 (mouse)			Not determined		4	94957579	150676858	Mouse
15039377	Bw45_m	body weight QTL 45 (mouse)					4	105705794	139705794	Mouse
15039378	Adip30_m	adiposity 30 (mouse)					4	105705794	139705794	Mouse
15039382	Ltgq7_m	liver triglyceride QTL 7 (mouse)					4	105705794	139705794	Mouse
12910794	Pwbwq8_m	post-weaning body weight QTL 8 (mouse)					4	105835310	141433838	Mouse
12910797	Pwgrq4_m	pre-weaning growth rate QTL 4 (mouse)					4	105835310	141433838	Mouse
12910808	Pwbwq9_m	post-weaning body weight QTL 9 (mouse)					4	105835310	141433838	Mouse
12910813	Pwbwq4_m	pre-weaning body weight QTL 4 (mouse)					4	105835310	141433838	Mouse
1357800	Tgq3_m	triglyceride QTL 3 (mouse)			Not determined		4	107055093	141055180	Mouse
1300809	Ccrs2_m	corpus callosum hemisphere surface size 2 (mouse)			Not determined		4	107264957	141265153	Mouse
1300781	Lith8_m	lithogenic gene 8 (mouse)			Not determined		4	107264957	141265153	Mouse
1300663	Start2_m	startle response 2 (mouse)			Not determined		4	107264957	141265153	Mouse
1301382	Arvm2_m	autoimmune renal vasculitis 2 (mouse)			Not determined		4	107791564	141791756	Mouse
10755522	Hgb1_m	hemoglobin 1 (mouse)					4	108477692	142477692	Mouse
10755521	Hct1_m	hematocrit 1 (mouse)					4	108477692	142477692	Mouse
10755520	Rbc1_m	red blood cell count 1 (mouse)					4	108477692	142477692	Mouse
1300839	Dyscalc2_m	dystrophic cardiac calcinosis 2 (mouse)			Not determined		4	111009051	145009280	Mouse
1300743	Skull6_m	skull morphology 6 (mouse)			Not determined		4	111009051	145009280	Mouse
15039385	Mvlq3_m	macrovesicular liver lesion QTL 3 (mouse)					4	112182386	146182386	Mouse
4141001	Tgq17_m	triglyceride QTL 17 (mouse)			Not determined			112523489	146523489	Mouse
10047132	Albq19_m	albuminuria QTL 19 (mouse)			Not determined		4	112824389	146824389	Mouse
4142493	Femwf13_m	femur work to failure 13 (mouse)			Not determined			116154678	150154782	Mouse
1302078	Sluc21_m	susceptibility to lung cancer 21 (mouse)			Not determined		4	117401141	151401275	Mouse
14746982	Manh56_m	mandible shape 56 (mouse)					4	117815917	151815917	Mouse
1302102	Bis1_m	beta-carboline-induced seizures 1 (mouse)			Not determined		4	119864433	153864536	Mouse
1301964	Bw8q2_m	body weight at 8 weeks QTL 2 (mouse)			Not determined		4	119864433	153864536	Mouse
13503348	Bntq18_m	bone traits QTL 18 (mouse)					4	120617848	154617995	Mouse
10412210	Cypr6_m	cytokine production 6 (mouse)			Not determined		4	120617848	154617995	Mouse
4141180	Ssic1_m	susceptibility to small intestinal cancer 1 (mouse)			Not determined			120674005	154674151	Mouse
1300803	Sluc6_m	susceptibility to lung cancer 6 (mouse)			Not determined		4	120674005	154674151	Mouse
10043985	Stheal12_m	soft tissue heal 12 (mouse)			Not determined		4	121342649	155342753	Mouse
4142061	Chlq16_m	circulating hormone level QTL 16 (mouse)			Not determined		4	121342649	155342753	Mouse
1301452	Elsgp1_m	elevated serum gp70 1 (mouse)			Not determined		4	121342649	155342753	Mouse
27226757	Femd1_m	femur midshaft diameter 1, 5 week (mouse)					4	123993793	144326570	Mouse
4141065	Shali2_m	survival time to hyperoxic acute lung injury 2 (mouse)			Not determined			124055093	141572792	Mouse
1300917	Gasa1_m	gastritis type A susceptibility locus 1 (mouse)			Not determined		4	124055093	142438020	Mouse
1302149	Tlsr2_m	thymic lymphoma suppressor region 2 (mouse)			Not determined		4	124264957	142230960	Mouse
1301525	Lmb1_m	lupus in MRL and B6 F2 cross (mouse)			Not determined		4	124264957	150676858	Mouse
10755531	Lymph3_m	lymphocyte differential 3 (mouse)					4	124553483	156860686	Mouse
1300858	Tafat_m	tally ho associated mesenteric fat pad weight (mouse)			Not determined		4	124621281	156860686	Mouse
4142139	Adip12_m	adiposity 12 (mouse)			Not determined		4	124621281	156860686	Mouse
1301982	Pltiq1_m	phospholipid transfer protein inducibility QTL 1 (mouse)			Not determined		4	124621281	156860686	Mouse
1300933	Cdcs9_m	cytokine deficiency colitis susceptibility 9 (mouse)			Not determined		4	125230872	156860686	Mouse
1300621	Tpnr1_m	thermal pain response 1 (mouse)			Not determined		4	125230872	156860686	Mouse
10045620	Heal22_m	wound healing/regeneration 22 (mouse)			Not determined		4	125230872	156860686	Mouse
11533916	Mts1_m	mammary tumor susceptibility 1 (mouse)					4	125289325	156860686	Mouse
10043996	Gct5_m	granulosa cell tumorigenesis 5 (mouse)			Not determined		4	127784226	156860686	Mouse
4142481	Gct1_m	granulosa cell tumorigenesis 1 (mouse)			Not determined		4	127784226	156860686	Mouse
1301793	Tlsr3_m	thymic lymphoma suppressor region 3 (mouse)			Not determined		4	129465811	136864536	Mouse
1301584	Lrdg2_m	light induced retinal degeneration 2 (mouse)			Not determined		4	129465811	151654550	Mouse
4141154	Nba1_m	New Zealand Black autoimmunity 1 (mouse)			Not determined			131650724	140879275	Mouse
1300874	Gasa2_m	gastritis type A susceptibility locus 2 (mouse)			Not determined		4	133010494	156860686	Mouse
4142082	Psds2_m	psoriasis-like skin disease severity 2 (mouse)			Not determined		4	133154678	137617995	Mouse
1301267	Bcmd2_m	B cell maturation defect 2 (mouse)			Not determined		4	133154678	150789451	Mouse
4142077	Ignpq2_m	IgA nephropathy QTL 2 (mouse)			Not determined		4	133676733	156860686	Mouse
1301108	Scon2_m	sucrose consumption 2 (mouse)			Not determined		4	134654451	156860686	Mouse
1300537	Ap3q_m	alcohol preference 3 QTL (mouse)			Not determined		4	134654451	156860686	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	932
Count of miRNA genes:	527
Interacting mature miRNAs:	615
Transcripts:	ENSMUST00000030432, ENSMUST00000134135, ENSMUST00000135644, ENSMUST00000148613, ENSMUST00000151879
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001357529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001357530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_008254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006538564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH003600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK077842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK132035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK144768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK154033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK182431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK210917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK217644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL672076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB852743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX631310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S65036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000030432 ⟹ ENSMUSP00000030432

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	135,673,759 - 135,689,928 (+)	Ensembl
GRCm38.p6 Ensembl	4	135,946,448 - 135,962,617 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000134135

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	135,673,776 - 135,688,219 (+)	Ensembl
GRCm38.p6 Ensembl	4	135,946,465 - 135,960,908 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000135644

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	135,687,643 - 135,689,527 (+)	Ensembl
GRCm38.p6 Ensembl	4	135,960,332 - 135,962,216 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000148613

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	135,687,038 - 135,689,928 (+)	Ensembl
GRCm38.p6 Ensembl	4	135,959,727 - 135,962,617 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000151879

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	135,675,841 - 135,686,060 (+)	Ensembl
GRCm38.p6 Ensembl	4	135,948,530 - 135,958,749 (+)	Ensembl

RefSeq Acc Id:

NM_001357529 ⟹ NP_001344458

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	135,674,717 - 135,689,979 (+)	NCBI
GRCm38	4	135,947,406 - 135,962,668 (+)	NCBI

Sequence:

show sequence

GGCAGAGGCAGGCGGATTTCTGAGTTCGAGGGGAGCCTGGTCTACAAAGCGAGTTCCAGGACAG
CCAGGACTACACAGAGAAACCCTGTGTCGAAAGAAACAAAAACAAAAAAAAAACAAAAAAAAAA
AAAAACAAAAACAAAAAAAATGGGAAAGAAAAAGAAAGCCACTTCTGCATCTTTAGTCTACCCA
CTTCCAATGATTGCTCAGGGATCAAATGAAAAGGCAAATATCAACGTGAAAAGTTAAGGAAATA
AACCCGAGGGGGAGAGGGGGAGAGAATGAGAATTAAGTAACATGGTGGGTCATAATATCTATCT
ATCTATCTATCTATCTATCTAAGACAAAGTTTCTTTCTATATAACTTTGGTATTCACTACATAG
ACCAGGCTAGCTTCAAACTCAGAGCCTGCTATGACTCTGGGCTTACAGGCATGGACCACCATGC
CCAGCTAGGGATAATTTTTACAAACTAGTGTGAGGAAATGATCCCTCATGAGTCTTATGGCACA
AGATGGCACTTTTATTTCATTTGGTTTGGTTTGGTTGTTCCGTTTTTGGTTTGGTTTGGTTTTT
AAAGGCAGGCTTACTCATCCTTGGCTGTCTGGACTCAATTAGTAGACCAGGCTGGCTTTGAACT
CACAGAGATCTACTTGCCTCTGCCTCCCAAGTCCTGGGATTATTAAAGGGATTAAAGGCATGCA
CCACCAGGTGAGCTATCTGACTTGGGTCTGAGAACCCTACTCAGATCTTCTGTGGAGCCATCTC
TTCGACCCTGGGCTTTTTAAAAATTTCTCACATATCTCAGGCTGACCTCAAGTTTGCTGTGTAG
CAACTTGAAAGCAGCCATGAGCTTCTGATTCCCCCTGCTTCCATCTCCCAAGCGCTGGGCCTCA
GGCCTCGGGCCGCGAGCCACCACACCTGGCTGGGTTGTTGTGTTTAGAGCTGTGTGCTGGAGGA
AGTGGAACTAAGTTCACTGTGTTCCAGAAAAGGAAGTTGGAAGCAGGCTCTGCTTCAGTGTGTA
CTCACTGAGCCTCTGCTATGTCTCAGGGCCTTGGGAAGAGCAATGCACAGATCCAGTCCCTGAC
CTGTGACACTCGCGCCCCTCTGGGCGTTTTAGGTCTTTTTAGTCTGACAGTCTGTTGGAGGGAG
ACGTCGTTATATGGACCTTTCACTCAGCTTGACGACTTCTTGGGTTGTATTATTATTATTATTA
TTATTATTATTAATGTCATTATTAATTTTTAATTTTATGTGTATTGGTGTTTGCCTGCATGTCT
GTCTGTCTGTGTGAGGGTGTTGGATCCTTGAGTTGGAATTCCAGACAACGGTGAGCTGCTATGT
GGTTGCTGGAAATTGAACTCAGGTCCTCCGGCAGAGCAGCCAGTGCTCTTCACTGCTGAGCCAC
CTCTCCAGCGCCCTGCCGACTTCTTGTAATTCAGGTGAGCACCTCCTCCATGGGCACTTTGCCA
AAGCAGGTGAAGATCGTGGAAGTCGGTCCCCGAGATGGGCTGCAGAATGAAAAGAGTATTGTAC
CCACCCCAGTGAAGATCAGGCTGATCGACATGCTTTCCGAAGCAGGGCTCCCCGTGATCGAGGC
CACCAGCTTTGTTTCTCCCAAGTGGGTGCCACAGATGGCTGACCACTCTGACGTCTTGAAGGGC
ATTCAGAAGTTTCCCGGCATCAACTACCCAGTCCTGACTCCAAACATGAAAGGCTTTGAGGAAG
CGGTAGCTGCGGGTGCCAAGGAAGTGAGCGTCTTCGGTGCTGTGTCTGAGCTCTTCACCCGGAA
GAACGCGAACTGCTCTATAGAGGAGAGTTTCCAGCGCTTTGCTGGAGTCATGCAGGCGGCCCAG
GCCGCCAGCATCTCTGTGAGAGGGTATGTCTCCTGTGCCCTCGGATGCCCCTACGAGGGGAAGG
TCTCCCCGGCTAAAGTTGCTGAGGTTGCCAAGAAGTTGTACTCGATGGGCTGCTATGAGATCTC
CCTTGGGGACACCATCGGCGTAGGTACCCCAGGACTCATGAAAGACATGCTGACTGCTGTCATG
CATGAAGTGCCTGTGACAGCATTGGCTGTCCACTGCCATGATACCTATGGTCAAGCTCTGGCCA
ACACCTTGGTGGCCCTGCAGATGGGTGTGAGTGTTGTGGACTCCTCTGTGGCAGGACTTGGAGG
CTGTCCCTATGCAAAAGGGGCATCAGGGAACTTGGCTACTGAGGACCTGGTCTACATGCTGAAT
GGCTTAGGGATTCACACGGGTGTGAACCTCCAGAAACTTCTAGAAGCTGGGGACTTCATCTGTC
AAGCCCTTAACAGAAAAACTAGTTCCAAAGTGGCACAGGCCACCTGCAAGCTCTGAGACCCTCG
TTCGCCTGAACCAGAACGGAGGGAATTGGGTGTATACAATGATTCCTGGATGAAGAGATGGAAT
GAGAGCAAATGAGCCGGCATCACAGAGGTCCCTGTCCCTGATGATAAGGGCTAGAGCTGCCTGG
CCTGGGCCAGCTCCCCAGAGCTGTGCCTAAGCACTTGCTTGGGATGGCCCTGGGTGAGTCTGCC
TGCCAACAGAGCTGATGTCCACCGCCGCAGGGCCTTTGTTCTACCTCTGAGGACAGAGAGCAGT
TTCCCCTTATGCCAGCAGAGCATTTGCTGGAATGGTGGGGGTTGATCTGCATCTGTGGTCATCT
GCCAACGAAATCTCCACTCTGTGTGTGATTTTTTTGAAAACAGCTTATGTAATTAAAGGTTTAA
TTTTCTAATATAACATTCAAACGTGTGTTTATGGGTGGAGGAGTAAAATTGCTCTGAGGGAAGA
GG

hide sequence

RefSeq Acc Id:

NM_001357530 ⟹ NP_001344459

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	135,674,717 - 135,689,979 (+)	NCBI
GRCm38	4	135,947,406 - 135,962,668 (+)	NCBI

Sequence:

show sequence

GGCAGAGGCAGGCGGATTTCTGAGTTCGAGGGGAGCCTGGTCTACAAAGCGAGTTCCAGGACAG
CCAGGACTACACAGAGAAACCCTGTGTCGAAAGAAACAAAAACAAAAAAAAAACAAAAAAAAAA
AAAAACAAAAACAAAAAAAATGGGAAAGAAAAAGAAAGCCACTTCTGCATCTTTAGTCTACCCA
CTTCCAATGATTGCTCAGGGATCAAATGAAAAGGCAAATATCAACGTGAAAAGTTAAGGAAATA
AACCCGAGGGGGAGAGGGGGAGAGAATGAGAATTAAGTAACATGGTGGGTCATAATATCTATCT
ATCTATCTATCTATCTATCTAAGACAAAGTTTCTTTCTATATAACTTTGGTATTCACTACATAG
ACCAGGCTAGCTTCAAACTCAGAGCCTGCTATGACTCTGGGCTTACAGGCATGGACCACCATGC
CCAGCTAGGGATAATTTTTACAAACTAGTGTGAGGAAATGATCCCTCATGAGTCTTATGGCACA
AGATGGCACTTTTATTTCATTTGGTTTGGTTTGGTTGTTCCGTTTTTGGTTTGGTTTGGTTTTT
AAAGGCAGGCTTACTCATCCTTGGCTGTCTGGACTCAATTAGTAGACCAGGCTGGCTTTGAACT
CACAGAGATCTACTTGCCTCTGCCTCCCAAGTCCTGGGATTATTAAAGGGATTAAAGGCATGCA
CCACCAGGTGAGCTATCTGACTTGGGTCTGAGAACCCTACTCAGATCTTCTGTGGAGCCATCTC
TTCGACCCTGGGCTTTTTAAAAATTTCTCACATATCTCAGGCTGACCTCAAGTTTGCTGTGTAG
CAACTTGAAAGCAGCCATGAGCTTCTGATTCCCCCTGCTTCCATCTCCCAAGCGCTGGGCCTCA
GGCCTCGGGCCGCGAGCCACCACACCTGGCTGGGTTGTTGTGTTTAGAGCTGTGTGCTGGAGGA
AGTGGAACTAAGTTCACTGTGTTCCAGAAAAGGAAGTTGGAAGCAGGCTCTGCTTCAGTGTGTA
CTCACTGAGCCTCTGCTATGTCTCAGGGCCTTGGGAAGAGCAATGCACAGATCCAGTCCCTGAC
CTGTGACACTCGCGCCCCTCTGGGCGTTTTAGGTCTTTTTAGTCTGACAGTCTGTTGGAGGGAG
ACGTCGTTATATGGACCTTTCACTCAGCTTGACGACTTCTTGGGTTGTATTATTATTATTATTA
TTATTATTATTAATGTCATTATTAATTTTTAATTTTATGTGTATTGGTGTTTGCCTGCATGTCT
GTCTGTCTGTGTGAGGGTGTTGGATCCTTGAGTTGGAATTCCAGACAACGGTGAGCTGCTATGT
GGTTGCTGGAAATTGAACTCAGGTCCTCCGGCAGAGCAGCCAGTGCTCTTCACTGCTGAGCCAC
CTCTCCAGCGCCCTGCCGACTTCTTGTAATTCAGGTGAGCACCTCCTCCATGGGCACTTTGCCA
AAGCAGGTGAAGATCGTGGAAGTCGGTCCCCGAGATGGGCTGCAGAATGAAAAGAGTATTGTAC
CCACCCCAGTGAAGATCAGGCTGATCGACATGCTTTCCGAAGCAGGGCTCCCCGTGATCGAGGC
CACCAGCTTTGTTTCTCCCAAGTGGGTGCCACAGGGCCACACCTTTTAACAGCACCACTCCCTG
GGCCGAGCATATACAAACCATCCCAGAATTGCTGTTTCATAGCAAACAATCCCTTTGATAGCAC
CAGGCAATGCAGAAGGAGTGGCGCCCAGGGCCCCACCAGAGAAGGTTCTTGATGGCTGACCACT
CTGACGTCTTGAAGGGCATTCAGAAGTTTCCCGGCATCAACTACCCAGTCCTGACTCCAAACAT
GAAAGGCTTTGAGGAAGCGGTAGCTGCGGGTGCCAAGGAAGTGAGCGTCTTCGGTGCTGTGTCT
GAGCTCTTCACCCGGAAGAACGCGAACTGCTCTATAGAGGAGAGTTTCCAGCGCTTTGCTGGAG
TCATGCAGGCGGCCCAGGCCGCCAGCATCTCTGTGAGAGGGTATGTCTCCTGTGCCCTCGGATG
CCCCTACGAGGGGAAGGTCTCCCCGGCTAAAGTTGCTGAGGTTGCCAAGAAGTTGTACTCGATG
GGCTGCTATGAGATCTCCCTTGGGGACACCATCGGCGTAGGTACCCCAGGACTCATGAAAGACA
TGCTGACTGCTGTCATGCATGAAGTGCCTGTGACAGCATTGGCTGTCCACTGCCATGATACCTA
TGGTCAAGCTCTGGCCAACACCTTGGTGGCCCTGCAGATGGGTGTGAGTGTTGTGGACTCCTCT
GTGGCAGGACTTGGAGGCTGTCCCTATGCAAAAGGGGCATCAGGGAACTTGGCTACTGAGGACC
TGGTCTACATGCTGAATGGCTTAGGGATTCACACGGGTGTGAACCTCCAGAAACTTCTAGAAGC
TGGGGACTTCATCTGTCAAGCCCTTAACAGAAAAACTAGTTCCAAAGTGGCACAGGCCACCTGC
AAGCTCTGAGACCCTCGTTCGCCTGAACCAGAACGGAGGGAATTGGGTGTATACAATGATTCCT
GGATGAAGAGATGGAATGAGAGCAAATGAGCCGGCATCACAGAGGTCCCTGTCCCTGATGATAA
GGGCTAGAGCTGCCTGGCCTGGGCCAGCTCCCCAGAGCTGTGCCTAAGCACTTGCTTGGGATGG
CCCTGGGTGAGTCTGCCTGCCAACAGAGCTGATGTCCACCGCCGCAGGGCCTTTGTTCTACCTC
TGAGGACAGAGAGCAGTTTCCCCTTATGCCAGCAGAGCATTTGCTGGAATGGTGGGGGTTGATC
TGCATCTGTGGTCATCTGCCAACGAAATCTCCACTCTGTGTGTGATTTTTTTGAAAACAGCTTA
TGTAATTAAAGGTTTAATTTTCTAATATAACATTCAAACGTGTGTTTATGGGTGGAGGAGTAAA
ATTGCTCTGAGGGAAGAGG

hide sequence

RefSeq Acc Id:

NM_008254 ⟹ NP_032280

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	135,673,759 - 135,689,979 (+)	NCBI
GRCm38	4	135,946,448 - 135,962,668 (+)	NCBI
MGSCv37	4	135,502,368 - 135,518,532 (+)	RGD
Celera	4	134,147,609 - 134,163,748 (+)	RGD
cM Map	4		ENTREZGENE

Sequence:

show sequence

GTGGTGCCCAGTGGGTTGGCCTCCGGAGTGAAGATGGCGTCAGTGAGGAAGGCTTTCCCGCGGA
GGCTGGTGGGCTTGACGTCCCTCCGGGCTGTGAGCACCTCCTCCATGGGCACTTTGCCAAAGCA
GGTGAAGATCGTGGAAGTCGGTCCCCGAGATGGGCTGCAGAATGAAAAGAGTATTGTACCCACC
CCAGTGAAGATCAGGCTGATCGACATGCTTTCCGAAGCAGGGCTCCCCGTGATCGAGGCCACCA
GCTTTGTTTCTCCCAAGTGGGTGCCACAGATGGCTGACCACTCTGACGTCTTGAAGGGCATTCA
GAAGTTTCCCGGCATCAACTACCCAGTCCTGACTCCAAACATGAAAGGCTTTGAGGAAGCGGTA
GCTGCGGGTGCCAAGGAAGTGAGCGTCTTCGGTGCTGTGTCTGAGCTCTTCACCCGGAAGAACG
CGAACTGCTCTATAGAGGAGAGTTTCCAGCGCTTTGCTGGAGTCATGCAGGCGGCCCAGGCCGC
CAGCATCTCTGTGAGAGGGTATGTCTCCTGTGCCCTCGGATGCCCCTACGAGGGGAAGGTCTCC
CCGGCTAAAGTTGCTGAGGTTGCCAAGAAGTTGTACTCGATGGGCTGCTATGAGATCTCCCTTG
GGGACACCATCGGCGTAGGTACCCCAGGACTCATGAAAGACATGCTGACTGCTGTCATGCATGA
AGTGCCTGTGACAGCATTGGCTGTCCACTGCCATGATACCTATGGTCAAGCTCTGGCCAACACC
TTGGTGGCCCTGCAGATGGGTGTGAGTGTTGTGGACTCCTCTGTGGCAGGACTTGGAGGCTGTC
CCTATGCAAAAGGGGCATCAGGGAACTTGGCTACTGAGGACCTGGTCTACATGCTGAATGGCTT
AGGGATTCACACGGGTGTGAACCTCCAGAAACTTCTAGAAGCTGGGGACTTCATCTGTCAAGCC
CTTAACAGAAAAACTAGTTCCAAAGTGGCACAGGCCACCTGCAAGCTCTGAGACCCTCGTTCGC
CTGAACCAGAACGGAGGGAATTGGGTGTATACAATGATTCCTGGATGAAGAGATGGAATGAGAG
CAAATGAGCCGGCATCACAGAGGTCCCTGTCCCTGATGATAAGGGCTAGAGCTGCCTGGCCTGG
GCCAGCTCCCCAGAGCTGTGCCTAAGCACTTGCTTGGGATGGCCCTGGGTGAGTCTGCCTGCCA
ACAGAGCTGATGTCCACCGCCGCAGGGCCTTTGTTCTACCTCTGAGGACAGAGAGCAGTTTCCC
CTTATGCCAGCAGAGCATTTGCTGGAATGGTGGGGGTTGATCTGCATCTGTGGTCATCTGCCAA
CGAAATCTCCACTCTGTGTGTGATTTTTTTGAAAACAGCTTATGTAATTAAAGGTTTAATTTTC
TAATATAACATTCAAACGTGTGTTTATGGGTGGAGGAGTAAAATTGCTCTGAGGGAAGAGG

hide sequence

RefSeq Acc Id:

XM_006538564 ⟹ XP_006538627

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	135,673,745 - 135,689,926 (+)	NCBI
GRCm38	4	135,946,448 - 135,962,615 (+)	NCBI

Sequence:

show sequence

GGATCGGCGGTCACGTGGTGCCCAGTGGGTTGGCCTCCGGAGTGAAGATGGCGTCAGTGAGGAA
GGCTTTCCCGCGGAGGCTGGTGGGCTTGACGTCCCTCCGGGCTGTGAGCACCTCCTCCATGGGC
ACTTTGCCAAAGCAGGTGAAGATCGTGGAAGTCGGTCCCCGAGATGGGCTGCAGAATGAAAAGA
GTATTGTACCCACCCCAGTGAAGATCAGGCTGATCGACATGCTTTCCGAAGCAGGGCTCCCCGT
GATCGAGGCCACCAGCTTTGTTTCTCCCAAGTGGGTGCCACAGGGCCACACCTTTTAACAGCAC
CACTCCCTGGGCCGAGCATATACAAACCATCCCAGAATTGCTGTTTCATAGCAAACAATCCCTT
TGATAGCACCAGGCAATGCAGAAGGAGTGGCGCCCAGGGCCCCACCAGAGAAGGTTCTTGATGG
CTGACCACTCTGACGTCTTGAAGGGCATTCAGAAGTTTCCCGGCATCAACTACCCAGTCCTGAC
TCCAAACATGAAAGGCTTTGAGGAAGCGGTAGCTGCGGGTGCCAAGGAAGTGAGCGTCTTCGGT
GCTGTGTCTGAGCTCTTCACCCGGAAGAACGCGAACTGCTCTATAGAGGAGAGTTTCCAGCGCT
TTGCTGGAGTCATGCAGGCGGCCCAGGCCGCCAGCATCTCTGTGAGAGGGTATGTCTCCTGTGC
CCTCGGATGCCCCTACGAGGGGAAGGTCTCCCCGGCTAAAGTTGCTGAGGTTGCCAAGAAGTTG
TACTCGATGGGCTGCTATGAGATCTCCCTTGGGGACACCATCGGCGTAGGTACCCCAGGACTCA
TGAAAGACATGCTGACTGCTGTCATGCATGAAGTGCCTGTGACAGCATTGGCTGTCCACTGCCA
TGATACCTATGGTCAAGCTCTGGCCAACACCTTGGTGGCCCTGCAGATGGGTGTGAGTGTTGTG
GACTCCTCTGTGGCAGGACTTGGAGGCTGTCCCTATGCAAAAGGGGCATCAGGGAACTTGGCTA
CTGAGGACCTGGTCTACATGCTGAATGGCTTAGGGATTCACACGGGTGTGAACCTCCAGAAACT
TCTAGAAGCTGGGGACTTCATCTGTCAAGCCCTTAACAGAAAAACTAGTTCCAAAGTGGCACAG
GCCACCTGCAAGCTCTGAGACCCTCGTTCGCCTGAACCAGAACGGAGGGAATTGGGTGTATACA
ATGATTCCTGGATGAAGAGATGGAATGAGAGCAAATGAGCCGGCATCACAGAGGTCCCTGTCCC
TGATGATAAGGGCTAGAGCTGCCTGGCCTGGGCCAGCTCCCCAGAGCTGTGCCTAAGCACTTGC
TTGGGATGGCCCTGGGTGAGTCTGCCTGCCAACAGAGCTGATGTCCACCGCCGCAGGGCCTTTG
TTCTACCTCTGAGGACAGAGAGCAGTTTCCCCTTATGCCAGCAGAGCATTTGCTGGAATGGTGG
GGGTTGATCTGCATCTGTGGTCATCTGCCAACGAAATCTCCACTCTGTGTGTGATTTTTTTGAA
AACAGCTTATGTAATTAAAGGTTTAATTTTCTAATATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001344458	(Get FASTA)	NCBI Sequence Viewer
	NP_001344459	(Get FASTA)	NCBI Sequence Viewer
	NP_032280	(Get FASTA)	NCBI Sequence Viewer
	XP_006538627	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB03107	(Get FASTA)	NCBI Sequence Viewer
	AAB27965	(Get FASTA)	NCBI Sequence Viewer
	AAH25440	(Get FASTA)	NCBI Sequence Viewer
	BAE20956	(Get FASTA)	NCBI Sequence Viewer
	BAE26056	(Get FASTA)	NCBI Sequence Viewer
	BAE26328	(Get FASTA)	NCBI Sequence Viewer
	BAE32329	(Get FASTA)	NCBI Sequence Viewer
	EDL29963	(Get FASTA)	NCBI Sequence Viewer
	P38060	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_032280 ⟸ NM_008254
- Peptide Label:	isoform 1 precursor
- UniProtKB:	P38060 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLS EAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFG AVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKL YSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVV DSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQ ATCKL hide sequence

RefSeq Acc Id:

XP_006538627 ⟸ XM_006538564

- Peptide Label:

isoform X1

- Sequence:

show sequence

MQKEWRPGPHQRRFLMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSEL
FTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGC
YEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVA
GLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQATCKL

hide sequence

RefSeq Acc Id:	NP_001344459 ⟸ NM_001357530
- Peptide Label:	isoform 3

RefSeq Acc Id:	NP_001344458 ⟸ NM_001357529
- Peptide Label:	isoform 2

RefSeq Acc Id:

ENSMUSP00000030432 ⟸ ENSMUST00000030432

Protein Domains

Pyruvate carboxyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P38060-F1-model_v2	AlphaFold	P38060	1-325	view protein structure

Promoters

RGD ID:

6835472

Promoter ID:

MM_KWN:40177

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000022820, OTTMUST00000022821, UC008VHJ.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	135,501,911 - 135,502,477 (+)	MPROMDB

RGD ID:

6835469

Promoter ID:

MM_KWN:40178

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour

Transcripts:

OTTMUST00000022822

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	135,503,811 - 135,504,311 (+)	MPROMDB

RGD ID:

6835470

Promoter ID:

MM_KWN:40179

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Brain, Kidney

Transcripts:

OTTMUST00000022823

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	135,514,551 - 135,515,051 (+)	MPROMDB

RGD ID:

6835471

Promoter ID:

MM_KWN:40180

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_4Hour, Brain, Kidney, Liver, Lung

Transcripts:

OTTMUST00000022824

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	135,515,381 - 135,516,797 (+)	MPROMDB

RGD ID:

6885116

Promoter ID:

EPDNEW_M5995

Type:

multiple initiation site

Name:

Hmgcl_1

Description:

Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A lyase , transcriptvariant 1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	4	135,946,465 - 135,946,525	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96158	AgrOrtholog
Ensembl Genes	ENSMUSG00000028672	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000030432	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000030432	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.20.20.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HMG_CoA_lyase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HMGL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYR_CT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:15356	UniProtKB/Swiss-Prot
MGD	MGI:96158	ENTREZGENE
NCBI Gene	15356	ENTREZGENE
PANTHER	PTHR42738	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HMGL-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hmgcl	PhenoGen
PROSITE	HMG_COA_LYASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYR_CT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	HMGCL_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3UMP2_MOUSE	UniProtKB/TrEMBL
UniProt Secondary	Q8QZS6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype