Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase) - Rat Genome Database

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Gene: Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase) Mus musculus
Analyze
Symbol: Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
RGD ID: 733717
MGI Page MGI
Description: Predicted to enable several functions, including fatty-acyl-CoA binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Acts upstream of or within mitochondrion organization. Located in mitochondrion. Is expressed in alimentary system; cranium; and liver. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxy-3-methylglutarate-CoA lyase; AW476067; HL; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,673,745 - 135,689,979 (+)NCBIGRCm39mm39
GRCm39 Ensembl4135,673,759 - 135,689,928 (+)Ensembl
GRCm384135,946,448 - 135,962,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,946,448 - 135,962,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,502,368 - 135,518,532 (+)NCBIGRCm37mm9NCBIm37
MGSCv364135,218,521 - 135,234,689 (+)NCBImm8
Celera4134,147,609 - 134,163,748 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency. Mitchell GA, etal., J Biol Chem. 1993 Feb 25;268(6):4376-81.
3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
4. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Molecular genetics of HMG-CoA lyase deficiency. Pie J, etal., Mol Genet Metab. 2007 Nov;92(3):198-209. Epub 2007 Aug 9.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver. Williamson DH, etal., Biochem J. 1968 Jul;108(3):353-61.
Additional References at PubMed
PMID:7873878   PMID:8102917   PMID:8617516   PMID:9003443   PMID:9680378   PMID:9817922   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932  
PMID:12855751   PMID:12865426   PMID:14610273   PMID:14681479   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16916647   PMID:18614015   PMID:21267068   PMID:21873635   PMID:22496890  
PMID:23375831   PMID:23861731   PMID:26767982   PMID:27689697   PMID:28378742   PMID:28380375   PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Hmgcl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394135,673,745 - 135,689,979 (+)NCBIGRCm39mm39
GRCm39 Ensembl4135,673,759 - 135,689,928 (+)Ensembl
GRCm384135,946,448 - 135,962,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,946,448 - 135,962,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv374135,502,368 - 135,518,532 (+)NCBIGRCm37mm9NCBIm37
MGSCv364135,218,521 - 135,234,689 (+)NCBImm8
Celera4134,147,609 - 134,163,748 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map468.14NCBI
HMGCL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38123,801,885 - 23,825,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl123,801,885 - 23,838,620 (-)EnsemblGRCh38hg38GRCh38
GRCh37124,128,375 - 24,151,919 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,000,954 - 24,024,536 (-)NCBINCBI36hg18NCBI36
Build 34123,873,682 - 23,897,218NCBI
Celera122,457,935 - 22,481,518 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef122,379,944 - 22,403,530 (-)NCBIHuRef
CHM1_1124,241,156 - 24,264,719 (-)NCBICHM1_1
T2T-CHM13v2.0123,636,860 - 23,660,403 (-)NCBI
Hmgcl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,178,203 - 148,192,072 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5148,178,252 - 148,192,068 (+)Ensembl
Rnor_6.05154,294,841 - 154,308,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,294,806 - 154,308,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05158,059,692 - 158,073,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,730,232 - 154,743,974 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15154,740,270 - 154,754,013 (+)NCBI
Celera5146,585,153 - 146,598,872 (+)NCBICelera
Cytogenetic Map5q36NCBI
Hmgcl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554523,720,103 - 3,735,192 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554523,720,103 - 3,734,730 (-)NCBIChiLan1.0ChiLan1.0
HMGCL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1123,977,723 - 24,016,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl123,977,723 - 24,001,150 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0122,993,489 - 23,017,307 (-)NCBIMhudiblu_PPA_v0panPan3
HMGCL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,688,736 - 75,703,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,688,827 - 75,702,965 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,258,838 - 72,273,447 (+)NCBI
ROS_Cfam_1.0276,248,035 - 76,262,645 (+)NCBI
ROS_Cfam_1.0 Ensembl276,248,094 - 76,262,650 (+)Ensembl
UMICH_Zoey_3.1273,070,389 - 73,084,998 (+)NCBI
UNSW_CanFamBas_1.0274,077,019 - 74,091,642 (+)NCBI
UU_Cfam_GSD_1.0275,082,631 - 75,097,245 (+)NCBI
Hmgcl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,130,437 - 43,146,341 (-)NCBI
SpeTri2.0NW_0049364748,955,216 - 8,971,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl681,611,422 - 81,630,429 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1681,611,516 - 81,630,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2675,396,399 - 75,415,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGCL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120108,846,313 - 108,883,702 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20108,860,613 - 108,884,473 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660337,451,331 - 7,475,377 (-)NCBIVero_WHO_p1.0
Hmgcl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247648,348,724 - 8,363,220 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247648,349,288 - 8,363,178 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AW476067  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384135,962,174 - 135,962,296UniSTSGRCm38
MGSCv374135,518,089 - 135,518,211UniSTSGRCm37
Celera4134,163,305 - 134,163,427UniSTS
Cytogenetic Map4D3UniSTS
cM Map465.6UniSTS
Whitehead/MRC_RH41795.25UniSTS
Hmgcl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D3UniSTS
cM Map465.6UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301793Tlsr3_mthymic lymphoma suppressor region 3 (mouse)Not determined4129465811136864536Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4141154Nba1_mNew Zealand Black autoimmunity 1 (mouse)Not determined131650724140879275Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
4142082Psds2_mpsoriasis-like skin disease severity 2 (mouse)Not determined4133154678137617995Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:932
Count of miRNA genes:527
Interacting mature miRNAs:615
Transcripts:ENSMUST00000030432, ENSMUST00000134135, ENSMUST00000135644, ENSMUST00000148613, ENSMUST00000151879
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB852743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX631310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S65036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000030432   ⟹   ENSMUSP00000030432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4135,673,759 - 135,689,928 (+)Ensembl
GRCm38.p6 Ensembl4135,946,448 - 135,962,617 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134135
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4135,673,776 - 135,688,219 (+)Ensembl
GRCm38.p6 Ensembl4135,946,465 - 135,960,908 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135644
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4135,687,643 - 135,689,527 (+)Ensembl
GRCm38.p6 Ensembl4135,960,332 - 135,962,216 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148613
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4135,687,038 - 135,689,928 (+)Ensembl
GRCm38.p6 Ensembl4135,959,727 - 135,962,617 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151879
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4135,675,841 - 135,686,060 (+)Ensembl
GRCm38.p6 Ensembl4135,948,530 - 135,958,749 (+)Ensembl
RefSeq Acc Id: NM_001357529   ⟹   NP_001344458
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394135,674,717 - 135,689,979 (+)NCBI
GRCm384135,947,406 - 135,962,668 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357530   ⟹   NP_001344459
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394135,674,717 - 135,689,979 (+)NCBI
GRCm384135,947,406 - 135,962,668 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008254   ⟹   NP_032280
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394135,673,759 - 135,689,979 (+)NCBI
GRCm384135,946,448 - 135,962,668 (+)NCBI
MGSCv374135,502,368 - 135,518,532 (+)RGD
Celera4134,147,609 - 134,163,748 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538564   ⟹   XP_006538627
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394135,673,745 - 135,689,926 (+)NCBI
GRCm384135,946,448 - 135,962,615 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032280   ⟸   NM_008254
- Peptide Label: isoform 1 precursor
- UniProtKB: P38060 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006538627   ⟸   XM_006538564
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001344459   ⟸   NM_001357530
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001344458   ⟸   NM_001357529
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000030432   ⟸   ENSMUST00000030432
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38060-F1-model_v2 AlphaFold P38060 1-325 view protein structure

Promoters
RGD ID:6835472
Promoter ID:MM_KWN:40177
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000022820,   OTTMUST00000022821,   UC008VHJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364135,501,911 - 135,502,477 (+)MPROMDB
RGD ID:6835469
Promoter ID:MM_KWN:40178
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:OTTMUST00000022822
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364135,503,811 - 135,504,311 (+)MPROMDB
RGD ID:6835470
Promoter ID:MM_KWN:40179
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000022823
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364135,514,551 - 135,515,051 (+)MPROMDB
RGD ID:6835471
Promoter ID:MM_KWN:40180
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000022824
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364135,515,381 - 135,516,797 (+)MPROMDB
RGD ID:6885116
Promoter ID:EPDNEW_M5995
Type:multiple initiation site
Name:Hmgcl_1
Description:Mus musculus 3-hydroxy-3-methylglutaryl-Coenzyme A lyase , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384135,946,465 - 135,946,525EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96158 AgrOrtholog
Ensembl Genes ENSMUSG00000028672 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000030432 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030432 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_CoA_lyase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15356 UniProtKB/Swiss-Prot
MGD MGI:96158 ENTREZGENE
NCBI Gene 15356 ENTREZGENE
PANTHER PTHR42738 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMGL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmgcl PhenoGen
PROSITE HMG_COA_LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HMGCL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UMP2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8QZS6 UniProtKB/Swiss-Prot